| . | Unadjusted . | Adjusted . | |||
|---|---|---|---|---|---|
| Variable . | HR (95% CI) . | P-value . | HR (95% CI) . | P-value . | |
| All-cause mortality | Baseline Hb | 1.25 (0.98–1.59) | .070 | 1.00 (0.76–1.33) | .994 |
| Time-averaged Hb | 2.45 (1.71–3.51) | <.001 | 183 (1.19–2.81) | .006 | |
| MACE | Baseline Hb | 1.18 (0.90–1.54) | .225 | 1.02 (0.76–1.38) | .874 |
| Time-averaged Hb | 2.33 (1.55–3.50) | <.001 | 1.99 (1.16–3.40) | .012 | |
| MACE+ | Baseline Hb | 1.29 (1.06–1.57) | .012 | 0.99 (0.76–1.28) | .283 |
| Time-averaged Hb | 2.44 (1.78–3.34) | <.001 | 1.77 (1.15–2.73) | .010 | |
| Hospitalization | Baseline Hb | 1.16 (1.01–1.33) | .034 | 0.98 (0.84–1.15) | .832 |
| Time-averaged Hb | 1.39 (1.16–1.67) | <.001 | 1.13 (0.93–1.37) | .220 | |
| Transfer to HD | Baseline Hb | 1.09 (0.84–1.41) | .529 | 0.90 (0.69–1.19) | .470 |
| Time-averaged Hb | 1.42 (0.95–2.12) | .088 | 1.03 (0.66–1.59) | .912 | |
| First-episode peritonitis | Baseline Hb | 0.98 (0.80–1.20) | .850 | 1.00 (0.80–1.23) | .965 |
| Time-averaged Hb | 0.72 (0.48–1.07) | .106 | 0.73 (0.48–1.09) | .124 | |
| . | Unadjusted . | Adjusted . | |||
|---|---|---|---|---|---|
| Variable . | HR (95% CI) . | P-value . | HR (95% CI) . | P-value . | |
| All-cause mortality | Baseline Hb | 1.25 (0.98–1.59) | .070 | 1.00 (0.76–1.33) | .994 |
| Time-averaged Hb | 2.45 (1.71–3.51) | <.001 | 183 (1.19–2.81) | .006 | |
| MACE | Baseline Hb | 1.18 (0.90–1.54) | .225 | 1.02 (0.76–1.38) | .874 |
| Time-averaged Hb | 2.33 (1.55–3.50) | <.001 | 1.99 (1.16–3.40) | .012 | |
| MACE+ | Baseline Hb | 1.29 (1.06–1.57) | .012 | 0.99 (0.76–1.28) | .283 |
| Time-averaged Hb | 2.44 (1.78–3.34) | <.001 | 1.77 (1.15–2.73) | .010 | |
| Hospitalization | Baseline Hb | 1.16 (1.01–1.33) | .034 | 0.98 (0.84–1.15) | .832 |
| Time-averaged Hb | 1.39 (1.16–1.67) | <.001 | 1.13 (0.93–1.37) | .220 | |
| Transfer to HD | Baseline Hb | 1.09 (0.84–1.41) | .529 | 0.90 (0.69–1.19) | .470 |
| Time-averaged Hb | 1.42 (0.95–2.12) | .088 | 1.03 (0.66–1.59) | .912 | |
| First-episode peritonitis | Baseline Hb | 0.98 (0.80–1.20) | .850 | 1.00 (0.80–1.23) | .965 |
| Time-averaged Hb | 0.72 (0.48–1.07) | .106 | 0.73 (0.48–1.09) | .124 | |
MACE includes myocardial infarction, unstable angina, stroke and cardiovascular deaths.
Multivariable analysis, adjusting for the variables associated with each clinical outcome identified by proportional hazards models (Supplementary Tables 1 and 2).
| . | Unadjusted . | Adjusted . | |||
|---|---|---|---|---|---|
| Variable . | HR (95% CI) . | P-value . | HR (95% CI) . | P-value . | |
| All-cause mortality | Baseline Hb | 1.25 (0.98–1.59) | .070 | 1.00 (0.76–1.33) | .994 |
| Time-averaged Hb | 2.45 (1.71–3.51) | <.001 | 183 (1.19–2.81) | .006 | |
| MACE | Baseline Hb | 1.18 (0.90–1.54) | .225 | 1.02 (0.76–1.38) | .874 |
| Time-averaged Hb | 2.33 (1.55–3.50) | <.001 | 1.99 (1.16–3.40) | .012 | |
| MACE+ | Baseline Hb | 1.29 (1.06–1.57) | .012 | 0.99 (0.76–1.28) | .283 |
| Time-averaged Hb | 2.44 (1.78–3.34) | <.001 | 1.77 (1.15–2.73) | .010 | |
| Hospitalization | Baseline Hb | 1.16 (1.01–1.33) | .034 | 0.98 (0.84–1.15) | .832 |
| Time-averaged Hb | 1.39 (1.16–1.67) | <.001 | 1.13 (0.93–1.37) | .220 | |
| Transfer to HD | Baseline Hb | 1.09 (0.84–1.41) | .529 | 0.90 (0.69–1.19) | .470 |
| Time-averaged Hb | 1.42 (0.95–2.12) | .088 | 1.03 (0.66–1.59) | .912 | |
| First-episode peritonitis | Baseline Hb | 0.98 (0.80–1.20) | .850 | 1.00 (0.80–1.23) | .965 |
| Time-averaged Hb | 0.72 (0.48–1.07) | .106 | 0.73 (0.48–1.09) | .124 | |
| . | Unadjusted . | Adjusted . | |||
|---|---|---|---|---|---|
| Variable . | HR (95% CI) . | P-value . | HR (95% CI) . | P-value . | |
| All-cause mortality | Baseline Hb | 1.25 (0.98–1.59) | .070 | 1.00 (0.76–1.33) | .994 |
| Time-averaged Hb | 2.45 (1.71–3.51) | <.001 | 183 (1.19–2.81) | .006 | |
| MACE | Baseline Hb | 1.18 (0.90–1.54) | .225 | 1.02 (0.76–1.38) | .874 |
| Time-averaged Hb | 2.33 (1.55–3.50) | <.001 | 1.99 (1.16–3.40) | .012 | |
| MACE+ | Baseline Hb | 1.29 (1.06–1.57) | .012 | 0.99 (0.76–1.28) | .283 |
| Time-averaged Hb | 2.44 (1.78–3.34) | <.001 | 1.77 (1.15–2.73) | .010 | |
| Hospitalization | Baseline Hb | 1.16 (1.01–1.33) | .034 | 0.98 (0.84–1.15) | .832 |
| Time-averaged Hb | 1.39 (1.16–1.67) | <.001 | 1.13 (0.93–1.37) | .220 | |
| Transfer to HD | Baseline Hb | 1.09 (0.84–1.41) | .529 | 0.90 (0.69–1.19) | .470 |
| Time-averaged Hb | 1.42 (0.95–2.12) | .088 | 1.03 (0.66–1.59) | .912 | |
| First-episode peritonitis | Baseline Hb | 0.98 (0.80–1.20) | .850 | 1.00 (0.80–1.23) | .965 |
| Time-averaged Hb | 0.72 (0.48–1.07) | .106 | 0.73 (0.48–1.09) | .124 | |
MACE includes myocardial infarction, unstable angina, stroke and cardiovascular deaths.
Multivariable analysis, adjusting for the variables associated with each clinical outcome identified by proportional hazards models (Supplementary Tables 1 and 2).
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