Table 3 Open in new tab Comparison of...

miRNA	Relative levels in log₂ fold change (mean)	95% confidence interval of difference	p Value	q Value
hsa‐miR‐16‐5p	0.20	−0.21	−0.91 to 0.08	0.103	0.135
hsa‐miR‐148a‐3p	−0.15	0.13	−0.16 to 0.73	0.205	0.248
hsa‐miR‐106b‐3p	0.46	−0.48	−1.63 to −0.27	0.007*	0.021*
hsa‐miR‐140‐3p	0.08	−0.06	−0.79 to 0.51	0.669	0.620
hsa‐miR‐182‐5p	0.03	−0.08	−1.15 to 0.92	0.831	0.721
hsa‐miR‐183‐5p	−0.04	0.26	−0.97 to 1.56	0.641	0.620
hsa‐miR‐191‐5p	0.70	−0.71	−1.97 to −0.85	<0.001*	0.001*
hsa‐miR‐221‐3p	0.27	−0.24	−1.04 to 0.016	0.057	0.081
hsa‐miR‐25‐3p	−0.01	−0.02	−0.50 to 0.48	0.953	0.750
hsa‐miR‐363‐3p	0.35	−0.42	−1.41 to −0.11	0.022*	0.043*
hsa‐miR‐451a	0.49	−0.43	−1.53 to −0.31	0.003*	0.019*
hsa‐miR‐93‐3p	0.54	−0.43	−1.61 to −0.32	0.004*	0.019*
hsa‐miR‐96‐5p	−0.23	0.23	−0.30 to 1.21	0.233	0.262
hsa‐miR‐103a‐3p	0.53	−0.46	−1.97 to −0.01	0.047*	0.075
hsa‐miR‐19b‐3p	0.35	−0.32	−1.32 to −0.01	0.048*	0.075
hsa‐miR‐15b‐5p	−0.69	0.24	0.14 to 1.71	0.022*	0.042*
hsa‐miR‐335‐5p	0.19	−0.12	−0.83 to 0.22	0.250	0.262
hsa‐let‐7g‐5p	0.26	−0.24	−0.91 to −0.08	0.021*	0.043*
hsa‐miR‐29c‐3p	0.03	−0.01	−0.54 to 0.46	0.870	0.721
hsa‐miR‐93‐5p	0.33	−0.39	−1.21 to −0.22	0.005*	0.020*

miRNA

Relative levels in log₂ fold change (mean)

95% confidence interval of difference

p Value

q Value

OI (n = 48)

Controls (n = 48)

hsa‐miR‐16‐5p

0.20

−0.21

−0.91 to 0.08

0.103

0.135

hsa‐miR‐148a‐3p

−0.15

0.13

−0.16 to 0.73

0.205

0.248

hsa‐miR‐106b‐3p

0.46

−0.48

−1.63 to −0.27

0.007*

0.021*

hsa‐miR‐140‐3p

0.08

−0.06

−0.79 to 0.51

0.669

0.620

hsa‐miR‐182‐5p

0.03

−0.08

−1.15 to 0.92

0.831

0.721

hsa‐miR‐183‐5p

−0.04

0.26

−0.97 to 1.56

0.641

0.620

hsa‐miR‐191‐5p

0.70

−0.71

−1.97 to −0.85

<0.001*

0.001*

hsa‐miR‐221‐3p

0.27

−0.24

−1.04 to 0.016

0.057

0.081

hsa‐miR‐25‐3p

−0.01

−0.02

−0.50 to 0.48

0.953

0.750

hsa‐miR‐363‐3p

0.35

−0.42

−1.41 to −0.11

0.022*

0.043*

hsa‐miR‐451a

0.49

−0.43

−1.53 to −0.31

0.003*

0.019*

hsa‐miR‐93‐3p

0.54

−0.43

−1.61 to −0.32

0.004*

0.019*

hsa‐miR‐96‐5p

−0.23

0.23

−0.30 to 1.21

0.233

0.262

hsa‐miR‐103a‐3p

0.53

−0.46

−1.97 to −0.01

0.047*

0.075

hsa‐miR‐19b‐3p

0.35

−0.32

−1.32 to −0.01

0.048*

0.075

hsa‐miR‐15b‐5p

−0.69

0.24

0.14 to 1.71

0.022*

0.042*

hsa‐miR‐335‐5p

0.19

−0.12

−0.83 to 0.22

0.250

0.262

hsa‐let‐7g‐5p

0.26

−0.24

−0.91 to −0.08

0.021*

0.043*

hsa‐miR‐29c‐3p

0.03

−0.01

−0.54 to 0.46

0.870

0.721

hsa‐miR‐93‐5p

0.33

−0.39

−1.21 to −0.22

0.005*

0.020*

miRNA	Relative levels in log₂ fold change (mean)	95% confidence interval of difference	p Value	q Value
hsa‐miR‐16‐5p	0.20	−0.21	−0.91 to 0.08	0.103	0.135
hsa‐miR‐148a‐3p	−0.15	0.13	−0.16 to 0.73	0.205	0.248
hsa‐miR‐106b‐3p	0.46	−0.48	−1.63 to −0.27	0.007*	0.021*
hsa‐miR‐140‐3p	0.08	−0.06	−0.79 to 0.51	0.669	0.620
hsa‐miR‐182‐5p	0.03	−0.08	−1.15 to 0.92	0.831	0.721
hsa‐miR‐183‐5p	−0.04	0.26	−0.97 to 1.56	0.641	0.620
hsa‐miR‐191‐5p	0.70	−0.71	−1.97 to −0.85	<0.001*	0.001*
hsa‐miR‐221‐3p	0.27	−0.24	−1.04 to 0.016	0.057	0.081
hsa‐miR‐25‐3p	−0.01	−0.02	−0.50 to 0.48	0.953	0.750
hsa‐miR‐363‐3p	0.35	−0.42	−1.41 to −0.11	0.022*	0.043*
hsa‐miR‐451a	0.49	−0.43	−1.53 to −0.31	0.003*	0.019*
hsa‐miR‐93‐3p	0.54	−0.43	−1.61 to −0.32	0.004*	0.019*
hsa‐miR‐96‐5p	−0.23	0.23	−0.30 to 1.21	0.233	0.262
hsa‐miR‐103a‐3p	0.53	−0.46	−1.97 to −0.01	0.047*	0.075
hsa‐miR‐19b‐3p	0.35	−0.32	−1.32 to −0.01	0.048*	0.075
hsa‐miR‐15b‐5p	−0.69	0.24	0.14 to 1.71	0.022*	0.042*
hsa‐miR‐335‐5p	0.19	−0.12	−0.83 to 0.22	0.250	0.262
hsa‐let‐7g‐5p	0.26	−0.24	−0.91 to −0.08	0.021*	0.043*
hsa‐miR‐29c‐3p	0.03	−0.01	−0.54 to 0.46	0.870	0.721
hsa‐miR‐93‐5p	0.33	−0.39	−1.21 to −0.22	0.005*	0.020*

Table 3

Open in new tab

Comparison of the miRNA Levels (Means) in Serum of Osteogenesis Imperfecta (OI) Patients and Controls

miRNA	Relative levels in log₂ fold change (mean)		95% confidence interval of difference	p Value	q Value
miRNA	OI (n = 48)	Controls (n = 48)	95% confidence interval of difference	p Value	q Value
hsa‐miR‐16‐5p	0.20	−0.21	−0.91 to 0.08	0.103	0.135
hsa‐miR‐148a‐3p	−0.15	0.13	−0.16 to 0.73	0.205	0.248
hsa‐miR‐106b‐3p	0.46	−0.48	−1.63 to −0.27	0.007*	0.021*
hsa‐miR‐140‐3p	0.08	−0.06	−0.79 to 0.51	0.669	0.620
hsa‐miR‐182‐5p	0.03	−0.08	−1.15 to 0.92	0.831	0.721
hsa‐miR‐183‐5p	−0.04	0.26	−0.97 to 1.56	0.641	0.620
hsa‐miR‐191‐5p	0.70	−0.71	−1.97 to −0.85	<0.001*	0.001*
hsa‐miR‐221‐3p	0.27	−0.24	−1.04 to 0.016	0.057	0.081
hsa‐miR‐25‐3p	−0.01	−0.02	−0.50 to 0.48	0.953	0.750
hsa‐miR‐363‐3p	0.35	−0.42	−1.41 to −0.11	0.022*	0.043*
hsa‐miR‐451a	0.49	−0.43	−1.53 to −0.31	0.003*	0.019*
hsa‐miR‐93‐3p	0.54	−0.43	−1.61 to −0.32	0.004*	0.019*
hsa‐miR‐96‐5p	−0.23	0.23	−0.30 to 1.21	0.233	0.262
hsa‐miR‐103a‐3p	0.53	−0.46	−1.97 to −0.01	0.047*	0.075
hsa‐miR‐19b‐3p	0.35	−0.32	−1.32 to −0.01	0.048*	0.075
hsa‐miR‐15b‐5p	−0.69	0.24	0.14 to 1.71	0.022*	0.042*
hsa‐miR‐335‐5p	0.19	−0.12	−0.83 to 0.22	0.250	0.262
hsa‐let‐7g‐5p	0.26	−0.24	−0.91 to −0.08	0.021*	0.043*
hsa‐miR‐29c‐3p	0.03	−0.01	−0.54 to 0.46	0.870	0.721
hsa‐miR‐93‐5p	0.33	−0.39	−1.21 to −0.22	0.005*	0.020*

miRNA	Relative levels in log₂ fold change (mean)		95% confidence interval of difference	p Value	q Value
miRNA	OI (n = 48)	Controls (n = 48)	95% confidence interval of difference	p Value	q Value
hsa‐miR‐16‐5p	0.20	−0.21	−0.91 to 0.08	0.103	0.135
hsa‐miR‐148a‐3p	−0.15	0.13	−0.16 to 0.73	0.205	0.248
hsa‐miR‐106b‐3p	0.46	−0.48	−1.63 to −0.27	0.007*	0.021*
hsa‐miR‐140‐3p	0.08	−0.06	−0.79 to 0.51	0.669	0.620
hsa‐miR‐182‐5p	0.03	−0.08	−1.15 to 0.92	0.831	0.721
hsa‐miR‐183‐5p	−0.04	0.26	−0.97 to 1.56	0.641	0.620
hsa‐miR‐191‐5p	0.70	−0.71	−1.97 to −0.85	<0.001*	0.001*
hsa‐miR‐221‐3p	0.27	−0.24	−1.04 to 0.016	0.057	0.081
hsa‐miR‐25‐3p	−0.01	−0.02	−0.50 to 0.48	0.953	0.750
hsa‐miR‐363‐3p	0.35	−0.42	−1.41 to −0.11	0.022*	0.043*
hsa‐miR‐451a	0.49	−0.43	−1.53 to −0.31	0.003*	0.019*
hsa‐miR‐93‐3p	0.54	−0.43	−1.61 to −0.32	0.004*	0.019*
hsa‐miR‐96‐5p	−0.23	0.23	−0.30 to 1.21	0.233	0.262
hsa‐miR‐103a‐3p	0.53	−0.46	−1.97 to −0.01	0.047*	0.075
hsa‐miR‐19b‐3p	0.35	−0.32	−1.32 to −0.01	0.048*	0.075
hsa‐miR‐15b‐5p	−0.69	0.24	0.14 to 1.71	0.022*	0.042*
hsa‐miR‐335‐5p	0.19	−0.12	−0.83 to 0.22	0.250	0.262
hsa‐let‐7g‐5p	0.26	−0.24	−0.91 to −0.08	0.021*	0.043*
hsa‐miR‐29c‐3p	0.03	−0.01	−0.54 to 0.46	0.870	0.721
hsa‐miR‐93‐5p	0.33	−0.39	−1.21 to −0.22	0.005*	0.020*

Note: The circulating levels of 19 selected miRNAs were analyzed by RT‐qPCR in 48 sera of OI patients and 48 sera of controls. Results are log₂ fold change of miRNA expression level in OI sera versus control sera, after normalization and relative level expression. The p value is corrected by false discovery rate (FDR) according Benjamini–Hochberg method (q value).

Values of p or FDR p < .05.

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