Serum HAI Antibody Responses in Participants Vaccinated With 2010–2016 TIVs Containing CA/09 A(H1N1)pdm09-like Antigens
| . | Year . | . | HAI Antibody Titers . | Fold Increases . | Main HAI Antibody . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Group: Donora . | Birth . | Immunization . | Serab . | RG-K163 . | RG-K163Q . | X-179A . | RG-K163 . | RG-K163Q . | X-179A . | Increase . | Composition . |
| G1 | |||||||||||
| 1 | 1979 | 2013 | Pre | 320 | 20 | 160 | K163 | ||||
| Post | 320 | 20 | 320 | 1 | 1 | 2 | No | K163 | |||
| 2 | 1983 | 2016 | Pre | 160 | 40 | 160 | K163 | ||||
| Post | 160 | 40 | 160 | 1 | 1 | 1 | No | K163 | |||
| 3 | 1974 | 2016 | Pre | 320 | < | 160 | K163 | ||||
| Post | 320 | < | 160 | 1 | 1 | 1 | No | K163 | |||
| G2 | |||||||||||
| 4 | 1978 | 2010 | Pre | 80 | < | 80 | K163 | ||||
| Post | 640 | 320 | 640 | 8 | 64 | 8 | Non-K163 | K163 + non-K163 | |||
| 5 | 1971 | 2010 | Pre | 80 | < | 80 | K163 | ||||
| Post | 640 | 320 | 640 | 8 | 64 | 8 | Non-K163 | K163 + non-K163 | |||
| 6 | 1977 | 2014 | Pre | 80 | < | 80 | K163 | ||||
| Post | 160 | 160 | 320 | 2 | 32 | 4 | Non-K163 | K163 + non-K163 | |||
| 7 | 1977 | 2014 | Pre | 80 | < | 80 | K163 | ||||
| Post | 320 | 320 | 640 | 4 | 64 | 8 | Non-K163 | K163 + non-K163 | |||
| G3 | |||||||||||
| 8 | 1969 | 2010 | Pre | < | < | < | |||||
| Post | 640 | < | 640 | 64 | 1 | 128 | K163 | K163 | |||
| 9 | 1980 | 2011 | Pre | < | < | < | |||||
| Post | 160 | < | 320 | 32 | 1 | 64 | K163 | K163 | |||
| 10 | 1961 | 2011 | Pre | < | < | < | |||||
| Post | 320 | < | 320 | 64 | 1 | 64 | K163 | K163 | |||
| 11 | 1977 | 2015 | Pre | < | < | < | |||||
| Post | 160 | < | 160 | 32 | 1 | 32 | K163 | K163 | |||
| . | Year . | . | HAI Antibody Titers . | Fold Increases . | Main HAI Antibody . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Group: Donora . | Birth . | Immunization . | Serab . | RG-K163 . | RG-K163Q . | X-179A . | RG-K163 . | RG-K163Q . | X-179A . | Increase . | Composition . |
| G1 | |||||||||||
| 1 | 1979 | 2013 | Pre | 320 | 20 | 160 | K163 | ||||
| Post | 320 | 20 | 320 | 1 | 1 | 2 | No | K163 | |||
| 2 | 1983 | 2016 | Pre | 160 | 40 | 160 | K163 | ||||
| Post | 160 | 40 | 160 | 1 | 1 | 1 | No | K163 | |||
| 3 | 1974 | 2016 | Pre | 320 | < | 160 | K163 | ||||
| Post | 320 | < | 160 | 1 | 1 | 1 | No | K163 | |||
| G2 | |||||||||||
| 4 | 1978 | 2010 | Pre | 80 | < | 80 | K163 | ||||
| Post | 640 | 320 | 640 | 8 | 64 | 8 | Non-K163 | K163 + non-K163 | |||
| 5 | 1971 | 2010 | Pre | 80 | < | 80 | K163 | ||||
| Post | 640 | 320 | 640 | 8 | 64 | 8 | Non-K163 | K163 + non-K163 | |||
| 6 | 1977 | 2014 | Pre | 80 | < | 80 | K163 | ||||
| Post | 160 | 160 | 320 | 2 | 32 | 4 | Non-K163 | K163 + non-K163 | |||
| 7 | 1977 | 2014 | Pre | 80 | < | 80 | K163 | ||||
| Post | 320 | 320 | 640 | 4 | 64 | 8 | Non-K163 | K163 + non-K163 | |||
| G3 | |||||||||||
| 8 | 1969 | 2010 | Pre | < | < | < | |||||
| Post | 640 | < | 640 | 64 | 1 | 128 | K163 | K163 | |||
| 9 | 1980 | 2011 | Pre | < | < | < | |||||
| Post | 160 | < | 320 | 32 | 1 | 64 | K163 | K163 | |||
| 10 | 1961 | 2011 | Pre | < | < | < | |||||
| Post | 320 | < | 320 | 64 | 1 | 64 | K163 | K163 | |||
| 11 | 1977 | 2015 | Pre | < | < | < | |||||
| Post | 160 | < | 160 | 32 | 1 | 32 | K163 | K163 | |||
K163 antibodies are defined as antibodies with ≥4-fold reduction in HAI antibody titers to RG-K163Q vs RG-K163. Blank cells indicate not applicable.
Abbreviations: HAI, hemagglutination inhibition; Post, postvaccination; Pre, prevaccination; RG, reverse genetics; TIV, trivalent influenza vaccine.
aUS adults were immunized with inactivated TIV containing CA/09 A(H1N1)pdm09-like antigens.
bSera collected at prevaccination and 21 to 28 days postvaccination were tested by HAI assays with the X-179A vaccine strain and 2 RG viruses. <, HAI antibody titers ≤10.
Serum HAI Antibody Responses in Participants Vaccinated With 2010–2016 TIVs Containing CA/09 A(H1N1)pdm09-like Antigens
| . | Year . | . | HAI Antibody Titers . | Fold Increases . | Main HAI Antibody . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Group: Donora . | Birth . | Immunization . | Serab . | RG-K163 . | RG-K163Q . | X-179A . | RG-K163 . | RG-K163Q . | X-179A . | Increase . | Composition . |
| G1 | |||||||||||
| 1 | 1979 | 2013 | Pre | 320 | 20 | 160 | K163 | ||||
| Post | 320 | 20 | 320 | 1 | 1 | 2 | No | K163 | |||
| 2 | 1983 | 2016 | Pre | 160 | 40 | 160 | K163 | ||||
| Post | 160 | 40 | 160 | 1 | 1 | 1 | No | K163 | |||
| 3 | 1974 | 2016 | Pre | 320 | < | 160 | K163 | ||||
| Post | 320 | < | 160 | 1 | 1 | 1 | No | K163 | |||
| G2 | |||||||||||
| 4 | 1978 | 2010 | Pre | 80 | < | 80 | K163 | ||||
| Post | 640 | 320 | 640 | 8 | 64 | 8 | Non-K163 | K163 + non-K163 | |||
| 5 | 1971 | 2010 | Pre | 80 | < | 80 | K163 | ||||
| Post | 640 | 320 | 640 | 8 | 64 | 8 | Non-K163 | K163 + non-K163 | |||
| 6 | 1977 | 2014 | Pre | 80 | < | 80 | K163 | ||||
| Post | 160 | 160 | 320 | 2 | 32 | 4 | Non-K163 | K163 + non-K163 | |||
| 7 | 1977 | 2014 | Pre | 80 | < | 80 | K163 | ||||
| Post | 320 | 320 | 640 | 4 | 64 | 8 | Non-K163 | K163 + non-K163 | |||
| G3 | |||||||||||
| 8 | 1969 | 2010 | Pre | < | < | < | |||||
| Post | 640 | < | 640 | 64 | 1 | 128 | K163 | K163 | |||
| 9 | 1980 | 2011 | Pre | < | < | < | |||||
| Post | 160 | < | 320 | 32 | 1 | 64 | K163 | K163 | |||
| 10 | 1961 | 2011 | Pre | < | < | < | |||||
| Post | 320 | < | 320 | 64 | 1 | 64 | K163 | K163 | |||
| 11 | 1977 | 2015 | Pre | < | < | < | |||||
| Post | 160 | < | 160 | 32 | 1 | 32 | K163 | K163 | |||
| . | Year . | . | HAI Antibody Titers . | Fold Increases . | Main HAI Antibody . | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Group: Donora . | Birth . | Immunization . | Serab . | RG-K163 . | RG-K163Q . | X-179A . | RG-K163 . | RG-K163Q . | X-179A . | Increase . | Composition . |
| G1 | |||||||||||
| 1 | 1979 | 2013 | Pre | 320 | 20 | 160 | K163 | ||||
| Post | 320 | 20 | 320 | 1 | 1 | 2 | No | K163 | |||
| 2 | 1983 | 2016 | Pre | 160 | 40 | 160 | K163 | ||||
| Post | 160 | 40 | 160 | 1 | 1 | 1 | No | K163 | |||
| 3 | 1974 | 2016 | Pre | 320 | < | 160 | K163 | ||||
| Post | 320 | < | 160 | 1 | 1 | 1 | No | K163 | |||
| G2 | |||||||||||
| 4 | 1978 | 2010 | Pre | 80 | < | 80 | K163 | ||||
| Post | 640 | 320 | 640 | 8 | 64 | 8 | Non-K163 | K163 + non-K163 | |||
| 5 | 1971 | 2010 | Pre | 80 | < | 80 | K163 | ||||
| Post | 640 | 320 | 640 | 8 | 64 | 8 | Non-K163 | K163 + non-K163 | |||
| 6 | 1977 | 2014 | Pre | 80 | < | 80 | K163 | ||||
| Post | 160 | 160 | 320 | 2 | 32 | 4 | Non-K163 | K163 + non-K163 | |||
| 7 | 1977 | 2014 | Pre | 80 | < | 80 | K163 | ||||
| Post | 320 | 320 | 640 | 4 | 64 | 8 | Non-K163 | K163 + non-K163 | |||
| G3 | |||||||||||
| 8 | 1969 | 2010 | Pre | < | < | < | |||||
| Post | 640 | < | 640 | 64 | 1 | 128 | K163 | K163 | |||
| 9 | 1980 | 2011 | Pre | < | < | < | |||||
| Post | 160 | < | 320 | 32 | 1 | 64 | K163 | K163 | |||
| 10 | 1961 | 2011 | Pre | < | < | < | |||||
| Post | 320 | < | 320 | 64 | 1 | 64 | K163 | K163 | |||
| 11 | 1977 | 2015 | Pre | < | < | < | |||||
| Post | 160 | < | 160 | 32 | 1 | 32 | K163 | K163 | |||
K163 antibodies are defined as antibodies with ≥4-fold reduction in HAI antibody titers to RG-K163Q vs RG-K163. Blank cells indicate not applicable.
Abbreviations: HAI, hemagglutination inhibition; Post, postvaccination; Pre, prevaccination; RG, reverse genetics; TIV, trivalent influenza vaccine.
aUS adults were immunized with inactivated TIV containing CA/09 A(H1N1)pdm09-like antigens.
bSera collected at prevaccination and 21 to 28 days postvaccination were tested by HAI assays with the X-179A vaccine strain and 2 RG viruses. <, HAI antibody titers ≤10.
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