Known arrhythmia reports from all the sources including the individual case reports, as well as Radboudumc and GenIDA registries
| Source . | Cardiac arrhythmia . | Treatment . | Age at diagnosis (years) . | Structural heart disease . | Mutation variant . | Zygosity (inheritance) . |
|---|---|---|---|---|---|---|
| Radboudumc | Paroxysmal atrial fibrillation | Metoprolol | 25 | No | GRCh38 g.137728442C>T EHMT1 c.736C>T p.(Arg246a) | Heterozygous (unknown) |
| Radboudumc | Supraventricular tachycardia (SVT) | Ablation and verapamil | 18 | No | GRCh38 g.137798894C>T EHMT1 c.2587C>T p.(Gln863a) | Heterozygous (unknown) |
| Radboudumc | Paroxysmal SVT (accelerated nodal rhythm) | Verapamil | 23 | No | GRCh38 g.137776794dup EHMT1 c.1968dup p.(Gln657Alafsa41) | Heterozygous (unknown) |
| Radboudumc | Non-sustained ventricular tachycardia (NSVT) | Monitoring/expectative | 22 | Valvular insufficiency normal EF | GRCh38 NC_000009.12 g.pter(203862_534475) del(137507220_138125938) | Heterozygous (unknown) |
| GenIDA | Bursts of atrial fibrillation | Unknown | <29 | Not reported | Unknown | Unknown |
| GenIDA | Chronic atrial ectopic tachycardia | Unknown | <19 | Not reported | Unknown | Unknown |
| Patient 1 | Paroxysmal atrial fibrillation, atrial flutter, premature atrial contractions (PACs), NSVT | Pulmonary vein isolation ablation | 23 | No | EHMT1 16 kb intragenic duplication encompassing exons 5–6a | Heterozygous (paternal) |
| Patient 2 | Paroxysmal atrial fibrillation | Metoprolol | 25 | No | EHMT1 IVS22-1G>A c.3259G>A | Heterozygous (de novo) |
| Patient 3 | Unstable SVT (incessant atrial tachycardia) | Atenolol, amiodarone | 17 | No | EHMT1 c.3462-10C-G (IVS 24-10C-G) | Heterozygous (unknown) |
| Source . | Cardiac arrhythmia . | Treatment . | Age at diagnosis (years) . | Structural heart disease . | Mutation variant . | Zygosity (inheritance) . |
|---|---|---|---|---|---|---|
| Radboudumc | Paroxysmal atrial fibrillation | Metoprolol | 25 | No | GRCh38 g.137728442C>T EHMT1 c.736C>T p.(Arg246a) | Heterozygous (unknown) |
| Radboudumc | Supraventricular tachycardia (SVT) | Ablation and verapamil | 18 | No | GRCh38 g.137798894C>T EHMT1 c.2587C>T p.(Gln863a) | Heterozygous (unknown) |
| Radboudumc | Paroxysmal SVT (accelerated nodal rhythm) | Verapamil | 23 | No | GRCh38 g.137776794dup EHMT1 c.1968dup p.(Gln657Alafsa41) | Heterozygous (unknown) |
| Radboudumc | Non-sustained ventricular tachycardia (NSVT) | Monitoring/expectative | 22 | Valvular insufficiency normal EF | GRCh38 NC_000009.12 g.pter(203862_534475) del(137507220_138125938) | Heterozygous (unknown) |
| GenIDA | Bursts of atrial fibrillation | Unknown | <29 | Not reported | Unknown | Unknown |
| GenIDA | Chronic atrial ectopic tachycardia | Unknown | <19 | Not reported | Unknown | Unknown |
| Patient 1 | Paroxysmal atrial fibrillation, atrial flutter, premature atrial contractions (PACs), NSVT | Pulmonary vein isolation ablation | 23 | No | EHMT1 16 kb intragenic duplication encompassing exons 5–6a | Heterozygous (paternal) |
| Patient 2 | Paroxysmal atrial fibrillation | Metoprolol | 25 | No | EHMT1 IVS22-1G>A c.3259G>A | Heterozygous (de novo) |
| Patient 3 | Unstable SVT (incessant atrial tachycardia) | Atenolol, amiodarone | 17 | No | EHMT1 c.3462-10C-G (IVS 24-10C-G) | Heterozygous (unknown) |
Atrial arrhythmias are delineated in bold.
aPatient also harboured heterozygous PRKAG2, c.1571T>G (p.Ile524Arg) variant of uncertain significance.
Known arrhythmia reports from all the sources including the individual case reports, as well as Radboudumc and GenIDA registries
| Source . | Cardiac arrhythmia . | Treatment . | Age at diagnosis (years) . | Structural heart disease . | Mutation variant . | Zygosity (inheritance) . |
|---|---|---|---|---|---|---|
| Radboudumc | Paroxysmal atrial fibrillation | Metoprolol | 25 | No | GRCh38 g.137728442C>T EHMT1 c.736C>T p.(Arg246a) | Heterozygous (unknown) |
| Radboudumc | Supraventricular tachycardia (SVT) | Ablation and verapamil | 18 | No | GRCh38 g.137798894C>T EHMT1 c.2587C>T p.(Gln863a) | Heterozygous (unknown) |
| Radboudumc | Paroxysmal SVT (accelerated nodal rhythm) | Verapamil | 23 | No | GRCh38 g.137776794dup EHMT1 c.1968dup p.(Gln657Alafsa41) | Heterozygous (unknown) |
| Radboudumc | Non-sustained ventricular tachycardia (NSVT) | Monitoring/expectative | 22 | Valvular insufficiency normal EF | GRCh38 NC_000009.12 g.pter(203862_534475) del(137507220_138125938) | Heterozygous (unknown) |
| GenIDA | Bursts of atrial fibrillation | Unknown | <29 | Not reported | Unknown | Unknown |
| GenIDA | Chronic atrial ectopic tachycardia | Unknown | <19 | Not reported | Unknown | Unknown |
| Patient 1 | Paroxysmal atrial fibrillation, atrial flutter, premature atrial contractions (PACs), NSVT | Pulmonary vein isolation ablation | 23 | No | EHMT1 16 kb intragenic duplication encompassing exons 5–6a | Heterozygous (paternal) |
| Patient 2 | Paroxysmal atrial fibrillation | Metoprolol | 25 | No | EHMT1 IVS22-1G>A c.3259G>A | Heterozygous (de novo) |
| Patient 3 | Unstable SVT (incessant atrial tachycardia) | Atenolol, amiodarone | 17 | No | EHMT1 c.3462-10C-G (IVS 24-10C-G) | Heterozygous (unknown) |
| Source . | Cardiac arrhythmia . | Treatment . | Age at diagnosis (years) . | Structural heart disease . | Mutation variant . | Zygosity (inheritance) . |
|---|---|---|---|---|---|---|
| Radboudumc | Paroxysmal atrial fibrillation | Metoprolol | 25 | No | GRCh38 g.137728442C>T EHMT1 c.736C>T p.(Arg246a) | Heterozygous (unknown) |
| Radboudumc | Supraventricular tachycardia (SVT) | Ablation and verapamil | 18 | No | GRCh38 g.137798894C>T EHMT1 c.2587C>T p.(Gln863a) | Heterozygous (unknown) |
| Radboudumc | Paroxysmal SVT (accelerated nodal rhythm) | Verapamil | 23 | No | GRCh38 g.137776794dup EHMT1 c.1968dup p.(Gln657Alafsa41) | Heterozygous (unknown) |
| Radboudumc | Non-sustained ventricular tachycardia (NSVT) | Monitoring/expectative | 22 | Valvular insufficiency normal EF | GRCh38 NC_000009.12 g.pter(203862_534475) del(137507220_138125938) | Heterozygous (unknown) |
| GenIDA | Bursts of atrial fibrillation | Unknown | <29 | Not reported | Unknown | Unknown |
| GenIDA | Chronic atrial ectopic tachycardia | Unknown | <19 | Not reported | Unknown | Unknown |
| Patient 1 | Paroxysmal atrial fibrillation, atrial flutter, premature atrial contractions (PACs), NSVT | Pulmonary vein isolation ablation | 23 | No | EHMT1 16 kb intragenic duplication encompassing exons 5–6a | Heterozygous (paternal) |
| Patient 2 | Paroxysmal atrial fibrillation | Metoprolol | 25 | No | EHMT1 IVS22-1G>A c.3259G>A | Heterozygous (de novo) |
| Patient 3 | Unstable SVT (incessant atrial tachycardia) | Atenolol, amiodarone | 17 | No | EHMT1 c.3462-10C-G (IVS 24-10C-G) | Heterozygous (unknown) |
Atrial arrhythmias are delineated in bold.
aPatient also harboured heterozygous PRKAG2, c.1571T>G (p.Ile524Arg) variant of uncertain significance.
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