Echocardiographic parameter evolution between the last available measurement within 18 months and baseline measurement expressed as annualized absolute difference mean and signed-rank testing for a mean equal to zero
| Parameter . | Baseline mean . | Last measure mean . | Absolute difference mean . | Standard error of the mean . | P-value . |
|---|---|---|---|---|---|
| Left ventricular ejection fraction (LVEF) (%) | 56.01 | 53.89 | −1.544 | 1.562 | 0.1675 |
| LV global longitudinal strain (%) | −12.53 | −10.92 | 1.473 | 0.354 | <0.0001 |
| Average LV basal longitudinal strain (%) | −5.70 | −4.63 | 1.137 | 0.442 | 0.0044 |
| Average LV apical longitudinal strain (%) | −18.94 | −16.48 | 2.227 | 0.595 | <0.0001 |
| LV apical/mid + basal longitudinal strain | 2.43 | 2.43 | 0.012 | 0.111 | 0.9050 |
| Global work index (mmHg%) | 1408.57 | 1027.26 | −299.005 | 153.605 | <0.0001 |
| Global constructive work (mmHg%) | 1438.16 | 1250.39 | −182.760 | 38.938 | <0.0001 |
| Global wasted work (mmHg%) | 162.22 | 144.52 | −16.918 | 13.297 | 0.2329 |
| Global work efficiency (%) | 86.01 | 85.51 | −0.433 | 1.048 | 0.3767 |
| RV free wall strain (%) | −18.36 | −17.11 | 1.571 | 1.193 | 0.1502 |
| RV apical/mid + bas longitudinal strain | 1.34 | 1.71 | 0.204 | 0.368 | 0.4396 |
| Tricuspid annular plane systolic excursion (mm) | 16.57 | 14.92 | −2.154 | 0.590 | 0.0010 |
| LA strain during reservoir phase (%, positive value) | 8.81 | 7.65 | −1.689 | 0.588 | 0.0067 |
| LA strain during contraction phase (%, negative value) | −2.40 | −1.95 | 0.699 | 0.415 | 0.2717 |
| LA volume index | 54.79 | 56.08 | 0.127 | 1.644 | 0.8964 |
| LV ED diameter (mm) | 44.28 | 42.32 | −2.284 | 0.767 | 0.0019 |
| Posterior wall thickness, diastole (mm) | 14.37 | 15.13 | 0.504 | 0.290 | 0.0302 |
| Inter-ventricular septal wall thickness, diastole (mm) | 15.97 | 16.72 | 0.473 | 0.311 | 0.0684 |
| LVOT VTI | 16.96 | 16.18 | −0.509 | 0.523 | 0.3865 |
| Parameter . | Baseline mean . | Last measure mean . | Absolute difference mean . | Standard error of the mean . | P-value . |
|---|---|---|---|---|---|
| Left ventricular ejection fraction (LVEF) (%) | 56.01 | 53.89 | −1.544 | 1.562 | 0.1675 |
| LV global longitudinal strain (%) | −12.53 | −10.92 | 1.473 | 0.354 | <0.0001 |
| Average LV basal longitudinal strain (%) | −5.70 | −4.63 | 1.137 | 0.442 | 0.0044 |
| Average LV apical longitudinal strain (%) | −18.94 | −16.48 | 2.227 | 0.595 | <0.0001 |
| LV apical/mid + basal longitudinal strain | 2.43 | 2.43 | 0.012 | 0.111 | 0.9050 |
| Global work index (mmHg%) | 1408.57 | 1027.26 | −299.005 | 153.605 | <0.0001 |
| Global constructive work (mmHg%) | 1438.16 | 1250.39 | −182.760 | 38.938 | <0.0001 |
| Global wasted work (mmHg%) | 162.22 | 144.52 | −16.918 | 13.297 | 0.2329 |
| Global work efficiency (%) | 86.01 | 85.51 | −0.433 | 1.048 | 0.3767 |
| RV free wall strain (%) | −18.36 | −17.11 | 1.571 | 1.193 | 0.1502 |
| RV apical/mid + bas longitudinal strain | 1.34 | 1.71 | 0.204 | 0.368 | 0.4396 |
| Tricuspid annular plane systolic excursion (mm) | 16.57 | 14.92 | −2.154 | 0.590 | 0.0010 |
| LA strain during reservoir phase (%, positive value) | 8.81 | 7.65 | −1.689 | 0.588 | 0.0067 |
| LA strain during contraction phase (%, negative value) | −2.40 | −1.95 | 0.699 | 0.415 | 0.2717 |
| LA volume index | 54.79 | 56.08 | 0.127 | 1.644 | 0.8964 |
| LV ED diameter (mm) | 44.28 | 42.32 | −2.284 | 0.767 | 0.0019 |
| Posterior wall thickness, diastole (mm) | 14.37 | 15.13 | 0.504 | 0.290 | 0.0302 |
| Inter-ventricular septal wall thickness, diastole (mm) | 15.97 | 16.72 | 0.473 | 0.311 | 0.0684 |
| LVOT VTI | 16.96 | 16.18 | −0.509 | 0.523 | 0.3865 |
Echocardiographic parameter evolution between the last available measurement within 18 months and baseline measurement expressed as annualized absolute difference mean and signed-rank testing for a mean equal to zero
| Parameter . | Baseline mean . | Last measure mean . | Absolute difference mean . | Standard error of the mean . | P-value . |
|---|---|---|---|---|---|
| Left ventricular ejection fraction (LVEF) (%) | 56.01 | 53.89 | −1.544 | 1.562 | 0.1675 |
| LV global longitudinal strain (%) | −12.53 | −10.92 | 1.473 | 0.354 | <0.0001 |
| Average LV basal longitudinal strain (%) | −5.70 | −4.63 | 1.137 | 0.442 | 0.0044 |
| Average LV apical longitudinal strain (%) | −18.94 | −16.48 | 2.227 | 0.595 | <0.0001 |
| LV apical/mid + basal longitudinal strain | 2.43 | 2.43 | 0.012 | 0.111 | 0.9050 |
| Global work index (mmHg%) | 1408.57 | 1027.26 | −299.005 | 153.605 | <0.0001 |
| Global constructive work (mmHg%) | 1438.16 | 1250.39 | −182.760 | 38.938 | <0.0001 |
| Global wasted work (mmHg%) | 162.22 | 144.52 | −16.918 | 13.297 | 0.2329 |
| Global work efficiency (%) | 86.01 | 85.51 | −0.433 | 1.048 | 0.3767 |
| RV free wall strain (%) | −18.36 | −17.11 | 1.571 | 1.193 | 0.1502 |
| RV apical/mid + bas longitudinal strain | 1.34 | 1.71 | 0.204 | 0.368 | 0.4396 |
| Tricuspid annular plane systolic excursion (mm) | 16.57 | 14.92 | −2.154 | 0.590 | 0.0010 |
| LA strain during reservoir phase (%, positive value) | 8.81 | 7.65 | −1.689 | 0.588 | 0.0067 |
| LA strain during contraction phase (%, negative value) | −2.40 | −1.95 | 0.699 | 0.415 | 0.2717 |
| LA volume index | 54.79 | 56.08 | 0.127 | 1.644 | 0.8964 |
| LV ED diameter (mm) | 44.28 | 42.32 | −2.284 | 0.767 | 0.0019 |
| Posterior wall thickness, diastole (mm) | 14.37 | 15.13 | 0.504 | 0.290 | 0.0302 |
| Inter-ventricular septal wall thickness, diastole (mm) | 15.97 | 16.72 | 0.473 | 0.311 | 0.0684 |
| LVOT VTI | 16.96 | 16.18 | −0.509 | 0.523 | 0.3865 |
| Parameter . | Baseline mean . | Last measure mean . | Absolute difference mean . | Standard error of the mean . | P-value . |
|---|---|---|---|---|---|
| Left ventricular ejection fraction (LVEF) (%) | 56.01 | 53.89 | −1.544 | 1.562 | 0.1675 |
| LV global longitudinal strain (%) | −12.53 | −10.92 | 1.473 | 0.354 | <0.0001 |
| Average LV basal longitudinal strain (%) | −5.70 | −4.63 | 1.137 | 0.442 | 0.0044 |
| Average LV apical longitudinal strain (%) | −18.94 | −16.48 | 2.227 | 0.595 | <0.0001 |
| LV apical/mid + basal longitudinal strain | 2.43 | 2.43 | 0.012 | 0.111 | 0.9050 |
| Global work index (mmHg%) | 1408.57 | 1027.26 | −299.005 | 153.605 | <0.0001 |
| Global constructive work (mmHg%) | 1438.16 | 1250.39 | −182.760 | 38.938 | <0.0001 |
| Global wasted work (mmHg%) | 162.22 | 144.52 | −16.918 | 13.297 | 0.2329 |
| Global work efficiency (%) | 86.01 | 85.51 | −0.433 | 1.048 | 0.3767 |
| RV free wall strain (%) | −18.36 | −17.11 | 1.571 | 1.193 | 0.1502 |
| RV apical/mid + bas longitudinal strain | 1.34 | 1.71 | 0.204 | 0.368 | 0.4396 |
| Tricuspid annular plane systolic excursion (mm) | 16.57 | 14.92 | −2.154 | 0.590 | 0.0010 |
| LA strain during reservoir phase (%, positive value) | 8.81 | 7.65 | −1.689 | 0.588 | 0.0067 |
| LA strain during contraction phase (%, negative value) | −2.40 | −1.95 | 0.699 | 0.415 | 0.2717 |
| LA volume index | 54.79 | 56.08 | 0.127 | 1.644 | 0.8964 |
| LV ED diameter (mm) | 44.28 | 42.32 | −2.284 | 0.767 | 0.0019 |
| Posterior wall thickness, diastole (mm) | 14.37 | 15.13 | 0.504 | 0.290 | 0.0302 |
| Inter-ventricular septal wall thickness, diastole (mm) | 15.97 | 16.72 | 0.473 | 0.311 | 0.0684 |
| LVOT VTI | 16.96 | 16.18 | −0.509 | 0.523 | 0.3865 |
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