Table 1
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Demographic and phenotypic features of children and adolescents with ulcerative colitis [UC] or IBD-unclassified [IBD-U] at time of diagnosis.

Acute severe
colitis
n = 105		Mild to moderate colitis
n = 273		p-value
UC: IBD-U96 [91%] 9 [9%]241 [88%] 32 [12%]0.65
Male n [%]44 [42%]143 [52%]0.07
Age at diagnosis14 [11.2-15.7]*13 [9.7-15.3]0.05
Duration of symptoms [weeks]8 [4-19]14 [6.5-29]<0.001
Family history [1st-degree relative]17 [16%]46 [17%]0.80
Ethnicity
Caucasian65 [65%]150 [58%]0.009
South Asian14 [14%]42 [16%]
African/Caribbean -15 [6%]
Other10 [10%]12 [4%]
Mixed11 [11%]42 [16%]
Disease extent
E1-25 [9%]<0.001
E2-21 [8%]
E314 [13%]34 [13%]
E491 [87%]187 [70%]
Clinical disease activity at presentation
PUCAI75 [70-80]45 [30-55]<0.001
Mayo endoscopic score
Mayo 1-90 [33%]<0.001
Mayo 240 [38%]137 [51%]
Mayo 365 [62%]44 [16%]
Laboratory parameters at presentation
Albumin g/L31 [25-35]40 [35-43]<0.001
Hb g/L104 [86-121]115 [99-127]<0.001
CRP mg/L14 [5-36]5 [1-9.9]<0.001
ESR mm/h29 [18-50]22 [12-38]0.002
Platelets [109/L]416 [334-528]376 [304-469]0.008
Anthropometric measurements at presentation
Height z-score0.28 ± 1.160.19 ± 1.090.51
Weight z-score-0.14 ± 1.13-0.02 ± 1.280.41
BMI z-score-0.41 ± 1.27-0.26 ± 1.460.34
Acute severe
colitis
n = 105		Mild to moderate colitis
n = 273		p-value
UC: IBD-U96 [91%] 9 [9%]241 [88%] 32 [12%]0.65
Male n [%]44 [42%]143 [52%]0.07
Age at diagnosis14 [11.2-15.7]*13 [9.7-15.3]0.05
Duration of symptoms [weeks]8 [4-19]14 [6.5-29]<0.001
Family history [1st-degree relative]17 [16%]46 [17%]0.80
Ethnicity
Caucasian65 [65%]150 [58%]0.009
South Asian14 [14%]42 [16%]
African/Caribbean -15 [6%]
Other10 [10%]12 [4%]
Mixed11 [11%]42 [16%]
Disease extent
E1-25 [9%]<0.001
E2-21 [8%]
E314 [13%]34 [13%]
E491 [87%]187 [70%]
Clinical disease activity at presentation
PUCAI75 [70-80]45 [30-55]<0.001
Mayo endoscopic score
Mayo 1-90 [33%]<0.001
Mayo 240 [38%]137 [51%]
Mayo 365 [62%]44 [16%]
Laboratory parameters at presentation
Albumin g/L31 [25-35]40 [35-43]<0.001
Hb g/L104 [86-121]115 [99-127]<0.001
CRP mg/L14 [5-36]5 [1-9.9]<0.001
ESR mm/h29 [18-50]22 [12-38]0.002
Platelets [109/L]416 [334-528]376 [304-469]0.008
Anthropometric measurements at presentation
Height z-score0.28 ± 1.160.19 ± 1.090.51
Weight z-score-0.14 ± 1.13-0.02 ± 1.280.41
BMI z-score-0.41 ± 1.27-0.26 ± 1.460.34

Values are presented as n [%], mean ± standard deviation, or median [interquartile range], as appropriate

PUCAI: Pediatric Ulcerative Colitis Activity Index; PGA: Physician’s Global Assessment; ESR: erythrocyte sedimentation rate; CRP: C reactive protein; Hb: haemoglobin.

*Seven children with ASUC were diagnosed prior to age 6 years [age range: 2.75-5.58 years].

Table 1
Open in new tab

Demographic and phenotypic features of children and adolescents with ulcerative colitis [UC] or IBD-unclassified [IBD-U] at time of diagnosis.

Acute severe
colitis
n = 105		Mild to moderate colitis
n = 273		p-value
UC: IBD-U96 [91%] 9 [9%]241 [88%] 32 [12%]0.65
Male n [%]44 [42%]143 [52%]0.07
Age at diagnosis14 [11.2-15.7]*13 [9.7-15.3]0.05
Duration of symptoms [weeks]8 [4-19]14 [6.5-29]<0.001
Family history [1st-degree relative]17 [16%]46 [17%]0.80
Ethnicity
Caucasian65 [65%]150 [58%]0.009
South Asian14 [14%]42 [16%]
African/Caribbean -15 [6%]
Other10 [10%]12 [4%]
Mixed11 [11%]42 [16%]
Disease extent
E1-25 [9%]<0.001
E2-21 [8%]
E314 [13%]34 [13%]
E491 [87%]187 [70%]
Clinical disease activity at presentation
PUCAI75 [70-80]45 [30-55]<0.001
Mayo endoscopic score
Mayo 1-90 [33%]<0.001
Mayo 240 [38%]137 [51%]
Mayo 365 [62%]44 [16%]
Laboratory parameters at presentation
Albumin g/L31 [25-35]40 [35-43]<0.001
Hb g/L104 [86-121]115 [99-127]<0.001
CRP mg/L14 [5-36]5 [1-9.9]<0.001
ESR mm/h29 [18-50]22 [12-38]0.002
Platelets [109/L]416 [334-528]376 [304-469]0.008
Anthropometric measurements at presentation
Height z-score0.28 ± 1.160.19 ± 1.090.51
Weight z-score-0.14 ± 1.13-0.02 ± 1.280.41
BMI z-score-0.41 ± 1.27-0.26 ± 1.460.34
Acute severe
colitis
n = 105		Mild to moderate colitis
n = 273		p-value
UC: IBD-U96 [91%] 9 [9%]241 [88%] 32 [12%]0.65
Male n [%]44 [42%]143 [52%]0.07
Age at diagnosis14 [11.2-15.7]*13 [9.7-15.3]0.05
Duration of symptoms [weeks]8 [4-19]14 [6.5-29]<0.001
Family history [1st-degree relative]17 [16%]46 [17%]0.80
Ethnicity
Caucasian65 [65%]150 [58%]0.009
South Asian14 [14%]42 [16%]
African/Caribbean -15 [6%]
Other10 [10%]12 [4%]
Mixed11 [11%]42 [16%]
Disease extent
E1-25 [9%]<0.001
E2-21 [8%]
E314 [13%]34 [13%]
E491 [87%]187 [70%]
Clinical disease activity at presentation
PUCAI75 [70-80]45 [30-55]<0.001
Mayo endoscopic score
Mayo 1-90 [33%]<0.001
Mayo 240 [38%]137 [51%]
Mayo 365 [62%]44 [16%]
Laboratory parameters at presentation
Albumin g/L31 [25-35]40 [35-43]<0.001
Hb g/L104 [86-121]115 [99-127]<0.001
CRP mg/L14 [5-36]5 [1-9.9]<0.001
ESR mm/h29 [18-50]22 [12-38]0.002
Platelets [109/L]416 [334-528]376 [304-469]0.008
Anthropometric measurements at presentation
Height z-score0.28 ± 1.160.19 ± 1.090.51
Weight z-score-0.14 ± 1.13-0.02 ± 1.280.41
BMI z-score-0.41 ± 1.27-0.26 ± 1.460.34

Values are presented as n [%], mean ± standard deviation, or median [interquartile range], as appropriate

PUCAI: Pediatric Ulcerative Colitis Activity Index; PGA: Physician’s Global Assessment; ESR: erythrocyte sedimentation rate; CRP: C reactive protein; Hb: haemoglobin.

*Seven children with ASUC were diagnosed prior to age 6 years [age range: 2.75-5.58 years].

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