Table 1 Open in new tab HR-PQCT I vs μCT...

	Left radius	Left tibia
	Mean ± SD	Mean ± SD	HR-PQCT I—μCT [95% CI]	HR-PQCT I—μCT [95% CI]	R²	Mean ± SD	Mean ± SD	HR-PQCT I—μCT [95% CI]	HR-PQCT I—μCT [95% CI]	R²
BV/TV	0.203 ± 0.044	0.131 ± 0.030	0.071^b [0.040, 0.103]	54.3 [30.2, 78.4]	0.92	0.228 ± 0.042	0.137 ± 0.029	0.091^b [0.061, 0.122]	66.8 [44.5, 89.1]	0.93
pBV/TV	0.073 ± 0.032	0.095 ± 0.032	−0.022^b [−0.049, 0.005]	−23.1 [−51.3, 5.1]	0.92	0.084 ± 0.029	0.108 ± 0.028	−0.025^b [−0.049, −0.001]	−22.8 [−45.0, −0.5]	0.83
rBV/TV	0.130 ± 0.021	0.036 ± 0.008	0.093^b [0.080, 0.107]	256.7 [219.7, 293.8]	0.23	0.145 ± 0.026	0.029 ± 0.007	0.116^b [0.100, 0.132]	404.0 [348.5, 459.5]	0.47
aBV/TV	0.079 ± 0.025	0.095 ± 0.027	−0.015^b [−0.037, 0.007]	−16.2 [−39.7, 7.3]	0.93	0.084 ± 0.021	0.104 ± 0.025	−0.020^b [−0.040, −0.001]	−19.6 [−38.4, −0.7]	0.87
pBV/BV	0.347 ± 0.095	0.708 ± 0.094	−0.361^b [−0.441, −0.282]	−51.0 [−62.2, −39.8]	0.84	0.361 ± 0.087	0.784 ± 0.062	−0.423^b [−0.487, −0.359]	−54.0 [−62.1, −45.8]	0.68
rBV/BV	0.653 ± 0.095	0.292 ± 0.094	0.361^b [0.282, 0.441]	123.6 [96.3, 150.8]	0.84	0.639 ± 0.087	0.216 ± 0.062	0.423^b [0.359, 0.487]	195.8 [166.3, 225.3]	0.68
pTb.N	1.213 ± 0.171	1.661 ± 0.143	−0.448^b [−0.581, −0.315]	−27.0 [−35.0, −19.0]	0.80	1.305 ± 0.123	1.647 ± 0.104	−0.342^b [−0.438, −0.246]	−20.8 [−26.6, −14.9]	0.35
rTb.N	1.638 ± 0.105	1.495 ± 0.122	0.143^b [0.047, 0.238]	9.5 [3.1, 15.9]	0.08	1.762 ± 0.130	1.323 ± 0.130	0.439^b [0.330, 0.548]	33.2 [24.9, 41.4]	0.43
pTb.Th	0.223 ± 0.008	0.133 ± 0.010	0.090^b [0.082, 0.098]	67.7 [61.9, 73.5]	0.40	0.222 ± 0.011	0.141 ± 0.012	0.080^b [0.071, 0.090]	56.9 [50.0, 63.9]	0.67
rTb.Th	0.223 ± 0.007	0.135 ± 0.010	0.088^b [0.081, 0.095]	65.0 [59.9, 70.2]	0.63	0.217 ± 0.005	0.143 ± 0.013	0.073^b [0.065, 0.082]	51.0 [45.0, 57.0]	0.57
pTb.S	0.171 ± 0.012	0.150 ± 0.015	0.022^a [0.010, 0.033]	14.4 [6.8, 22.0]	0.60	0.162 ± 0.011	0.168 ± 0.019	−0.006^a [−0.019, 0.007]	−3.6 [−11.5, 4.3]	0.70
rTb.l	0.699 ± 0.034	0.686 ± 0.018	0.013^b [−0.009, 0.036]	1.9 [−1.3, 5.2]	0.63	0.658 ± 0.016	0.686 ± 0.032	−0.028^b [−0.049, −0.007]	−4.1 [−7.2, −1.0]	0.28
R-R Junc.D^c	2.050 ± 0.430	1.470 ± 0.522	0.580^b [0.177, 0.983]	39.5 [12.1, 66.8]	0.08	2.554 ± 0.583	0.936 ± 0.460	1.617^b [1.176, 2.059]	172.7 [125.5, 219.9]	0.45
P-R Junc.D^c	2.297 ± 0.752	5.181 ± 0.979	−2.884^b [−3.619, −2.149]	−55.7 [−69.8, −41.5]	0.15	2.947 ± 0.651	4.397 ± 1.227	−1.450^b [−2.276, −0.623]	−33.0 [−51.8, −14.2]	0.08
P-P Junc.D^c	1.185 ± 0.459	4.982 ± 1.082	−3.797^b [−3.013, −1.450]	−76.2 [−90.3, −62.2]	0.54	1.487 ± 0.385	4.666 ± 1.095	−3.179^b [−3.870, −2.488]	−68.1 [−82.9, −53.3]	0.15
PR Ratio	0.565 ± 0.245	2.796 ± 1.290	−2.232^b [−3.013, −1.450]	−79.8 [−107.8, −51.9]	0.83	0.593 ± 0.223	3.986 ± 1.378	−3.392^b [−4.223, −2.562]	−85.1 [−106.0, 64.3]	0.60
PR N Ratio	0.740 ± 0.089	1.120 ± 0.149	−0.380^b [−0.483, −0.277]	−33.9 [−43.1, −24.7]	0.85	0.744 ± 0.081	1.253 ± 0.115	−0.509^b [−0.593, −0.426]	−40.6 [−47.3, −34.0]	0.65

Left radius

Left tibia

HR-PQCT I^c

μCT^c

Absolute difference

% Difference

Coefficient of determination

HR-PQCT I^c

μCT^c

Absolute difference

% Difference

Coefficient of determination

Mean ± SD

HR-PQCT I—μCT
[95% CI]

R²

Mean ± SD

HR-PQCT I—μCT
[95% CI]

R²

BV/TV

0.203 ± 0.044

0.131 ± 0.030

0.071^b [0.040, 0.103]

54.3 [30.2, 78.4]

0.92

0.228 ± 0.042

0.137 ± 0.029

0.091^b
[0.061, 0.122]

66.8
[44.5, 89.1]

0.93

pBV/TV

0.073 ± 0.032

0.095 ± 0.032

−0.022^b
[−0.049, 0.005]

−23.1
[−51.3, 5.1]

0.92

0.084 ± 0.029

0.108 ± 0.028

−0.025^b
[−0.049, −0.001]

−22.8
[−45.0, −0.5]

0.83

rBV/TV

0.130 ± 0.021

0.036 ± 0.008

0.093^b [0.080, 0.107]

256.7 [219.7, 293.8]

0.23

0.145 ± 0.026

0.029 ± 0.007

0.116^b [0.100, 0.132]

404.0 [348.5, 459.5]

0.47

aBV/TV

0.079 ± 0.025

0.095 ± 0.027

−0.015^b
[−0.037, 0.007]

−16.2
[−39.7, 7.3]

0.93

0.084 ± 0.021

0.104 ± 0.025

−0.020^b
[−0.040, −0.001]

−19.6
[−38.4, −0.7]

0.87

pBV/BV

0.347 ± 0.095

0.708 ± 0.094

−0.361^b
[−0.441, −0.282]

−51.0
[−62.2, −39.8]

0.84

0.361 ± 0.087

0.784 ± 0.062

−0.423^b
[−0.487, −0.359]

−54.0
[−62.1, −45.8]

0.68

rBV/BV

0.653 ± 0.095

0.292 ± 0.094

0.361^b [0.282, 0.441]

123.6
[96.3, 150.8]

0.84

0.639 ± 0.087

0.216 ± 0.062

0.423^b [0.359, 0.487]

195.8 [166.3, 225.3]

0.68

pTb.N

1.213 ± 0.171

1.661 ± 0.143

−0.448^b
[−0.581, −0.315]

−27.0
[−35.0, −19.0]

0.80

1.305 ± 0.123

1.647 ± 0.104

−0.342^b
[−0.438, −0.246]

−20.8
[−26.6, −14.9]

0.35

rTb.N

1.638 ± 0.105

1.495 ± 0.122

0.143^b [0.047, 0.238]

9.5
[3.1, 15.9]

0.08

1.762 ± 0.130

1.323 ± 0.130

0.439^b [0.330, 0.548]

33.2
[24.9, 41.4]

0.43

pTb.Th

0.223 ± 0.008

0.133 ± 0.010

0.090^b [0.082, 0.098]

67.7
[61.9, 73.5]

0.40

0.222 ± 0.011

0.141 ± 0.012

0.080^b [0.071, 0.090]

56.9
[50.0, 63.9]

0.67

rTb.Th

0.223 ± 0.007

0.135 ± 0.010

0.088^b [0.081, 0.095]

65.0
[59.9, 70.2]

0.63

0.217 ± 0.005

0.143 ± 0.013

0.073^b [0.065, 0.082]

51.0
[45.0, 57.0]

0.57

pTb.S

0.171 ± 0.012

0.150 ± 0.015

0.022^a [0.010, 0.033]

14.4
[6.8, 22.0]

0.60

0.162 ± 0.011

0.168 ± 0.019

−0.006^a
[−0.019, 0.007]

−3.6
[−11.5, 4.3]

0.70

rTb.l

0.699 ± 0.034

0.686 ± 0.018

0.013^b
[−0.009, 0.036]

1.9
[−1.3, 5.2]

0.63

0.658 ± 0.016

0.686 ± 0.032

−0.028^b
[−0.049, −0.007]

−4.1
[−7.2, −1.0]

0.28

R-R Junc.D^c

2.050 ± 0.430

1.470 ± 0.522

0.580^b [0.177, 0.983]

39.5
[12.1, 66.8]

0.08

2.554 ± 0.583

0.936 ± 0.460

1.617^b [1.176, 2.059]

172.7 [125.5, 219.9]

0.45

P-R Junc.D^c

2.297 ± 0.752

5.181 ± 0.979

−2.884^b
[−3.619, −2.149]

−55.7
[−69.8, −41.5]

0.15

2.947 ± 0.651

4.397 ± 1.227

−1.450^b
[−2.276, −0.623]

−33.0
[−51.8, −14.2]

0.08

P-P Junc.D^c

1.185 ± 0.459

4.982 ± 1.082

−3.797^b
[−3.013, −1.450]

−76.2
[−90.3, −62.2]

0.54

1.487 ± 0.385

4.666 ± 1.095

−3.179^b
[−3.870, −2.488]

−68.1
[−82.9, −53.3]

0.15

PR Ratio

0.565 ± 0.245

2.796 ± 1.290

−2.232^b
[−3.013, −1.450]

−79.8
[−107.8, −51.9]

0.83

0.593 ± 0.223

3.986 ± 1.378

−3.392^b
[−4.223, −2.562]

−85.1
[−106.0, 64.3]

0.60

PR N Ratio

0.740 ± 0.089

1.120 ± 0.149

−0.380^b
[−0.483, −0.277]

−33.9
[−43.1, −24.7]

0.85

0.744 ± 0.081

1.253 ± 0.115

−0.509^b
[−0.593, −0.426]

−40.6 [−47.3, −34.0]

0.65

	Left radius	Left tibia
	Mean ± SD	Mean ± SD	HR-PQCT I—μCT [95% CI]	HR-PQCT I—μCT [95% CI]	R²	Mean ± SD	Mean ± SD	HR-PQCT I—μCT [95% CI]	HR-PQCT I—μCT [95% CI]	R²
BV/TV	0.203 ± 0.044	0.131 ± 0.030	0.071^b [0.040, 0.103]	54.3 [30.2, 78.4]	0.92	0.228 ± 0.042	0.137 ± 0.029	0.091^b [0.061, 0.122]	66.8 [44.5, 89.1]	0.93
pBV/TV	0.073 ± 0.032	0.095 ± 0.032	−0.022^b [−0.049, 0.005]	−23.1 [−51.3, 5.1]	0.92	0.084 ± 0.029	0.108 ± 0.028	−0.025^b [−0.049, −0.001]	−22.8 [−45.0, −0.5]	0.83
rBV/TV	0.130 ± 0.021	0.036 ± 0.008	0.093^b [0.080, 0.107]	256.7 [219.7, 293.8]	0.23	0.145 ± 0.026	0.029 ± 0.007	0.116^b [0.100, 0.132]	404.0 [348.5, 459.5]	0.47
aBV/TV	0.079 ± 0.025	0.095 ± 0.027	−0.015^b [−0.037, 0.007]	−16.2 [−39.7, 7.3]	0.93	0.084 ± 0.021	0.104 ± 0.025	−0.020^b [−0.040, −0.001]	−19.6 [−38.4, −0.7]	0.87
pBV/BV	0.347 ± 0.095	0.708 ± 0.094	−0.361^b [−0.441, −0.282]	−51.0 [−62.2, −39.8]	0.84	0.361 ± 0.087	0.784 ± 0.062	−0.423^b [−0.487, −0.359]	−54.0 [−62.1, −45.8]	0.68
rBV/BV	0.653 ± 0.095	0.292 ± 0.094	0.361^b [0.282, 0.441]	123.6 [96.3, 150.8]	0.84	0.639 ± 0.087	0.216 ± 0.062	0.423^b [0.359, 0.487]	195.8 [166.3, 225.3]	0.68
pTb.N	1.213 ± 0.171	1.661 ± 0.143	−0.448^b [−0.581, −0.315]	−27.0 [−35.0, −19.0]	0.80	1.305 ± 0.123	1.647 ± 0.104	−0.342^b [−0.438, −0.246]	−20.8 [−26.6, −14.9]	0.35
rTb.N	1.638 ± 0.105	1.495 ± 0.122	0.143^b [0.047, 0.238]	9.5 [3.1, 15.9]	0.08	1.762 ± 0.130	1.323 ± 0.130	0.439^b [0.330, 0.548]	33.2 [24.9, 41.4]	0.43
pTb.Th	0.223 ± 0.008	0.133 ± 0.010	0.090^b [0.082, 0.098]	67.7 [61.9, 73.5]	0.40	0.222 ± 0.011	0.141 ± 0.012	0.080^b [0.071, 0.090]	56.9 [50.0, 63.9]	0.67
rTb.Th	0.223 ± 0.007	0.135 ± 0.010	0.088^b [0.081, 0.095]	65.0 [59.9, 70.2]	0.63	0.217 ± 0.005	0.143 ± 0.013	0.073^b [0.065, 0.082]	51.0 [45.0, 57.0]	0.57
pTb.S	0.171 ± 0.012	0.150 ± 0.015	0.022^a [0.010, 0.033]	14.4 [6.8, 22.0]	0.60	0.162 ± 0.011	0.168 ± 0.019	−0.006^a [−0.019, 0.007]	−3.6 [−11.5, 4.3]	0.70
rTb.l	0.699 ± 0.034	0.686 ± 0.018	0.013^b [−0.009, 0.036]	1.9 [−1.3, 5.2]	0.63	0.658 ± 0.016	0.686 ± 0.032	−0.028^b [−0.049, −0.007]	−4.1 [−7.2, −1.0]	0.28
R-R Junc.D^c	2.050 ± 0.430	1.470 ± 0.522	0.580^b [0.177, 0.983]	39.5 [12.1, 66.8]	0.08	2.554 ± 0.583	0.936 ± 0.460	1.617^b [1.176, 2.059]	172.7 [125.5, 219.9]	0.45
P-R Junc.D^c	2.297 ± 0.752	5.181 ± 0.979	−2.884^b [−3.619, −2.149]	−55.7 [−69.8, −41.5]	0.15	2.947 ± 0.651	4.397 ± 1.227	−1.450^b [−2.276, −0.623]	−33.0 [−51.8, −14.2]	0.08
P-P Junc.D^c	1.185 ± 0.459	4.982 ± 1.082	−3.797^b [−3.013, −1.450]	−76.2 [−90.3, −62.2]	0.54	1.487 ± 0.385	4.666 ± 1.095	−3.179^b [−3.870, −2.488]	−68.1 [−82.9, −53.3]	0.15
PR Ratio	0.565 ± 0.245	2.796 ± 1.290	−2.232^b [−3.013, −1.450]	−79.8 [−107.8, −51.9]	0.83	0.593 ± 0.223	3.986 ± 1.378	−3.392^b [−4.223, −2.562]	−85.1 [−106.0, 64.3]	0.60
PR N Ratio	0.740 ± 0.089	1.120 ± 0.149	−0.380^b [−0.483, −0.277]	−33.9 [−43.1, −24.7]	0.85	0.744 ± 0.081	1.253 ± 0.115	−0.509^b [−0.593, −0.426]	−40.6 [−47.3, −34.0]	0.65

Left radius

Left tibia

HR-PQCT I^c

μCT^c

Absolute difference

% Difference

Coefficient of determination

HR-PQCT I^c

μCT^c

Absolute difference

% Difference

Coefficient of determination

Mean ± SD

HR-PQCT I—μCT
[95% CI]

R²

Mean ± SD

HR-PQCT I—μCT
[95% CI]

R²

BV/TV

0.203 ± 0.044

0.131 ± 0.030

0.071^b [0.040, 0.103]

54.3 [30.2, 78.4]

0.92

0.228 ± 0.042

0.137 ± 0.029

0.091^b
[0.061, 0.122]

66.8
[44.5, 89.1]

0.93

pBV/TV

0.073 ± 0.032

0.095 ± 0.032

−0.022^b
[−0.049, 0.005]

−23.1
[−51.3, 5.1]

0.92

0.084 ± 0.029

0.108 ± 0.028

−0.025^b
[−0.049, −0.001]

−22.8
[−45.0, −0.5]

0.83

rBV/TV

0.130 ± 0.021

0.036 ± 0.008

0.093^b [0.080, 0.107]

256.7 [219.7, 293.8]

0.23

0.145 ± 0.026

0.029 ± 0.007

0.116^b [0.100, 0.132]

404.0 [348.5, 459.5]

0.47

aBV/TV

0.079 ± 0.025

0.095 ± 0.027

−0.015^b
[−0.037, 0.007]

−16.2
[−39.7, 7.3]

0.93

0.084 ± 0.021

0.104 ± 0.025

−0.020^b
[−0.040, −0.001]

−19.6
[−38.4, −0.7]

0.87

pBV/BV

0.347 ± 0.095

0.708 ± 0.094

−0.361^b
[−0.441, −0.282]

−51.0
[−62.2, −39.8]

0.84

0.361 ± 0.087

0.784 ± 0.062

−0.423^b
[−0.487, −0.359]

−54.0
[−62.1, −45.8]

0.68

rBV/BV

0.653 ± 0.095

0.292 ± 0.094

0.361^b [0.282, 0.441]

123.6
[96.3, 150.8]

0.84

0.639 ± 0.087

0.216 ± 0.062

0.423^b [0.359, 0.487]

195.8 [166.3, 225.3]

0.68

pTb.N

1.213 ± 0.171

1.661 ± 0.143

−0.448^b
[−0.581, −0.315]

−27.0
[−35.0, −19.0]

0.80

1.305 ± 0.123

1.647 ± 0.104

−0.342^b
[−0.438, −0.246]

−20.8
[−26.6, −14.9]

0.35

rTb.N

1.638 ± 0.105

1.495 ± 0.122

0.143^b [0.047, 0.238]

9.5
[3.1, 15.9]

0.08

1.762 ± 0.130

1.323 ± 0.130

0.439^b [0.330, 0.548]

33.2
[24.9, 41.4]

0.43

pTb.Th

0.223 ± 0.008

0.133 ± 0.010

0.090^b [0.082, 0.098]

67.7
[61.9, 73.5]

0.40

0.222 ± 0.011

0.141 ± 0.012

0.080^b [0.071, 0.090]

56.9
[50.0, 63.9]

0.67

rTb.Th

0.223 ± 0.007

0.135 ± 0.010

0.088^b [0.081, 0.095]

65.0
[59.9, 70.2]

0.63

0.217 ± 0.005

0.143 ± 0.013

0.073^b [0.065, 0.082]

51.0
[45.0, 57.0]

0.57

pTb.S

0.171 ± 0.012

0.150 ± 0.015

0.022^a [0.010, 0.033]

14.4
[6.8, 22.0]

0.60

0.162 ± 0.011

0.168 ± 0.019

−0.006^a
[−0.019, 0.007]

−3.6
[−11.5, 4.3]

0.70

rTb.l

0.699 ± 0.034

0.686 ± 0.018

0.013^b
[−0.009, 0.036]

1.9
[−1.3, 5.2]

0.63

0.658 ± 0.016

0.686 ± 0.032

−0.028^b
[−0.049, −0.007]

−4.1
[−7.2, −1.0]

0.28

R-R Junc.D^c

2.050 ± 0.430

1.470 ± 0.522

0.580^b [0.177, 0.983]

39.5
[12.1, 66.8]

0.08

2.554 ± 0.583

0.936 ± 0.460

1.617^b [1.176, 2.059]

172.7 [125.5, 219.9]

0.45

P-R Junc.D^c

2.297 ± 0.752

5.181 ± 0.979

−2.884^b
[−3.619, −2.149]

−55.7
[−69.8, −41.5]

0.15

2.947 ± 0.651

4.397 ± 1.227

−1.450^b
[−2.276, −0.623]

−33.0
[−51.8, −14.2]

0.08

P-P Junc.D^c

1.185 ± 0.459

4.982 ± 1.082

−3.797^b
[−3.013, −1.450]

−76.2
[−90.3, −62.2]

0.54

1.487 ± 0.385

4.666 ± 1.095

−3.179^b
[−3.870, −2.488]

−68.1
[−82.9, −53.3]

0.15

PR Ratio

0.565 ± 0.245

2.796 ± 1.290

−2.232^b
[−3.013, −1.450]

−79.8
[−107.8, −51.9]

0.83

0.593 ± 0.223

3.986 ± 1.378

−3.392^b
[−4.223, −2.562]

−85.1
[−106.0, 64.3]

0.60

PR N Ratio

0.740 ± 0.089

1.120 ± 0.149

−0.380^b
[−0.483, −0.277]

−33.9
[−43.1, −24.7]

0.85

0.744 ± 0.081

1.253 ± 0.115

−0.509^b
[−0.593, −0.426]

−40.6 [−47.3, −34.0]

0.65

Table 1

Open in new tab

HR-PQCT I vs μCT ITS morphological parameters in the distal radius and tibia with difference and correlation coefficients calculated.

	Left radius					Left tibia
	HR-PQCT I^c	μCT^c	Absolute difference	% Difference	Coefficient of determination	HR-PQCT I^c	μCT^c	Absolute difference	% Difference	Coefficient of determination
	Mean ± SD	Mean ± SD	HR-PQCT I—μCT [95% CI]	HR-PQCT I—μCT [95% CI]	R²	Mean ± SD	Mean ± SD	HR-PQCT I—μCT [95% CI]	HR-PQCT I—μCT [95% CI]	R²
BV/TV	0.203 ± 0.044	0.131 ± 0.030	0.071^b [0.040, 0.103]	54.3 [30.2, 78.4]	0.92	0.228 ± 0.042	0.137 ± 0.029	0.091^b [0.061, 0.122]	66.8 [44.5, 89.1]	0.93
pBV/TV	0.073 ± 0.032	0.095 ± 0.032	−0.022^b [−0.049, 0.005]	−23.1 [−51.3, 5.1]	0.92	0.084 ± 0.029	0.108 ± 0.028	−0.025^b [−0.049, −0.001]	−22.8 [−45.0, −0.5]	0.83
rBV/TV	0.130 ± 0.021	0.036 ± 0.008	0.093^b [0.080, 0.107]	256.7 [219.7, 293.8]	0.23	0.145 ± 0.026	0.029 ± 0.007	0.116^b [0.100, 0.132]	404.0 [348.5, 459.5]	0.47
aBV/TV	0.079 ± 0.025	0.095 ± 0.027	−0.015^b [−0.037, 0.007]	−16.2 [−39.7, 7.3]	0.93	0.084 ± 0.021	0.104 ± 0.025	−0.020^b [−0.040, −0.001]	−19.6 [−38.4, −0.7]	0.87
pBV/BV	0.347 ± 0.095	0.708 ± 0.094	−0.361^b [−0.441, −0.282]	−51.0 [−62.2, −39.8]	0.84	0.361 ± 0.087	0.784 ± 0.062	−0.423^b [−0.487, −0.359]	−54.0 [−62.1, −45.8]	0.68
rBV/BV	0.653 ± 0.095	0.292 ± 0.094	0.361^b [0.282, 0.441]	123.6 [96.3, 150.8]	0.84	0.639 ± 0.087	0.216 ± 0.062	0.423^b [0.359, 0.487]	195.8 [166.3, 225.3]	0.68
pTb.N	1.213 ± 0.171	1.661 ± 0.143	−0.448^b [−0.581, −0.315]	−27.0 [−35.0, −19.0]	0.80	1.305 ± 0.123	1.647 ± 0.104	−0.342^b [−0.438, −0.246]	−20.8 [−26.6, −14.9]	0.35
rTb.N	1.638 ± 0.105	1.495 ± 0.122	0.143^b [0.047, 0.238]	9.5 [3.1, 15.9]	0.08	1.762 ± 0.130	1.323 ± 0.130	0.439^b [0.330, 0.548]	33.2 [24.9, 41.4]	0.43
pTb.Th	0.223 ± 0.008	0.133 ± 0.010	0.090^b [0.082, 0.098]	67.7 [61.9, 73.5]	0.40	0.222 ± 0.011	0.141 ± 0.012	0.080^b [0.071, 0.090]	56.9 [50.0, 63.9]	0.67
rTb.Th	0.223 ± 0.007	0.135 ± 0.010	0.088^b [0.081, 0.095]	65.0 [59.9, 70.2]	0.63	0.217 ± 0.005	0.143 ± 0.013	0.073^b [0.065, 0.082]	51.0 [45.0, 57.0]	0.57
pTb.S	0.171 ± 0.012	0.150 ± 0.015	0.022^a [0.010, 0.033]	14.4 [6.8, 22.0]	0.60	0.162 ± 0.011	0.168 ± 0.019	−0.006^a [−0.019, 0.007]	−3.6 [−11.5, 4.3]	0.70
rTb.l	0.699 ± 0.034	0.686 ± 0.018	0.013^b [−0.009, 0.036]	1.9 [−1.3, 5.2]	0.63	0.658 ± 0.016	0.686 ± 0.032	−0.028^b [−0.049, −0.007]	−4.1 [−7.2, −1.0]	0.28
R-R Junc.D^c	2.050 ± 0.430	1.470 ± 0.522	0.580^b [0.177, 0.983]	39.5 [12.1, 66.8]	0.08	2.554 ± 0.583	0.936 ± 0.460	1.617^b [1.176, 2.059]	172.7 [125.5, 219.9]	0.45
P-R Junc.D^c	2.297 ± 0.752	5.181 ± 0.979	−2.884^b [−3.619, −2.149]	−55.7 [−69.8, −41.5]	0.15	2.947 ± 0.651	4.397 ± 1.227	−1.450^b [−2.276, −0.623]	−33.0 [−51.8, −14.2]	0.08
P-P Junc.D^c	1.185 ± 0.459	4.982 ± 1.082	−3.797^b [−3.013, −1.450]	−76.2 [−90.3, −62.2]	0.54	1.487 ± 0.385	4.666 ± 1.095	−3.179^b [−3.870, −2.488]	−68.1 [−82.9, −53.3]	0.15
PR Ratio	0.565 ± 0.245	2.796 ± 1.290	−2.232^b [−3.013, −1.450]	−79.8 [−107.8, −51.9]	0.83	0.593 ± 0.223	3.986 ± 1.378	−3.392^b [−4.223, −2.562]	−85.1 [−106.0, 64.3]	0.60
PR N Ratio	0.740 ± 0.089	1.120 ± 0.149	−0.380^b [−0.483, −0.277]	−33.9 [−43.1, −24.7]	0.85	0.744 ± 0.081	1.253 ± 0.115	−0.509^b [−0.593, −0.426]	−40.6 [−47.3, −34.0]	0.65

	Left radius					Left tibia
	HR-PQCT I^c	μCT^c	Absolute difference	% Difference	Coefficient of determination	HR-PQCT I^c	μCT^c	Absolute difference	% Difference	Coefficient of determination
	Mean ± SD	Mean ± SD	HR-PQCT I—μCT [95% CI]	HR-PQCT I—μCT [95% CI]	R²	Mean ± SD	Mean ± SD	HR-PQCT I—μCT [95% CI]	HR-PQCT I—μCT [95% CI]	R²
BV/TV	0.203 ± 0.044	0.131 ± 0.030	0.071^b [0.040, 0.103]	54.3 [30.2, 78.4]	0.92	0.228 ± 0.042	0.137 ± 0.029	0.091^b [0.061, 0.122]	66.8 [44.5, 89.1]	0.93
pBV/TV	0.073 ± 0.032	0.095 ± 0.032	−0.022^b [−0.049, 0.005]	−23.1 [−51.3, 5.1]	0.92	0.084 ± 0.029	0.108 ± 0.028	−0.025^b [−0.049, −0.001]	−22.8 [−45.0, −0.5]	0.83
rBV/TV	0.130 ± 0.021	0.036 ± 0.008	0.093^b [0.080, 0.107]	256.7 [219.7, 293.8]	0.23	0.145 ± 0.026	0.029 ± 0.007	0.116^b [0.100, 0.132]	404.0 [348.5, 459.5]	0.47
aBV/TV	0.079 ± 0.025	0.095 ± 0.027	−0.015^b [−0.037, 0.007]	−16.2 [−39.7, 7.3]	0.93	0.084 ± 0.021	0.104 ± 0.025	−0.020^b [−0.040, −0.001]	−19.6 [−38.4, −0.7]	0.87
pBV/BV	0.347 ± 0.095	0.708 ± 0.094	−0.361^b [−0.441, −0.282]	−51.0 [−62.2, −39.8]	0.84	0.361 ± 0.087	0.784 ± 0.062	−0.423^b [−0.487, −0.359]	−54.0 [−62.1, −45.8]	0.68
rBV/BV	0.653 ± 0.095	0.292 ± 0.094	0.361^b [0.282, 0.441]	123.6 [96.3, 150.8]	0.84	0.639 ± 0.087	0.216 ± 0.062	0.423^b [0.359, 0.487]	195.8 [166.3, 225.3]	0.68
pTb.N	1.213 ± 0.171	1.661 ± 0.143	−0.448^b [−0.581, −0.315]	−27.0 [−35.0, −19.0]	0.80	1.305 ± 0.123	1.647 ± 0.104	−0.342^b [−0.438, −0.246]	−20.8 [−26.6, −14.9]	0.35
rTb.N	1.638 ± 0.105	1.495 ± 0.122	0.143^b [0.047, 0.238]	9.5 [3.1, 15.9]	0.08	1.762 ± 0.130	1.323 ± 0.130	0.439^b [0.330, 0.548]	33.2 [24.9, 41.4]	0.43
pTb.Th	0.223 ± 0.008	0.133 ± 0.010	0.090^b [0.082, 0.098]	67.7 [61.9, 73.5]	0.40	0.222 ± 0.011	0.141 ± 0.012	0.080^b [0.071, 0.090]	56.9 [50.0, 63.9]	0.67
rTb.Th	0.223 ± 0.007	0.135 ± 0.010	0.088^b [0.081, 0.095]	65.0 [59.9, 70.2]	0.63	0.217 ± 0.005	0.143 ± 0.013	0.073^b [0.065, 0.082]	51.0 [45.0, 57.0]	0.57
pTb.S	0.171 ± 0.012	0.150 ± 0.015	0.022^a [0.010, 0.033]	14.4 [6.8, 22.0]	0.60	0.162 ± 0.011	0.168 ± 0.019	−0.006^a [−0.019, 0.007]	−3.6 [−11.5, 4.3]	0.70
rTb.l	0.699 ± 0.034	0.686 ± 0.018	0.013^b [−0.009, 0.036]	1.9 [−1.3, 5.2]	0.63	0.658 ± 0.016	0.686 ± 0.032	−0.028^b [−0.049, −0.007]	−4.1 [−7.2, −1.0]	0.28
R-R Junc.D^c	2.050 ± 0.430	1.470 ± 0.522	0.580^b [0.177, 0.983]	39.5 [12.1, 66.8]	0.08	2.554 ± 0.583	0.936 ± 0.460	1.617^b [1.176, 2.059]	172.7 [125.5, 219.9]	0.45
P-R Junc.D^c	2.297 ± 0.752	5.181 ± 0.979	−2.884^b [−3.619, −2.149]	−55.7 [−69.8, −41.5]	0.15	2.947 ± 0.651	4.397 ± 1.227	−1.450^b [−2.276, −0.623]	−33.0 [−51.8, −14.2]	0.08
P-P Junc.D^c	1.185 ± 0.459	4.982 ± 1.082	−3.797^b [−3.013, −1.450]	−76.2 [−90.3, −62.2]	0.54	1.487 ± 0.385	4.666 ± 1.095	−3.179^b [−3.870, −2.488]	−68.1 [−82.9, −53.3]	0.15
PR Ratio	0.565 ± 0.245	2.796 ± 1.290	−2.232^b [−3.013, −1.450]	−79.8 [−107.8, −51.9]	0.83	0.593 ± 0.223	3.986 ± 1.378	−3.392^b [−4.223, −2.562]	−85.1 [−106.0, 64.3]	0.60
PR N Ratio	0.740 ± 0.089	1.120 ± 0.149	−0.380^b [−0.483, −0.277]	−33.9 [−43.1, −24.7]	0.85	0.744 ± 0.081	1.253 ± 0.115	−0.509^b [−0.593, −0.426]	−40.6 [−47.3, −34.0]	0.65

^aP < .05, ^bP < .0001; Abbreviation: ^cHR-pQCT, high-resolution peripheral quantitative computed tomography; ITS, individual trabecula segmentation; μCT, micro-computed tomography; P-P Junc.D, plate-to-plate junction density; P-R Junc.D, plate-to-rod junction density; R-R Junc.D, rod-to-rod junction density.

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