Table 2 Open in new tab Association...

Exposure^a	Outcome^a	Model 1	Model 2
CTx	Fasting glucose	−0.124 (−0.182, −0.066)	<0.001	−0.049 (−0.093, −0.005)	0.027
Hb_A1c	−0.100 (−0.158, −0.041)	0.001	−0.017 (−0.048, 0.014)	0.271
NTx	Fasting glucose	−0.089 (−0.148, −0.031)	0.003	−0.057 (−0.100, −0.013)	0.011
Hb_A1c	−0.05 (−0.109, 0.009)	0.097	−0.014 (−0.044, 0.017)	0.388
OC	Fasting glucose	−0.173 (−0.230, −0.116)	<0.001	−0.052 (−0.097, −0.008)	0.020
Hb_A1c	−0.147 (−0.204, −0.089)	<0.001	−0.018 (−0.049, 0.014)	0.271
P1NP	Fasting glucose	−0.118 (−0.175, −0.060)	<0.001	−0.042 (−0.085, 0.002)	0.061
Hb_A1c	−0.104 (−0.162, −0.046)	<0.001	−0.019 (−0.050, 0.012)	0.219

Exposure^a	Outcome^a	Model 1	Model 2
CTx	Fasting glucose	−0.124 (−0.182, −0.066)	<0.001	−0.049 (−0.093, −0.005)	0.027
Hb_A1c	−0.100 (−0.158, −0.041)	0.001	−0.017 (−0.048, 0.014)	0.271
NTx	Fasting glucose	−0.089 (−0.148, −0.031)	0.003	−0.057 (−0.100, −0.013)	0.011
Hb_A1c	−0.05 (−0.109, 0.009)	0.097	−0.014 (−0.044, 0.017)	0.388
OC	Fasting glucose	−0.173 (−0.230, −0.116)	<0.001	−0.052 (−0.097, −0.008)	0.020
Hb_A1c	−0.147 (−0.204, −0.089)	<0.001	−0.018 (−0.049, 0.014)	0.271
P1NP	Fasting glucose	−0.118 (−0.175, −0.060)	<0.001	−0.042 (−0.085, 0.002)	0.061
Hb_A1c	−0.104 (−0.162, −0.046)	<0.001	−0.019 (−0.050, 0.012)	0.219

Table 2

Association Between Bone Turnover Markers and Glycemic Traits Among HKOS‐FU Participants

Exposure^a	Outcome^a	Model 1		Model 2
Exposure^a	Outcome^a	Estimate (95% CI)	p	Estimate (95% CI)	p
CTx	Fasting glucose	−0.124 (−0.182, −0.066)	<0.001	−0.049 (−0.093, −0.005)	0.027
CTx	Hb_A1c	−0.100 (−0.158, −0.041)	0.001	−0.017 (−0.048, 0.014)	0.271
NTx	Fasting glucose	−0.089 (−0.148, −0.031)	0.003	−0.057 (−0.100, −0.013)	0.011
NTx	Hb_A1c	−0.05 (−0.109, 0.009)	0.097	−0.014 (−0.044, 0.017)	0.388
OC	Fasting glucose	−0.173 (−0.230, −0.116)	<0.001	−0.052 (−0.097, −0.008)	0.020
OC	Hb_A1c	−0.147 (−0.204, −0.089)	<0.001	−0.018 (−0.049, 0.014)	0.271
P1NP	Fasting glucose	−0.118 (−0.175, −0.060)	<0.001	−0.042 (−0.085, 0.002)	0.061
P1NP	Hb_A1c	−0.104 (−0.162, −0.046)	<0.001	−0.019 (−0.050, 0.012)	0.219

Exposure^a	Outcome^a	Model 1		Model 2
Exposure^a	Outcome^a	Estimate (95% CI)	p	Estimate (95% CI)	p
CTx	Fasting glucose	−0.124 (−0.182, −0.066)	<0.001	−0.049 (−0.093, −0.005)	0.027
CTx	Hb_A1c	−0.100 (−0.158, −0.041)	0.001	−0.017 (−0.048, 0.014)	0.271
NTx	Fasting glucose	−0.089 (−0.148, −0.031)	0.003	−0.057 (−0.100, −0.013)	0.011
NTx	Hb_A1c	−0.05 (−0.109, 0.009)	0.097	−0.014 (−0.044, 0.017)	0.388
OC	Fasting glucose	−0.173 (−0.230, −0.116)	<0.001	−0.052 (−0.097, −0.008)	0.020
OC	Hb_A1c	−0.147 (−0.204, −0.089)	<0.001	−0.018 (−0.049, 0.014)	0.271
P1NP	Fasting glucose	−0.118 (−0.175, −0.060)	<0.001	−0.042 (−0.085, 0.002)	0.061
P1NP	Hb_A1c	−0.104 (−0.162, −0.046)	<0.001	−0.019 (−0.050, 0.012)	0.219

Model 1: Adjusted with age and sex. Model 2: Adjusted with age, sex, BMI, total cholesterol, triglycerides, smoking, drinking, physical activity, and presence of diabetes.

BMI = body mass index; CI = confidence interval; CTx = C‐terminal of telopeptides of type 1 collagen; Hb_A1c = glycated hemoglobin; HKOS = Hong Kong Osteoporosis Study; HKOS‐FU = HKOS follow‐up; NTx = N‐terminal of telopeptides of type 1 collagen; OC = osteocalcin; P1NP = N‐terminal of propeptides of type 1 collagen.

All bone turnover markers, fasting glucose, and HbA1c values were standardized.

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