Table 1: Open in new tab Patient...

Characteristics	All cases (n = 460)	Non-cancer-related adverse events within 1 year	P-value
Age (years)	71 (64–76)	70 (63–46)	74 (69–78)	0.003
Sex
Male	248 (54)	183 (50)	65 (69)	0.001
Female	212 (46)	183 (50)	29 (31)
BMI (kg/m²)	23 (20–25)	23 (21–25)	22 (20–25)	0.27
Smoking history
Never	205 (44)	172 (47)	33 (35)	0.048
Former	242 (53)	186 (51)	56 (60)
Current	13 (3)	8 (2)	5 (5)
Hypertension
No	241 (52)	191 (52)	50 (53)	0.86
Yes	219 (48)	175 (48)	44 (47)
Coronary artery disease
No	418 (91)	338 (92)	80 (85)	0.030
Yes	42 (9)	28 (8)	14 (15)
Diabetes mellitus
No	365 (79)	291 (80)	74 (79)	0.87
Yes	95 (21)	75 (20)	20 (21)
History of atrial fibrillation
No	433 (94)	346 (95)	87 (93)	0.47
Yes	27 (6)	20 (5)	7 (7)
Chemotherapy
No	448 (97)	357 (98)	91 (97)	0.69
Yes	12 (3)	9 (2)	3 (3)
BNP (pg/ml)	23 (13–41)	22 (12–38)	31 (17–56)	0.002
%FEV₁ (%)	99 (86–113)	100 (88–113)	90 (77–110)	0.002
Surgical approach
MIS	382 (83)	312 (85)	70 (75)	0.013
Thoracotomy	78 (17)	54 (15)	24 (25)
Surgery
Segmentectomy	162 (35)	135 (37)	27 (29)	0.14
Lobectomy	298 (65)	231 (63)	67 (71)
Number of resected subsegments	6 (4–10)	6 (4–10)	10 (6–10)	0.003
POAF
No	421 (92)	342 (93)	79 (84)	0.004
Yes	39 (8)	24 (7)	15 (16)

Characteristics

All cases (n = 460)

Non-cancer-related adverse events within 1 year

P-value

No (n = 366) (84%)^a

Yes (n = 94) (16%)^a

Age (years)

71 (64–76)

70 (63–46)

74 (69–78)

0.003

Sex

Male

248 (54)

183 (50)

65 (69)

0.001

Female

212 (46)

183 (50)

29 (31)

BMI (kg/m²)

23 (20–25)

23 (21–25)

22 (20–25)

0.27

Smoking history

Never

205 (44)

172 (47)

33 (35)

0.048

Former

242 (53)

186 (51)

56 (60)

Current

13 (3)

8 (2)

5 (5)

Hypertension

241 (52)

191 (52)

50 (53)

0.86

Yes

219 (48)

175 (48)

44 (47)

Coronary artery disease

418 (91)

338 (92)

80 (85)

0.030

Yes

42 (9)

28 (8)

14 (15)

Diabetes mellitus

365 (79)

291 (80)

74 (79)

0.87

Yes

95 (21)

75 (20)

20 (21)

History of atrial fibrillation

433 (94)

346 (95)

87 (93)

0.47

Yes

27 (6)

20 (5)

7 (7)

Chemotherapy

448 (97)

357 (98)

91 (97)

0.69

Yes

12 (3)

9 (2)

3 (3)

BNP (pg/ml)

23 (13–41)

22 (12–38)

31 (17–56)

0.002

%FEV₁ (%)

99 (86–113)

100 (88–113)

90 (77–110)

0.002

Surgical approach

MIS

382 (83)

312 (85)

70 (75)

0.013

Thoracotomy

78 (17)

54 (15)

24 (25)

Surgery

Segmentectomy

162 (35)

135 (37)

27 (29)

0.14

Lobectomy

298 (65)

231 (63)

67 (71)

Number of resected subsegments

6 (4–10)

10 (6–10)

0.003

POAF

421 (92)

342 (93)

79 (84)

0.004

Yes

39 (8)

24 (7)

15 (16)

Characteristics	All cases (n = 460)	Non-cancer-related adverse events within 1 year	P-value
Age (years)	71 (64–76)	70 (63–46)	74 (69–78)	0.003
Sex
Male	248 (54)	183 (50)	65 (69)	0.001
Female	212 (46)	183 (50)	29 (31)
BMI (kg/m²)	23 (20–25)	23 (21–25)	22 (20–25)	0.27
Smoking history
Never	205 (44)	172 (47)	33 (35)	0.048
Former	242 (53)	186 (51)	56 (60)
Current	13 (3)	8 (2)	5 (5)
Hypertension
No	241 (52)	191 (52)	50 (53)	0.86
Yes	219 (48)	175 (48)	44 (47)
Coronary artery disease
No	418 (91)	338 (92)	80 (85)	0.030
Yes	42 (9)	28 (8)	14 (15)
Diabetes mellitus
No	365 (79)	291 (80)	74 (79)	0.87
Yes	95 (21)	75 (20)	20 (21)
History of atrial fibrillation
No	433 (94)	346 (95)	87 (93)	0.47
Yes	27 (6)	20 (5)	7 (7)
Chemotherapy
No	448 (97)	357 (98)	91 (97)	0.69
Yes	12 (3)	9 (2)	3 (3)
BNP (pg/ml)	23 (13–41)	22 (12–38)	31 (17–56)	0.002
%FEV₁ (%)	99 (86–113)	100 (88–113)	90 (77–110)	0.002
Surgical approach
MIS	382 (83)	312 (85)	70 (75)	0.013
Thoracotomy	78 (17)	54 (15)	24 (25)
Surgery
Segmentectomy	162 (35)	135 (37)	27 (29)	0.14
Lobectomy	298 (65)	231 (63)	67 (71)
Number of resected subsegments	6 (4–10)	6 (4–10)	10 (6–10)	0.003
POAF
No	421 (92)	342 (93)	79 (84)	0.004
Yes	39 (8)	24 (7)	15 (16)

Table 1:

Open in new tab

Patient demographics and comparison between patients with and without non-cancer-related adverse events within 1 year

Characteristics	All cases (n = 460)	Non-cancer-related adverse events within 1 year		P-value
Characteristics	All cases (n = 460)	No (n = 366) (84%)^a	Yes (n = 94) (16%)^a	P-value
Age (years)	71 (64–76)	70 (63–46)	74 (69–78)	0.003
Sex
Male	248 (54)	183 (50)	65 (69)	0.001
Female	212 (46)	183 (50)	29 (31)
BMI (kg/m²)	23 (20–25)	23 (21–25)	22 (20–25)	0.27
Smoking history
Never	205 (44)	172 (47)	33 (35)	0.048
Former	242 (53)	186 (51)	56 (60)
Current	13 (3)	8 (2)	5 (5)
Hypertension
No	241 (52)	191 (52)	50 (53)	0.86
Yes	219 (48)	175 (48)	44 (47)
Coronary artery disease
No	418 (91)	338 (92)	80 (85)	0.030
Yes	42 (9)	28 (8)	14 (15)
Diabetes mellitus
No	365 (79)	291 (80)	74 (79)	0.87
Yes	95 (21)	75 (20)	20 (21)
History of atrial fibrillation
No	433 (94)	346 (95)	87 (93)	0.47
Yes	27 (6)	20 (5)	7 (7)
Chemotherapy
No	448 (97)	357 (98)	91 (97)	0.69
Yes	12 (3)	9 (2)	3 (3)
BNP (pg/ml)	23 (13–41)	22 (12–38)	31 (17–56)	0.002
%FEV₁ (%)	99 (86–113)	100 (88–113)	90 (77–110)	0.002
Surgical approach
MIS	382 (83)	312 (85)	70 (75)	0.013
Thoracotomy	78 (17)	54 (15)	24 (25)
Surgery
Segmentectomy	162 (35)	135 (37)	27 (29)	0.14
Lobectomy	298 (65)	231 (63)	67 (71)
Number of resected subsegments	6 (4–10)	6 (4–10)	10 (6–10)	0.003
POAF
No	421 (92)	342 (93)	79 (84)	0.004
Yes	39 (8)	24 (7)	15 (16)

Characteristics	All cases (n = 460)	Non-cancer-related adverse events within 1 year		P-value
Characteristics	All cases (n = 460)	No (n = 366) (84%)^a	Yes (n = 94) (16%)^a	P-value
Age (years)	71 (64–76)	70 (63–46)	74 (69–78)	0.003
Sex
Male	248 (54)	183 (50)	65 (69)	0.001
Female	212 (46)	183 (50)	29 (31)
BMI (kg/m²)	23 (20–25)	23 (21–25)	22 (20–25)	0.27
Smoking history
Never	205 (44)	172 (47)	33 (35)	0.048
Former	242 (53)	186 (51)	56 (60)
Current	13 (3)	8 (2)	5 (5)
Hypertension
No	241 (52)	191 (52)	50 (53)	0.86
Yes	219 (48)	175 (48)	44 (47)
Coronary artery disease
No	418 (91)	338 (92)	80 (85)	0.030
Yes	42 (9)	28 (8)	14 (15)
Diabetes mellitus
No	365 (79)	291 (80)	74 (79)	0.87
Yes	95 (21)	75 (20)	20 (21)
History of atrial fibrillation
No	433 (94)	346 (95)	87 (93)	0.47
Yes	27 (6)	20 (5)	7 (7)
Chemotherapy
No	448 (97)	357 (98)	91 (97)	0.69
Yes	12 (3)	9 (2)	3 (3)
BNP (pg/ml)	23 (13–41)	22 (12–38)	31 (17–56)	0.002
%FEV₁ (%)	99 (86–113)	100 (88–113)	90 (77–110)	0.002
Surgical approach
MIS	382 (83)	312 (85)	70 (75)	0.013
Thoracotomy	78 (17)	54 (15)	24 (25)
Surgery
Segmentectomy	162 (35)	135 (37)	27 (29)	0.14
Lobectomy	298 (65)	231 (63)	67 (71)
Number of resected subsegments	6 (4–10)	6 (4–10)	10 (6–10)	0.003
POAF
No	421 (92)	342 (93)	79 (84)	0.004
Yes	39 (8)	24 (7)	15 (16)

Data are shown as number (%) or median (25–75 percentiles).

Percentages among all 460 patients.

BMI: body mass index; BNP: brain natriuretic peptide; %FEV₁: percentage-predicted forced expiratory volume in 1 s; MIS: minimally invasive surgery; POAF: postoperative atrial fibrillation.

The bold font indicates statistical significance.

This Feature Is Available To Subscribers Only