Table 6 Open in new tab Mendelian...

Exposure	Outcome	Methods	SNPs	Estimate^a	95% CI	p	Q‐statistic	Q p
eBMD	2hGlu	IVW	539	0.043	0.007, 0.079	0.020	428.401	>0.999
Weighted median	0.015	−0.044, 0.073	0.627
ConMix	0.060	0.020, 0.100	0.015
MR‐Egger	−0.007	−0.074, 0.060	0.834			0.083
T2DM	IVW	479	1.064	1.036, 1.093	<0.001	451.349	0.804
Weighted median	1.085	1.039, 1.134	<0.001
ConMix	1.062	1.020, 1.128	0.010
MR‐Egger	1.063	1.012, 1.116	0.015			0.946

Exposure	Outcome	Methods	SNPs	Estimate^a	95% CI	p	Q‐statistic	Q p
eBMD	2hGlu	IVW	539	0.043	0.007, 0.079	0.020	428.401	>0.999
Weighted median	0.015	−0.044, 0.073	0.627
ConMix	0.060	0.020, 0.100	0.015
MR‐Egger	−0.007	−0.074, 0.060	0.834			0.083
T2DM	IVW	479	1.064	1.036, 1.093	<0.001	451.349	0.804
Weighted median	1.085	1.039, 1.134	<0.001
ConMix	1.062	1.020, 1.128	0.010
MR‐Egger	1.063	1.012, 1.116	0.015			0.946

Table 6

Mendelian Randomization Results Showing the Causal Associations of eBMD With 2hGlu and T2DM

Exposure	Outcome	Methods	SNPs	Estimate^a	95% CI	p	Q‐statistic	Q p	p for MR‐Egger intercept test
eBMD	2hGlu	IVW	539	0.043	0.007, 0.079	0.020	428.401	>0.999
		Weighted median		0.015	−0.044, 0.073	0.627
		ConMix		0.060	0.020, 0.100	0.015
		MR‐Egger		−0.007	−0.074, 0.060	0.834			0.083
	T2DM	IVW	479	1.064	1.036, 1.093	<0.001	451.349	0.804
		Weighted median		1.085	1.039, 1.134	<0.001
		ConMix		1.062	1.020, 1.128	0.010
		MR‐Egger		1.063	1.012, 1.116	0.015			0.946

Exposure	Outcome	Methods	SNPs	Estimate^a	95% CI	p	Q‐statistic	Q p	p for MR‐Egger intercept test
eBMD	2hGlu	IVW	539	0.043	0.007, 0.079	0.020	428.401	>0.999
		Weighted median		0.015	−0.044, 0.073	0.627
		ConMix		0.060	0.020, 0.100	0.015
		MR‐Egger		−0.007	−0.074, 0.060	0.834			0.083
	T2DM	IVW	479	1.064	1.036, 1.093	<0.001	451.349	0.804
		Weighted median		1.085	1.039, 1.134	<0.001
		ConMix		1.062	1.020, 1.128	0.010
		MR‐Egger		1.063	1.012, 1.116	0.015			0.946

2hGlu = 2‐h glucose level after an oral glucose challenge test; ConMix = Contamination Mixture; eBMD = estimated bone mineral density; BMI = body mass index; IVW = inverse‐variance weighted; MR = Mendelian randomization; CI = confidence interval; OR = odds ratio; SD = standard deviation; SNP = single‐nucleotide polymorphism; T2DM = type 2 diabetes mellitus.

Estimates are presented as standardized β for 2hGlu and OR for T2DM per SD increase in eBMD.

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