Table 5: Open in new tab...

Year

Author

Study design, N

Biomarker

Outcome

Findings

2022

Devereaux [34]

Prospective registry, 13 862

TnI

Biomarker elevations after different surgical procedures

Varied considerably across procedures

2022

Niclauss [82]

Retrospective, 400

TnT
CK-MB

Biomarker elevations after different surgical procedures

Both biomarkers highest in AVR + CABG and MV surgery (compared to isolated CABG or AVR and aortic surgery)

2022

Zhou [83]

Registry, 10 253

TnT

Biomarker elevations after different surgical procedures;
Mortality or LCOS

Compared to CABG, MVR on average resulted in similar peak TnT concentrations, AV surgery in ∼50% lower and CABG/MVR+ AV surgery 50% higher TnT concentrations
The strength of association between TnT and the outcome was similar after all types of procedures

2015

Mastro [84]

Registry, 200

TnI
CK-MB

Magnitude and release pattern of cardiac injury biomarkers

Largest magnitude after MV surgery and combined surgery, intermediate after CABG and lowest after AV surgery or thoracic aortic surgery

2014

Paparella [85]

Registry, 965

TnI

TnI elevations
Mortality

TnI was higher after MV than after AV surgery and was an independent predictor of mortality

Table 5:

Open in new tab

Procedure-specific associations between cardiac injury biomarkers and outcomes

Year	Author	Study design, N	Biomarker	Outcome	Findings
2022	Devereaux [34]	Prospective registry, 13 862	TnI	Biomarker elevations after different surgical procedures	Varied considerably across procedures
2022	Niclauss [82]	Retrospective, 400	TnT CK-MB	Biomarker elevations after different surgical procedures	Both biomarkers highest in AVR + CABG and MV surgery (compared to isolated CABG or AVR and aortic surgery)
2022	Zhou [83]	Registry, 10 253	TnT	Biomarker elevations after different surgical procedures; Mortality or LCOS	Compared to CABG, MVR on average resulted in similar peak TnT concentrations, AV surgery in ∼50% lower and CABG/MVR+ AV surgery 50% higher TnT concentrations The strength of association between TnT and the outcome was similar after all types of procedures
2015	Mastro [84]	Registry, 200	TnI CK-MB	Magnitude and release pattern of cardiac injury biomarkers	Largest magnitude after MV surgery and combined surgery, intermediate after CABG and lowest after AV surgery or thoracic aortic surgery
2014	Paparella [85]	Registry, 965	TnI	TnI elevations Mortality	TnI was higher after MV than after AV surgery and was an independent predictor of mortality

Year	Author	Study design, N	Biomarker	Outcome	Findings
2022	Devereaux [34]	Prospective registry, 13 862	TnI	Biomarker elevations after different surgical procedures	Varied considerably across procedures
2022	Niclauss [82]	Retrospective, 400	TnT CK-MB	Biomarker elevations after different surgical procedures	Both biomarkers highest in AVR + CABG and MV surgery (compared to isolated CABG or AVR and aortic surgery)
2022	Zhou [83]	Registry, 10 253	TnT	Biomarker elevations after different surgical procedures; Mortality or LCOS	Compared to CABG, MVR on average resulted in similar peak TnT concentrations, AV surgery in ∼50% lower and CABG/MVR+ AV surgery 50% higher TnT concentrations The strength of association between TnT and the outcome was similar after all types of procedures
2015	Mastro [84]	Registry, 200	TnI CK-MB	Magnitude and release pattern of cardiac injury biomarkers	Largest magnitude after MV surgery and combined surgery, intermediate after CABG and lowest after AV surgery or thoracic aortic surgery
2014	Paparella [85]	Registry, 965	TnI	TnI elevations Mortality	TnI was higher after MV than after AV surgery and was an independent predictor of mortality

AV: aortic valve; AVR: aortic valve replacement; CABG: coronary artery bypass graft; CK-MB: creatine kinase MB; LCOS: low cardiac output syndrome; MV: mitral valve; MVR: mitral valve regurgitation; TnI: troponin I; TnT: troponin.

This Feature Is Available To Subscribers Only