. | APOE ε4a(n = 30) . | APOE ε3/3(n = 30) . | APOE ε4/4(n = 10) . | APOE ε3/4(n = 10) . | APOE ε3/3(n = 10) . |
|---|---|---|---|---|---|
| Female/male . | 19/11 . | 18/12 . | 9/1 . | 7/3 . | 8/2 . |
| Age | 65.3 (7.9) | 66.6 (8.3) | 61.2 (9.4) | 65.0 (8.5) | 64 (11.1) |
| Range | 49–74 | 49–79 | 49–74 | 49–74 | 50–79 |
| Education (years) | 10.6 (3.5) | 10.2 (3.3) | 11.7 (3.1) | 10.7 (4.0) | 11.8 (3.1) |
| Range | 6–17 | 6–16 | 8–16 | 6–17 | 9–16 |
| MMSE | 28.2 (1.5) | 27.9 (1.7) | 28.5 (1.4) | 28.4 (1.4) | 28.1 (2.1) |
| Range | 24–30 | 24–30 | 26–30 | 26–30 | 24–30 |
| MMSEb (2 years later) | 28.3 (1.5) | 28.3 (1.6) | 27.9 (2.0) | 28.7 (1.1) | 28.3 (1.6) |
| Range | 25–30 | 26–30 | 25–30 | 27–30 | 26–30 |
| SRB | 25.0 (2.4) | 22.6 (4.8) | 23.7 (2.8) | 25.3 (2.4) | 23.2 (3.8) |
| Range | 16–29 | 11–29 | 16–26 | 22–29 | 17–28 |
| SRBb (2 years later) | 24.9 (2.5) | 23.4 (4.5) | 24.3 (3.2) | 25.3 (1.8) | 23.4 (4.5) |
| Range | 18–28 | 14–28 | 18–27 | 23–28 | 14–28 |
| AD in family (N) | 2 | 0 | 0 | 1 | 0 |
. | APOE ε4a(n = 30) . | APOE ε3/3(n = 30) . | APOE ε4/4(n = 10) . | APOE ε3/4(n = 10) . | APOE ε3/3(n = 10) . |
|---|---|---|---|---|---|
| Female/male . | 19/11 . | 18/12 . | 9/1 . | 7/3 . | 8/2 . |
| Age | 65.3 (7.9) | 66.6 (8.3) | 61.2 (9.4) | 65.0 (8.5) | 64 (11.1) |
| Range | 49–74 | 49–79 | 49–74 | 49–74 | 50–79 |
| Education (years) | 10.6 (3.5) | 10.2 (3.3) | 11.7 (3.1) | 10.7 (4.0) | 11.8 (3.1) |
| Range | 6–17 | 6–16 | 8–16 | 6–17 | 9–16 |
| MMSE | 28.2 (1.5) | 27.9 (1.7) | 28.5 (1.4) | 28.4 (1.4) | 28.1 (2.1) |
| Range | 24–30 | 24–30 | 26–30 | 26–30 | 24–30 |
| MMSEb (2 years later) | 28.3 (1.5) | 28.3 (1.6) | 27.9 (2.0) | 28.7 (1.1) | 28.3 (1.6) |
| Range | 25–30 | 26–30 | 25–30 | 27–30 | 26–30 |
| SRB | 25.0 (2.4) | 22.6 (4.8) | 23.7 (2.8) | 25.3 (2.4) | 23.2 (3.8) |
| Range | 16–29 | 11–29 | 16–26 | 22–29 | 17–28 |
| SRBb (2 years later) | 24.9 (2.5) | 23.4 (4.5) | 24.3 (3.2) | 25.3 (1.8) | 23.4 (4.5) |
| Range | 18–28 | 14–28 | 18–27 | 23–28 | 14–28 |
| AD in family (N) | 2 | 0 | 0 | 1 | 0 |
Means and standard deviations (in parentheses).
MMSE = Mini-Mental State Examination (maximum = 30). SRB = word comprehension (maximum = 30). AD in family = first-degree family history of AD. The three right-most columns represent the matched subgroups.
Carriers of at least one copy of the APOE ε4 allele: 10 with APOE ε4/4; 20 with APOE ε3/4;
follow-up test; ∼2 years after fMRI-testing.
. | APOE ε4a(n = 30) . | APOE ε3/3(n = 30) . | APOE ε4/4(n = 10) . | APOE ε3/4(n = 10) . | APOE ε3/3(n = 10) . |
|---|---|---|---|---|---|
| Female/male . | 19/11 . | 18/12 . | 9/1 . | 7/3 . | 8/2 . |
| Age | 65.3 (7.9) | 66.6 (8.3) | 61.2 (9.4) | 65.0 (8.5) | 64 (11.1) |
| Range | 49–74 | 49–79 | 49–74 | 49–74 | 50–79 |
| Education (years) | 10.6 (3.5) | 10.2 (3.3) | 11.7 (3.1) | 10.7 (4.0) | 11.8 (3.1) |
| Range | 6–17 | 6–16 | 8–16 | 6–17 | 9–16 |
| MMSE | 28.2 (1.5) | 27.9 (1.7) | 28.5 (1.4) | 28.4 (1.4) | 28.1 (2.1) |
| Range | 24–30 | 24–30 | 26–30 | 26–30 | 24–30 |
| MMSEb (2 years later) | 28.3 (1.5) | 28.3 (1.6) | 27.9 (2.0) | 28.7 (1.1) | 28.3 (1.6) |
| Range | 25–30 | 26–30 | 25–30 | 27–30 | 26–30 |
| SRB | 25.0 (2.4) | 22.6 (4.8) | 23.7 (2.8) | 25.3 (2.4) | 23.2 (3.8) |
| Range | 16–29 | 11–29 | 16–26 | 22–29 | 17–28 |
| SRBb (2 years later) | 24.9 (2.5) | 23.4 (4.5) | 24.3 (3.2) | 25.3 (1.8) | 23.4 (4.5) |
| Range | 18–28 | 14–28 | 18–27 | 23–28 | 14–28 |
| AD in family (N) | 2 | 0 | 0 | 1 | 0 |
. | APOE ε4a(n = 30) . | APOE ε3/3(n = 30) . | APOE ε4/4(n = 10) . | APOE ε3/4(n = 10) . | APOE ε3/3(n = 10) . |
|---|---|---|---|---|---|
| Female/male . | 19/11 . | 18/12 . | 9/1 . | 7/3 . | 8/2 . |
| Age | 65.3 (7.9) | 66.6 (8.3) | 61.2 (9.4) | 65.0 (8.5) | 64 (11.1) |
| Range | 49–74 | 49–79 | 49–74 | 49–74 | 50–79 |
| Education (years) | 10.6 (3.5) | 10.2 (3.3) | 11.7 (3.1) | 10.7 (4.0) | 11.8 (3.1) |
| Range | 6–17 | 6–16 | 8–16 | 6–17 | 9–16 |
| MMSE | 28.2 (1.5) | 27.9 (1.7) | 28.5 (1.4) | 28.4 (1.4) | 28.1 (2.1) |
| Range | 24–30 | 24–30 | 26–30 | 26–30 | 24–30 |
| MMSEb (2 years later) | 28.3 (1.5) | 28.3 (1.6) | 27.9 (2.0) | 28.7 (1.1) | 28.3 (1.6) |
| Range | 25–30 | 26–30 | 25–30 | 27–30 | 26–30 |
| SRB | 25.0 (2.4) | 22.6 (4.8) | 23.7 (2.8) | 25.3 (2.4) | 23.2 (3.8) |
| Range | 16–29 | 11–29 | 16–26 | 22–29 | 17–28 |
| SRBb (2 years later) | 24.9 (2.5) | 23.4 (4.5) | 24.3 (3.2) | 25.3 (1.8) | 23.4 (4.5) |
| Range | 18–28 | 14–28 | 18–27 | 23–28 | 14–28 |
| AD in family (N) | 2 | 0 | 0 | 1 | 0 |
Means and standard deviations (in parentheses).
MMSE = Mini-Mental State Examination (maximum = 30). SRB = word comprehension (maximum = 30). AD in family = first-degree family history of AD. The three right-most columns represent the matched subgroups.
Carriers of at least one copy of the APOE ε4 allele: 10 with APOE ε4/4; 20 with APOE ε3/4;
follow-up test; ∼2 years after fMRI-testing.
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