| Study (year) | Age (years), sex | Bisphosphonate (dose) | Indication | Reported QT change | Calciuma | Time of BP infusion before ECG | Reported arrhythmia |
| Aldave & Jaiswal (2014) | 73, woman | ZA | Multiple myeloma | Prolongation (500 ms) | Hypocalcemia (0.66 mmol/L – ionized) | 11 days | None reported |
| Bonilla et al. (2014) | 55, woman | Ibandronate | N/A | Prolongation (575 ms) | Normal | 15 days | Non‐sustained polymorphic VT, ventricular ectopy |
| Mishra, Wong & Jonklaas (2001) | 62, woman | Pamidronate (90 mg) | Thyroid cancer with bone metastases | Prolongation (unknown) | Hypocalcemia (0.10 mmol/L – ionized) | 35 days | Junctional rhythm |
| Patel, Brahmbatt & Ramu (2005) | 74, man | ZA | Prostate cancer with bone metastases | Prolongation (>500 ms) | Hypocalcemia (0.19 mmol/L – serum) | 4 days | None reported |
| Varma & Kerrigan (1993) | 71, woman | Pamidronate (30 mg) | Hypercalcemia of malignancy | Prolongation (550 ms) | Hypocalcemia (1.8 mmol/L – serum)b | 15/19 daysc | Sinus rhythm |
| Study (year) | Age (years), sex | Bisphosphonate (dose) | Indication | Reported QT change | Calciuma | Time of BP infusion before ECG | Reported arrhythmia |
| Aldave & Jaiswal (2014) | 73, woman | ZA | Multiple myeloma | Prolongation (500 ms) | Hypocalcemia (0.66 mmol/L – ionized) | 11 days | None reported |
| Bonilla et al. (2014) | 55, woman | Ibandronate | N/A | Prolongation (575 ms) | Normal | 15 days | Non‐sustained polymorphic VT, ventricular ectopy |
| Mishra, Wong & Jonklaas (2001) | 62, woman | Pamidronate (90 mg) | Thyroid cancer with bone metastases | Prolongation (unknown) | Hypocalcemia (0.10 mmol/L – ionized) | 35 days | Junctional rhythm |
| Patel, Brahmbatt & Ramu (2005) | 74, man | ZA | Prostate cancer with bone metastases | Prolongation (>500 ms) | Hypocalcemia (0.19 mmol/L – serum) | 4 days | None reported |
| Varma & Kerrigan (1993) | 71, woman | Pamidronate (30 mg) | Hypercalcemia of malignancy | Prolongation (550 ms) | Hypocalcemia (1.8 mmol/L – serum)b | 15/19 daysc | Sinus rhythm |
Abbreviations: BP = bisphosphonate; ECG = electrocardiogram; VT = ventricular tachycardia; ZA = zoledronic acid.
Values that were provided in mg/dL were converted to mmol/L as 1 mg/dL = 0.055 mmol/L.
Patient received two doses of pamidronate (30 mg) 15 and 19 days before ECG.
Days 12 to 19 of admission.
| Study (year) | Age (years), sex | Bisphosphonate (dose) | Indication | Reported QT change | Calciuma | Time of BP infusion before ECG | Reported arrhythmia |
| Aldave & Jaiswal (2014) | 73, woman | ZA | Multiple myeloma | Prolongation (500 ms) | Hypocalcemia (0.66 mmol/L – ionized) | 11 days | None reported |
| Bonilla et al. (2014) | 55, woman | Ibandronate | N/A | Prolongation (575 ms) | Normal | 15 days | Non‐sustained polymorphic VT, ventricular ectopy |
| Mishra, Wong & Jonklaas (2001) | 62, woman | Pamidronate (90 mg) | Thyroid cancer with bone metastases | Prolongation (unknown) | Hypocalcemia (0.10 mmol/L – ionized) | 35 days | Junctional rhythm |
| Patel, Brahmbatt & Ramu (2005) | 74, man | ZA | Prostate cancer with bone metastases | Prolongation (>500 ms) | Hypocalcemia (0.19 mmol/L – serum) | 4 days | None reported |
| Varma & Kerrigan (1993) | 71, woman | Pamidronate (30 mg) | Hypercalcemia of malignancy | Prolongation (550 ms) | Hypocalcemia (1.8 mmol/L – serum)b | 15/19 daysc | Sinus rhythm |
| Study (year) | Age (years), sex | Bisphosphonate (dose) | Indication | Reported QT change | Calciuma | Time of BP infusion before ECG | Reported arrhythmia |
| Aldave & Jaiswal (2014) | 73, woman | ZA | Multiple myeloma | Prolongation (500 ms) | Hypocalcemia (0.66 mmol/L – ionized) | 11 days | None reported |
| Bonilla et al. (2014) | 55, woman | Ibandronate | N/A | Prolongation (575 ms) | Normal | 15 days | Non‐sustained polymorphic VT, ventricular ectopy |
| Mishra, Wong & Jonklaas (2001) | 62, woman | Pamidronate (90 mg) | Thyroid cancer with bone metastases | Prolongation (unknown) | Hypocalcemia (0.10 mmol/L – ionized) | 35 days | Junctional rhythm |
| Patel, Brahmbatt & Ramu (2005) | 74, man | ZA | Prostate cancer with bone metastases | Prolongation (>500 ms) | Hypocalcemia (0.19 mmol/L – serum) | 4 days | None reported |
| Varma & Kerrigan (1993) | 71, woman | Pamidronate (30 mg) | Hypercalcemia of malignancy | Prolongation (550 ms) | Hypocalcemia (1.8 mmol/L – serum)b | 15/19 daysc | Sinus rhythm |
Abbreviations: BP = bisphosphonate; ECG = electrocardiogram; VT = ventricular tachycardia; ZA = zoledronic acid.
Values that were provided in mg/dL were converted to mmol/L as 1 mg/dL = 0.055 mmol/L.
Patient received two doses of pamidronate (30 mg) 15 and 19 days before ECG.
Days 12 to 19 of admission.
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