| Outcome . | Number of casesa . | Odds ratio (95% CI)b . | ||||||
|---|---|---|---|---|---|---|---|---|
| CC . | CT . | TT . | CC . | CT . | TT . | Per T allele . | Per 25% higher tHcyc . | |
| Intracerebral haemorrhage | 1805 | 2684 | 1384 | 1.00 (0.95–1.05) | 1.09 (1.04–1.13) | 1.24 (1.17–1.32) | 1.09 (1.05–1.13) | 1.19 (1.10–1.28) |
| Ischaemic stroke | 4670 | 7220 | 4092 | 1.00 (0.97–1.03) | 1.05 (1.02–1.07) | 1.11 (1.07–1.15) | 1.05 (1.02–1.08) | 1.10 (1.04–1.16) |
| Total stroke | 6658 | 10 142 | 5582 | 1.00 (0.97–1.03) | 1.05 (1.03–1.08) | 1.13 (1.09–1.17) | 1.06 (1.03–1.08) | 1.12 (1.07–1.17) |
| Myocardial infarction | 846 | 1335 | 701 | 1.00 (0.93–1.07) | 1.05 (0.99–1.11) | 1.03 (0.96–1.12) | 1.02 (0.96–1.08) | 1.03 (0.92–1.14) |
| Other ischaemic heart disease | 5103 | 7956 | 4110 | 1.00 (0.97–1.03) | 1.03 (1.01–1.06) | 1.05 (1.01–1.09) | 1.00 (0.98–1.03) | 1.00 (0.95–1.05) |
| All ischaemic heart disease | 5671 | 8945 | 4636 | 1.00 (0.97–1.03) | 1.03 (1.01–1.06) | 1.04 (1.01–1.08) | 1.01 (0.98–1.03) | 1.01 (0.96–1.05) |
| Outcome . | Number of casesa . | Odds ratio (95% CI)b . | ||||||
|---|---|---|---|---|---|---|---|---|
| CC . | CT . | TT . | CC . | CT . | TT . | Per T allele . | Per 25% higher tHcyc . | |
| Intracerebral haemorrhage | 1805 | 2684 | 1384 | 1.00 (0.95–1.05) | 1.09 (1.04–1.13) | 1.24 (1.17–1.32) | 1.09 (1.05–1.13) | 1.19 (1.10–1.28) |
| Ischaemic stroke | 4670 | 7220 | 4092 | 1.00 (0.97–1.03) | 1.05 (1.02–1.07) | 1.11 (1.07–1.15) | 1.05 (1.02–1.08) | 1.10 (1.04–1.16) |
| Total stroke | 6658 | 10 142 | 5582 | 1.00 (0.97–1.03) | 1.05 (1.03–1.08) | 1.13 (1.09–1.17) | 1.06 (1.03–1.08) | 1.12 (1.07–1.17) |
| Myocardial infarction | 846 | 1335 | 701 | 1.00 (0.93–1.07) | 1.05 (0.99–1.11) | 1.03 (0.96–1.12) | 1.02 (0.96–1.08) | 1.03 (0.92–1.14) |
| Other ischaemic heart disease | 5103 | 7956 | 4110 | 1.00 (0.97–1.03) | 1.03 (1.01–1.06) | 1.05 (1.01–1.09) | 1.00 (0.98–1.03) | 1.00 (0.95–1.05) |
| All ischaemic heart disease | 5671 | 8945 | 4636 | 1.00 (0.97–1.03) | 1.03 (1.01–1.06) | 1.04 (1.01–1.08) | 1.01 (0.98–1.03) | 1.01 (0.96–1.05) |
The cases are compared with a common set of controls for each outcome. The number of controls for each MTHFR C677T genotype was 38 908 for CC, 51 479 for CT and 23 185 for TT. CC, CT and TT refer to two cytosine, one cytosine and one thymine, and two thymine alleles at position 677 of the MTHFR polymorphism, respectively. tHcy refers to plasma total homocysteine levels.
All analyses were region stratified and adjusted for age, age-squared and regional principal components.
OR per 25 higher tHcy is the odds ratio weighted by the expected effects of MTHFR C677T genotypes on homocysteine levels: TT = 1, CT = 0.25, CC = 0.
| Outcome . | Number of casesa . | Odds ratio (95% CI)b . | ||||||
|---|---|---|---|---|---|---|---|---|
| CC . | CT . | TT . | CC . | CT . | TT . | Per T allele . | Per 25% higher tHcyc . | |
| Intracerebral haemorrhage | 1805 | 2684 | 1384 | 1.00 (0.95–1.05) | 1.09 (1.04–1.13) | 1.24 (1.17–1.32) | 1.09 (1.05–1.13) | 1.19 (1.10–1.28) |
| Ischaemic stroke | 4670 | 7220 | 4092 | 1.00 (0.97–1.03) | 1.05 (1.02–1.07) | 1.11 (1.07–1.15) | 1.05 (1.02–1.08) | 1.10 (1.04–1.16) |
| Total stroke | 6658 | 10 142 | 5582 | 1.00 (0.97–1.03) | 1.05 (1.03–1.08) | 1.13 (1.09–1.17) | 1.06 (1.03–1.08) | 1.12 (1.07–1.17) |
| Myocardial infarction | 846 | 1335 | 701 | 1.00 (0.93–1.07) | 1.05 (0.99–1.11) | 1.03 (0.96–1.12) | 1.02 (0.96–1.08) | 1.03 (0.92–1.14) |
| Other ischaemic heart disease | 5103 | 7956 | 4110 | 1.00 (0.97–1.03) | 1.03 (1.01–1.06) | 1.05 (1.01–1.09) | 1.00 (0.98–1.03) | 1.00 (0.95–1.05) |
| All ischaemic heart disease | 5671 | 8945 | 4636 | 1.00 (0.97–1.03) | 1.03 (1.01–1.06) | 1.04 (1.01–1.08) | 1.01 (0.98–1.03) | 1.01 (0.96–1.05) |
| Outcome . | Number of casesa . | Odds ratio (95% CI)b . | ||||||
|---|---|---|---|---|---|---|---|---|
| CC . | CT . | TT . | CC . | CT . | TT . | Per T allele . | Per 25% higher tHcyc . | |
| Intracerebral haemorrhage | 1805 | 2684 | 1384 | 1.00 (0.95–1.05) | 1.09 (1.04–1.13) | 1.24 (1.17–1.32) | 1.09 (1.05–1.13) | 1.19 (1.10–1.28) |
| Ischaemic stroke | 4670 | 7220 | 4092 | 1.00 (0.97–1.03) | 1.05 (1.02–1.07) | 1.11 (1.07–1.15) | 1.05 (1.02–1.08) | 1.10 (1.04–1.16) |
| Total stroke | 6658 | 10 142 | 5582 | 1.00 (0.97–1.03) | 1.05 (1.03–1.08) | 1.13 (1.09–1.17) | 1.06 (1.03–1.08) | 1.12 (1.07–1.17) |
| Myocardial infarction | 846 | 1335 | 701 | 1.00 (0.93–1.07) | 1.05 (0.99–1.11) | 1.03 (0.96–1.12) | 1.02 (0.96–1.08) | 1.03 (0.92–1.14) |
| Other ischaemic heart disease | 5103 | 7956 | 4110 | 1.00 (0.97–1.03) | 1.03 (1.01–1.06) | 1.05 (1.01–1.09) | 1.00 (0.98–1.03) | 1.00 (0.95–1.05) |
| All ischaemic heart disease | 5671 | 8945 | 4636 | 1.00 (0.97–1.03) | 1.03 (1.01–1.06) | 1.04 (1.01–1.08) | 1.01 (0.98–1.03) | 1.01 (0.96–1.05) |
The cases are compared with a common set of controls for each outcome. The number of controls for each MTHFR C677T genotype was 38 908 for CC, 51 479 for CT and 23 185 for TT. CC, CT and TT refer to two cytosine, one cytosine and one thymine, and two thymine alleles at position 677 of the MTHFR polymorphism, respectively. tHcy refers to plasma total homocysteine levels.
All analyses were region stratified and adjusted for age, age-squared and regional principal components.
OR per 25 higher tHcy is the odds ratio weighted by the expected effects of MTHFR C677T genotypes on homocysteine levels: TT = 1, CT = 0.25, CC = 0.
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