Propensity score analysis. Evaluation of the association between IVIG plus high or low dose corticosteroids in relation of the following outcomes: clinical worsening, need for intensive care, ventilatory support, vasoactive agents use, heart disease at last follow-up and length of hospitalization
| . | Before IPTW propensity method . | After IPTW propensity method . | ||||
|---|---|---|---|---|---|---|
| . | IVIG + high-dose CSs (n = 127) . | IVIG + low-dose CSs (n = 48) . | OR (95% CI) . | IVIG + high-dose CSs (n = 159.5) . | IVIG + low-dose CSs (n = 146.9) . | ORa(95% CI) . |
| OUTCOME | ||||||
| At least one worsening/poor response, n (%) | 42 (33.1) | 28 (58.3) | 0.4 (0.2, 0.7) | 55.8 (35.0) | 86.3 (58.8) | 0.4 (0.2, 0.6) |
| Need for intensive care, n (%) | 31 (24.4) | 14 (29.2) | 0.7 (0.4, 1.6) | 39.4 (24.7) | 32.9 (22.4) | 1.2 (0.7, 2.1) |
| Need for ventilatory support, n (%) | 22 (17.3) | 10 (20.8) | 0.8 (0.3, 1.8) | 28.0 (17.5) | 27.6 (18.8) | 0.6 (0.3, 1.2) |
| Need for vasoactive agents n (%) | 19 (15.0) | 3 (6.3) | 2.3 (0.7, 7.8) | 20.9 (13.1) | 9.9 (6.7) | 2.4 (1.1, 5.4) |
| Heart disease at the last follow-up, n (%) | 50 (39.4) | 15 (31.3) | 1.4 (0.7, 2.9) | 64.8 (40.6) | 53.4 (36.3) | 1.2 (0.7, 1.9) |
| Length of hospitalization >11 days, n (%) | 46 (36.2) | 32 (66.7) | 0.3 (0.1, 0.6) | 59.8 (37.5) | 93.3 (63.5) | 0.3 (0.2, 0.5) |
| . | Before IPTW propensity method . | After IPTW propensity method . | ||||
|---|---|---|---|---|---|---|
| . | IVIG + high-dose CSs (n = 127) . | IVIG + low-dose CSs (n = 48) . | OR (95% CI) . | IVIG + high-dose CSs (n = 159.5) . | IVIG + low-dose CSs (n = 146.9) . | ORa(95% CI) . |
| OUTCOME | ||||||
| At least one worsening/poor response, n (%) | 42 (33.1) | 28 (58.3) | 0.4 (0.2, 0.7) | 55.8 (35.0) | 86.3 (58.8) | 0.4 (0.2, 0.6) |
| Need for intensive care, n (%) | 31 (24.4) | 14 (29.2) | 0.7 (0.4, 1.6) | 39.4 (24.7) | 32.9 (22.4) | 1.2 (0.7, 2.1) |
| Need for ventilatory support, n (%) | 22 (17.3) | 10 (20.8) | 0.8 (0.3, 1.8) | 28.0 (17.5) | 27.6 (18.8) | 0.6 (0.3, 1.2) |
| Need for vasoactive agents n (%) | 19 (15.0) | 3 (6.3) | 2.3 (0.7, 7.8) | 20.9 (13.1) | 9.9 (6.7) | 2.4 (1.1, 5.4) |
| Heart disease at the last follow-up, n (%) | 50 (39.4) | 15 (31.3) | 1.4 (0.7, 2.9) | 64.8 (40.6) | 53.4 (36.3) | 1.2 (0.7, 1.9) |
| Length of hospitalization >11 days, n (%) | 46 (36.2) | 32 (66.7) | 0.3 (0.1, 0.6) | 59.8 (37.5) | 93.3 (63.5) | 0.3 (0.2, 0.5) |
IPTW: inverse probability of treatment weighting; OR, odds ratio.
Adjusted by sex and ethnicity.
Propensity score analysis. Evaluation of the association between IVIG plus high or low dose corticosteroids in relation of the following outcomes: clinical worsening, need for intensive care, ventilatory support, vasoactive agents use, heart disease at last follow-up and length of hospitalization
| . | Before IPTW propensity method . | After IPTW propensity method . | ||||
|---|---|---|---|---|---|---|
| . | IVIG + high-dose CSs (n = 127) . | IVIG + low-dose CSs (n = 48) . | OR (95% CI) . | IVIG + high-dose CSs (n = 159.5) . | IVIG + low-dose CSs (n = 146.9) . | ORa(95% CI) . |
| OUTCOME | ||||||
| At least one worsening/poor response, n (%) | 42 (33.1) | 28 (58.3) | 0.4 (0.2, 0.7) | 55.8 (35.0) | 86.3 (58.8) | 0.4 (0.2, 0.6) |
| Need for intensive care, n (%) | 31 (24.4) | 14 (29.2) | 0.7 (0.4, 1.6) | 39.4 (24.7) | 32.9 (22.4) | 1.2 (0.7, 2.1) |
| Need for ventilatory support, n (%) | 22 (17.3) | 10 (20.8) | 0.8 (0.3, 1.8) | 28.0 (17.5) | 27.6 (18.8) | 0.6 (0.3, 1.2) |
| Need for vasoactive agents n (%) | 19 (15.0) | 3 (6.3) | 2.3 (0.7, 7.8) | 20.9 (13.1) | 9.9 (6.7) | 2.4 (1.1, 5.4) |
| Heart disease at the last follow-up, n (%) | 50 (39.4) | 15 (31.3) | 1.4 (0.7, 2.9) | 64.8 (40.6) | 53.4 (36.3) | 1.2 (0.7, 1.9) |
| Length of hospitalization >11 days, n (%) | 46 (36.2) | 32 (66.7) | 0.3 (0.1, 0.6) | 59.8 (37.5) | 93.3 (63.5) | 0.3 (0.2, 0.5) |
| . | Before IPTW propensity method . | After IPTW propensity method . | ||||
|---|---|---|---|---|---|---|
| . | IVIG + high-dose CSs (n = 127) . | IVIG + low-dose CSs (n = 48) . | OR (95% CI) . | IVIG + high-dose CSs (n = 159.5) . | IVIG + low-dose CSs (n = 146.9) . | ORa(95% CI) . |
| OUTCOME | ||||||
| At least one worsening/poor response, n (%) | 42 (33.1) | 28 (58.3) | 0.4 (0.2, 0.7) | 55.8 (35.0) | 86.3 (58.8) | 0.4 (0.2, 0.6) |
| Need for intensive care, n (%) | 31 (24.4) | 14 (29.2) | 0.7 (0.4, 1.6) | 39.4 (24.7) | 32.9 (22.4) | 1.2 (0.7, 2.1) |
| Need for ventilatory support, n (%) | 22 (17.3) | 10 (20.8) | 0.8 (0.3, 1.8) | 28.0 (17.5) | 27.6 (18.8) | 0.6 (0.3, 1.2) |
| Need for vasoactive agents n (%) | 19 (15.0) | 3 (6.3) | 2.3 (0.7, 7.8) | 20.9 (13.1) | 9.9 (6.7) | 2.4 (1.1, 5.4) |
| Heart disease at the last follow-up, n (%) | 50 (39.4) | 15 (31.3) | 1.4 (0.7, 2.9) | 64.8 (40.6) | 53.4 (36.3) | 1.2 (0.7, 1.9) |
| Length of hospitalization >11 days, n (%) | 46 (36.2) | 32 (66.7) | 0.3 (0.1, 0.6) | 59.8 (37.5) | 93.3 (63.5) | 0.3 (0.2, 0.5) |
IPTW: inverse probability of treatment weighting; OR, odds ratio.
Adjusted by sex and ethnicity.
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