Table 2. Open in new tab Anti-SARS-CoV-2...

	All Pre-V₃ Measurements	Post-V₂ Measurements Only	Post-V₃ Measurements Only
Total Ig
Infected	5.10	1.63	.89–2.37	<.001	8.84	4.83	1.86–7.81	.003	12.34	1.40	.60–2.21	<.001
Uninfected	1.31	7.29	12.07
IgG
Infected	6.81	2.14	.73–3.55	.003	16.72	6.52	1.08–11.96	.022	18.65	1.69	.33–3.07	.016
Uninfected	1.37	14.69	15.71

	All Pre-V₃ Measurements	Post-V₂ Measurements Only	Post-V₃ Measurements Only
Total Ig
Infected	5.10	1.63	.89–2.37	<.001	8.84	4.83	1.86–7.81	.003	12.34	1.40	.60–2.21	<.001
Uninfected	1.31	7.29	12.07
IgG
Infected	6.81	2.14	.73–3.55	.003	16.72	6.52	1.08–11.96	.022	18.65	1.69	.33–3.07	.016
Uninfected	1.37	14.69	15.71

Table 2.

Anti-SARS-CoV-2 Total Ig and IgG P/N Levels Between Participants Infected During Follow-up With at Least 1 Postinfection Sample and Those Never Infected

	All Pre-V₃ Measurements				Post-V₂ Measurements Only				Post-V₃ Measurements Only
	Median	DE	95% CI	P Value	Median	DE	95% CI	P Value	Median	DE	95% CI	P Value
Total Ig
Infected	5.10	1.63	.89–2.37	<.001	8.84	4.83	1.86–7.81	.003	12.34	1.40	.60–2.21	<.001
Uninfected	1.31	1.63	.89–2.37	<.001	7.29	4.83	1.86–7.81	.003	12.07	1.40	.60–2.21	<.001
IgG
Infected	6.81	2.14	.73–3.55	.003	16.72	6.52	1.08–11.96	.022	18.65	1.69	.33–3.07	.016
Uninfected	1.37	2.14	.73–3.55	.003	14.69	6.52	1.08–11.96	.022	15.71	1.69	.33–3.07	.016

	All Pre-V₃ Measurements				Post-V₂ Measurements Only				Post-V₃ Measurements Only
	Median	DE	95% CI	P Value	Median	DE	95% CI	P Value	Median	DE	95% CI	P Value
Total Ig
Infected	5.10	1.63	.89–2.37	<.001	8.84	4.83	1.86–7.81	.003	12.34	1.40	.60–2.21	<.001
Uninfected	1.31	1.63	.89–2.37	<.001	7.29	4.83	1.86–7.81	.003	12.07	1.40	.60–2.21	<.001
IgG
Infected	6.81	2.14	.73–3.55	.003	16.72	6.52	1.08–11.96	.022	18.65	1.69	.33–3.07	.016
Uninfected	1.37	2.14	.73–3.55	.003	14.69	6.52	1.08–11.96	.022	15.71	1.69	.33–3.07	.016

Analysis was limited to participants for whom at least 1 prevaccination and 1 postvaccination sample was collected (n = 99) and included pre- and postinfection measurements. For the analysis of all pre-V₃ measurements, individuals who had only a post-V₃ infection were excluded.

Abbreviations: DE, difference estimate; Ig, immunoglobulin; IgG, immunoglobulin G; P/N, positive-to-negative ratio; post-V₁, post–vaccine 1; post-V₂, post–vaccine 2; post-V₃, postboost.

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