Exploratory cohort: demographic details and AP Pons and MCP diameters at first scan
| Diagnosis . | Male:female (% male) . | Age of motor onset (years) Mean ± SD . | Age at first scan (years) Mean ± SD . | Patients with multiple scans (N, %) . | Mean AP Pons (axial) mm . | Mean AP Pons (sagittal) mm . | Mean MCP mm . |
|---|---|---|---|---|---|---|---|
| MSA-C Definite/Possible/Probable (n = 88) | 53:35 (60.2) | 56.4 ± 8.2 | 60.0 ± 8.1 | 60 (68.2) | 19.3 ± 2.6 | 19.9 ± 2.5 | 12.0 ± 2.6 |
| MSA-C Definite (n = 14) | 8:6 (57.1) | 55.8 ± 8.7 | 60.2 ± 7.4 | 7 (50.0) | 18.0 ± 2.2 | 18.9 ± 2.8 | 11.1 ± 2.5 |
| MSA-Possible/Probable (n = 74) | 45:29 (60.8) | 56.6 ± 8.2 | 59.9 ± 8.3 | 53 (71.6) | 19.5 ± 2.7 | 20.0 ± 2.5 | 12.1 ± 2.6 |
| Other ataxias (n = 78) | 49:29 (62.8) | 37.8 ± 17.9 | 48.2 ± 15.8 | 22 (28.2) | 20.7 ± 2.6 | 21.6 ± 2.4 | 14.3 ± 2.1 |
| FA (n = 13) | 7:6 (53.9) | 15.5 ± 10.7 | 36.6 ± 16.9 | 0 | 20.2 ± 2.0 | 22.1 ± 1.7 | 14.5 ± 1.5 |
| ILOCA (n = 15) | 10:5 (66.7) | 38.3 ± 11.8 | 48.4 ± 11.8 | 7 (46.7) | 22.1 ± 2.3 | 21.9 ± 2.2 | 15.1 ± 2.2 |
| SCA1 (n = 8) | 4:4 (50.0) | 44.3 ± 11.0 | 52.3 ± 10.3 | 1 (12.5) | 18.6 ± 2.2 | 19.4 ± 1.8 | 12.3 ± 1.9 |
| SCA2 (n = 5) | 3:2 (60.0) | 26.4 ± 14.7 | 33.9 ± 9.7 | 2 (40.0) | 17.7 ± 4.2 | 18.1 ± 3.9 | 11.8 ± 3.3 |
| SCA3 (n = 12) | 7:5 (58.3) | 42.0 ± 14.0 | 48.6 ± 12.0 | 1 (8.3) | 20.1 ± 2.0 | 21.1 ± 1.7 | 14.0 ± 1.5 |
| SCA5 (n = 1) | 0:1 (0) | 48.0 | 50.7 | 0 (0) | 22.1 | 22.7 | 16.0 |
| SCA6 (n = 8) | 4:4 (50.0) | 48.4 ± 10.8 | 58.8 ± 7.8 | 2 (25.0) | 23.2 ± 1.4 | 23.3 ± 1.4 | 16.0 ± 1.1 |
| SCA7 (n = 3) | 3:0 (100) | 32.0 ± 28.0 | 37.7 ± 31.2 | 0 (0) | 18.6 ± 0.7 | 20.7 ± 1.5 | 13.8 ± 0.9 |
| SCA8 (n = 5) | 3:2 (60.0) | 43.6 ± 15.5 | 56.8 ± 15.6 | 2 (40.0) | 23.0 ± 1.8 | 23.0 ± 1.9 | 15.5 ± 1.7 |
| SCA17 (n = 2) | 2:0 (100) | 25.5 ± 14.8 | 35.3 ± 21.0 | 1 (50.0) | 21.5 ± 0.2 | 21.6 ± 1.3 | 15.6 ± 0.4 |
| FXTAS (n = 6) | 6:0 (100) | 64.0 ± 9.9 | 66.2 ± 10.2 | 6 (100) | 20.4 ± 1.8 | 20.7 ± 1.8 | 13.3 ± 1.6 |
| Diagnosis . | Male:female (% male) . | Age of motor onset (years) Mean ± SD . | Age at first scan (years) Mean ± SD . | Patients with multiple scans (N, %) . | Mean AP Pons (axial) mm . | Mean AP Pons (sagittal) mm . | Mean MCP mm . |
|---|---|---|---|---|---|---|---|
| MSA-C Definite/Possible/Probable (n = 88) | 53:35 (60.2) | 56.4 ± 8.2 | 60.0 ± 8.1 | 60 (68.2) | 19.3 ± 2.6 | 19.9 ± 2.5 | 12.0 ± 2.6 |
| MSA-C Definite (n = 14) | 8:6 (57.1) | 55.8 ± 8.7 | 60.2 ± 7.4 | 7 (50.0) | 18.0 ± 2.2 | 18.9 ± 2.8 | 11.1 ± 2.5 |
| MSA-Possible/Probable (n = 74) | 45:29 (60.8) | 56.6 ± 8.2 | 59.9 ± 8.3 | 53 (71.6) | 19.5 ± 2.7 | 20.0 ± 2.5 | 12.1 ± 2.6 |
| Other ataxias (n = 78) | 49:29 (62.8) | 37.8 ± 17.9 | 48.2 ± 15.8 | 22 (28.2) | 20.7 ± 2.6 | 21.6 ± 2.4 | 14.3 ± 2.1 |
| FA (n = 13) | 7:6 (53.9) | 15.5 ± 10.7 | 36.6 ± 16.9 | 0 | 20.2 ± 2.0 | 22.1 ± 1.7 | 14.5 ± 1.5 |
| ILOCA (n = 15) | 10:5 (66.7) | 38.3 ± 11.8 | 48.4 ± 11.8 | 7 (46.7) | 22.1 ± 2.3 | 21.9 ± 2.2 | 15.1 ± 2.2 |
| SCA1 (n = 8) | 4:4 (50.0) | 44.3 ± 11.0 | 52.3 ± 10.3 | 1 (12.5) | 18.6 ± 2.2 | 19.4 ± 1.8 | 12.3 ± 1.9 |
| SCA2 (n = 5) | 3:2 (60.0) | 26.4 ± 14.7 | 33.9 ± 9.7 | 2 (40.0) | 17.7 ± 4.2 | 18.1 ± 3.9 | 11.8 ± 3.3 |
| SCA3 (n = 12) | 7:5 (58.3) | 42.0 ± 14.0 | 48.6 ± 12.0 | 1 (8.3) | 20.1 ± 2.0 | 21.1 ± 1.7 | 14.0 ± 1.5 |
| SCA5 (n = 1) | 0:1 (0) | 48.0 | 50.7 | 0 (0) | 22.1 | 22.7 | 16.0 |
| SCA6 (n = 8) | 4:4 (50.0) | 48.4 ± 10.8 | 58.8 ± 7.8 | 2 (25.0) | 23.2 ± 1.4 | 23.3 ± 1.4 | 16.0 ± 1.1 |
| SCA7 (n = 3) | 3:0 (100) | 32.0 ± 28.0 | 37.7 ± 31.2 | 0 (0) | 18.6 ± 0.7 | 20.7 ± 1.5 | 13.8 ± 0.9 |
| SCA8 (n = 5) | 3:2 (60.0) | 43.6 ± 15.5 | 56.8 ± 15.6 | 2 (40.0) | 23.0 ± 1.8 | 23.0 ± 1.9 | 15.5 ± 1.7 |
| SCA17 (n = 2) | 2:0 (100) | 25.5 ± 14.8 | 35.3 ± 21.0 | 1 (50.0) | 21.5 ± 0.2 | 21.6 ± 1.3 | 15.6 ± 0.4 |
| FXTAS (n = 6) | 6:0 (100) | 64.0 ± 9.9 | 66.2 ± 10.2 | 6 (100) | 20.4 ± 1.8 | 20.7 ± 1.8 | 13.3 ± 1.6 |
MSA-C, multiple system atrophy of the cerebellar type; FA, Friedreich’s ataxia; ILOCA, idiopathic late-onset cerebellar ataxia; SCA, spinocerebellar ataxia; FXTAS, fragile X-associated tremor/ataxia syndrome.
Exploratory cohort: demographic details and AP Pons and MCP diameters at first scan
| Diagnosis . | Male:female (% male) . | Age of motor onset (years) Mean ± SD . | Age at first scan (years) Mean ± SD . | Patients with multiple scans (N, %) . | Mean AP Pons (axial) mm . | Mean AP Pons (sagittal) mm . | Mean MCP mm . |
|---|---|---|---|---|---|---|---|
| MSA-C Definite/Possible/Probable (n = 88) | 53:35 (60.2) | 56.4 ± 8.2 | 60.0 ± 8.1 | 60 (68.2) | 19.3 ± 2.6 | 19.9 ± 2.5 | 12.0 ± 2.6 |
| MSA-C Definite (n = 14) | 8:6 (57.1) | 55.8 ± 8.7 | 60.2 ± 7.4 | 7 (50.0) | 18.0 ± 2.2 | 18.9 ± 2.8 | 11.1 ± 2.5 |
| MSA-Possible/Probable (n = 74) | 45:29 (60.8) | 56.6 ± 8.2 | 59.9 ± 8.3 | 53 (71.6) | 19.5 ± 2.7 | 20.0 ± 2.5 | 12.1 ± 2.6 |
| Other ataxias (n = 78) | 49:29 (62.8) | 37.8 ± 17.9 | 48.2 ± 15.8 | 22 (28.2) | 20.7 ± 2.6 | 21.6 ± 2.4 | 14.3 ± 2.1 |
| FA (n = 13) | 7:6 (53.9) | 15.5 ± 10.7 | 36.6 ± 16.9 | 0 | 20.2 ± 2.0 | 22.1 ± 1.7 | 14.5 ± 1.5 |
| ILOCA (n = 15) | 10:5 (66.7) | 38.3 ± 11.8 | 48.4 ± 11.8 | 7 (46.7) | 22.1 ± 2.3 | 21.9 ± 2.2 | 15.1 ± 2.2 |
| SCA1 (n = 8) | 4:4 (50.0) | 44.3 ± 11.0 | 52.3 ± 10.3 | 1 (12.5) | 18.6 ± 2.2 | 19.4 ± 1.8 | 12.3 ± 1.9 |
| SCA2 (n = 5) | 3:2 (60.0) | 26.4 ± 14.7 | 33.9 ± 9.7 | 2 (40.0) | 17.7 ± 4.2 | 18.1 ± 3.9 | 11.8 ± 3.3 |
| SCA3 (n = 12) | 7:5 (58.3) | 42.0 ± 14.0 | 48.6 ± 12.0 | 1 (8.3) | 20.1 ± 2.0 | 21.1 ± 1.7 | 14.0 ± 1.5 |
| SCA5 (n = 1) | 0:1 (0) | 48.0 | 50.7 | 0 (0) | 22.1 | 22.7 | 16.0 |
| SCA6 (n = 8) | 4:4 (50.0) | 48.4 ± 10.8 | 58.8 ± 7.8 | 2 (25.0) | 23.2 ± 1.4 | 23.3 ± 1.4 | 16.0 ± 1.1 |
| SCA7 (n = 3) | 3:0 (100) | 32.0 ± 28.0 | 37.7 ± 31.2 | 0 (0) | 18.6 ± 0.7 | 20.7 ± 1.5 | 13.8 ± 0.9 |
| SCA8 (n = 5) | 3:2 (60.0) | 43.6 ± 15.5 | 56.8 ± 15.6 | 2 (40.0) | 23.0 ± 1.8 | 23.0 ± 1.9 | 15.5 ± 1.7 |
| SCA17 (n = 2) | 2:0 (100) | 25.5 ± 14.8 | 35.3 ± 21.0 | 1 (50.0) | 21.5 ± 0.2 | 21.6 ± 1.3 | 15.6 ± 0.4 |
| FXTAS (n = 6) | 6:0 (100) | 64.0 ± 9.9 | 66.2 ± 10.2 | 6 (100) | 20.4 ± 1.8 | 20.7 ± 1.8 | 13.3 ± 1.6 |
| Diagnosis . | Male:female (% male) . | Age of motor onset (years) Mean ± SD . | Age at first scan (years) Mean ± SD . | Patients with multiple scans (N, %) . | Mean AP Pons (axial) mm . | Mean AP Pons (sagittal) mm . | Mean MCP mm . |
|---|---|---|---|---|---|---|---|
| MSA-C Definite/Possible/Probable (n = 88) | 53:35 (60.2) | 56.4 ± 8.2 | 60.0 ± 8.1 | 60 (68.2) | 19.3 ± 2.6 | 19.9 ± 2.5 | 12.0 ± 2.6 |
| MSA-C Definite (n = 14) | 8:6 (57.1) | 55.8 ± 8.7 | 60.2 ± 7.4 | 7 (50.0) | 18.0 ± 2.2 | 18.9 ± 2.8 | 11.1 ± 2.5 |
| MSA-Possible/Probable (n = 74) | 45:29 (60.8) | 56.6 ± 8.2 | 59.9 ± 8.3 | 53 (71.6) | 19.5 ± 2.7 | 20.0 ± 2.5 | 12.1 ± 2.6 |
| Other ataxias (n = 78) | 49:29 (62.8) | 37.8 ± 17.9 | 48.2 ± 15.8 | 22 (28.2) | 20.7 ± 2.6 | 21.6 ± 2.4 | 14.3 ± 2.1 |
| FA (n = 13) | 7:6 (53.9) | 15.5 ± 10.7 | 36.6 ± 16.9 | 0 | 20.2 ± 2.0 | 22.1 ± 1.7 | 14.5 ± 1.5 |
| ILOCA (n = 15) | 10:5 (66.7) | 38.3 ± 11.8 | 48.4 ± 11.8 | 7 (46.7) | 22.1 ± 2.3 | 21.9 ± 2.2 | 15.1 ± 2.2 |
| SCA1 (n = 8) | 4:4 (50.0) | 44.3 ± 11.0 | 52.3 ± 10.3 | 1 (12.5) | 18.6 ± 2.2 | 19.4 ± 1.8 | 12.3 ± 1.9 |
| SCA2 (n = 5) | 3:2 (60.0) | 26.4 ± 14.7 | 33.9 ± 9.7 | 2 (40.0) | 17.7 ± 4.2 | 18.1 ± 3.9 | 11.8 ± 3.3 |
| SCA3 (n = 12) | 7:5 (58.3) | 42.0 ± 14.0 | 48.6 ± 12.0 | 1 (8.3) | 20.1 ± 2.0 | 21.1 ± 1.7 | 14.0 ± 1.5 |
| SCA5 (n = 1) | 0:1 (0) | 48.0 | 50.7 | 0 (0) | 22.1 | 22.7 | 16.0 |
| SCA6 (n = 8) | 4:4 (50.0) | 48.4 ± 10.8 | 58.8 ± 7.8 | 2 (25.0) | 23.2 ± 1.4 | 23.3 ± 1.4 | 16.0 ± 1.1 |
| SCA7 (n = 3) | 3:0 (100) | 32.0 ± 28.0 | 37.7 ± 31.2 | 0 (0) | 18.6 ± 0.7 | 20.7 ± 1.5 | 13.8 ± 0.9 |
| SCA8 (n = 5) | 3:2 (60.0) | 43.6 ± 15.5 | 56.8 ± 15.6 | 2 (40.0) | 23.0 ± 1.8 | 23.0 ± 1.9 | 15.5 ± 1.7 |
| SCA17 (n = 2) | 2:0 (100) | 25.5 ± 14.8 | 35.3 ± 21.0 | 1 (50.0) | 21.5 ± 0.2 | 21.6 ± 1.3 | 15.6 ± 0.4 |
| FXTAS (n = 6) | 6:0 (100) | 64.0 ± 9.9 | 66.2 ± 10.2 | 6 (100) | 20.4 ± 1.8 | 20.7 ± 1.8 | 13.3 ± 1.6 |
MSA-C, multiple system atrophy of the cerebellar type; FA, Friedreich’s ataxia; ILOCA, idiopathic late-onset cerebellar ataxia; SCA, spinocerebellar ataxia; FXTAS, fragile X-associated tremor/ataxia syndrome.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
