| Characteristic . | LDL cholesterol >160 (n = 149) . | Non-HDL cholesterol >190 (n = 197) . | Low HDL cholesterol (men <40, women <50) (n = 1026) . | Total triglycerides >150 (n = 587) . | ||||
|---|---|---|---|---|---|---|---|---|
| No. (%) . | OR (95% CI) . | No. (%) . | OR (95% CI) . | No. (%) . | OR (95% CI) . | No. (%) . | OR (95% CI) . | |
| Age at diagnosis, y | 1.0 (0.9, 1.0) | |||||||
| 35 and older, male, or 45 and older, female | 61 (9.9) | 2.7 (1.9 to 3.8) | 83 (13.5) | 2.6 (1.9 to 3.6) | 188 (30.6) | 0.7 (0.5 to 0.9) | 199 (32.4) | 2.3 (1.8 to 2.9) |
| 35 and younger, male, or 45 and younger, female | 88 (3.2) | 1.0 | 114 (4.1) | 1.0 | 838 (30.0) | 1.0 | 388 (13.9) | 1.0 |
| Race and ethnicity | ||||||||
| Black | 15 (2.7) | 0.7 (0.4 to 1.2) | 18 (3.2) | 0.6 (0.3 to 0.9) | 136 (24.0) | 0.5 (0.4 to 0.7) | 41 (7.2) | 0.3 (0.2 to 0.4) |
| Non-Black | 134 (4.7) | 1.0 | 179 (6.3) | 1.0 | 890 (31.4) | 1.0 | 546 (19.0) | 1.0 |
| Hispanic | ||||||||
| Non-Hispanic | ||||||||
| Clinical characteristics | ||||||||
| Hypertension (grade 2-4) | 60 (10.9) | 1.3 (0.9 to 1.9) | 222 (40.4) | 1.3 (1.0 to 1.7) | 161 (29.3) | 1.5 (1.1 to 1.9) | ||
| No hypertension | 137 (4.8) | 1.0 | 804 (28.1) | 1.0 | 426 (14.9) | 1.0 | ||
| Diabetes (grade 2-4) | 19 (14.2) | 1.6 (0.9 to 2.8) | 71 (53.0) | 2.1 (1.4 to 3.2) | 49 (36.6) | 1.9 (1.2 to 2.8) | ||
| No diabetes | 178 (5.4) | 1.0 | 955 (29.2) | 1.0 | 538 (16.4) | 1.0 | ||
| History of hypothyroidism | 111 (35.5) | 1.2 (0.9 to 1.6) | ||||||
| No history of hypothyroidism | 915 (29.6) | 1.0 | ||||||
| Chronic kidney disease (grade 1-4) | 11 (14.3) | 2.1 (1.0 to 4.3) | 22 (28.6) | 0.7 (0.3 to 1.1) | 25 (32.5) | 1.8 (1.0 to 3.1) | ||
| No chronic kidney disease | 186 (5.6) | 1.0 | 1004 (30.2) | 1.0 | 562 (16.9) | 1.0 | ||
| Family history of prematurec atherosclerotic disease | 159 (39.3) | 1.4 (1.1 to 1.8) | ||||||
| No family history of premature coronary heart disease | 867 (28.9) | 1.0 | ||||||
| BMI ≥ 30 | 71 (6.7) | 1.8 (1.3 to 2.5) | 99 (9.3) | 2.1 (1.6 to 2.9) | 524 (49.2) | 3.5 (2.9 to 4.1) | 279 (26.2) | 2.3 (1.9 to 2.8) |
| BMI < 30 | 78 (3.3) | 1.0 | 98 (4.2) | 1.0 | 502 (21.5) | 1.0 | 308 (13.2) | 1.0 |
| History of smoking | 64 (6.3) | 1.7 (1.2 to 2.4) | 86 (8.5) | 1.8 (1.4 to 2.5) | 341 (33.6) | 1.5 (1.2 to 1.8) | 229 (22.5) | 1.6 (1.3 to 2.0) |
| No history of smoking | 85 (3.6) | 1.0 | 111 (4.6) | 1.0 | 685 (28.7) | 1.0 | 358 (15.0) | 1.0 |
| Sedentary lifestyled | 546 (35.8) | 1.5 (1.3 to 1.8) | 288 (18.9) | 1.1 (0.9 to 1.4) | ||||
| Nonsedentary lifestyle | 454 (25.5) | 1.0 | 284 (15.9) | 1.0 | ||||
| Healthy eatinge | 752 (29.3) | 0.9 (0.7 to 1.1) | ||||||
| Nonhealthy eating | 231 (32.5) | 1.0 | ||||||
| Risky drinkingf | 306 (25.3) | 0.7 (0.6 to 0.8) | ||||||
| No risky drinking | 720 (32.8) | 1.0 | ||||||
| Treatment factors | ||||||||
| Cranial RT | 68 (7.3) | 2.1 (1.5 to 3.1) | 87 (9.3) | 2.2 (1.6 to 3.0) | 342 (36.7) | 1.3 (1.1 to 1.6) | 209 (22.5) | 1.4 (1.1 to 1.7) |
| No cranial RT | 81 (3.3) | 1.0 | 110 (4.4) | 1.0 | 684 (27.6) | 1.0 | 378 (15.3) | 1.0 |
| Chest RT | ||||||||
| No chest RT | ||||||||
| Abdominal RT | 42 (7.2) | 1.4 (0.9 to 2.0) | 115 (19.7) | 1.3 (1.0 to 1.7) | ||||
| No abdominal RT | 155 (5.5) | 1.0 | 472 (16.7) | 1.0 | ||||
| Total body irradiation for hematopoietic cell transplantation | 2 (2.7) | 1.2 (0.3 to 4.2) | 13 (17.6) | 6.7 (3.5 to 13.0) | 34 (46.0) | 2.9 (1.7 to 4.7) | 38 (51.4) | 9.9 (6.0 to 16.3) |
| No total body irradiation for hematopoietic cell transplantation | 147 (4.4) | 1.0 | 184 (5.5) | 1.0 | 992 (29.8) | 1.0 | 549 (16.5) | 1.0 |
| Glucocorticoid | 80 (5.2) | 1.0 (0.7 to 1.5) | 98 (6.4) | 0.9 (0.6 to 1.3) | 508 (33.0) | 0.9 (0.8 to 1.3) | 297 (19.3) | 1.2 (1.0 to 1.6) |
| No glucocorticoid | 69 (3.7) | 1.0 | 99 (5.3) | 1.0 | 518 (27.8) | 1.0 | 290 (15.5) | 1.0 |
| Asparaginase | 361 (34.3) | 1.2 (0.9 to 1.6) | ||||||
| No asparaginase | 665 (28.3) | 1.0 | ||||||
| Platinum | 11 (2.5) | 0.8 (0.4 to 1.4) | 14 (3.2) | 0.7 (0.4 to 1.2) | 118 (27.1) | 1.1 (0.8 to 1.4) | 64 (14.7) | 1.2 (0.9 to 1.7) |
| No platinum | 138 (4.7) | 1.0 | 183 (6.2) | 1.0 | 908 (30.6) | 1.0 | 523 (17.6) | 1.0 |
| Anthracycline | 82 (4.2) | 1.1 (0.8 to 1.6) | 104 (5.3) | 1.0 (0.8 to 1.4) | 583 (29.9) | 1.0 (0.8 to 1.2) | 320 (16.4) | 1.0 (0.8 to 1.2) |
| No anthracycline | 67 (4.6) | 1.0 | 93 (6.4) | 1.0 | 443 (30.4) | 1.0 | 267 (18.3) | 1.0 |
| Characteristic . | LDL cholesterol >160 (n = 149) . | Non-HDL cholesterol >190 (n = 197) . | Low HDL cholesterol (men <40, women <50) (n = 1026) . | Total triglycerides >150 (n = 587) . | ||||
|---|---|---|---|---|---|---|---|---|
| No. (%) . | OR (95% CI) . | No. (%) . | OR (95% CI) . | No. (%) . | OR (95% CI) . | No. (%) . | OR (95% CI) . | |
| Age at diagnosis, y | 1.0 (0.9, 1.0) | |||||||
| 35 and older, male, or 45 and older, female | 61 (9.9) | 2.7 (1.9 to 3.8) | 83 (13.5) | 2.6 (1.9 to 3.6) | 188 (30.6) | 0.7 (0.5 to 0.9) | 199 (32.4) | 2.3 (1.8 to 2.9) |
| 35 and younger, male, or 45 and younger, female | 88 (3.2) | 1.0 | 114 (4.1) | 1.0 | 838 (30.0) | 1.0 | 388 (13.9) | 1.0 |
| Race and ethnicity | ||||||||
| Black | 15 (2.7) | 0.7 (0.4 to 1.2) | 18 (3.2) | 0.6 (0.3 to 0.9) | 136 (24.0) | 0.5 (0.4 to 0.7) | 41 (7.2) | 0.3 (0.2 to 0.4) |
| Non-Black | 134 (4.7) | 1.0 | 179 (6.3) | 1.0 | 890 (31.4) | 1.0 | 546 (19.0) | 1.0 |
| Hispanic | ||||||||
| Non-Hispanic | ||||||||
| Clinical characteristics | ||||||||
| Hypertension (grade 2-4) | 60 (10.9) | 1.3 (0.9 to 1.9) | 222 (40.4) | 1.3 (1.0 to 1.7) | 161 (29.3) | 1.5 (1.1 to 1.9) | ||
| No hypertension | 137 (4.8) | 1.0 | 804 (28.1) | 1.0 | 426 (14.9) | 1.0 | ||
| Diabetes (grade 2-4) | 19 (14.2) | 1.6 (0.9 to 2.8) | 71 (53.0) | 2.1 (1.4 to 3.2) | 49 (36.6) | 1.9 (1.2 to 2.8) | ||
| No diabetes | 178 (5.4) | 1.0 | 955 (29.2) | 1.0 | 538 (16.4) | 1.0 | ||
| History of hypothyroidism | 111 (35.5) | 1.2 (0.9 to 1.6) | ||||||
| No history of hypothyroidism | 915 (29.6) | 1.0 | ||||||
| Chronic kidney disease (grade 1-4) | 11 (14.3) | 2.1 (1.0 to 4.3) | 22 (28.6) | 0.7 (0.3 to 1.1) | 25 (32.5) | 1.8 (1.0 to 3.1) | ||
| No chronic kidney disease | 186 (5.6) | 1.0 | 1004 (30.2) | 1.0 | 562 (16.9) | 1.0 | ||
| Family history of prematurec atherosclerotic disease | 159 (39.3) | 1.4 (1.1 to 1.8) | ||||||
| No family history of premature coronary heart disease | 867 (28.9) | 1.0 | ||||||
| BMI ≥ 30 | 71 (6.7) | 1.8 (1.3 to 2.5) | 99 (9.3) | 2.1 (1.6 to 2.9) | 524 (49.2) | 3.5 (2.9 to 4.1) | 279 (26.2) | 2.3 (1.9 to 2.8) |
| BMI < 30 | 78 (3.3) | 1.0 | 98 (4.2) | 1.0 | 502 (21.5) | 1.0 | 308 (13.2) | 1.0 |
| History of smoking | 64 (6.3) | 1.7 (1.2 to 2.4) | 86 (8.5) | 1.8 (1.4 to 2.5) | 341 (33.6) | 1.5 (1.2 to 1.8) | 229 (22.5) | 1.6 (1.3 to 2.0) |
| No history of smoking | 85 (3.6) | 1.0 | 111 (4.6) | 1.0 | 685 (28.7) | 1.0 | 358 (15.0) | 1.0 |
| Sedentary lifestyled | 546 (35.8) | 1.5 (1.3 to 1.8) | 288 (18.9) | 1.1 (0.9 to 1.4) | ||||
| Nonsedentary lifestyle | 454 (25.5) | 1.0 | 284 (15.9) | 1.0 | ||||
| Healthy eatinge | 752 (29.3) | 0.9 (0.7 to 1.1) | ||||||
| Nonhealthy eating | 231 (32.5) | 1.0 | ||||||
| Risky drinkingf | 306 (25.3) | 0.7 (0.6 to 0.8) | ||||||
| No risky drinking | 720 (32.8) | 1.0 | ||||||
| Treatment factors | ||||||||
| Cranial RT | 68 (7.3) | 2.1 (1.5 to 3.1) | 87 (9.3) | 2.2 (1.6 to 3.0) | 342 (36.7) | 1.3 (1.1 to 1.6) | 209 (22.5) | 1.4 (1.1 to 1.7) |
| No cranial RT | 81 (3.3) | 1.0 | 110 (4.4) | 1.0 | 684 (27.6) | 1.0 | 378 (15.3) | 1.0 |
| Chest RT | ||||||||
| No chest RT | ||||||||
| Abdominal RT | 42 (7.2) | 1.4 (0.9 to 2.0) | 115 (19.7) | 1.3 (1.0 to 1.7) | ||||
| No abdominal RT | 155 (5.5) | 1.0 | 472 (16.7) | 1.0 | ||||
| Total body irradiation for hematopoietic cell transplantation | 2 (2.7) | 1.2 (0.3 to 4.2) | 13 (17.6) | 6.7 (3.5 to 13.0) | 34 (46.0) | 2.9 (1.7 to 4.7) | 38 (51.4) | 9.9 (6.0 to 16.3) |
| No total body irradiation for hematopoietic cell transplantation | 147 (4.4) | 1.0 | 184 (5.5) | 1.0 | 992 (29.8) | 1.0 | 549 (16.5) | 1.0 |
| Glucocorticoid | 80 (5.2) | 1.0 (0.7 to 1.5) | 98 (6.4) | 0.9 (0.6 to 1.3) | 508 (33.0) | 0.9 (0.8 to 1.3) | 297 (19.3) | 1.2 (1.0 to 1.6) |
| No glucocorticoid | 69 (3.7) | 1.0 | 99 (5.3) | 1.0 | 518 (27.8) | 1.0 | 290 (15.5) | 1.0 |
| Asparaginase | 361 (34.3) | 1.2 (0.9 to 1.6) | ||||||
| No asparaginase | 665 (28.3) | 1.0 | ||||||
| Platinum | 11 (2.5) | 0.8 (0.4 to 1.4) | 14 (3.2) | 0.7 (0.4 to 1.2) | 118 (27.1) | 1.1 (0.8 to 1.4) | 64 (14.7) | 1.2 (0.9 to 1.7) |
| No platinum | 138 (4.7) | 1.0 | 183 (6.2) | 1.0 | 908 (30.6) | 1.0 | 523 (17.6) | 1.0 |
| Anthracycline | 82 (4.2) | 1.1 (0.8 to 1.6) | 104 (5.3) | 1.0 (0.8 to 1.4) | 583 (29.9) | 1.0 (0.8 to 1.2) | 320 (16.4) | 1.0 (0.8 to 1.2) |
| No anthracycline | 67 (4.6) | 1.0 | 93 (6.4) | 1.0 | 443 (30.4) | 1.0 | 267 (18.3) | 1.0 |
The elastic-net regularization technique was used, adjusting for all variables in rows of this table as well as for cardiovascular outcome occurrence before SJLIFE evaluation. Variables not improving model accuracy were not selected in the each of models. BMI = body mass index; CHD = coronary heart disease; CI = confidence interval; HDL = high-density lipoprotein; LDL = low-density lipoprotein; OR = odds ratio; RT = radiotherapy; SJLIFE = St. Jude Lifetime Cohort Study.
Bold font indicates statistically significant results.
First-degree male relative with CHD before age 55 years; first-degree female relative with CHD before age 65 years.
Rarely or never physical activity.
National Health and Nutrition Examination Survey Healthy Eating Index > 50.8.
>3 drinks per day or >7 per week (females), >4 drinks per day or >14 per week (males).
| Characteristic . | LDL cholesterol >160 (n = 149) . | Non-HDL cholesterol >190 (n = 197) . | Low HDL cholesterol (men <40, women <50) (n = 1026) . | Total triglycerides >150 (n = 587) . | ||||
|---|---|---|---|---|---|---|---|---|
| No. (%) . | OR (95% CI) . | No. (%) . | OR (95% CI) . | No. (%) . | OR (95% CI) . | No. (%) . | OR (95% CI) . | |
| Age at diagnosis, y | 1.0 (0.9, 1.0) | |||||||
| 35 and older, male, or 45 and older, female | 61 (9.9) | 2.7 (1.9 to 3.8) | 83 (13.5) | 2.6 (1.9 to 3.6) | 188 (30.6) | 0.7 (0.5 to 0.9) | 199 (32.4) | 2.3 (1.8 to 2.9) |
| 35 and younger, male, or 45 and younger, female | 88 (3.2) | 1.0 | 114 (4.1) | 1.0 | 838 (30.0) | 1.0 | 388 (13.9) | 1.0 |
| Race and ethnicity | ||||||||
| Black | 15 (2.7) | 0.7 (0.4 to 1.2) | 18 (3.2) | 0.6 (0.3 to 0.9) | 136 (24.0) | 0.5 (0.4 to 0.7) | 41 (7.2) | 0.3 (0.2 to 0.4) |
| Non-Black | 134 (4.7) | 1.0 | 179 (6.3) | 1.0 | 890 (31.4) | 1.0 | 546 (19.0) | 1.0 |
| Hispanic | ||||||||
| Non-Hispanic | ||||||||
| Clinical characteristics | ||||||||
| Hypertension (grade 2-4) | 60 (10.9) | 1.3 (0.9 to 1.9) | 222 (40.4) | 1.3 (1.0 to 1.7) | 161 (29.3) | 1.5 (1.1 to 1.9) | ||
| No hypertension | 137 (4.8) | 1.0 | 804 (28.1) | 1.0 | 426 (14.9) | 1.0 | ||
| Diabetes (grade 2-4) | 19 (14.2) | 1.6 (0.9 to 2.8) | 71 (53.0) | 2.1 (1.4 to 3.2) | 49 (36.6) | 1.9 (1.2 to 2.8) | ||
| No diabetes | 178 (5.4) | 1.0 | 955 (29.2) | 1.0 | 538 (16.4) | 1.0 | ||
| History of hypothyroidism | 111 (35.5) | 1.2 (0.9 to 1.6) | ||||||
| No history of hypothyroidism | 915 (29.6) | 1.0 | ||||||
| Chronic kidney disease (grade 1-4) | 11 (14.3) | 2.1 (1.0 to 4.3) | 22 (28.6) | 0.7 (0.3 to 1.1) | 25 (32.5) | 1.8 (1.0 to 3.1) | ||
| No chronic kidney disease | 186 (5.6) | 1.0 | 1004 (30.2) | 1.0 | 562 (16.9) | 1.0 | ||
| Family history of prematurec atherosclerotic disease | 159 (39.3) | 1.4 (1.1 to 1.8) | ||||||
| No family history of premature coronary heart disease | 867 (28.9) | 1.0 | ||||||
| BMI ≥ 30 | 71 (6.7) | 1.8 (1.3 to 2.5) | 99 (9.3) | 2.1 (1.6 to 2.9) | 524 (49.2) | 3.5 (2.9 to 4.1) | 279 (26.2) | 2.3 (1.9 to 2.8) |
| BMI < 30 | 78 (3.3) | 1.0 | 98 (4.2) | 1.0 | 502 (21.5) | 1.0 | 308 (13.2) | 1.0 |
| History of smoking | 64 (6.3) | 1.7 (1.2 to 2.4) | 86 (8.5) | 1.8 (1.4 to 2.5) | 341 (33.6) | 1.5 (1.2 to 1.8) | 229 (22.5) | 1.6 (1.3 to 2.0) |
| No history of smoking | 85 (3.6) | 1.0 | 111 (4.6) | 1.0 | 685 (28.7) | 1.0 | 358 (15.0) | 1.0 |
| Sedentary lifestyled | 546 (35.8) | 1.5 (1.3 to 1.8) | 288 (18.9) | 1.1 (0.9 to 1.4) | ||||
| Nonsedentary lifestyle | 454 (25.5) | 1.0 | 284 (15.9) | 1.0 | ||||
| Healthy eatinge | 752 (29.3) | 0.9 (0.7 to 1.1) | ||||||
| Nonhealthy eating | 231 (32.5) | 1.0 | ||||||
| Risky drinkingf | 306 (25.3) | 0.7 (0.6 to 0.8) | ||||||
| No risky drinking | 720 (32.8) | 1.0 | ||||||
| Treatment factors | ||||||||
| Cranial RT | 68 (7.3) | 2.1 (1.5 to 3.1) | 87 (9.3) | 2.2 (1.6 to 3.0) | 342 (36.7) | 1.3 (1.1 to 1.6) | 209 (22.5) | 1.4 (1.1 to 1.7) |
| No cranial RT | 81 (3.3) | 1.0 | 110 (4.4) | 1.0 | 684 (27.6) | 1.0 | 378 (15.3) | 1.0 |
| Chest RT | ||||||||
| No chest RT | ||||||||
| Abdominal RT | 42 (7.2) | 1.4 (0.9 to 2.0) | 115 (19.7) | 1.3 (1.0 to 1.7) | ||||
| No abdominal RT | 155 (5.5) | 1.0 | 472 (16.7) | 1.0 | ||||
| Total body irradiation for hematopoietic cell transplantation | 2 (2.7) | 1.2 (0.3 to 4.2) | 13 (17.6) | 6.7 (3.5 to 13.0) | 34 (46.0) | 2.9 (1.7 to 4.7) | 38 (51.4) | 9.9 (6.0 to 16.3) |
| No total body irradiation for hematopoietic cell transplantation | 147 (4.4) | 1.0 | 184 (5.5) | 1.0 | 992 (29.8) | 1.0 | 549 (16.5) | 1.0 |
| Glucocorticoid | 80 (5.2) | 1.0 (0.7 to 1.5) | 98 (6.4) | 0.9 (0.6 to 1.3) | 508 (33.0) | 0.9 (0.8 to 1.3) | 297 (19.3) | 1.2 (1.0 to 1.6) |
| No glucocorticoid | 69 (3.7) | 1.0 | 99 (5.3) | 1.0 | 518 (27.8) | 1.0 | 290 (15.5) | 1.0 |
| Asparaginase | 361 (34.3) | 1.2 (0.9 to 1.6) | ||||||
| No asparaginase | 665 (28.3) | 1.0 | ||||||
| Platinum | 11 (2.5) | 0.8 (0.4 to 1.4) | 14 (3.2) | 0.7 (0.4 to 1.2) | 118 (27.1) | 1.1 (0.8 to 1.4) | 64 (14.7) | 1.2 (0.9 to 1.7) |
| No platinum | 138 (4.7) | 1.0 | 183 (6.2) | 1.0 | 908 (30.6) | 1.0 | 523 (17.6) | 1.0 |
| Anthracycline | 82 (4.2) | 1.1 (0.8 to 1.6) | 104 (5.3) | 1.0 (0.8 to 1.4) | 583 (29.9) | 1.0 (0.8 to 1.2) | 320 (16.4) | 1.0 (0.8 to 1.2) |
| No anthracycline | 67 (4.6) | 1.0 | 93 (6.4) | 1.0 | 443 (30.4) | 1.0 | 267 (18.3) | 1.0 |
| Characteristic . | LDL cholesterol >160 (n = 149) . | Non-HDL cholesterol >190 (n = 197) . | Low HDL cholesterol (men <40, women <50) (n = 1026) . | Total triglycerides >150 (n = 587) . | ||||
|---|---|---|---|---|---|---|---|---|
| No. (%) . | OR (95% CI) . | No. (%) . | OR (95% CI) . | No. (%) . | OR (95% CI) . | No. (%) . | OR (95% CI) . | |
| Age at diagnosis, y | 1.0 (0.9, 1.0) | |||||||
| 35 and older, male, or 45 and older, female | 61 (9.9) | 2.7 (1.9 to 3.8) | 83 (13.5) | 2.6 (1.9 to 3.6) | 188 (30.6) | 0.7 (0.5 to 0.9) | 199 (32.4) | 2.3 (1.8 to 2.9) |
| 35 and younger, male, or 45 and younger, female | 88 (3.2) | 1.0 | 114 (4.1) | 1.0 | 838 (30.0) | 1.0 | 388 (13.9) | 1.0 |
| Race and ethnicity | ||||||||
| Black | 15 (2.7) | 0.7 (0.4 to 1.2) | 18 (3.2) | 0.6 (0.3 to 0.9) | 136 (24.0) | 0.5 (0.4 to 0.7) | 41 (7.2) | 0.3 (0.2 to 0.4) |
| Non-Black | 134 (4.7) | 1.0 | 179 (6.3) | 1.0 | 890 (31.4) | 1.0 | 546 (19.0) | 1.0 |
| Hispanic | ||||||||
| Non-Hispanic | ||||||||
| Clinical characteristics | ||||||||
| Hypertension (grade 2-4) | 60 (10.9) | 1.3 (0.9 to 1.9) | 222 (40.4) | 1.3 (1.0 to 1.7) | 161 (29.3) | 1.5 (1.1 to 1.9) | ||
| No hypertension | 137 (4.8) | 1.0 | 804 (28.1) | 1.0 | 426 (14.9) | 1.0 | ||
| Diabetes (grade 2-4) | 19 (14.2) | 1.6 (0.9 to 2.8) | 71 (53.0) | 2.1 (1.4 to 3.2) | 49 (36.6) | 1.9 (1.2 to 2.8) | ||
| No diabetes | 178 (5.4) | 1.0 | 955 (29.2) | 1.0 | 538 (16.4) | 1.0 | ||
| History of hypothyroidism | 111 (35.5) | 1.2 (0.9 to 1.6) | ||||||
| No history of hypothyroidism | 915 (29.6) | 1.0 | ||||||
| Chronic kidney disease (grade 1-4) | 11 (14.3) | 2.1 (1.0 to 4.3) | 22 (28.6) | 0.7 (0.3 to 1.1) | 25 (32.5) | 1.8 (1.0 to 3.1) | ||
| No chronic kidney disease | 186 (5.6) | 1.0 | 1004 (30.2) | 1.0 | 562 (16.9) | 1.0 | ||
| Family history of prematurec atherosclerotic disease | 159 (39.3) | 1.4 (1.1 to 1.8) | ||||||
| No family history of premature coronary heart disease | 867 (28.9) | 1.0 | ||||||
| BMI ≥ 30 | 71 (6.7) | 1.8 (1.3 to 2.5) | 99 (9.3) | 2.1 (1.6 to 2.9) | 524 (49.2) | 3.5 (2.9 to 4.1) | 279 (26.2) | 2.3 (1.9 to 2.8) |
| BMI < 30 | 78 (3.3) | 1.0 | 98 (4.2) | 1.0 | 502 (21.5) | 1.0 | 308 (13.2) | 1.0 |
| History of smoking | 64 (6.3) | 1.7 (1.2 to 2.4) | 86 (8.5) | 1.8 (1.4 to 2.5) | 341 (33.6) | 1.5 (1.2 to 1.8) | 229 (22.5) | 1.6 (1.3 to 2.0) |
| No history of smoking | 85 (3.6) | 1.0 | 111 (4.6) | 1.0 | 685 (28.7) | 1.0 | 358 (15.0) | 1.0 |
| Sedentary lifestyled | 546 (35.8) | 1.5 (1.3 to 1.8) | 288 (18.9) | 1.1 (0.9 to 1.4) | ||||
| Nonsedentary lifestyle | 454 (25.5) | 1.0 | 284 (15.9) | 1.0 | ||||
| Healthy eatinge | 752 (29.3) | 0.9 (0.7 to 1.1) | ||||||
| Nonhealthy eating | 231 (32.5) | 1.0 | ||||||
| Risky drinkingf | 306 (25.3) | 0.7 (0.6 to 0.8) | ||||||
| No risky drinking | 720 (32.8) | 1.0 | ||||||
| Treatment factors | ||||||||
| Cranial RT | 68 (7.3) | 2.1 (1.5 to 3.1) | 87 (9.3) | 2.2 (1.6 to 3.0) | 342 (36.7) | 1.3 (1.1 to 1.6) | 209 (22.5) | 1.4 (1.1 to 1.7) |
| No cranial RT | 81 (3.3) | 1.0 | 110 (4.4) | 1.0 | 684 (27.6) | 1.0 | 378 (15.3) | 1.0 |
| Chest RT | ||||||||
| No chest RT | ||||||||
| Abdominal RT | 42 (7.2) | 1.4 (0.9 to 2.0) | 115 (19.7) | 1.3 (1.0 to 1.7) | ||||
| No abdominal RT | 155 (5.5) | 1.0 | 472 (16.7) | 1.0 | ||||
| Total body irradiation for hematopoietic cell transplantation | 2 (2.7) | 1.2 (0.3 to 4.2) | 13 (17.6) | 6.7 (3.5 to 13.0) | 34 (46.0) | 2.9 (1.7 to 4.7) | 38 (51.4) | 9.9 (6.0 to 16.3) |
| No total body irradiation for hematopoietic cell transplantation | 147 (4.4) | 1.0 | 184 (5.5) | 1.0 | 992 (29.8) | 1.0 | 549 (16.5) | 1.0 |
| Glucocorticoid | 80 (5.2) | 1.0 (0.7 to 1.5) | 98 (6.4) | 0.9 (0.6 to 1.3) | 508 (33.0) | 0.9 (0.8 to 1.3) | 297 (19.3) | 1.2 (1.0 to 1.6) |
| No glucocorticoid | 69 (3.7) | 1.0 | 99 (5.3) | 1.0 | 518 (27.8) | 1.0 | 290 (15.5) | 1.0 |
| Asparaginase | 361 (34.3) | 1.2 (0.9 to 1.6) | ||||||
| No asparaginase | 665 (28.3) | 1.0 | ||||||
| Platinum | 11 (2.5) | 0.8 (0.4 to 1.4) | 14 (3.2) | 0.7 (0.4 to 1.2) | 118 (27.1) | 1.1 (0.8 to 1.4) | 64 (14.7) | 1.2 (0.9 to 1.7) |
| No platinum | 138 (4.7) | 1.0 | 183 (6.2) | 1.0 | 908 (30.6) | 1.0 | 523 (17.6) | 1.0 |
| Anthracycline | 82 (4.2) | 1.1 (0.8 to 1.6) | 104 (5.3) | 1.0 (0.8 to 1.4) | 583 (29.9) | 1.0 (0.8 to 1.2) | 320 (16.4) | 1.0 (0.8 to 1.2) |
| No anthracycline | 67 (4.6) | 1.0 | 93 (6.4) | 1.0 | 443 (30.4) | 1.0 | 267 (18.3) | 1.0 |
The elastic-net regularization technique was used, adjusting for all variables in rows of this table as well as for cardiovascular outcome occurrence before SJLIFE evaluation. Variables not improving model accuracy were not selected in the each of models. BMI = body mass index; CHD = coronary heart disease; CI = confidence interval; HDL = high-density lipoprotein; LDL = low-density lipoprotein; OR = odds ratio; RT = radiotherapy; SJLIFE = St. Jude Lifetime Cohort Study.
Bold font indicates statistically significant results.
First-degree male relative with CHD before age 55 years; first-degree female relative with CHD before age 65 years.
Rarely or never physical activity.
National Health and Nutrition Examination Survey Healthy Eating Index > 50.8.
>3 drinks per day or >7 per week (females), >4 drinks per day or >14 per week (males).
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