Characteristics of the Study Population of Infants Born 1995–2007 With Continuous Enrollment in Tennessee Medicaid and who did not Receive RSV Immunoprophylaxis During the First Year of Life Stratified by RSV LRTI Requiring Intensive Care Unit Admission Status
| . | Infants Without Severe RSV LRTI . | Infants With Severe RSV LRTI . | Total . |
|---|---|---|---|
| Sample size, n (%) | 428 652 (100) | 713 (0) | 429 365 (100) |
| Demographic predictors | |||
| Infant sex, n (%) | |||
| Male | 219 181 (51) | 420 (59) | 219 601 (51) |
| Female | 209 466 (49) | 293 (41) | 209 759 (49) |
| Missing, n (%) | 5 (0) | 0 (0) | 5 (0) |
| Birth month, median (IQR) | 7 (4–10) | 9 (3–11) | 7 (4–10) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Number of living siblings at delivery, median (IQR) | 1 (0–2) | 1 (0–2) | 1 (0–2) |
| Missing, n (%) | 1058 (0) | 0 (0) | 1058 (0) |
| Maternal smoking during pregnancy, n (%) | 114 449 (27) | 277 (39) | 114 726 (27) |
| Missing, n (%) | 681 (0) | 1 (0) | 682 (0) |
| Maternal age at delivery (y), median (IQR) | 22 (20–26) | 22 (20–26) | 22 (20–26) |
| Missing, n (%) | 570 (0) | 1 (0) | 571 (0) |
| Maternal education at delivery, n (%) | |||
| No high school diploma | 157 502 (37) | 342 (48) | 157 844 (37) |
| High school diploma | 185 457 (43) | 283 (40) | 185 740 (43) |
| At least some college | 84 511 (20) | 86 (12) | 84 597 (20) |
| Missing, n (%) | 1182 (0) | 2 (0) | 1184 (0) |
| Maternal region of residence at delivery, n (%) | |||
| Urban | 148 316 (35) | 284 (40) | 148 600 (35) |
| Suburban | 110 661 (26) | 192 (27) | 110 853 (26) |
| Rural | 168 995 (39) | 237 (33) | 169 232 (39) |
| Missing, n (%) | 680 (0) | 0 (0) | 680 (0) |
| Clinical predictors | |||
| Birth weight (g), median (IQR) | 3232 (2892–3572) | 2919 (2353–3374) | 3232 (2892–3572) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Delivery method, n (%) | |||
| Vaginal | 322 936 (75) | 494 (69) | 323 430 (75) |
| Cesarean section | 105 588 (25) | 219 (31) | 105 807 (25) |
| Missing, n (%) | 128 (0) | 0 (0) | 128 (0) |
| Type of birth, n (%) | |||
| Singleton | 419 910 (98) | 669 (94) | 420 579 (98) |
| Twin | 8614 (2) | 42 (6) | 8656 (2) |
| Triplet or more | 125 (0) | – | – |
| Missing, n (%) | 3 (0) | – | – |
| Gestational age (wk), median (IQR) | 39 (38–40) | 38 (36–39) | 39 (38–40) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Apgar score, median (IQR) | 9 (9–9) | 9 (9–9) | 9 (9–9) |
| Missing, n (%) | 3059 (1) | 7 (1) | 3066 (1) |
| CPAP during birth hospitalization, n (%) | 1321 (0) | 15 (2) | 1336 (0) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Ventilation during birth hospitalization, n (%) | 2762 (1) | 45 (6) | 2807 (1) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Bronchopulmonary dysplasia, n (%) | 719 (0) | 17 (2) | 736 (0) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Congenital anomalies of the respiratory system, n (%) | 613 (0) | – | – |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Cyanotic heart disease, n (%) | 569 (0) | 13 (2) | 582 (0) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Down syndrome, n (%) | 348 (0) | – | – |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| . | Infants Without Severe RSV LRTI . | Infants With Severe RSV LRTI . | Total . |
|---|---|---|---|
| Sample size, n (%) | 428 652 (100) | 713 (0) | 429 365 (100) |
| Demographic predictors | |||
| Infant sex, n (%) | |||
| Male | 219 181 (51) | 420 (59) | 219 601 (51) |
| Female | 209 466 (49) | 293 (41) | 209 759 (49) |
| Missing, n (%) | 5 (0) | 0 (0) | 5 (0) |
| Birth month, median (IQR) | 7 (4–10) | 9 (3–11) | 7 (4–10) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Number of living siblings at delivery, median (IQR) | 1 (0–2) | 1 (0–2) | 1 (0–2) |
| Missing, n (%) | 1058 (0) | 0 (0) | 1058 (0) |
| Maternal smoking during pregnancy, n (%) | 114 449 (27) | 277 (39) | 114 726 (27) |
| Missing, n (%) | 681 (0) | 1 (0) | 682 (0) |
| Maternal age at delivery (y), median (IQR) | 22 (20–26) | 22 (20–26) | 22 (20–26) |
| Missing, n (%) | 570 (0) | 1 (0) | 571 (0) |
| Maternal education at delivery, n (%) | |||
| No high school diploma | 157 502 (37) | 342 (48) | 157 844 (37) |
| High school diploma | 185 457 (43) | 283 (40) | 185 740 (43) |
| At least some college | 84 511 (20) | 86 (12) | 84 597 (20) |
| Missing, n (%) | 1182 (0) | 2 (0) | 1184 (0) |
| Maternal region of residence at delivery, n (%) | |||
| Urban | 148 316 (35) | 284 (40) | 148 600 (35) |
| Suburban | 110 661 (26) | 192 (27) | 110 853 (26) |
| Rural | 168 995 (39) | 237 (33) | 169 232 (39) |
| Missing, n (%) | 680 (0) | 0 (0) | 680 (0) |
| Clinical predictors | |||
| Birth weight (g), median (IQR) | 3232 (2892–3572) | 2919 (2353–3374) | 3232 (2892–3572) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Delivery method, n (%) | |||
| Vaginal | 322 936 (75) | 494 (69) | 323 430 (75) |
| Cesarean section | 105 588 (25) | 219 (31) | 105 807 (25) |
| Missing, n (%) | 128 (0) | 0 (0) | 128 (0) |
| Type of birth, n (%) | |||
| Singleton | 419 910 (98) | 669 (94) | 420 579 (98) |
| Twin | 8614 (2) | 42 (6) | 8656 (2) |
| Triplet or more | 125 (0) | – | – |
| Missing, n (%) | 3 (0) | – | – |
| Gestational age (wk), median (IQR) | 39 (38–40) | 38 (36–39) | 39 (38–40) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Apgar score, median (IQR) | 9 (9–9) | 9 (9–9) | 9 (9–9) |
| Missing, n (%) | 3059 (1) | 7 (1) | 3066 (1) |
| CPAP during birth hospitalization, n (%) | 1321 (0) | 15 (2) | 1336 (0) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Ventilation during birth hospitalization, n (%) | 2762 (1) | 45 (6) | 2807 (1) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Bronchopulmonary dysplasia, n (%) | 719 (0) | 17 (2) | 736 (0) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Congenital anomalies of the respiratory system, n (%) | 613 (0) | – | – |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Cyanotic heart disease, n (%) | 569 (0) | 13 (2) | 582 (0) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Down syndrome, n (%) | 348 (0) | – | – |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
–, Data suppressed (n < 10). Length of birth hospitalization is not listed as single imputation was used to assign 62% of infants for which infant discharge date was missing.
Abbreviations: CPAP, continuous positive airway pressure; IQR, interquartile range; LRTI, lower respiratory tract infection; RSV, respiratory syncytial virus.
Characteristics of the Study Population of Infants Born 1995–2007 With Continuous Enrollment in Tennessee Medicaid and who did not Receive RSV Immunoprophylaxis During the First Year of Life Stratified by RSV LRTI Requiring Intensive Care Unit Admission Status
| . | Infants Without Severe RSV LRTI . | Infants With Severe RSV LRTI . | Total . |
|---|---|---|---|
| Sample size, n (%) | 428 652 (100) | 713 (0) | 429 365 (100) |
| Demographic predictors | |||
| Infant sex, n (%) | |||
| Male | 219 181 (51) | 420 (59) | 219 601 (51) |
| Female | 209 466 (49) | 293 (41) | 209 759 (49) |
| Missing, n (%) | 5 (0) | 0 (0) | 5 (0) |
| Birth month, median (IQR) | 7 (4–10) | 9 (3–11) | 7 (4–10) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Number of living siblings at delivery, median (IQR) | 1 (0–2) | 1 (0–2) | 1 (0–2) |
| Missing, n (%) | 1058 (0) | 0 (0) | 1058 (0) |
| Maternal smoking during pregnancy, n (%) | 114 449 (27) | 277 (39) | 114 726 (27) |
| Missing, n (%) | 681 (0) | 1 (0) | 682 (0) |
| Maternal age at delivery (y), median (IQR) | 22 (20–26) | 22 (20–26) | 22 (20–26) |
| Missing, n (%) | 570 (0) | 1 (0) | 571 (0) |
| Maternal education at delivery, n (%) | |||
| No high school diploma | 157 502 (37) | 342 (48) | 157 844 (37) |
| High school diploma | 185 457 (43) | 283 (40) | 185 740 (43) |
| At least some college | 84 511 (20) | 86 (12) | 84 597 (20) |
| Missing, n (%) | 1182 (0) | 2 (0) | 1184 (0) |
| Maternal region of residence at delivery, n (%) | |||
| Urban | 148 316 (35) | 284 (40) | 148 600 (35) |
| Suburban | 110 661 (26) | 192 (27) | 110 853 (26) |
| Rural | 168 995 (39) | 237 (33) | 169 232 (39) |
| Missing, n (%) | 680 (0) | 0 (0) | 680 (0) |
| Clinical predictors | |||
| Birth weight (g), median (IQR) | 3232 (2892–3572) | 2919 (2353–3374) | 3232 (2892–3572) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Delivery method, n (%) | |||
| Vaginal | 322 936 (75) | 494 (69) | 323 430 (75) |
| Cesarean section | 105 588 (25) | 219 (31) | 105 807 (25) |
| Missing, n (%) | 128 (0) | 0 (0) | 128 (0) |
| Type of birth, n (%) | |||
| Singleton | 419 910 (98) | 669 (94) | 420 579 (98) |
| Twin | 8614 (2) | 42 (6) | 8656 (2) |
| Triplet or more | 125 (0) | – | – |
| Missing, n (%) | 3 (0) | – | – |
| Gestational age (wk), median (IQR) | 39 (38–40) | 38 (36–39) | 39 (38–40) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Apgar score, median (IQR) | 9 (9–9) | 9 (9–9) | 9 (9–9) |
| Missing, n (%) | 3059 (1) | 7 (1) | 3066 (1) |
| CPAP during birth hospitalization, n (%) | 1321 (0) | 15 (2) | 1336 (0) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Ventilation during birth hospitalization, n (%) | 2762 (1) | 45 (6) | 2807 (1) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Bronchopulmonary dysplasia, n (%) | 719 (0) | 17 (2) | 736 (0) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Congenital anomalies of the respiratory system, n (%) | 613 (0) | – | – |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Cyanotic heart disease, n (%) | 569 (0) | 13 (2) | 582 (0) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Down syndrome, n (%) | 348 (0) | – | – |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| . | Infants Without Severe RSV LRTI . | Infants With Severe RSV LRTI . | Total . |
|---|---|---|---|
| Sample size, n (%) | 428 652 (100) | 713 (0) | 429 365 (100) |
| Demographic predictors | |||
| Infant sex, n (%) | |||
| Male | 219 181 (51) | 420 (59) | 219 601 (51) |
| Female | 209 466 (49) | 293 (41) | 209 759 (49) |
| Missing, n (%) | 5 (0) | 0 (0) | 5 (0) |
| Birth month, median (IQR) | 7 (4–10) | 9 (3–11) | 7 (4–10) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Number of living siblings at delivery, median (IQR) | 1 (0–2) | 1 (0–2) | 1 (0–2) |
| Missing, n (%) | 1058 (0) | 0 (0) | 1058 (0) |
| Maternal smoking during pregnancy, n (%) | 114 449 (27) | 277 (39) | 114 726 (27) |
| Missing, n (%) | 681 (0) | 1 (0) | 682 (0) |
| Maternal age at delivery (y), median (IQR) | 22 (20–26) | 22 (20–26) | 22 (20–26) |
| Missing, n (%) | 570 (0) | 1 (0) | 571 (0) |
| Maternal education at delivery, n (%) | |||
| No high school diploma | 157 502 (37) | 342 (48) | 157 844 (37) |
| High school diploma | 185 457 (43) | 283 (40) | 185 740 (43) |
| At least some college | 84 511 (20) | 86 (12) | 84 597 (20) |
| Missing, n (%) | 1182 (0) | 2 (0) | 1184 (0) |
| Maternal region of residence at delivery, n (%) | |||
| Urban | 148 316 (35) | 284 (40) | 148 600 (35) |
| Suburban | 110 661 (26) | 192 (27) | 110 853 (26) |
| Rural | 168 995 (39) | 237 (33) | 169 232 (39) |
| Missing, n (%) | 680 (0) | 0 (0) | 680 (0) |
| Clinical predictors | |||
| Birth weight (g), median (IQR) | 3232 (2892–3572) | 2919 (2353–3374) | 3232 (2892–3572) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Delivery method, n (%) | |||
| Vaginal | 322 936 (75) | 494 (69) | 323 430 (75) |
| Cesarean section | 105 588 (25) | 219 (31) | 105 807 (25) |
| Missing, n (%) | 128 (0) | 0 (0) | 128 (0) |
| Type of birth, n (%) | |||
| Singleton | 419 910 (98) | 669 (94) | 420 579 (98) |
| Twin | 8614 (2) | 42 (6) | 8656 (2) |
| Triplet or more | 125 (0) | – | – |
| Missing, n (%) | 3 (0) | – | – |
| Gestational age (wk), median (IQR) | 39 (38–40) | 38 (36–39) | 39 (38–40) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Apgar score, median (IQR) | 9 (9–9) | 9 (9–9) | 9 (9–9) |
| Missing, n (%) | 3059 (1) | 7 (1) | 3066 (1) |
| CPAP during birth hospitalization, n (%) | 1321 (0) | 15 (2) | 1336 (0) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Ventilation during birth hospitalization, n (%) | 2762 (1) | 45 (6) | 2807 (1) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Bronchopulmonary dysplasia, n (%) | 719 (0) | 17 (2) | 736 (0) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Congenital anomalies of the respiratory system, n (%) | 613 (0) | – | – |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Cyanotic heart disease, n (%) | 569 (0) | 13 (2) | 582 (0) |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
| Down syndrome, n (%) | 348 (0) | – | – |
| Missing, n (%) | 0 (0) | 0 (0) | 0 (0) |
–, Data suppressed (n < 10). Length of birth hospitalization is not listed as single imputation was used to assign 62% of infants for which infant discharge date was missing.
Abbreviations: CPAP, continuous positive airway pressure; IQR, interquartile range; LRTI, lower respiratory tract infection; RSV, respiratory syncytial virus.
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