Table 2 Open in new tab... | Oxford Academic

Variable	n	Statistics	Units^a	Main endpoint	Test^b	Cardiovascular death	HF hospitalization free survival
LV ED diameter (mm)	113	44.4 ± 6.35	6	1.42	1.04	1.95	0.0292		1.33	0.98	1.82	0.0712	1.14	0.88	1.48	0.3286
IV septal wall thickness (mm)	113	16.0 (14.0–18.0)	4	1.18	0.79	1.76	0.4075		0.95	0.57	1.59	0.8484	1.07	0.72	1.60	0.7268
LVEF (%)	113	55.7 ± 12.7	10	0.60	0.48	0.76	<0.0001		0.58	0.47	0.70	<0.0001	0.67	0.55	0.81	<0.0001
LV ED volume (mL)	113	107 ± 37.8	38	1.24	0.90	1.70	0.1827		1.23	0.87	1.74	0.2406	1.21	0.91	1.61	0.1904
LV ES volume (mL)	113	43.0 (29.0–63.0)	30	Spline			0.0062	0.0220	Spline			<0.0001	Spline			<0.0001
E velocity (cm/s)	113	88.0 (75.0–100)	25	0.94	0.70	1.25	0.6559		1.13	0.88	1.44	0.3364	1.05	0.77	1.43	0.7421
Deceleration time (ms)	113	164 (138–205)	60	0.80	0.56	1.14	0.2067		0.73	0.50	1.06	0.1005	0.89	0.64	1.22	0.4637
A velocity (cm/s)	56	66.4 ± 29.7	30	1.29	0.64	2.60	0.4762		1.75	0.58	5.29	0.3187	1.48	0.78	2.82	0.2277
E/A ratio	56	1.27 (0.99–2.17)	0.5	0.97	0.76	1.23	0.7987		0.87	0.59	1.27	0.4616	0.86	0.70	1.06	0.1657
eʹ septal wall (cm/s)	112	4.85 (3.75–6.00)	2	0.76	0.49	1.17	0.2090		0.67	0.40	1.13	0.1308	0.78	0.54	1.13	0.1881
eʹ lateral wall (cm/s)	110	6.00 (5.00–7.10)	2	0.76	0.51	1.14	0.1840		0.82	0.57	1.18	0.2900	0.93	0.68	1.27	0.6612
E/eʹ	111	16.0 (12.5–20.5)	8	Spline			0.0851	0.0090	Spline			0.9072	Spline			0.2710
aʹ	112	3.67 ± 4.36	4	0.60	0.39	0.91	0.0170		0.55	0.33	0.93	0.0258	0.61	0.41	0.90	0.0135
RV ED area (cm²)	111	18.0 ± 5.00	5	Spline			0.0161	0.0020	Spline		<0.0001	0.0016	Spline			0.0001
RV basal diameter (mm)	111	37.6 ± 7.16	7	1.33	0.97	1.82	0.0785		1.63	1.17	2.27	0.0039	1.44	1.08	1.93	0.0145
RV annulus diameter (mm)	111	34.7 ± 6.15	6	1.41	1.04	1.90	0.0268		1.68	1.27	2.23	0.0003	1.46	1.14	1.88	0.0026
RV free wall thickness (mm)	107	7.32 ± 1.78	2	1.34	0.94	1.90	0.1088		1.40	0.95	2.07	0.0867	1.05	0.76	1.43	0.7814
TAPSE (mm)	110	16.7 ± 5.52	5	0.72	0.51	1.01	0.0547		0.64	0.42	0.99	0.0451	0.70	0.52	0.95	0.0234
RV systolic pressure (mmHg)	90	42.7 ± 11.6	12	1.29	0.88	1.90	0.1924		1.18	0.81	1.73	0.3795	1.10	0.81	1.49	0.5477
RA pressure (mmHg)	109	7.65 ± 4.61	5	1.70	1.18	2.45	0.0043		1.89	1.25	2.87	0.0026	1.80	1.31	2.48	0.0003
Mitral regurgitation	113	57.5 (65)	1	1.58	0.46	5.39	0.0713		0.95	0.27	3.31	0.0575	1.09	0.40	2.93	0.0350
	24.8 (28)	2+	3.20	0.91	11.2			2.51	0.70	8.95		2.46	0.89	6.83
Aortic regurgitation	113	44.2 (50)	1	2.14	0.97	4.73	0.1537		1.69	0.72	3.95	0.4776	1.64	0.84	3.18	0.3337
	12.4 (14)	2+	2.08	0.74	5.84			1.48	0.47	4.65		1.17	0.44	3.10
LVOT VTI (cm)	113	16.8 ± 4.97	5	0.61	0.41	0.89	0.0106		0.49	0.29	0.82	0.0061	0.57	0.38	0.85	0.0062
Stroke volume index (mL/m²)	113	34.6 ± 11.4	11	0.63	0.44	0.91	0.0130		0.53	0.32	0.89	0.0164	0.60	0.40	0.90	0.0146
LAVI (mL/m²)	113	53.0 (43.0–64.0)	20	1.10	0.77	1.56	0.6058		1.27	0.88	1.83	0.2033	1.29	0.95	1.76	0.1006
Right atrial area (cm²)	111	20.0 (16.0–25.3)	10	1.40	0.94	2.11	0.1018		1.77	1.28	2.44	0.0005	1.45	1.08	1.95	0.0127
Interatrial septum thickness (mm)	111	4.27 ± 0.85	1	0.96	0.63	1.47	0.8673		0.98	0.55	1.75	0.9521	0.82	0.53	1.27	0.3782

Variable

Statistics

Units^a

Main endpoint

Test^b

Cardiovascular death

HF hospitalization free survival

LCL

UCL

P-value

LCL

UCL

P-value

LCL

UCL

P-value

LV ED diameter (mm)

113

44.4 ± 6.35

1.42

1.04

1.95

0.0292

1.33

0.98

1.82

0.0712

1.14

0.88

1.48

0.3286

IV septal wall thickness (mm)

113

16.0 (14.0–18.0)

1.18

0.79

1.76

0.4075

0.95

0.57

1.59

0.8484

1.07

0.72

1.60

0.7268

LVEF (%)

113

55.7 ± 12.7

0.60

0.48

0.76

<0.0001

0.58

0.47

0.70

<0.0001

0.67

0.55

0.81

<0.0001

LV ED volume (mL)

113

107 ± 37.8

1.24

0.90

1.70

0.1827

1.23

0.87

1.74

0.2406

1.21

0.91

1.61

0.1904

LV ES volume (mL)

113

43.0 (29.0–63.0)

Spline

0.0062

0.0220

Spline

<0.0001

Spline

<0.0001

E velocity (cm/s)

113

88.0 (75.0–100)

0.94

0.70

1.25

0.6559

1.13

0.88

1.44

0.3364

1.05

0.77

1.43

0.7421

Deceleration time (ms)

113

164 (138–205)

0.80

0.56

1.14

0.2067

0.73

0.50

1.06

0.1005

0.89

0.64

1.22

0.4637

A velocity (cm/s)

66.4 ± 29.7

1.29

0.64

2.60

0.4762

1.75

0.58

5.29

0.3187

1.48

0.78

2.82

0.2277

E/A ratio

1.27 (0.99–2.17)

0.5

0.97

0.76

1.23

0.7987

0.87

0.59

1.27

0.4616

0.86

0.70

1.06

0.1657

eʹ septal wall (cm/s)

112

4.85 (3.75–6.00)

0.76

0.49

1.17

0.2090

0.67

0.40

1.13

0.1308

0.78

0.54

1.13

0.1881

eʹ lateral wall (cm/s)

110

6.00 (5.00–7.10)

0.76

0.51

1.14

0.1840

0.82

0.57

1.18

0.2900

0.93

0.68

1.27

0.6612

E/eʹ

111

16.0 (12.5–20.5)

Spline

0.0851

0.0090

Spline

0.9072

Spline

0.2710

aʹ

112

3.67 ± 4.36

0.60

0.39

0.91

0.0170

0.55

0.33

0.93

0.0258

0.61

0.41

0.90

0.0135

RV ED area (cm²)

111

18.0 ± 5.00

Spline

0.0161

0.0020

Spline

<0.0001

0.0016

Spline

0.0001

RV basal diameter (mm)

111

37.6 ± 7.16

1.33

0.97

1.82

0.0785

1.63

1.17

2.27

0.0039

1.44

1.08

1.93

0.0145

RV annulus diameter (mm)

111

34.7 ± 6.15

1.41

1.04

1.90

0.0268

1.68

1.27

2.23

0.0003

1.46

1.14

1.88

0.0026

RV free wall thickness (mm)

107

7.32 ± 1.78

1.34

0.94

1.90

0.1088

1.40

0.95

2.07

0.0867

1.05

0.76

1.43

0.7814

TAPSE (mm)

110

16.7 ± 5.52

0.72

0.51

1.01

0.0547

0.64

0.42

0.99

0.0451

0.70

0.52

0.95

0.0234

RV systolic pressure (mmHg)

42.7 ± 11.6

1.29

0.88

1.90

0.1924

1.18

0.81

1.73

0.3795

1.10

0.81

1.49

0.5477

RA pressure (mmHg)

109

7.65 ± 4.61

1.70

1.18

2.45

0.0043

1.89

1.25

2.87

0.0026

1.80

1.31

2.48

0.0003

Mitral regurgitation

113

57.5 (65)

1.58

0.46

5.39

0.0713

0.95

0.27

3.31

0.0575

1.09

0.40

2.93

0.0350

24.8 (28)

3.20

0.91

11.2

2.51

0.70

8.95

2.46

0.89

6.83

Aortic regurgitation

113

44.2 (50)

2.14

0.97

4.73

0.1537

1.69

0.72

3.95

0.4776

1.64

0.84

3.18

0.3337

12.4 (14)

2.08

0.74

5.84

1.48

0.47

4.65

1.17

0.44

3.10

LVOT VTI (cm)

113

16.8 ± 4.97

0.61

0.41

0.89

0.0106

0.49

0.29

0.82

0.0061

0.57

0.38

0.85

0.0062

Stroke volume index (mL/m²)

113

34.6 ± 11.4

0.63

0.44

0.91

0.0130

0.53

0.32

0.89

0.0164

0.60

0.40

0.90

0.0146

LAVI (mL/m²)

113

53.0 (43.0–64.0)

1.10

0.77

1.56

0.6058

1.27

0.88

1.83

0.2033

1.29

0.95

1.76

0.1006

Right atrial area (cm²)

111

20.0 (16.0–25.3)

1.40

0.94

2.11

0.1018

1.77

1.28

2.44

0.0005

1.45

1.08

1.95

0.0127

Interatrial septum thickness (mm)

111

4.27 ± 0.85

0.96

0.63

1.47

0.8673

0.98

0.55

1.75

0.9521

0.82

0.53

1.27

0.3782

Variable	n	Statistics	Units^a	Main endpoint	Test^b	Cardiovascular death	HF hospitalization free survival
LV ED diameter (mm)	113	44.4 ± 6.35	6	1.42	1.04	1.95	0.0292		1.33	0.98	1.82	0.0712	1.14	0.88	1.48	0.3286
IV septal wall thickness (mm)	113	16.0 (14.0–18.0)	4	1.18	0.79	1.76	0.4075		0.95	0.57	1.59	0.8484	1.07	0.72	1.60	0.7268
LVEF (%)	113	55.7 ± 12.7	10	0.60	0.48	0.76	<0.0001		0.58	0.47	0.70	<0.0001	0.67	0.55	0.81	<0.0001
LV ED volume (mL)	113	107 ± 37.8	38	1.24	0.90	1.70	0.1827		1.23	0.87	1.74	0.2406	1.21	0.91	1.61	0.1904
LV ES volume (mL)	113	43.0 (29.0–63.0)	30	Spline			0.0062	0.0220	Spline			<0.0001	Spline			<0.0001
E velocity (cm/s)	113	88.0 (75.0–100)	25	0.94	0.70	1.25	0.6559		1.13	0.88	1.44	0.3364	1.05	0.77	1.43	0.7421
Deceleration time (ms)	113	164 (138–205)	60	0.80	0.56	1.14	0.2067		0.73	0.50	1.06	0.1005	0.89	0.64	1.22	0.4637
A velocity (cm/s)	56	66.4 ± 29.7	30	1.29	0.64	2.60	0.4762		1.75	0.58	5.29	0.3187	1.48	0.78	2.82	0.2277
E/A ratio	56	1.27 (0.99–2.17)	0.5	0.97	0.76	1.23	0.7987		0.87	0.59	1.27	0.4616	0.86	0.70	1.06	0.1657
eʹ septal wall (cm/s)	112	4.85 (3.75–6.00)	2	0.76	0.49	1.17	0.2090		0.67	0.40	1.13	0.1308	0.78	0.54	1.13	0.1881
eʹ lateral wall (cm/s)	110	6.00 (5.00–7.10)	2	0.76	0.51	1.14	0.1840		0.82	0.57	1.18	0.2900	0.93	0.68	1.27	0.6612
E/eʹ	111	16.0 (12.5–20.5)	8	Spline			0.0851	0.0090	Spline			0.9072	Spline			0.2710
aʹ	112	3.67 ± 4.36	4	0.60	0.39	0.91	0.0170		0.55	0.33	0.93	0.0258	0.61	0.41	0.90	0.0135
RV ED area (cm²)	111	18.0 ± 5.00	5	Spline			0.0161	0.0020	Spline		<0.0001	0.0016	Spline			0.0001
RV basal diameter (mm)	111	37.6 ± 7.16	7	1.33	0.97	1.82	0.0785		1.63	1.17	2.27	0.0039	1.44	1.08	1.93	0.0145
RV annulus diameter (mm)	111	34.7 ± 6.15	6	1.41	1.04	1.90	0.0268		1.68	1.27	2.23	0.0003	1.46	1.14	1.88	0.0026
RV free wall thickness (mm)	107	7.32 ± 1.78	2	1.34	0.94	1.90	0.1088		1.40	0.95	2.07	0.0867	1.05	0.76	1.43	0.7814
TAPSE (mm)	110	16.7 ± 5.52	5	0.72	0.51	1.01	0.0547		0.64	0.42	0.99	0.0451	0.70	0.52	0.95	0.0234
RV systolic pressure (mmHg)	90	42.7 ± 11.6	12	1.29	0.88	1.90	0.1924		1.18	0.81	1.73	0.3795	1.10	0.81	1.49	0.5477
RA pressure (mmHg)	109	7.65 ± 4.61	5	1.70	1.18	2.45	0.0043		1.89	1.25	2.87	0.0026	1.80	1.31	2.48	0.0003
Mitral regurgitation	113	57.5 (65)	1	1.58	0.46	5.39	0.0713		0.95	0.27	3.31	0.0575	1.09	0.40	2.93	0.0350
	24.8 (28)	2+	3.20	0.91	11.2			2.51	0.70	8.95		2.46	0.89	6.83
Aortic regurgitation	113	44.2 (50)	1	2.14	0.97	4.73	0.1537		1.69	0.72	3.95	0.4776	1.64	0.84	3.18	0.3337
	12.4 (14)	2+	2.08	0.74	5.84			1.48	0.47	4.65		1.17	0.44	3.10
LVOT VTI (cm)	113	16.8 ± 4.97	5	0.61	0.41	0.89	0.0106		0.49	0.29	0.82	0.0061	0.57	0.38	0.85	0.0062
Stroke volume index (mL/m²)	113	34.6 ± 11.4	11	0.63	0.44	0.91	0.0130		0.53	0.32	0.89	0.0164	0.60	0.40	0.90	0.0146
LAVI (mL/m²)	113	53.0 (43.0–64.0)	20	1.10	0.77	1.56	0.6058		1.27	0.88	1.83	0.2033	1.29	0.95	1.76	0.1006
Right atrial area (cm²)	111	20.0 (16.0–25.3)	10	1.40	0.94	2.11	0.1018		1.77	1.28	2.44	0.0005	1.45	1.08	1.95	0.0127
Interatrial septum thickness (mm)	111	4.27 ± 0.85	1	0.96	0.63	1.47	0.8673		0.98	0.55	1.75	0.9521	0.82	0.53	1.27	0.3782

Variable

Statistics

Units^a

Main endpoint

Test^b

Cardiovascular death

HF hospitalization free survival

LCL

UCL

P-value

LCL

UCL

P-value

LCL

UCL

P-value

LV ED diameter (mm)

113

44.4 ± 6.35

1.42

1.04

1.95

0.0292

1.33

0.98

1.82

0.0712

1.14

0.88

1.48

0.3286

IV septal wall thickness (mm)

113

16.0 (14.0–18.0)

1.18

0.79

1.76

0.4075

0.95

0.57

1.59

0.8484

1.07

0.72

1.60

0.7268

LVEF (%)

113

55.7 ± 12.7

0.60

0.48

0.76

<0.0001

0.58

0.47

0.70

<0.0001

0.67

0.55

0.81

<0.0001

LV ED volume (mL)

113

107 ± 37.8

1.24

0.90

1.70

0.1827

1.23

0.87

1.74

0.2406

1.21

0.91

1.61

0.1904

LV ES volume (mL)

113

43.0 (29.0–63.0)

Spline

0.0062

0.0220

Spline

<0.0001

Spline

<0.0001

E velocity (cm/s)

113

88.0 (75.0–100)

0.94

0.70

1.25

0.6559

1.13

0.88

1.44

0.3364

1.05

0.77

1.43

0.7421

Deceleration time (ms)

113

164 (138–205)

0.80

0.56

1.14

0.2067

0.73

0.50

1.06

0.1005

0.89

0.64

1.22

0.4637

A velocity (cm/s)

66.4 ± 29.7

1.29

0.64

2.60

0.4762

1.75

0.58

5.29

0.3187

1.48

0.78

2.82

0.2277

E/A ratio

1.27 (0.99–2.17)

0.5

0.97

0.76

1.23

0.7987

0.87

0.59

1.27

0.4616

0.86

0.70

1.06

0.1657

eʹ septal wall (cm/s)

112

4.85 (3.75–6.00)

0.76

0.49

1.17

0.2090

0.67

0.40

1.13

0.1308

0.78

0.54

1.13

0.1881

eʹ lateral wall (cm/s)

110

6.00 (5.00–7.10)

0.76

0.51

1.14

0.1840

0.82

0.57

1.18

0.2900

0.93

0.68

1.27

0.6612

E/eʹ

111

16.0 (12.5–20.5)

Spline

0.0851

0.0090

Spline

0.9072

Spline

0.2710

aʹ

112

3.67 ± 4.36

0.60

0.39

0.91

0.0170

0.55

0.33

0.93

0.0258

0.61

0.41

0.90

0.0135

RV ED area (cm²)

111

18.0 ± 5.00

Spline

0.0161

0.0020

Spline

<0.0001

0.0016

Spline

0.0001

RV basal diameter (mm)

111

37.6 ± 7.16

1.33

0.97

1.82

0.0785

1.63

1.17

2.27

0.0039

1.44

1.08

1.93

0.0145

RV annulus diameter (mm)

111

34.7 ± 6.15

1.41

1.04

1.90

0.0268

1.68

1.27

2.23

0.0003

1.46

1.14

1.88

0.0026

RV free wall thickness (mm)

107

7.32 ± 1.78

1.34

0.94

1.90

0.1088

1.40

0.95

2.07

0.0867

1.05

0.76

1.43

0.7814

TAPSE (mm)

110

16.7 ± 5.52

0.72

0.51

1.01

0.0547

0.64

0.42

0.99

0.0451

0.70

0.52

0.95

0.0234

RV systolic pressure (mmHg)

42.7 ± 11.6

1.29

0.88

1.90

0.1924

1.18

0.81

1.73

0.3795

1.10

0.81

1.49

0.5477

RA pressure (mmHg)

109

7.65 ± 4.61

1.70

1.18

2.45

0.0043

1.89

1.25

2.87

0.0026

1.80

1.31

2.48

0.0003

Mitral regurgitation

113

57.5 (65)

1.58

0.46

5.39

0.0713

0.95

0.27

3.31

0.0575

1.09

0.40

2.93

0.0350

24.8 (28)

3.20

0.91

11.2

2.51

0.70

8.95

2.46

0.89

6.83

Aortic regurgitation

113

44.2 (50)

2.14

0.97

4.73

0.1537

1.69

0.72

3.95

0.4776

1.64

0.84

3.18

0.3337

12.4 (14)

2.08

0.74

5.84

1.48

0.47

4.65

1.17

0.44

3.10

LVOT VTI (cm)

113

16.8 ± 4.97

0.61

0.41

0.89

0.0106

0.49

0.29

0.82

0.0061

0.57

0.38

0.85

0.0062

Stroke volume index (mL/m²)

113

34.6 ± 11.4

0.63

0.44

0.91

0.0130

0.53

0.32

0.89

0.0164

0.60

0.40

0.90

0.0146

LAVI (mL/m²)

113

53.0 (43.0–64.0)

1.10

0.77

1.56

0.6058

1.27

0.88

1.83

0.2033

1.29

0.95

1.76

0.1006

Right atrial area (cm²)

111

20.0 (16.0–25.3)

1.40

0.94

2.11

0.1018

1.77

1.28

2.44

0.0005

1.45

1.08

1.95

0.0127

Interatrial septum thickness (mm)

111

4.27 ± 0.85

0.96

0.63

1.47

0.8673

0.98

0.55

1.75

0.9521

0.82

0.53

1.27

0.3782

Table 2

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Echocardiographic parameters at baseline and univariate association with overall death (main endpoint), cardiovascular death, and heart failure hospitalization free survival (secondary endpoints)

Variable	n	Statistics	Units^a	Main endpoint				Test^b	Cardiovascular death				HF hospitalization free survival
Variable	n	Statistics	Units^a	HR	LCL	UCL	P-value	Test^b	HR	LCL	UCL	P-value	HR	LCL	UCL	P-value
LV ED diameter (mm)	113	44.4 ± 6.35	6	1.42	1.04	1.95	0.0292		1.33	0.98	1.82	0.0712	1.14	0.88	1.48	0.3286
IV septal wall thickness (mm)	113	16.0 (14.0–18.0)	4	1.18	0.79	1.76	0.4075		0.95	0.57	1.59	0.8484	1.07	0.72	1.60	0.7268
LVEF (%)	113	55.7 ± 12.7	10	0.60	0.48	0.76	<0.0001		0.58	0.47	0.70	<0.0001	0.67	0.55	0.81	<0.0001
LV ED volume (mL)	113	107 ± 37.8	38	1.24	0.90	1.70	0.1827		1.23	0.87	1.74	0.2406	1.21	0.91	1.61	0.1904
LV ES volume (mL)	113	43.0 (29.0–63.0)	30	Spline			0.0062	0.0220	Spline			<0.0001	Spline			<0.0001
E velocity (cm/s)	113	88.0 (75.0–100)	25	0.94	0.70	1.25	0.6559		1.13	0.88	1.44	0.3364	1.05	0.77	1.43	0.7421
Deceleration time (ms)	113	164 (138–205)	60	0.80	0.56	1.14	0.2067		0.73	0.50	1.06	0.1005	0.89	0.64	1.22	0.4637
A velocity (cm/s)	56	66.4 ± 29.7	30	1.29	0.64	2.60	0.4762		1.75	0.58	5.29	0.3187	1.48	0.78	2.82	0.2277
E/A ratio	56	1.27 (0.99–2.17)	0.5	0.97	0.76	1.23	0.7987		0.87	0.59	1.27	0.4616	0.86	0.70	1.06	0.1657
eʹ septal wall (cm/s)	112	4.85 (3.75–6.00)	2	0.76	0.49	1.17	0.2090		0.67	0.40	1.13	0.1308	0.78	0.54	1.13	0.1881
eʹ lateral wall (cm/s)	110	6.00 (5.00–7.10)	2	0.76	0.51	1.14	0.1840		0.82	0.57	1.18	0.2900	0.93	0.68	1.27	0.6612
E/eʹ	111	16.0 (12.5–20.5)	8	Spline			0.0851	0.0090	Spline			0.9072	Spline			0.2710
aʹ	112	3.67 ± 4.36	4	0.60	0.39	0.91	0.0170		0.55	0.33	0.93	0.0258	0.61	0.41	0.90	0.0135
RV ED area (cm²)	111	18.0 ± 5.00	5	Spline			0.0161	0.0020	Spline		<0.0001	0.0016	Spline			0.0001
RV basal diameter (mm)	111	37.6 ± 7.16	7	1.33	0.97	1.82	0.0785		1.63	1.17	2.27	0.0039	1.44	1.08	1.93	0.0145
RV annulus diameter (mm)	111	34.7 ± 6.15	6	1.41	1.04	1.90	0.0268		1.68	1.27	2.23	0.0003	1.46	1.14	1.88	0.0026
RV free wall thickness (mm)	107	7.32 ± 1.78	2	1.34	0.94	1.90	0.1088		1.40	0.95	2.07	0.0867	1.05	0.76	1.43	0.7814
TAPSE (mm)	110	16.7 ± 5.52	5	0.72	0.51	1.01	0.0547		0.64	0.42	0.99	0.0451	0.70	0.52	0.95	0.0234
RV systolic pressure (mmHg)	90	42.7 ± 11.6	12	1.29	0.88	1.90	0.1924		1.18	0.81	1.73	0.3795	1.10	0.81	1.49	0.5477
RA pressure (mmHg)	109	7.65 ± 4.61	5	1.70	1.18	2.45	0.0043		1.89	1.25	2.87	0.0026	1.80	1.31	2.48	0.0003
Mitral regurgitation	113	57.5 (65)	1	1.58	0.46	5.39	0.0713		0.95	0.27	3.31	0.0575	1.09	0.40	2.93	0.0350
Mitral regurgitation		24.8 (28)	2+	3.20	0.91	11.2			2.51	0.70	8.95		2.46	0.89	6.83
Aortic regurgitation	113	44.2 (50)	1	2.14	0.97	4.73	0.1537		1.69	0.72	3.95	0.4776	1.64	0.84	3.18	0.3337
Aortic regurgitation		12.4 (14)	2+	2.08	0.74	5.84			1.48	0.47	4.65		1.17	0.44	3.10
LVOT VTI (cm)	113	16.8 ± 4.97	5	0.61	0.41	0.89	0.0106		0.49	0.29	0.82	0.0061	0.57	0.38	0.85	0.0062
Stroke volume index (mL/m²)	113	34.6 ± 11.4	11	0.63	0.44	0.91	0.0130		0.53	0.32	0.89	0.0164	0.60	0.40	0.90	0.0146
LAVI (mL/m²)	113	53.0 (43.0–64.0)	20	1.10	0.77	1.56	0.6058		1.27	0.88	1.83	0.2033	1.29	0.95	1.76	0.1006
Right atrial area (cm²)	111	20.0 (16.0–25.3)	10	1.40	0.94	2.11	0.1018		1.77	1.28	2.44	0.0005	1.45	1.08	1.95	0.0127
Interatrial septum thickness (mm)	111	4.27 ± 0.85	1	0.96	0.63	1.47	0.8673		0.98	0.55	1.75	0.9521	0.82	0.53	1.27	0.3782

Variable	n	Statistics	Units^a	Main endpoint				Test^b	Cardiovascular death				HF hospitalization free survival
Variable	n	Statistics	Units^a	HR	LCL	UCL	P-value	Test^b	HR	LCL	UCL	P-value	HR	LCL	UCL	P-value
LV ED diameter (mm)	113	44.4 ± 6.35	6	1.42	1.04	1.95	0.0292		1.33	0.98	1.82	0.0712	1.14	0.88	1.48	0.3286
IV septal wall thickness (mm)	113	16.0 (14.0–18.0)	4	1.18	0.79	1.76	0.4075		0.95	0.57	1.59	0.8484	1.07	0.72	1.60	0.7268
LVEF (%)	113	55.7 ± 12.7	10	0.60	0.48	0.76	<0.0001		0.58	0.47	0.70	<0.0001	0.67	0.55	0.81	<0.0001
LV ED volume (mL)	113	107 ± 37.8	38	1.24	0.90	1.70	0.1827		1.23	0.87	1.74	0.2406	1.21	0.91	1.61	0.1904
LV ES volume (mL)	113	43.0 (29.0–63.0)	30	Spline			0.0062	0.0220	Spline			<0.0001	Spline			<0.0001
E velocity (cm/s)	113	88.0 (75.0–100)	25	0.94	0.70	1.25	0.6559		1.13	0.88	1.44	0.3364	1.05	0.77	1.43	0.7421
Deceleration time (ms)	113	164 (138–205)	60	0.80	0.56	1.14	0.2067		0.73	0.50	1.06	0.1005	0.89	0.64	1.22	0.4637
A velocity (cm/s)	56	66.4 ± 29.7	30	1.29	0.64	2.60	0.4762		1.75	0.58	5.29	0.3187	1.48	0.78	2.82	0.2277
E/A ratio	56	1.27 (0.99–2.17)	0.5	0.97	0.76	1.23	0.7987		0.87	0.59	1.27	0.4616	0.86	0.70	1.06	0.1657
eʹ septal wall (cm/s)	112	4.85 (3.75–6.00)	2	0.76	0.49	1.17	0.2090		0.67	0.40	1.13	0.1308	0.78	0.54	1.13	0.1881
eʹ lateral wall (cm/s)	110	6.00 (5.00–7.10)	2	0.76	0.51	1.14	0.1840		0.82	0.57	1.18	0.2900	0.93	0.68	1.27	0.6612
E/eʹ	111	16.0 (12.5–20.5)	8	Spline			0.0851	0.0090	Spline			0.9072	Spline			0.2710
aʹ	112	3.67 ± 4.36	4	0.60	0.39	0.91	0.0170		0.55	0.33	0.93	0.0258	0.61	0.41	0.90	0.0135
RV ED area (cm²)	111	18.0 ± 5.00	5	Spline			0.0161	0.0020	Spline		<0.0001	0.0016	Spline			0.0001
RV basal diameter (mm)	111	37.6 ± 7.16	7	1.33	0.97	1.82	0.0785		1.63	1.17	2.27	0.0039	1.44	1.08	1.93	0.0145
RV annulus diameter (mm)	111	34.7 ± 6.15	6	1.41	1.04	1.90	0.0268		1.68	1.27	2.23	0.0003	1.46	1.14	1.88	0.0026
RV free wall thickness (mm)	107	7.32 ± 1.78	2	1.34	0.94	1.90	0.1088		1.40	0.95	2.07	0.0867	1.05	0.76	1.43	0.7814
TAPSE (mm)	110	16.7 ± 5.52	5	0.72	0.51	1.01	0.0547		0.64	0.42	0.99	0.0451	0.70	0.52	0.95	0.0234
RV systolic pressure (mmHg)	90	42.7 ± 11.6	12	1.29	0.88	1.90	0.1924		1.18	0.81	1.73	0.3795	1.10	0.81	1.49	0.5477
RA pressure (mmHg)	109	7.65 ± 4.61	5	1.70	1.18	2.45	0.0043		1.89	1.25	2.87	0.0026	1.80	1.31	2.48	0.0003
Mitral regurgitation	113	57.5 (65)	1	1.58	0.46	5.39	0.0713		0.95	0.27	3.31	0.0575	1.09	0.40	2.93	0.0350
Mitral regurgitation		24.8 (28)	2+	3.20	0.91	11.2			2.51	0.70	8.95		2.46	0.89	6.83
Aortic regurgitation	113	44.2 (50)	1	2.14	0.97	4.73	0.1537		1.69	0.72	3.95	0.4776	1.64	0.84	3.18	0.3337
Aortic regurgitation		12.4 (14)	2+	2.08	0.74	5.84			1.48	0.47	4.65		1.17	0.44	3.10
LVOT VTI (cm)	113	16.8 ± 4.97	5	0.61	0.41	0.89	0.0106		0.49	0.29	0.82	0.0061	0.57	0.38	0.85	0.0062
Stroke volume index (mL/m²)	113	34.6 ± 11.4	11	0.63	0.44	0.91	0.0130		0.53	0.32	0.89	0.0164	0.60	0.40	0.90	0.0146
LAVI (mL/m²)	113	53.0 (43.0–64.0)	20	1.10	0.77	1.56	0.6058		1.27	0.88	1.83	0.2033	1.29	0.95	1.76	0.1006
Right atrial area (cm²)	111	20.0 (16.0–25.3)	10	1.40	0.94	2.11	0.1018		1.77	1.28	2.44	0.0005	1.45	1.08	1.95	0.0127
Interatrial septum thickness (mm)	111	4.27 ± 0.85	1	0.96	0.63	1.47	0.8673		0.98	0.55	1.75	0.9521	0.82	0.53	1.27	0.3782

Values are percentage (frequency), mean ± standard deviation, or median (first—third quartile).

ED, end-diastolic; ES, end-systolic; GLS, global longitudinal strain; HR, hazard ratio; LCL (and UCL), lower (and upper) confidence limits; LAVI, left atrial volume index; LA, left atrium; LV, left ventricle; LVEF, left ventricle ejection fraction; RA, right atrium; RV, right ventricle; TAPSE, tricuspid annular plane excursion; VTI, velocity-time integral.

^aThe units of change in the continuous explanatory variable for which the customized hazard ratio is estimated.

^bKolmogorov-type supremum test, derived from cumulative sums of martingale residuals to assess the functional form of a covariate.

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