Table 2 Open in new tab Hazard ratios a...

CVD subtypes	Age group,	Total population (n = 15 672 028)	LDL-C < 100 mg/dL (n = 5 480 875)
CVD	18–99	105 174	<0.001	1.10 (1.09–1.11)		35 223	<0.001	1.04 (1.02–1.05)
	18–44	5659	<0.001	1.13 (1.09–1.17)	0.003	1991	<0.001	1.13 (1.07–1.19)	<0.001
	45–64	25 079	<0.001	1.08 (1.06–1.09)		8531	0.192	1.02 (0.99–1.04)
	65–99	74 436	<0.001	1.06 (1.05–1.07)		24 701	0.465	0.99 (0.98–1.01)
Ischaemic heart disease	18–99	27 745	<0.001	1.22 (1.20–1.24)		8582	<0.001	1.12 (1.09–1.15)
	18–44	1680	<0.001	1.26 (1.18–1.35)	0.012	441	<0.001	1.22 (1.09–1.36)	0.036
	45–64	8082	<0.001	1.20 (1.17–1.24)		2457	<0.001	1.11 (1.06–1.16)
	65–99	17 983	<0.001	1.16 (1.13–1.18)		5684	<0.001	1.06 (1.03–1.10)
Acute myocardial infarction	18–99	20 623	<0.001	1.24 (1.22–1.26)		6260	<0.001	1.15 (1.12–1.19)
	18–44	1164	<0.001	1.23 (1.14–1.33)	0.332	302	0.006	1.21 (1.06–1.38)	0.428
	45–64	6122	<0.001	1.22 (1.18–1.26)		1811	<0.001	1.13 (1.07–1.19)
	65–99	13 337	<0.001	1.18 (1.16–1.21)		4147	<0.001	1.10 (1.06–1.15)
Haemorrhagic stroke	18–99	16 575	0.746	1.00 (0.98–1.02)		6114	0.994	1.00 (0.97–1.03)
	18–44	1869	0.023	1.07 (1.01–1.14)	0.007	783	0.013	1.11 (1.02–1.21)	0.003
	45–64	5940	0.191	0.98 (0.94–1.01)		2199	0.280	0.97 (0.93–1.02)
	65–99	8766	0.012	0.96 (0.93–0.99)		3132	0.011	0.94 (0.90–0.99)
Ischaemic stroke	18–99	13 166	<0.001	1.10 (1.07–1.13)		4198	0.010	1.05 (1.01–1.09)
	18–44	151	0.371	1.10 (0.89–1.37)	0.964	43	0.179	1.28 (0.89–1.85)	0.360
	45–64	1803	0.005	1.09 (1.03–1.16)		582	0.951	1.00 (0.91–1.10)
	65–99	11 212	<0.001	1.08 (1.06–1.11)		3573	0.051	1.04 (1.00–1.09)
Heart failure	18–99	6638	0.387	1.02 (0.98–1.05)		2358	0.001	0.91 (0.87–0.97)
	18–44	73	0.511	0.90 (0.66–1.23)	0.018	34	0.256	0.79 (0.53–1.19)	0.563
	45–64	708	0.011	1.14 (1.03–1.26)		266	0.524	0.95 (0.83–1.10)
	65–99	5857	0.288	0.98 (0.94–1.02)		2058	<0.001	0.89 (0.84–0.94)

CVD subtypes

Age group,

Total population (n = 15 672 028)

LDL-C < 100 mg/dL (n = 5 480 875)

(ICD-10)

Years

No. of death

P-value

HR (95% CI)

P_{heterogeneity} (age)

No. of death

P-value

HR (95% CI)

P_{heterogeneity} (age)

CVD

18–99

105 174

<0.001

1.10 (1.09–1.11)

35 223

<0.001

1.04 (1.02–1.05)

18–44

5659

<0.001

1.13 (1.09–1.17)

0.003

1991

<0.001

1.13 (1.07–1.19)

<0.001

45–64

25 079

<0.001

1.08 (1.06–1.09)

8531

0.192

1.02 (0.99–1.04)

65–99

74 436

<0.001

1.06 (1.05–1.07)

24 701

0.465

0.99 (0.98–1.01)

Ischaemic heart disease

18–99

27 745

<0.001

1.22 (1.20–1.24)

8582

<0.001

1.12 (1.09–1.15)

18–44

1680

<0.001

1.26 (1.18–1.35)

0.012

441

<0.001

1.22 (1.09–1.36)

0.036

45–64

8082

<0.001

1.20 (1.17–1.24)

2457

<0.001

1.11 (1.06–1.16)

65–99

17 983

<0.001

1.16 (1.13–1.18)

5684

<0.001

1.06 (1.03–1.10)

Acute myocardial infarction

18–99

20 623

<0.001

1.24 (1.22–1.26)

6260

<0.001

1.15 (1.12–1.19)

18–44

1164

<0.001

1.23 (1.14–1.33)

0.332

302

0.006

1.21 (1.06–1.38)

0.428

45–64

6122

<0.001

1.22 (1.18–1.26)

1811

<0.001

1.13 (1.07–1.19)

65–99

13 337

<0.001

1.18 (1.16–1.21)

4147

<0.001

1.10 (1.06–1.15)

Haemorrhagic stroke

18–99

16 575

0.746

1.00 (0.98–1.02)

6114

0.994

1.00 (0.97–1.03)

18–44

1869

0.023

1.07 (1.01–1.14)

0.007

783

0.013

1.11 (1.02–1.21)

0.003

45–64

5940

0.191

0.98 (0.94–1.01)

2199

0.280

0.97 (0.93–1.02)

65–99

8766

0.012

0.96 (0.93–0.99)

3132

0.011

0.94 (0.90–0.99)

Ischaemic stroke

18–99

13 166

<0.001

1.10 (1.07–1.13)

4198

0.010

1.05 (1.01–1.09)

18–44

151

0.371

1.10 (0.89–1.37)

0.964

0.179

1.28 (0.89–1.85)

0.360

45–64

1803

0.005

1.09 (1.03–1.16)

582

0.951

1.00 (0.91–1.10)

65–99

11 212

<0.001

1.08 (1.06–1.11)

3573

0.051

1.04 (1.00–1.09)

Heart failure

18–99

6638

0.387

1.02 (0.98–1.05)

2358

0.001

0.91 (0.87–0.97)

18–44

0.511

0.90 (0.66–1.23)

0.018

0.256

0.79 (0.53–1.19)

0.563

45–64

708

0.011

1.14 (1.03–1.26)

266

0.524

0.95 (0.83–1.10)

65–99

5857

0.288

0.98 (0.94–1.02)

2058

<0.001

0.89 (0.84–0.94)

CVD subtypes	Age group,	Total population (n = 15 672 028)	LDL-C < 100 mg/dL (n = 5 480 875)
CVD	18–99	105 174	<0.001	1.10 (1.09–1.11)		35 223	<0.001	1.04 (1.02–1.05)
	18–44	5659	<0.001	1.13 (1.09–1.17)	0.003	1991	<0.001	1.13 (1.07–1.19)	<0.001
	45–64	25 079	<0.001	1.08 (1.06–1.09)		8531	0.192	1.02 (0.99–1.04)
	65–99	74 436	<0.001	1.06 (1.05–1.07)		24 701	0.465	0.99 (0.98–1.01)
Ischaemic heart disease	18–99	27 745	<0.001	1.22 (1.20–1.24)		8582	<0.001	1.12 (1.09–1.15)
	18–44	1680	<0.001	1.26 (1.18–1.35)	0.012	441	<0.001	1.22 (1.09–1.36)	0.036
	45–64	8082	<0.001	1.20 (1.17–1.24)		2457	<0.001	1.11 (1.06–1.16)
	65–99	17 983	<0.001	1.16 (1.13–1.18)		5684	<0.001	1.06 (1.03–1.10)
Acute myocardial infarction	18–99	20 623	<0.001	1.24 (1.22–1.26)		6260	<0.001	1.15 (1.12–1.19)
	18–44	1164	<0.001	1.23 (1.14–1.33)	0.332	302	0.006	1.21 (1.06–1.38)	0.428
	45–64	6122	<0.001	1.22 (1.18–1.26)		1811	<0.001	1.13 (1.07–1.19)
	65–99	13 337	<0.001	1.18 (1.16–1.21)		4147	<0.001	1.10 (1.06–1.15)
Haemorrhagic stroke	18–99	16 575	0.746	1.00 (0.98–1.02)		6114	0.994	1.00 (0.97–1.03)
	18–44	1869	0.023	1.07 (1.01–1.14)	0.007	783	0.013	1.11 (1.02–1.21)	0.003
	45–64	5940	0.191	0.98 (0.94–1.01)		2199	0.280	0.97 (0.93–1.02)
	65–99	8766	0.012	0.96 (0.93–0.99)		3132	0.011	0.94 (0.90–0.99)
Ischaemic stroke	18–99	13 166	<0.001	1.10 (1.07–1.13)		4198	0.010	1.05 (1.01–1.09)
	18–44	151	0.371	1.10 (0.89–1.37)	0.964	43	0.179	1.28 (0.89–1.85)	0.360
	45–64	1803	0.005	1.09 (1.03–1.16)		582	0.951	1.00 (0.91–1.10)
	65–99	11 212	<0.001	1.08 (1.06–1.11)		3573	0.051	1.04 (1.00–1.09)
Heart failure	18–99	6638	0.387	1.02 (0.98–1.05)		2358	0.001	0.91 (0.87–0.97)
	18–44	73	0.511	0.90 (0.66–1.23)	0.018	34	0.256	0.79 (0.53–1.19)	0.563
	45–64	708	0.011	1.14 (1.03–1.26)		266	0.524	0.95 (0.83–1.10)
	65–99	5857	0.288	0.98 (0.94–1.02)		2058	<0.001	0.89 (0.84–0.94)

Table 2

Open in new tab

Hazard ratios^a per two-fold increase in triglyceride for deaths from cardiovascular disease and subtypes by ages and in the <100 mg/dL low-density lipoprotein cholesterol range

CVD subtypes	Age group,	Total population (n = 15 672 028)				LDL-C < 100 mg/dL (n = 5 480 875)
(ICD-10)	Years	No. of death	P-value	HR (95% CI)	P_{heterogeneity} (age)	No. of death	P-value	HR (95% CI)	P_{heterogeneity} (age)
CVD	18–99	105 174	<0.001	1.10 (1.09–1.11)		35 223	<0.001	1.04 (1.02–1.05)
	18–44	5659	<0.001	1.13 (1.09–1.17)	0.003	1991	<0.001	1.13 (1.07–1.19)	<0.001
	45–64	25 079	<0.001	1.08 (1.06–1.09)		8531	0.192	1.02 (0.99–1.04)
	65–99	74 436	<0.001	1.06 (1.05–1.07)		24 701	0.465	0.99 (0.98–1.01)
Ischaemic heart disease	18–99	27 745	<0.001	1.22 (1.20–1.24)		8582	<0.001	1.12 (1.09–1.15)
	18–44	1680	<0.001	1.26 (1.18–1.35)	0.012	441	<0.001	1.22 (1.09–1.36)	0.036
	45–64	8082	<0.001	1.20 (1.17–1.24)		2457	<0.001	1.11 (1.06–1.16)
	65–99	17 983	<0.001	1.16 (1.13–1.18)		5684	<0.001	1.06 (1.03–1.10)
Acute myocardial infarction	18–99	20 623	<0.001	1.24 (1.22–1.26)		6260	<0.001	1.15 (1.12–1.19)
	18–44	1164	<0.001	1.23 (1.14–1.33)	0.332	302	0.006	1.21 (1.06–1.38)	0.428
	45–64	6122	<0.001	1.22 (1.18–1.26)		1811	<0.001	1.13 (1.07–1.19)
	65–99	13 337	<0.001	1.18 (1.16–1.21)		4147	<0.001	1.10 (1.06–1.15)
Haemorrhagic stroke	18–99	16 575	0.746	1.00 (0.98–1.02)		6114	0.994	1.00 (0.97–1.03)
	18–44	1869	0.023	1.07 (1.01–1.14)	0.007	783	0.013	1.11 (1.02–1.21)	0.003
	45–64	5940	0.191	0.98 (0.94–1.01)		2199	0.280	0.97 (0.93–1.02)
	65–99	8766	0.012	0.96 (0.93–0.99)		3132	0.011	0.94 (0.90–0.99)
Ischaemic stroke	18–99	13 166	<0.001	1.10 (1.07–1.13)		4198	0.010	1.05 (1.01–1.09)
	18–44	151	0.371	1.10 (0.89–1.37)	0.964	43	0.179	1.28 (0.89–1.85)	0.360
	45–64	1803	0.005	1.09 (1.03–1.16)		582	0.951	1.00 (0.91–1.10)
	65–99	11 212	<0.001	1.08 (1.06–1.11)		3573	0.051	1.04 (1.00–1.09)
Heart failure	18–99	6638	0.387	1.02 (0.98–1.05)		2358	0.001	0.91 (0.87–0.97)
	18–44	73	0.511	0.90 (0.66–1.23)	0.018	34	0.256	0.79 (0.53–1.19)	0.563
	45–64	708	0.011	1.14 (1.03–1.26)		266	0.524	0.95 (0.83–1.10)
	65–99	5857	0.288	0.98 (0.94–1.02)		2058	<0.001	0.89 (0.84–0.94)

CVD subtypes	Age group,	Total population (n = 15 672 028)				LDL-C < 100 mg/dL (n = 5 480 875)
(ICD-10)	Years	No. of death	P-value	HR (95% CI)	P_{heterogeneity} (age)	No. of death	P-value	HR (95% CI)	P_{heterogeneity} (age)
CVD	18–99	105 174	<0.001	1.10 (1.09–1.11)		35 223	<0.001	1.04 (1.02–1.05)
	18–44	5659	<0.001	1.13 (1.09–1.17)	0.003	1991	<0.001	1.13 (1.07–1.19)	<0.001
	45–64	25 079	<0.001	1.08 (1.06–1.09)		8531	0.192	1.02 (0.99–1.04)
	65–99	74 436	<0.001	1.06 (1.05–1.07)		24 701	0.465	0.99 (0.98–1.01)
Ischaemic heart disease	18–99	27 745	<0.001	1.22 (1.20–1.24)		8582	<0.001	1.12 (1.09–1.15)
	18–44	1680	<0.001	1.26 (1.18–1.35)	0.012	441	<0.001	1.22 (1.09–1.36)	0.036
	45–64	8082	<0.001	1.20 (1.17–1.24)		2457	<0.001	1.11 (1.06–1.16)
	65–99	17 983	<0.001	1.16 (1.13–1.18)		5684	<0.001	1.06 (1.03–1.10)
Acute myocardial infarction	18–99	20 623	<0.001	1.24 (1.22–1.26)		6260	<0.001	1.15 (1.12–1.19)
	18–44	1164	<0.001	1.23 (1.14–1.33)	0.332	302	0.006	1.21 (1.06–1.38)	0.428
	45–64	6122	<0.001	1.22 (1.18–1.26)		1811	<0.001	1.13 (1.07–1.19)
	65–99	13 337	<0.001	1.18 (1.16–1.21)		4147	<0.001	1.10 (1.06–1.15)
Haemorrhagic stroke	18–99	16 575	0.746	1.00 (0.98–1.02)		6114	0.994	1.00 (0.97–1.03)
	18–44	1869	0.023	1.07 (1.01–1.14)	0.007	783	0.013	1.11 (1.02–1.21)	0.003
	45–64	5940	0.191	0.98 (0.94–1.01)		2199	0.280	0.97 (0.93–1.02)
	65–99	8766	0.012	0.96 (0.93–0.99)		3132	0.011	0.94 (0.90–0.99)
Ischaemic stroke	18–99	13 166	<0.001	1.10 (1.07–1.13)		4198	0.010	1.05 (1.01–1.09)
	18–44	151	0.371	1.10 (0.89–1.37)	0.964	43	0.179	1.28 (0.89–1.85)	0.360
	45–64	1803	0.005	1.09 (1.03–1.16)		582	0.951	1.00 (0.91–1.10)
	65–99	11 212	<0.001	1.08 (1.06–1.11)		3573	0.051	1.04 (1.00–1.09)
Heart failure	18–99	6638	0.387	1.02 (0.98–1.05)		2358	0.001	0.91 (0.87–0.97)
	18–44	73	0.511	0.90 (0.66–1.23)	0.018	34	0.256	0.79 (0.53–1.19)	0.563
	45–64	708	0.011	1.14 (1.03–1.26)		266	0.524	0.95 (0.83–1.10)
	65–99	5857	0.288	0.98 (0.94–1.02)		2058	<0.001	0.89 (0.84–0.94)

To convert LDL-C from mg/dL to mmol/L, multiply by 0.02586.

CI, confidence interval; CVD, cardiovascular disease; HR, hazard ratio; ICD-10, International Classification of Diseases 10th revision; LDL-C, low-density lipoprotein cholesterol; TG, triglyceride.

^aHazard ratios were calculated by Cox models, after adjustment for age at baseline, sex, smoking status, alcohol use, physical activity, household income, body mass index, systolic blood pressure, diabetes status, cholesterol-lowering medication use, low-density lipoprotein cholesterol (for all participants only), and high-density lipoprotein cholesterol.

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