Effect of Treatment on Quality of Life Summary Scores and Bone Pain
| Time | Intensive (n = 270) | Symptomatic (n = 232) | Standardized mean difference (95% CI) | p | |
| Physical component summary | Year 1 | 185 (37.5 ± 0.9) | 153 (37.0 ± 0.9) | 1.6 (0.1–3.1) | 0.04 |
| Year 2 | 136 (36.1 ± 1.0) | 120 (36.9 ± 1.1) | 0.8 (−1.5 to 3.2) | 0.49 | |
| Year 3 | 172 (36.4 ± 0.9) | 160 (35.6 ± 0.9) | 0.9 (−1.1 to 2.9) | 0.39 | |
| Arthritis‐specific health index | Year 1 | 185 (37.6 ± 1.0) | 153 (36.4 ± 1.0) | 2.7 (1.3–4.0) | <0.001 |
| Year 2 | 136 (35.7 ± 1.2) | 120 (36.6 ± 1.2) | 0.7 (−1.6 to 2.9) | 0.57 | |
| Year 3 | 172 (36.6 ± 1.0) | 160 (36.1 ± 1.0) | 0.8 (−1.4 to 3.1) | 0.46 | |
| Mental component summary | Year 1 | 185 (46.9 ± 0.9) | 153 (47.6 ± 1.0) | 0.6, (−1.2 to 2.4) | 0.54 |
| Year 2 | 136 (46.6 ± 1.0) | 120 (48.2 ± 1.0) | −0.2 (−2.2 to 1.9) | 0.88 | |
| Year 3 | 172 (46.7 ± 0.9) | 160 (49.0 ± 1.0) | −2.4 (−4.3 to −0.4) | 0.019 | |
| Standard disability index | Year 1 | 185 (0.92 ± 0.06) | 153;1.02 ± 0.6) | −0.06 (−0.13 to 0.00) | 0.05 |
| Year 2 | 136 (1.05 ± 0.07) | 120 (1.03 ± 0.6) | −0.03 (−0.17 to 0.12) | 0.71 | |
| Year 3 | 172 (1.09 ± 0.07) | 160 (1.15 ± 0.7) | 0.04 (−0.10 to 0.19) | 0.56 | |
| Alternative disability index | Year 1 | 185 (0.72 ± 0.06) | 153 (0.76 ± 0.06) | 0.00 (−0.06 to 0.07) | 0.99 |
| Year 2 | 136 (0.84 ± 0.07) | 120 (0.80 ± 0.07) | −0.03 (−0.15 to 0.08) | 0.57 | |
| Year 3 | 172 (0.86 ± 0.06) | 160 (0.87 ± 0.06) | 0.04 (−0.09 to 0.17) | 0.57 | |
| Bone pain10 | Year 1 | 148 (54.8) | 115 (49.6) | 0.52 (−0.5 to 1.5) | 0.29 |
| Year 2 | 123 (45.6) | 104 (44.8) | 0.02 −0.6 to 0.7) | 0.94 | |
| Year 3 | 130 (48.1) | 112 (48.3) | 0.68 (−0.1 to 1.5) | 0.09 | |
| Bone pain due to PDB11 | Year 1 | 44 (16.3) | 40 (17.2) | −0.57 (−1.7 to 0.6) | 0.34 |
| Year 2 | 40 (14.8) | 36 (15.5) | 1.30 (0.3–2.3) | 0.009 | |
| Year 3 | 34 (12.6) | 37 (15.9) | −0.71 (−2.0 to 0.5) | 0.26 |
| Time | Intensive (n = 270) | Symptomatic (n = 232) | Standardized mean difference (95% CI) | p | |
| Physical component summary | Year 1 | 185 (37.5 ± 0.9) | 153 (37.0 ± 0.9) | 1.6 (0.1–3.1) | 0.04 |
| Year 2 | 136 (36.1 ± 1.0) | 120 (36.9 ± 1.1) | 0.8 (−1.5 to 3.2) | 0.49 | |
| Year 3 | 172 (36.4 ± 0.9) | 160 (35.6 ± 0.9) | 0.9 (−1.1 to 2.9) | 0.39 | |
| Arthritis‐specific health index | Year 1 | 185 (37.6 ± 1.0) | 153 (36.4 ± 1.0) | 2.7 (1.3–4.0) | <0.001 |
| Year 2 | 136 (35.7 ± 1.2) | 120 (36.6 ± 1.2) | 0.7 (−1.6 to 2.9) | 0.57 | |
| Year 3 | 172 (36.6 ± 1.0) | 160 (36.1 ± 1.0) | 0.8 (−1.4 to 3.1) | 0.46 | |
| Mental component summary | Year 1 | 185 (46.9 ± 0.9) | 153 (47.6 ± 1.0) | 0.6, (−1.2 to 2.4) | 0.54 |
| Year 2 | 136 (46.6 ± 1.0) | 120 (48.2 ± 1.0) | −0.2 (−2.2 to 1.9) | 0.88 | |
| Year 3 | 172 (46.7 ± 0.9) | 160 (49.0 ± 1.0) | −2.4 (−4.3 to −0.4) | 0.019 | |
| Standard disability index | Year 1 | 185 (0.92 ± 0.06) | 153;1.02 ± 0.6) | −0.06 (−0.13 to 0.00) | 0.05 |
| Year 2 | 136 (1.05 ± 0.07) | 120 (1.03 ± 0.6) | −0.03 (−0.17 to 0.12) | 0.71 | |
| Year 3 | 172 (1.09 ± 0.07) | 160 (1.15 ± 0.7) | 0.04 (−0.10 to 0.19) | 0.56 | |
| Alternative disability index | Year 1 | 185 (0.72 ± 0.06) | 153 (0.76 ± 0.06) | 0.00 (−0.06 to 0.07) | 0.99 |
| Year 2 | 136 (0.84 ± 0.07) | 120 (0.80 ± 0.07) | −0.03 (−0.15 to 0.08) | 0.57 | |
| Year 3 | 172 (0.86 ± 0.06) | 160 (0.87 ± 0.06) | 0.04 (−0.09 to 0.17) | 0.57 | |
| Bone pain10 | Year 1 | 148 (54.8) | 115 (49.6) | 0.52 (−0.5 to 1.5) | 0.29 |
| Year 2 | 123 (45.6) | 104 (44.8) | 0.02 −0.6 to 0.7) | 0.94 | |
| Year 3 | 130 (48.1) | 112 (48.3) | 0.68 (−0.1 to 1.5) | 0.09 | |
| Bone pain due to PDB11 | Year 1 | 44 (16.3) | 40 (17.2) | −0.57 (−1.7 to 0.6) | 0.34 |
| Year 2 | 40 (14.8) | 36 (15.5) | 1.30 (0.3–2.3) | 0.009 | |
| Year 3 | 34 (12.6) | 37 (15.9) | −0.71 (−2.0 to 0.5) | 0.26 |
Values are n (mean ± SE) or n (%) as indicated. Positive scores for standardized mean difference favor the intensive group and negative scores the symptomatic group. Comparison between groups is adjusted for IPTW (%).
IPTW = inverse probability of treatment weighted.
Patient reported bone pain.
Bone pain considered by the clinician to be due to Paget's disease.
Effect of Treatment on Quality of Life Summary Scores and Bone Pain
| Time | Intensive (n = 270) | Symptomatic (n = 232) | Standardized mean difference (95% CI) | p | |
| Physical component summary | Year 1 | 185 (37.5 ± 0.9) | 153 (37.0 ± 0.9) | 1.6 (0.1–3.1) | 0.04 |
| Year 2 | 136 (36.1 ± 1.0) | 120 (36.9 ± 1.1) | 0.8 (−1.5 to 3.2) | 0.49 | |
| Year 3 | 172 (36.4 ± 0.9) | 160 (35.6 ± 0.9) | 0.9 (−1.1 to 2.9) | 0.39 | |
| Arthritis‐specific health index | Year 1 | 185 (37.6 ± 1.0) | 153 (36.4 ± 1.0) | 2.7 (1.3–4.0) | <0.001 |
| Year 2 | 136 (35.7 ± 1.2) | 120 (36.6 ± 1.2) | 0.7 (−1.6 to 2.9) | 0.57 | |
| Year 3 | 172 (36.6 ± 1.0) | 160 (36.1 ± 1.0) | 0.8 (−1.4 to 3.1) | 0.46 | |
| Mental component summary | Year 1 | 185 (46.9 ± 0.9) | 153 (47.6 ± 1.0) | 0.6, (−1.2 to 2.4) | 0.54 |
| Year 2 | 136 (46.6 ± 1.0) | 120 (48.2 ± 1.0) | −0.2 (−2.2 to 1.9) | 0.88 | |
| Year 3 | 172 (46.7 ± 0.9) | 160 (49.0 ± 1.0) | −2.4 (−4.3 to −0.4) | 0.019 | |
| Standard disability index | Year 1 | 185 (0.92 ± 0.06) | 153;1.02 ± 0.6) | −0.06 (−0.13 to 0.00) | 0.05 |
| Year 2 | 136 (1.05 ± 0.07) | 120 (1.03 ± 0.6) | −0.03 (−0.17 to 0.12) | 0.71 | |
| Year 3 | 172 (1.09 ± 0.07) | 160 (1.15 ± 0.7) | 0.04 (−0.10 to 0.19) | 0.56 | |
| Alternative disability index | Year 1 | 185 (0.72 ± 0.06) | 153 (0.76 ± 0.06) | 0.00 (−0.06 to 0.07) | 0.99 |
| Year 2 | 136 (0.84 ± 0.07) | 120 (0.80 ± 0.07) | −0.03 (−0.15 to 0.08) | 0.57 | |
| Year 3 | 172 (0.86 ± 0.06) | 160 (0.87 ± 0.06) | 0.04 (−0.09 to 0.17) | 0.57 | |
| Bone pain10 | Year 1 | 148 (54.8) | 115 (49.6) | 0.52 (−0.5 to 1.5) | 0.29 |
| Year 2 | 123 (45.6) | 104 (44.8) | 0.02 −0.6 to 0.7) | 0.94 | |
| Year 3 | 130 (48.1) | 112 (48.3) | 0.68 (−0.1 to 1.5) | 0.09 | |
| Bone pain due to PDB11 | Year 1 | 44 (16.3) | 40 (17.2) | −0.57 (−1.7 to 0.6) | 0.34 |
| Year 2 | 40 (14.8) | 36 (15.5) | 1.30 (0.3–2.3) | 0.009 | |
| Year 3 | 34 (12.6) | 37 (15.9) | −0.71 (−2.0 to 0.5) | 0.26 |
| Time | Intensive (n = 270) | Symptomatic (n = 232) | Standardized mean difference (95% CI) | p | |
| Physical component summary | Year 1 | 185 (37.5 ± 0.9) | 153 (37.0 ± 0.9) | 1.6 (0.1–3.1) | 0.04 |
| Year 2 | 136 (36.1 ± 1.0) | 120 (36.9 ± 1.1) | 0.8 (−1.5 to 3.2) | 0.49 | |
| Year 3 | 172 (36.4 ± 0.9) | 160 (35.6 ± 0.9) | 0.9 (−1.1 to 2.9) | 0.39 | |
| Arthritis‐specific health index | Year 1 | 185 (37.6 ± 1.0) | 153 (36.4 ± 1.0) | 2.7 (1.3–4.0) | <0.001 |
| Year 2 | 136 (35.7 ± 1.2) | 120 (36.6 ± 1.2) | 0.7 (−1.6 to 2.9) | 0.57 | |
| Year 3 | 172 (36.6 ± 1.0) | 160 (36.1 ± 1.0) | 0.8 (−1.4 to 3.1) | 0.46 | |
| Mental component summary | Year 1 | 185 (46.9 ± 0.9) | 153 (47.6 ± 1.0) | 0.6, (−1.2 to 2.4) | 0.54 |
| Year 2 | 136 (46.6 ± 1.0) | 120 (48.2 ± 1.0) | −0.2 (−2.2 to 1.9) | 0.88 | |
| Year 3 | 172 (46.7 ± 0.9) | 160 (49.0 ± 1.0) | −2.4 (−4.3 to −0.4) | 0.019 | |
| Standard disability index | Year 1 | 185 (0.92 ± 0.06) | 153;1.02 ± 0.6) | −0.06 (−0.13 to 0.00) | 0.05 |
| Year 2 | 136 (1.05 ± 0.07) | 120 (1.03 ± 0.6) | −0.03 (−0.17 to 0.12) | 0.71 | |
| Year 3 | 172 (1.09 ± 0.07) | 160 (1.15 ± 0.7) | 0.04 (−0.10 to 0.19) | 0.56 | |
| Alternative disability index | Year 1 | 185 (0.72 ± 0.06) | 153 (0.76 ± 0.06) | 0.00 (−0.06 to 0.07) | 0.99 |
| Year 2 | 136 (0.84 ± 0.07) | 120 (0.80 ± 0.07) | −0.03 (−0.15 to 0.08) | 0.57 | |
| Year 3 | 172 (0.86 ± 0.06) | 160 (0.87 ± 0.06) | 0.04 (−0.09 to 0.17) | 0.57 | |
| Bone pain10 | Year 1 | 148 (54.8) | 115 (49.6) | 0.52 (−0.5 to 1.5) | 0.29 |
| Year 2 | 123 (45.6) | 104 (44.8) | 0.02 −0.6 to 0.7) | 0.94 | |
| Year 3 | 130 (48.1) | 112 (48.3) | 0.68 (−0.1 to 1.5) | 0.09 | |
| Bone pain due to PDB11 | Year 1 | 44 (16.3) | 40 (17.2) | −0.57 (−1.7 to 0.6) | 0.34 |
| Year 2 | 40 (14.8) | 36 (15.5) | 1.30 (0.3–2.3) | 0.009 | |
| Year 3 | 34 (12.6) | 37 (15.9) | −0.71 (−2.0 to 0.5) | 0.26 |
Values are n (mean ± SE) or n (%) as indicated. Positive scores for standardized mean difference favor the intensive group and negative scores the symptomatic group. Comparison between groups is adjusted for IPTW (%).
IPTW = inverse probability of treatment weighted.
Patient reported bone pain.
Bone pain considered by the clinician to be due to Paget's disease.
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