Table 1 Open in new tab Demographic...

	Aβ−negative (n = 460)	Aβ−positive (n = 372)
Sex, n Females, (%)	176 (58.67)	56 (38.62)	5 (33.33)	96 (58.90)	65 (49.24)	32 (41.56)
APOE4 carriers, n (%)	66 (22.00)	23 (15.86)	5 (33.33)	73 (44.79)	70 (53.03)	48 (62.34)
Age (years)	71.48 (7.31)	73.72 (8.48)	73.83 (8.43)	74.82 (7.57)	74.36 (7.39)	77.35 (8.93)
Education (years)	16.83 (2.30)	16.32 (2.74)	16.07 (2.60)	16.64 (2.34)	15.99 (2.49)	15.55 (2.48)
Centiloid values	4.09 (8.11)	1.18 (10.53)	1.63 (11.27)	53.47 (30.83)	75.78 (35.15)	90.14 (32.86)
Memory composite score	1.08 (0.61)^b,c	0.52 (0.62)^a,c	−0.55 (0.48)^a,b	1.00 (0.62)^b,c	0.07 (0.59)^a,c	−0.77 (0.57)^a,b
Executive composite score	1.20 (0.82)^b,c	0.61 (0.82)^a,c	−0.47 (0.95)^a,b	0.92 (0.77)^b,c	0.19 (0.92)^a,c	−0.79 (1.16)^a,b
Language composite score	0.89 (0.51)^b,c	0.52 (0.50)^a,c	−0.21 (0.39)^a,b	0.75 (0.49)^b,c	0.41 (0.55)^a,c	−0.18 (0.61)^a,b
Visuospatial composite score	0.13 (0.29)^b	0.01 (0.34)^a	−0.07 (0.44)	0.06 (0.36)^c	0.00 (0.38)^c	−0.43 (0.72)^a,b
Longitudinal sub-sample	CU (n = 96)	MCI (n = 40)	AD (n = 10)	CU (n = 90)	MCI (n = 66)	AD (n = 39)
Average number of tau-PET scan per participant	2.56 (0.87)	2.52 (0.72)	2.20 (0.42)	2.68 (0.75)	2.58 (0.66)	2.54 (0.60)
Average number of cognitive visits per participant	6.24 (3.45)	8.75 (5.59)^a,c	3.80 (3.88)	6.18 (3.83)	5.55 (4.21)	4.54 (4.02)

Aβ−negative (n = 460)

Aβ−positive (n = 372)

CU
(n = 300)

MCI
(n = 145)

AD
(n = 15)

CU
(n = 163)

MCI
(n = 132)

AD
(n = 77)

Sex, n Females, (%)

176 (58.67)

56 (38.62)

5 (33.33)

96 (58.90)

65 (49.24)

32 (41.56)

APOE4 carriers, n (%)

66 (22.00)

23 (15.86)

5 (33.33)

73 (44.79)

70 (53.03)

48 (62.34)

Age (years)

71.48 (7.31)

73.72 (8.48)

73.83 (8.43)

74.82 (7.57)

74.36 (7.39)

77.35 (8.93)

Education (years)

16.83 (2.30)

16.32 (2.74)

16.07 (2.60)

16.64 (2.34)

15.99 (2.49)

15.55 (2.48)

Centiloid values

4.09 (8.11)

1.18 (10.53)

1.63 (11.27)

53.47 (30.83)

75.78 (35.15)

90.14 (32.86)

Memory composite score

1.08 (0.61)^b,c

0.52 (0.62)^a,c

−0.55 (0.48)^a,b

1.00 (0.62)^b,c

0.07 (0.59)^a,c

−0.77 (0.57)^a,b

Executive composite score

1.20 (0.82)^b,c

0.61 (0.82)^a,c

−0.47 (0.95)^a,b

0.92 (0.77)^b,c

0.19 (0.92)^a,c

−0.79 (1.16)^a,b

Language composite score

0.89 (0.51)^b,c

0.52 (0.50)^a,c

−0.21 (0.39)^a,b

0.75 (0.49)^b,c

0.41 (0.55)^a,c

−0.18 (0.61)^a,b

Visuospatial composite score

0.13 (0.29)^b

0.01 (0.34)^a

−0.07 (0.44)

0.06 (0.36)^c

0.00 (0.38)^c

−0.43 (0.72)^a,b

Longitudinal sub-sample

CU
(n = 96)

MCI
(n = 40)

AD
(n = 10)

CU
(n = 90)

MCI
(n = 66)

AD
(n = 39)

Average number of tau-PET scan per participant

2.56 (0.87)

2.52 (0.72)

2.20 (0.42)

2.68 (0.75)

2.58 (0.66)

2.54 (0.60)

Average number of cognitive visits per participant

6.24 (3.45)

8.75 (5.59)^a,c

3.80 (3.88)

6.18 (3.83)

5.55 (4.21)

4.54 (4.02)

	Aβ−negative (n = 460)	Aβ−positive (n = 372)
Sex, n Females, (%)	176 (58.67)	56 (38.62)	5 (33.33)	96 (58.90)	65 (49.24)	32 (41.56)
APOE4 carriers, n (%)	66 (22.00)	23 (15.86)	5 (33.33)	73 (44.79)	70 (53.03)	48 (62.34)
Age (years)	71.48 (7.31)	73.72 (8.48)	73.83 (8.43)	74.82 (7.57)	74.36 (7.39)	77.35 (8.93)
Education (years)	16.83 (2.30)	16.32 (2.74)	16.07 (2.60)	16.64 (2.34)	15.99 (2.49)	15.55 (2.48)
Centiloid values	4.09 (8.11)	1.18 (10.53)	1.63 (11.27)	53.47 (30.83)	75.78 (35.15)	90.14 (32.86)
Memory composite score	1.08 (0.61)^b,c	0.52 (0.62)^a,c	−0.55 (0.48)^a,b	1.00 (0.62)^b,c	0.07 (0.59)^a,c	−0.77 (0.57)^a,b
Executive composite score	1.20 (0.82)^b,c	0.61 (0.82)^a,c	−0.47 (0.95)^a,b	0.92 (0.77)^b,c	0.19 (0.92)^a,c	−0.79 (1.16)^a,b
Language composite score	0.89 (0.51)^b,c	0.52 (0.50)^a,c	−0.21 (0.39)^a,b	0.75 (0.49)^b,c	0.41 (0.55)^a,c	−0.18 (0.61)^a,b
Visuospatial composite score	0.13 (0.29)^b	0.01 (0.34)^a	−0.07 (0.44)	0.06 (0.36)^c	0.00 (0.38)^c	−0.43 (0.72)^a,b
Longitudinal sub-sample	CU (n = 96)	MCI (n = 40)	AD (n = 10)	CU (n = 90)	MCI (n = 66)	AD (n = 39)
Average number of tau-PET scan per participant	2.56 (0.87)	2.52 (0.72)	2.20 (0.42)	2.68 (0.75)	2.58 (0.66)	2.54 (0.60)
Average number of cognitive visits per participant	6.24 (3.45)	8.75 (5.59)^a,c	3.80 (3.88)	6.18 (3.83)	5.55 (4.21)	4.54 (4.02)

Table 1

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Demographic information

	Aβ−negative (n = 460)			Aβ−positive (n = 372)
	CU (n = 300)	MCI (n = 145)	AD (n = 15)	CU (n = 163)	MCI (n = 132)	AD (n = 77)
Sex, n Females, (%)	176 (58.67)	56 (38.62)	5 (33.33)	96 (58.90)	65 (49.24)	32 (41.56)
APOE4 carriers, n (%)	66 (22.00)	23 (15.86)	5 (33.33)	73 (44.79)	70 (53.03)	48 (62.34)
Age (years)	71.48 (7.31)	73.72 (8.48)	73.83 (8.43)	74.82 (7.57)	74.36 (7.39)	77.35 (8.93)
Education (years)	16.83 (2.30)	16.32 (2.74)	16.07 (2.60)	16.64 (2.34)	15.99 (2.49)	15.55 (2.48)
Centiloid values	4.09 (8.11)	1.18 (10.53)	1.63 (11.27)	53.47 (30.83)	75.78 (35.15)	90.14 (32.86)
Memory composite score	1.08 (0.61)^b,c	0.52 (0.62)^a,c	−0.55 (0.48)^a,b	1.00 (0.62)^b,c	0.07 (0.59)^a,c	−0.77 (0.57)^a,b
Executive composite score	1.20 (0.82)^b,c	0.61 (0.82)^a,c	−0.47 (0.95)^a,b	0.92 (0.77)^b,c	0.19 (0.92)^a,c	−0.79 (1.16)^a,b
Language composite score	0.89 (0.51)^b,c	0.52 (0.50)^a,c	−0.21 (0.39)^a,b	0.75 (0.49)^b,c	0.41 (0.55)^a,c	−0.18 (0.61)^a,b
Visuospatial composite score	0.13 (0.29)^b	0.01 (0.34)^a	−0.07 (0.44)	0.06 (0.36)^c	0.00 (0.38)^c	−0.43 (0.72)^a,b
Longitudinal sub-sample	CU (n = 96)	MCI (n = 40)	AD (n = 10)	CU (n = 90)	MCI (n = 66)	AD (n = 39)
Average number of tau-PET scan per participant	2.56 (0.87)	2.52 (0.72)	2.20 (0.42)	2.68 (0.75)	2.58 (0.66)	2.54 (0.60)
Average number of cognitive visits per participant	6.24 (3.45)	8.75 (5.59)^a,c	3.80 (3.88)	6.18 (3.83)	5.55 (4.21)	4.54 (4.02)

	Aβ−negative (n = 460)			Aβ−positive (n = 372)
	CU (n = 300)	MCI (n = 145)	AD (n = 15)	CU (n = 163)	MCI (n = 132)	AD (n = 77)
Sex, n Females, (%)	176 (58.67)	56 (38.62)	5 (33.33)	96 (58.90)	65 (49.24)	32 (41.56)
APOE4 carriers, n (%)	66 (22.00)	23 (15.86)	5 (33.33)	73 (44.79)	70 (53.03)	48 (62.34)
Age (years)	71.48 (7.31)	73.72 (8.48)	73.83 (8.43)	74.82 (7.57)	74.36 (7.39)	77.35 (8.93)
Education (years)	16.83 (2.30)	16.32 (2.74)	16.07 (2.60)	16.64 (2.34)	15.99 (2.49)	15.55 (2.48)
Centiloid values	4.09 (8.11)	1.18 (10.53)	1.63 (11.27)	53.47 (30.83)	75.78 (35.15)	90.14 (32.86)
Memory composite score	1.08 (0.61)^b,c	0.52 (0.62)^a,c	−0.55 (0.48)^a,b	1.00 (0.62)^b,c	0.07 (0.59)^a,c	−0.77 (0.57)^a,b
Executive composite score	1.20 (0.82)^b,c	0.61 (0.82)^a,c	−0.47 (0.95)^a,b	0.92 (0.77)^b,c	0.19 (0.92)^a,c	−0.79 (1.16)^a,b
Language composite score	0.89 (0.51)^b,c	0.52 (0.50)^a,c	−0.21 (0.39)^a,b	0.75 (0.49)^b,c	0.41 (0.55)^a,c	−0.18 (0.61)^a,b
Visuospatial composite score	0.13 (0.29)^b	0.01 (0.34)^a	−0.07 (0.44)	0.06 (0.36)^c	0.00 (0.38)^c	−0.43 (0.72)^a,b
Longitudinal sub-sample	CU (n = 96)	MCI (n = 40)	AD (n = 10)	CU (n = 90)	MCI (n = 66)	AD (n = 39)
Average number of tau-PET scan per participant	2.56 (0.87)	2.52 (0.72)	2.20 (0.42)	2.68 (0.75)	2.58 (0.66)	2.54 (0.60)
Average number of cognitive visits per participant	6.24 (3.45)	8.75 (5.59)^a,c	3.80 (3.88)	6.18 (3.83)	5.55 (4.21)	4.54 (4.02)

^asignificantly different from the CU group.

^bsignificantly different from the MCI group.

^csignificantly different from the AD group. Values correspond to mean (standard deviation) unless otherwise specified. APOE4 positivity corresponds to having at least one e4 allele. Statistical tests were performed within each of Aβ-negative and Aβ-positive groups.

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