Laboratory Findings and Imaging at Diagnosis and Approximately 1 Year Postsurgery
| Reference range | Initial presentation | ~One year post surgery | |
| Biochemistry | |||
| Calcium (mmol/L) | 2.22–2.54 | 3.85 | 2.45 |
| Ionized calcium (mmol/L) | 1.22–1.37 | 2.12 | 1.26 |
| Phosphate (mmol/L) | 1.18–1.98 | 0.68 | 1.36 |
| PTH (ng/L) | 12–78 | 980 | 29 |
| Alkaline phosphatase (μkat/L) [U/L] | 2.07–7.92 [124–474] | 20.79 [1245] | 1.85 [111] |
| 25OHD (nmol/L) | 49 | 78 | |
| Calcium:creatinine ratio urine (mmol/mmol) | <0.6 | 2.3 | 0.36 |
| TSH (mU/L) | 0.73–4.09 | 1.06 | 1.54 |
| Free T4 (pmol/L) | 10.0–17.6 | 10.9 | 11.8 |
| Imaging | |||
| X ray knees and hips (2 views) | Multiple lytic lesions Subchondral resorption at SI joints. | Healing of multiple lucent osseous lesions. Resolution of SI joint widening. | |
| MRI whole body w/o contrast | Multifocal lesions throughout skeleton. Nonspecific lesion of the right parathyroid. | Interval decrease in size or resolution of multiple bone lesions, no new lesions. | |
| BMD | |||
| (L1–L4) Z score | 1.2 | 1.8 | |
| TBLH (g/cm2) | 0.970 | 1.233 | |
| AP Spine BMD (g/cm2) | 1.099 | 1.320 | |
| HRpQCT | See Table 2 | See Table 2 |
| Reference range | Initial presentation | ~One year post surgery | |
| Biochemistry | |||
| Calcium (mmol/L) | 2.22–2.54 | 3.85 | 2.45 |
| Ionized calcium (mmol/L) | 1.22–1.37 | 2.12 | 1.26 |
| Phosphate (mmol/L) | 1.18–1.98 | 0.68 | 1.36 |
| PTH (ng/L) | 12–78 | 980 | 29 |
| Alkaline phosphatase (μkat/L) [U/L] | 2.07–7.92 [124–474] | 20.79 [1245] | 1.85 [111] |
| 25OHD (nmol/L) | 49 | 78 | |
| Calcium:creatinine ratio urine (mmol/mmol) | <0.6 | 2.3 | 0.36 |
| TSH (mU/L) | 0.73–4.09 | 1.06 | 1.54 |
| Free T4 (pmol/L) | 10.0–17.6 | 10.9 | 11.8 |
| Imaging | |||
| X ray knees and hips (2 views) | Multiple lytic lesions Subchondral resorption at SI joints. | Healing of multiple lucent osseous lesions. Resolution of SI joint widening. | |
| MRI whole body w/o contrast | Multifocal lesions throughout skeleton. Nonspecific lesion of the right parathyroid. | Interval decrease in size or resolution of multiple bone lesions, no new lesions. | |
| BMD | |||
| (L1–L4) Z score | 1.2 | 1.8 | |
| TBLH (g/cm2) | 0.970 | 1.233 | |
| AP Spine BMD (g/cm2) | 1.099 | 1.320 | |
| HRpQCT | See Table 2 | See Table 2 |
SI = sacroiliac; TBLH = total body less head; AP = anteroposterior.
Laboratory Findings and Imaging at Diagnosis and Approximately 1 Year Postsurgery
| Reference range | Initial presentation | ~One year post surgery | |
| Biochemistry | |||
| Calcium (mmol/L) | 2.22–2.54 | 3.85 | 2.45 |
| Ionized calcium (mmol/L) | 1.22–1.37 | 2.12 | 1.26 |
| Phosphate (mmol/L) | 1.18–1.98 | 0.68 | 1.36 |
| PTH (ng/L) | 12–78 | 980 | 29 |
| Alkaline phosphatase (μkat/L) [U/L] | 2.07–7.92 [124–474] | 20.79 [1245] | 1.85 [111] |
| 25OHD (nmol/L) | 49 | 78 | |
| Calcium:creatinine ratio urine (mmol/mmol) | <0.6 | 2.3 | 0.36 |
| TSH (mU/L) | 0.73–4.09 | 1.06 | 1.54 |
| Free T4 (pmol/L) | 10.0–17.6 | 10.9 | 11.8 |
| Imaging | |||
| X ray knees and hips (2 views) | Multiple lytic lesions Subchondral resorption at SI joints. | Healing of multiple lucent osseous lesions. Resolution of SI joint widening. | |
| MRI whole body w/o contrast | Multifocal lesions throughout skeleton. Nonspecific lesion of the right parathyroid. | Interval decrease in size or resolution of multiple bone lesions, no new lesions. | |
| BMD | |||
| (L1–L4) Z score | 1.2 | 1.8 | |
| TBLH (g/cm2) | 0.970 | 1.233 | |
| AP Spine BMD (g/cm2) | 1.099 | 1.320 | |
| HRpQCT | See Table 2 | See Table 2 |
| Reference range | Initial presentation | ~One year post surgery | |
| Biochemistry | |||
| Calcium (mmol/L) | 2.22–2.54 | 3.85 | 2.45 |
| Ionized calcium (mmol/L) | 1.22–1.37 | 2.12 | 1.26 |
| Phosphate (mmol/L) | 1.18–1.98 | 0.68 | 1.36 |
| PTH (ng/L) | 12–78 | 980 | 29 |
| Alkaline phosphatase (μkat/L) [U/L] | 2.07–7.92 [124–474] | 20.79 [1245] | 1.85 [111] |
| 25OHD (nmol/L) | 49 | 78 | |
| Calcium:creatinine ratio urine (mmol/mmol) | <0.6 | 2.3 | 0.36 |
| TSH (mU/L) | 0.73–4.09 | 1.06 | 1.54 |
| Free T4 (pmol/L) | 10.0–17.6 | 10.9 | 11.8 |
| Imaging | |||
| X ray knees and hips (2 views) | Multiple lytic lesions Subchondral resorption at SI joints. | Healing of multiple lucent osseous lesions. Resolution of SI joint widening. | |
| MRI whole body w/o contrast | Multifocal lesions throughout skeleton. Nonspecific lesion of the right parathyroid. | Interval decrease in size or resolution of multiple bone lesions, no new lesions. | |
| BMD | |||
| (L1–L4) Z score | 1.2 | 1.8 | |
| TBLH (g/cm2) | 0.970 | 1.233 | |
| AP Spine BMD (g/cm2) | 1.099 | 1.320 | |
| HRpQCT | See Table 2 | See Table 2 |
SI = sacroiliac; TBLH = total body less head; AP = anteroposterior.
This PDF is available to Subscribers Only
View Article Abstract & Purchase OptionsFor full access to this pdf, sign in to an existing account, or purchase an annual subscription.
