Table 3.
Open in new tab

Incidence of Outpatient Clostridioides difficile Infection Episodesa, 2016–2021

CharacteristicOverall
No.Person-yearsIncidence (95% CI) per 100 000 PY
Overall10 54521 890 31448.2 (47.3–49.1)
Yearb
 201621043 616 55058.2 (55.7–60.7)
 201719293 780 19851 (48.8–53.4)
 201820843 927 37353.1 (50.8–55.4)
 201918854 005 21647.1 (45.0–49.2)
 202016734 095 52240.8 (38.9–42.9)
 202118884 132 31445.7 (43.7–47.8)
Sex
 Male391010 469 08137.3 (36.2–38.5)
 Female663511 421 23358.1 (56.7–59.5)
Age, y
 18–49332312 919 05025.7 (24.9–26.6)
 50–548531 909 76944.7 (41.7–47.8)
 55–5910051 864 91153.9 (50.6–57.3)
 60–6410201 613 98163.2 (59.4–67.2)
 65–6912561 466 71685.6 (81.0–90.5)
 70–741027919 582111.7 (105.0–118.7)
 75–79813590 652137.6 (128.3–147.4)
 80–84674355 693189.5 (175.5–204.4)
 ≥85574251 635228.1 (209.8–247.6)
Race/ethnicity
 White59938 464 64770.8 (69.0–72.6)
 Black7251 574 44746 (42.8–49.5)
 Asian5122 195 90923.3 (21.3–25.4)
 Hispanic29427 584 47838.8 (37.4–40.2)
 Pacific Islander/Other207465 82744.4 (38.6–50.9)
 Unknown1661 606 82710.3 (8.8–12.0)
CharacteristicOverall
No.Person-yearsIncidence (95% CI) per 100 000 PY
Overall10 54521 890 31448.2 (47.3–49.1)
Yearb
 201621043 616 55058.2 (55.7–60.7)
 201719293 780 19851 (48.8–53.4)
 201820843 927 37353.1 (50.8–55.4)
 201918854 005 21647.1 (45.0–49.2)
 202016734 095 52240.8 (38.9–42.9)
 202118884 132 31445.7 (43.7–47.8)
Sex
 Male391010 469 08137.3 (36.2–38.5)
 Female663511 421 23358.1 (56.7–59.5)
Age, y
 18–49332312 919 05025.7 (24.9–26.6)
 50–548531 909 76944.7 (41.7–47.8)
 55–5910051 864 91153.9 (50.6–57.3)
 60–6410201 613 98163.2 (59.4–67.2)
 65–6912561 466 71685.6 (81.0–90.5)
 70–741027919 582111.7 (105.0–118.7)
 75–79813590 652137.6 (128.3–147.4)
 80–84674355 693189.5 (175.5–204.4)
 ≥85574251 635228.1 (209.8–247.6)
Race/ethnicity
 White59938 464 64770.8 (69.0–72.6)
 Black7251 574 44746 (42.8–49.5)
 Asian5122 195 90923.3 (21.3–25.4)
 Hispanic29427 584 47838.8 (37.4–40.2)
 Pacific Islander/Other207465 82744.4 (38.6–50.9)
 Unknown1661 606 82710.3 (8.8–12.0)

Abbreviations: CI, confidence interval.

aOutpatient Clostridioides difficile episode defined patient seeking medical care with diarrhea with a positive C difficile laboratory test (1) without hospitalization on the date of stool specimen or within the subsequent 7 days; and (2) without evidence (laboratory or diagnostic) of an ongoing C difficile episode within the previous 56 days.

bCounts from individual years sum to greater than column total as participants can have CDI episodes in >1 year.

Table 3.
Open in new tab

Incidence of Outpatient Clostridioides difficile Infection Episodesa, 2016–2021

CharacteristicOverall
No.Person-yearsIncidence (95% CI) per 100 000 PY
Overall10 54521 890 31448.2 (47.3–49.1)
Yearb
 201621043 616 55058.2 (55.7–60.7)
 201719293 780 19851 (48.8–53.4)
 201820843 927 37353.1 (50.8–55.4)
 201918854 005 21647.1 (45.0–49.2)
 202016734 095 52240.8 (38.9–42.9)
 202118884 132 31445.7 (43.7–47.8)
Sex
 Male391010 469 08137.3 (36.2–38.5)
 Female663511 421 23358.1 (56.7–59.5)
Age, y
 18–49332312 919 05025.7 (24.9–26.6)
 50–548531 909 76944.7 (41.7–47.8)
 55–5910051 864 91153.9 (50.6–57.3)
 60–6410201 613 98163.2 (59.4–67.2)
 65–6912561 466 71685.6 (81.0–90.5)
 70–741027919 582111.7 (105.0–118.7)
 75–79813590 652137.6 (128.3–147.4)
 80–84674355 693189.5 (175.5–204.4)
 ≥85574251 635228.1 (209.8–247.6)
Race/ethnicity
 White59938 464 64770.8 (69.0–72.6)
 Black7251 574 44746 (42.8–49.5)
 Asian5122 195 90923.3 (21.3–25.4)
 Hispanic29427 584 47838.8 (37.4–40.2)
 Pacific Islander/Other207465 82744.4 (38.6–50.9)
 Unknown1661 606 82710.3 (8.8–12.0)
CharacteristicOverall
No.Person-yearsIncidence (95% CI) per 100 000 PY
Overall10 54521 890 31448.2 (47.3–49.1)
Yearb
 201621043 616 55058.2 (55.7–60.7)
 201719293 780 19851 (48.8–53.4)
 201820843 927 37353.1 (50.8–55.4)
 201918854 005 21647.1 (45.0–49.2)
 202016734 095 52240.8 (38.9–42.9)
 202118884 132 31445.7 (43.7–47.8)
Sex
 Male391010 469 08137.3 (36.2–38.5)
 Female663511 421 23358.1 (56.7–59.5)
Age, y
 18–49332312 919 05025.7 (24.9–26.6)
 50–548531 909 76944.7 (41.7–47.8)
 55–5910051 864 91153.9 (50.6–57.3)
 60–6410201 613 98163.2 (59.4–67.2)
 65–6912561 466 71685.6 (81.0–90.5)
 70–741027919 582111.7 (105.0–118.7)
 75–79813590 652137.6 (128.3–147.4)
 80–84674355 693189.5 (175.5–204.4)
 ≥85574251 635228.1 (209.8–247.6)
Race/ethnicity
 White59938 464 64770.8 (69.0–72.6)
 Black7251 574 44746 (42.8–49.5)
 Asian5122 195 90923.3 (21.3–25.4)
 Hispanic29427 584 47838.8 (37.4–40.2)
 Pacific Islander/Other207465 82744.4 (38.6–50.9)
 Unknown1661 606 82710.3 (8.8–12.0)

Abbreviations: CI, confidence interval.

aOutpatient Clostridioides difficile episode defined patient seeking medical care with diarrhea with a positive C difficile laboratory test (1) without hospitalization on the date of stool specimen or within the subsequent 7 days; and (2) without evidence (laboratory or diagnostic) of an ongoing C difficile episode within the previous 56 days.

bCounts from individual years sum to greater than column total as participants can have CDI episodes in >1 year.

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