Direct, indirect and total effect of independent and mediating variables on MMT-8 scores from causal mediation analysis
| Independent variable . | Mediator . | ACME . | ADE . | Total effect . | P-value . | Proportion mediated . |
|---|---|---|---|---|---|---|
| MSA subgroup | Atrophy | −0.41 (−3.07, 3.45) | 3.87 (0.13, 7.72) | 3.45 (−0.93, 8.56) | 0.144 | −0.12 (−5.14, 3.20) |
| Sex | Atrophy | 1.09 (−0.06, 2.84) | 1.84 (−0.12, 3.42) | 2.93 (0.44, 4.89) | 0.014 | 0.37 (−0.03, 1.07) |
| Diabetes | Atrophy | −0.77 (−3.10, 0.87) | 0.89 (−1.13, 3.28) | 0.12 (−1.83, 2.21) | 0.860 | −6.60 (−15.28, 13.65) |
| Age | Atrophy | −0.03 (−0.13, 0.04) | −0.06 (−0.14, 0.01) | −0.09 (−0.19, -0.01) | 0.032 | 0.37 (−1.01, 1.36) |
| BMI | Atrophy | 0.14 (−0.05, 0.42) | −0.11 (−0.30, 0.07) | 0.03 (−0.25, 0.33) | 0.830 | 4.94 (−12.26, 11.69) |
| Disease duration | Atrophy | −0.03 (−0.25, 0.05) | −0.16 (−0.26, 0.08) | −0.18 (−0.41, 0.07) | 0.110 | 0.14 (−0.83, 1.44) |
| MSA subgroup | Fatty infiltration | 0.63 (−0.98, 2.21) | 3.87 (−0.19, 7.91) | 4.50 (0.37, 7.59) | 0.042 | 0.14 (−0.32, 0.81) |
| Sex | Fatty infiltration | 0.24 (−0.24, 1.41) | 1.84 (−0.05, 3.68) | 2.08 (0.54, 3.71) | 0.012 | 0.11 (−0.15, 1.00) |
| Diabetes | Fatty infiltration | −0.05 (−0.76, 0.51) | 0.89 (−1.57, 3.15) | 0.84 (−1.52, 2.95) | 0.480 | −0.05 (−2.21, 1.82) |
| Age | Fatty infiltration | −0.01 (−0.07, 0.01) | −0.06 (−0.12, 0.01) | −0.07 (−0.15, -0.01) | 0.016 | 0.15 (−0.30, 1.18) |
| BMI | Fatty infiltration | −0.01 (−0.07, 0.06) | −0.11 (−0.31, 0.07) | −0.11 (−0.32, 0.06) | 0.190 | 0.04 (−1.75, 2.55) |
| Disease duration | Fatty infiltration | −0.02 (−0.16, 0.03) | −0.16 (−0.26, 0.05) | -0.18 (−0.27, -0.02) | 0.036 | 0.12 (−0.23, 1.37) |
| Independent variable . | Mediator . | ACME . | ADE . | Total effect . | P-value . | Proportion mediated . |
|---|---|---|---|---|---|---|
| MSA subgroup | Atrophy | −0.41 (−3.07, 3.45) | 3.87 (0.13, 7.72) | 3.45 (−0.93, 8.56) | 0.144 | −0.12 (−5.14, 3.20) |
| Sex | Atrophy | 1.09 (−0.06, 2.84) | 1.84 (−0.12, 3.42) | 2.93 (0.44, 4.89) | 0.014 | 0.37 (−0.03, 1.07) |
| Diabetes | Atrophy | −0.77 (−3.10, 0.87) | 0.89 (−1.13, 3.28) | 0.12 (−1.83, 2.21) | 0.860 | −6.60 (−15.28, 13.65) |
| Age | Atrophy | −0.03 (−0.13, 0.04) | −0.06 (−0.14, 0.01) | −0.09 (−0.19, -0.01) | 0.032 | 0.37 (−1.01, 1.36) |
| BMI | Atrophy | 0.14 (−0.05, 0.42) | −0.11 (−0.30, 0.07) | 0.03 (−0.25, 0.33) | 0.830 | 4.94 (−12.26, 11.69) |
| Disease duration | Atrophy | −0.03 (−0.25, 0.05) | −0.16 (−0.26, 0.08) | −0.18 (−0.41, 0.07) | 0.110 | 0.14 (−0.83, 1.44) |
| MSA subgroup | Fatty infiltration | 0.63 (−0.98, 2.21) | 3.87 (−0.19, 7.91) | 4.50 (0.37, 7.59) | 0.042 | 0.14 (−0.32, 0.81) |
| Sex | Fatty infiltration | 0.24 (−0.24, 1.41) | 1.84 (−0.05, 3.68) | 2.08 (0.54, 3.71) | 0.012 | 0.11 (−0.15, 1.00) |
| Diabetes | Fatty infiltration | −0.05 (−0.76, 0.51) | 0.89 (−1.57, 3.15) | 0.84 (−1.52, 2.95) | 0.480 | −0.05 (−2.21, 1.82) |
| Age | Fatty infiltration | −0.01 (−0.07, 0.01) | −0.06 (−0.12, 0.01) | −0.07 (−0.15, -0.01) | 0.016 | 0.15 (−0.30, 1.18) |
| BMI | Fatty infiltration | −0.01 (−0.07, 0.06) | −0.11 (−0.31, 0.07) | −0.11 (−0.32, 0.06) | 0.190 | 0.04 (−1.75, 2.55) |
| Disease duration | Fatty infiltration | −0.02 (−0.16, 0.03) | −0.16 (−0.26, 0.05) | -0.18 (−0.27, -0.02) | 0.036 | 0.12 (−0.23, 1.37) |
ACME: average causal mediation effect; ADE: average direct effect; FI: fatty infiltration; MSA: myositis-specific antibody; MSA subgroup, Antisynthetase antibody. Bold text indicates P < 0.05.
Direct, indirect and total effect of independent and mediating variables on MMT-8 scores from causal mediation analysis
| Independent variable . | Mediator . | ACME . | ADE . | Total effect . | P-value . | Proportion mediated . |
|---|---|---|---|---|---|---|
| MSA subgroup | Atrophy | −0.41 (−3.07, 3.45) | 3.87 (0.13, 7.72) | 3.45 (−0.93, 8.56) | 0.144 | −0.12 (−5.14, 3.20) |
| Sex | Atrophy | 1.09 (−0.06, 2.84) | 1.84 (−0.12, 3.42) | 2.93 (0.44, 4.89) | 0.014 | 0.37 (−0.03, 1.07) |
| Diabetes | Atrophy | −0.77 (−3.10, 0.87) | 0.89 (−1.13, 3.28) | 0.12 (−1.83, 2.21) | 0.860 | −6.60 (−15.28, 13.65) |
| Age | Atrophy | −0.03 (−0.13, 0.04) | −0.06 (−0.14, 0.01) | −0.09 (−0.19, -0.01) | 0.032 | 0.37 (−1.01, 1.36) |
| BMI | Atrophy | 0.14 (−0.05, 0.42) | −0.11 (−0.30, 0.07) | 0.03 (−0.25, 0.33) | 0.830 | 4.94 (−12.26, 11.69) |
| Disease duration | Atrophy | −0.03 (−0.25, 0.05) | −0.16 (−0.26, 0.08) | −0.18 (−0.41, 0.07) | 0.110 | 0.14 (−0.83, 1.44) |
| MSA subgroup | Fatty infiltration | 0.63 (−0.98, 2.21) | 3.87 (−0.19, 7.91) | 4.50 (0.37, 7.59) | 0.042 | 0.14 (−0.32, 0.81) |
| Sex | Fatty infiltration | 0.24 (−0.24, 1.41) | 1.84 (−0.05, 3.68) | 2.08 (0.54, 3.71) | 0.012 | 0.11 (−0.15, 1.00) |
| Diabetes | Fatty infiltration | −0.05 (−0.76, 0.51) | 0.89 (−1.57, 3.15) | 0.84 (−1.52, 2.95) | 0.480 | −0.05 (−2.21, 1.82) |
| Age | Fatty infiltration | −0.01 (−0.07, 0.01) | −0.06 (−0.12, 0.01) | −0.07 (−0.15, -0.01) | 0.016 | 0.15 (−0.30, 1.18) |
| BMI | Fatty infiltration | −0.01 (−0.07, 0.06) | −0.11 (−0.31, 0.07) | −0.11 (−0.32, 0.06) | 0.190 | 0.04 (−1.75, 2.55) |
| Disease duration | Fatty infiltration | −0.02 (−0.16, 0.03) | −0.16 (−0.26, 0.05) | -0.18 (−0.27, -0.02) | 0.036 | 0.12 (−0.23, 1.37) |
| Independent variable . | Mediator . | ACME . | ADE . | Total effect . | P-value . | Proportion mediated . |
|---|---|---|---|---|---|---|
| MSA subgroup | Atrophy | −0.41 (−3.07, 3.45) | 3.87 (0.13, 7.72) | 3.45 (−0.93, 8.56) | 0.144 | −0.12 (−5.14, 3.20) |
| Sex | Atrophy | 1.09 (−0.06, 2.84) | 1.84 (−0.12, 3.42) | 2.93 (0.44, 4.89) | 0.014 | 0.37 (−0.03, 1.07) |
| Diabetes | Atrophy | −0.77 (−3.10, 0.87) | 0.89 (−1.13, 3.28) | 0.12 (−1.83, 2.21) | 0.860 | −6.60 (−15.28, 13.65) |
| Age | Atrophy | −0.03 (−0.13, 0.04) | −0.06 (−0.14, 0.01) | −0.09 (−0.19, -0.01) | 0.032 | 0.37 (−1.01, 1.36) |
| BMI | Atrophy | 0.14 (−0.05, 0.42) | −0.11 (−0.30, 0.07) | 0.03 (−0.25, 0.33) | 0.830 | 4.94 (−12.26, 11.69) |
| Disease duration | Atrophy | −0.03 (−0.25, 0.05) | −0.16 (−0.26, 0.08) | −0.18 (−0.41, 0.07) | 0.110 | 0.14 (−0.83, 1.44) |
| MSA subgroup | Fatty infiltration | 0.63 (−0.98, 2.21) | 3.87 (−0.19, 7.91) | 4.50 (0.37, 7.59) | 0.042 | 0.14 (−0.32, 0.81) |
| Sex | Fatty infiltration | 0.24 (−0.24, 1.41) | 1.84 (−0.05, 3.68) | 2.08 (0.54, 3.71) | 0.012 | 0.11 (−0.15, 1.00) |
| Diabetes | Fatty infiltration | −0.05 (−0.76, 0.51) | 0.89 (−1.57, 3.15) | 0.84 (−1.52, 2.95) | 0.480 | −0.05 (−2.21, 1.82) |
| Age | Fatty infiltration | −0.01 (−0.07, 0.01) | −0.06 (−0.12, 0.01) | −0.07 (−0.15, -0.01) | 0.016 | 0.15 (−0.30, 1.18) |
| BMI | Fatty infiltration | −0.01 (−0.07, 0.06) | −0.11 (−0.31, 0.07) | −0.11 (−0.32, 0.06) | 0.190 | 0.04 (−1.75, 2.55) |
| Disease duration | Fatty infiltration | −0.02 (−0.16, 0.03) | −0.16 (−0.26, 0.05) | -0.18 (−0.27, -0.02) | 0.036 | 0.12 (−0.23, 1.37) |
ACME: average causal mediation effect; ADE: average direct effect; FI: fatty infiltration; MSA: myositis-specific antibody; MSA subgroup, Antisynthetase antibody. Bold text indicates P < 0.05.
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