Table 2 Open in new tab Cox regression...

Variable	Crude hazard ratio	95% Confidence interval	P value	Adjusted hazard ratio	95% Confidence interval	P value	Adjusted hazard ratio	95% Confidence interval	P value
Cardiac magnetic resonance imaging parameters
Total cardiac amyloidosis cohort
Baseline native T1 time^a	1.006	0.999–1.012	0.113	1.008	1.000–1.015	0.0448	n.a
Follow-up native T1 time^b	1.004	0.999–1.009	0.155	1.004	0.999–1.010	0.094	1.003	0.998–1.009	0.268
Change of native T1 time^b	1.003	0.996–1.009	0.396	1.002	0.996–1.009	0.466	1.003	0.996–1.010	0.470
Baseline extracellular volume^a	1.027	0.998–1.057	0.071	1.027	0.996–1.060	0.093	n.a
Follow-up extracellular volume^b	1.024	1.003–1.045	0.026	1.028	1.006–1.051	0.013	1.020	0.996–1.045	0.110
Change of extracellular volume^b	1.085	1.041–1.130	<0.001	1.113	1.063–1.166	<0.001	1.095	1.047–1.145	<0.001
Cardiac transthyretin amyloidosis cohort
Baseline native T1 time^a	1.004	0.995–1.013	0.373	1.004	0.994–1.014	0.423	n.a
Follow-up native T1 time^b	1.002	0.995–1.009	0.517	1.004	0.997–1.012	0.240	1.002	0.994–1.010	0.673
Change of native T1 time^b	1.004	0.995–1.013	0.358	1.007	0.997–1.017	0.179	1.006	0.996–1.016	0.267
Baseline extracellular volume^a	1.030	0.993–1.067	0.114	1.026	0.987–1.065	0.193	n.a
Follow-up extracellular volume^b	1.015	0.990–1.040	0.240	1.020	0.994–1.046	0.128	1.004	0.974–1.036	0.775
Change of extracellular volume^b	1.066	1.015–1.119	0.010	1.094	1.037–1.153	<0.001	1.073	1.015–1.134	0.013
Cardiac light chain amyloidosis cohort
Baseline native T1 time^a	1.006	0.996–1.016	0.217	1.008	0.995–1.020	0.235	n.a
Follow-up native T1 time^b	1.004	0.997–1.012	0.248	1.002	0.992–1.011	0.755	1.004	0.994–1.013	0.437
Change of native T1 time^b	1.004	0.994–1.014	0.439	0.997	0.985–1.009	0.621	1.000	0.988–1.011	0.959
Baseline extracellular volume^a	1.019	0.958–1.084	0.557	1.001	0.923–1.085	0.984	n.a
Follow-up extracellular volume^b	1.065	1.006–1.126	0.030	1.089	0.987–1.202	0.090	1.133	1.015–1.265	0.026
Change of extracellular volume^b	1.110	1.033–1.193	0.004	1.114	1.020–1.217	0.017	1.131	1.041–1.228	0.003

Variable

Crude hazard ratio

95% Confidence interval

P value

Adjusted hazard ratio

95% Confidence interval

P value

Adjusted hazard ratio

95% Confidence interval

P value

Univariable regression

Multivariable regression 1

Multivariable regression 2

Cardiac magnetic resonance imaging parameters

Total cardiac amyloidosis cohort

Baseline native T1 time^a

1.006

0.999–1.012

0.113

1.008

1.000–1.015

0.0448

n.a

Follow-up native T1 time^b

1.004

0.999–1.009

0.155

1.004

0.999–1.010

0.094

1.003

0.998–1.009

0.268

Change of native T1 time^b

1.003

0.996–1.009

0.396

1.002

0.996–1.009

0.466

1.003

0.996–1.010

0.470

Baseline extracellular volume^a

1.027

0.998–1.057

0.071

1.027

0.996–1.060

0.093

n.a

Follow-up extracellular volume^b

1.024

1.003–1.045

0.026

1.028

1.006–1.051

0.013

1.020

0.996–1.045

0.110

Change of extracellular volume^b

1.085

1.041–1.130

<0.001

1.113

1.063–1.166

<0.001

1.095

1.047–1.145

<0.001

Cardiac transthyretin amyloidosis cohort

Baseline native T1 time^a

1.004

0.995–1.013

0.373

1.004

0.994–1.014

0.423

n.a

Follow-up native T1 time^b

1.002

0.995–1.009

0.517

1.004

0.997–1.012

0.240

1.002

0.994–1.010

0.673

Change of native T1 time^b

1.004

0.995–1.013

0.358

1.007

0.997–1.017

0.179

1.006

0.996–1.016

0.267

Baseline extracellular volume^a

1.030

0.993–1.067

0.114

1.026

0.987–1.065

0.193

n.a

Follow-up extracellular volume^b

1.015

0.990–1.040

0.240

1.020

0.994–1.046

0.128

1.004

0.974–1.036

0.775

Change of extracellular volume^b

1.066

1.015–1.119

0.010

1.094

1.037–1.153

<0.001

1.073

1.015–1.134

0.013

Cardiac light chain amyloidosis cohort

Baseline native T1 time^a

1.006

0.996–1.016

0.217

1.008

0.995–1.020

0.235

n.a

Follow-up native T1 time^b

1.004

0.997–1.012

0.248

1.002

0.992–1.011

0.755

1.004

0.994–1.013

0.437

Change of native T1 time^b

1.004

0.994–1.014

0.439

0.997

0.985–1.009

0.621

1.000

0.988–1.011

0.959

Baseline extracellular volume^a

1.019

0.958–1.084

0.557

1.001

0.923–1.085

0.984

n.a

Follow-up extracellular volume^b

1.065

1.006–1.126

0.030

1.089

0.987–1.202

0.090

1.133

1.015–1.265

0.026

Change of extracellular volume^b

1.110

1.033–1.193

0.004

1.114

1.020–1.217

0.017

1.131

1.041–1.228

0.003

Variable	Crude hazard ratio	95% Confidence interval	P value	Adjusted hazard ratio	95% Confidence interval	P value	Adjusted hazard ratio	95% Confidence interval	P value
Cardiac magnetic resonance imaging parameters
Total cardiac amyloidosis cohort
Baseline native T1 time^a	1.006	0.999–1.012	0.113	1.008	1.000–1.015	0.0448	n.a
Follow-up native T1 time^b	1.004	0.999–1.009	0.155	1.004	0.999–1.010	0.094	1.003	0.998–1.009	0.268
Change of native T1 time^b	1.003	0.996–1.009	0.396	1.002	0.996–1.009	0.466	1.003	0.996–1.010	0.470
Baseline extracellular volume^a	1.027	0.998–1.057	0.071	1.027	0.996–1.060	0.093	n.a
Follow-up extracellular volume^b	1.024	1.003–1.045	0.026	1.028	1.006–1.051	0.013	1.020	0.996–1.045	0.110
Change of extracellular volume^b	1.085	1.041–1.130	<0.001	1.113	1.063–1.166	<0.001	1.095	1.047–1.145	<0.001
Cardiac transthyretin amyloidosis cohort
Baseline native T1 time^a	1.004	0.995–1.013	0.373	1.004	0.994–1.014	0.423	n.a
Follow-up native T1 time^b	1.002	0.995–1.009	0.517	1.004	0.997–1.012	0.240	1.002	0.994–1.010	0.673
Change of native T1 time^b	1.004	0.995–1.013	0.358	1.007	0.997–1.017	0.179	1.006	0.996–1.016	0.267
Baseline extracellular volume^a	1.030	0.993–1.067	0.114	1.026	0.987–1.065	0.193	n.a
Follow-up extracellular volume^b	1.015	0.990–1.040	0.240	1.020	0.994–1.046	0.128	1.004	0.974–1.036	0.775
Change of extracellular volume^b	1.066	1.015–1.119	0.010	1.094	1.037–1.153	<0.001	1.073	1.015–1.134	0.013
Cardiac light chain amyloidosis cohort
Baseline native T1 time^a	1.006	0.996–1.016	0.217	1.008	0.995–1.020	0.235	n.a
Follow-up native T1 time^b	1.004	0.997–1.012	0.248	1.002	0.992–1.011	0.755	1.004	0.994–1.013	0.437
Change of native T1 time^b	1.004	0.994–1.014	0.439	0.997	0.985–1.009	0.621	1.000	0.988–1.011	0.959
Baseline extracellular volume^a	1.019	0.958–1.084	0.557	1.001	0.923–1.085	0.984	n.a
Follow-up extracellular volume^b	1.065	1.006–1.126	0.030	1.089	0.987–1.202	0.090	1.133	1.015–1.265	0.026
Change of extracellular volume^b	1.110	1.033–1.193	0.004	1.114	1.020–1.217	0.017	1.131	1.041–1.228	0.003

Table 2

Open in new tab

Cox regression analyses (Model A) for the composite endpoint of all-cause death or heart failure hospitalization in the total, transthyretin, and light chain cardiac amyloidosis cohorts

Variable	Crude hazard ratio	95% Confidence interval	P value	Adjusted hazard ratio	95% Confidence interval	P value	Adjusted hazard ratio	95% Confidence interval	P value
	Univariable regression			Multivariable regression 1			Multivariable regression 2
Cardiac magnetic resonance imaging parameters
Total cardiac amyloidosis cohort
Baseline native T1 time^a	1.006	0.999–1.012	0.113	1.008	1.000–1.015	0.0448	n.a
Follow-up native T1 time^b	1.004	0.999–1.009	0.155	1.004	0.999–1.010	0.094	1.003	0.998–1.009	0.268
Change of native T1 time^b	1.003	0.996–1.009	0.396	1.002	0.996–1.009	0.466	1.003	0.996–1.010	0.470
Baseline extracellular volume^a	1.027	0.998–1.057	0.071	1.027	0.996–1.060	0.093	n.a
Follow-up extracellular volume^b	1.024	1.003–1.045	0.026	1.028	1.006–1.051	0.013	1.020	0.996–1.045	0.110
Change of extracellular volume^b	1.085	1.041–1.130	<0.001	1.113	1.063–1.166	<0.001	1.095	1.047–1.145	<0.001
Cardiac transthyretin amyloidosis cohort
Baseline native T1 time^a	1.004	0.995–1.013	0.373	1.004	0.994–1.014	0.423	n.a
Follow-up native T1 time^b	1.002	0.995–1.009	0.517	1.004	0.997–1.012	0.240	1.002	0.994–1.010	0.673
Change of native T1 time^b	1.004	0.995–1.013	0.358	1.007	0.997–1.017	0.179	1.006	0.996–1.016	0.267
Baseline extracellular volume^a	1.030	0.993–1.067	0.114	1.026	0.987–1.065	0.193	n.a
Follow-up extracellular volume^b	1.015	0.990–1.040	0.240	1.020	0.994–1.046	0.128	1.004	0.974–1.036	0.775
Change of extracellular volume^b	1.066	1.015–1.119	0.010	1.094	1.037–1.153	<0.001	1.073	1.015–1.134	0.013
Cardiac light chain amyloidosis cohort
Baseline native T1 time^a	1.006	0.996–1.016	0.217	1.008	0.995–1.020	0.235	n.a
Follow-up native T1 time^b	1.004	0.997–1.012	0.248	1.002	0.992–1.011	0.755	1.004	0.994–1.013	0.437
Change of native T1 time^b	1.004	0.994–1.014	0.439	0.997	0.985–1.009	0.621	1.000	0.988–1.011	0.959
Baseline extracellular volume^a	1.019	0.958–1.084	0.557	1.001	0.923–1.085	0.984	n.a
Follow-up extracellular volume^b	1.065	1.006–1.126	0.030	1.089	0.987–1.202	0.090	1.133	1.015–1.265	0.026
Change of extracellular volume^b	1.110	1.033–1.193	0.004	1.114	1.020–1.217	0.017	1.131	1.041–1.228	0.003

Variable	Crude hazard ratio	95% Confidence interval	P value	Adjusted hazard ratio	95% Confidence interval	P value	Adjusted hazard ratio	95% Confidence interval	P value
	Univariable regression			Multivariable regression 1			Multivariable regression 2
Cardiac magnetic resonance imaging parameters
Total cardiac amyloidosis cohort
Baseline native T1 time^a	1.006	0.999–1.012	0.113	1.008	1.000–1.015	0.0448	n.a
Follow-up native T1 time^b	1.004	0.999–1.009	0.155	1.004	0.999–1.010	0.094	1.003	0.998–1.009	0.268
Change of native T1 time^b	1.003	0.996–1.009	0.396	1.002	0.996–1.009	0.466	1.003	0.996–1.010	0.470
Baseline extracellular volume^a	1.027	0.998–1.057	0.071	1.027	0.996–1.060	0.093	n.a
Follow-up extracellular volume^b	1.024	1.003–1.045	0.026	1.028	1.006–1.051	0.013	1.020	0.996–1.045	0.110
Change of extracellular volume^b	1.085	1.041–1.130	<0.001	1.113	1.063–1.166	<0.001	1.095	1.047–1.145	<0.001
Cardiac transthyretin amyloidosis cohort
Baseline native T1 time^a	1.004	0.995–1.013	0.373	1.004	0.994–1.014	0.423	n.a
Follow-up native T1 time^b	1.002	0.995–1.009	0.517	1.004	0.997–1.012	0.240	1.002	0.994–1.010	0.673
Change of native T1 time^b	1.004	0.995–1.013	0.358	1.007	0.997–1.017	0.179	1.006	0.996–1.016	0.267
Baseline extracellular volume^a	1.030	0.993–1.067	0.114	1.026	0.987–1.065	0.193	n.a
Follow-up extracellular volume^b	1.015	0.990–1.040	0.240	1.020	0.994–1.046	0.128	1.004	0.974–1.036	0.775
Change of extracellular volume^b	1.066	1.015–1.119	0.010	1.094	1.037–1.153	<0.001	1.073	1.015–1.134	0.013
Cardiac light chain amyloidosis cohort
Baseline native T1 time^a	1.006	0.996–1.016	0.217	1.008	0.995–1.020	0.235	n.a
Follow-up native T1 time^b	1.004	0.997–1.012	0.248	1.002	0.992–1.011	0.755	1.004	0.994–1.013	0.437
Change of native T1 time^b	1.004	0.994–1.014	0.439	0.997	0.985–1.009	0.621	1.000	0.988–1.011	0.959
Baseline extracellular volume^a	1.019	0.958–1.084	0.557	1.001	0.923–1.085	0.984	n.a
Follow-up extracellular volume^b	1.065	1.006–1.126	0.030	1.089	0.987–1.202	0.090	1.133	1.015–1.265	0.026
Change of extracellular volume^b	1.110	1.033–1.193	0.004	1.114	1.020–1.217	0.017	1.131	1.041–1.228	0.003

Multivariable Model 1: Adjusted for baseline NT-proBNP, troponin T, and time interval between baseline and follow-up cardiac magnetic resonance (CMR) imaging.

Multivariable Model 2: Adjusted for follow-up NT-proBNP, follow-up troponin T, and time interval between baseline and follow-up cardiac magnetic resonance imaging.

^aStart date for the follow-up period (T0) is the date of baseline CMR.

^bT0 was date of follow-up CMR.

This Feature Is Available To Subscribers Only