Characteristics of anti-SAE + DM patients compared with anti-SAE – DM patients
| Characteristics . | Anti-SAE + DM, n = 49 . | Anti-SAE – DM, n = 85 . | Univariate analysis P-value . |
|---|---|---|---|
| Sex ratio (F/M) | 5.12 (41/8) | 1.93 (56/29) | P = 0.03 |
| Age at diagnosis, years | 53 (43, 62) | 50 (38, 62) | P = 0.39 |
| Skin disease, yes | 95.9 (47/49) | 92.9 (79/85) | P = 0.71 |
| Calcinosis | 10.2 (5/49) | 5.9 (5/85) | P = 0.50 |
| Ulceration | 18.4 (9/49) | 11.8 (10/85) | P = 0.31 |
| Proximal weakness | 69.4 (34/49) | 87.0 (74/85) | P = 0.02 |
| Worst proximal MRC evaluation (deltoid or psoas) | 4 (3, 5) | 3 (3, 4) | P = 0.006 |
| CK levels | 200 (94, 440) | 1967 (786, 7592) | P < 0.0001 |
| Dysphagia | 38.8 (19/49) | 41.2 (35/85) | P = 0.85 |
| Dyspnea | 26.5 (13/49) | 56.1 (32/57) | P = 0.003 |
| Interstitial lung disease | 21.0 (8/39) | 27.9 (19/68) | P = 0.49 |
| Arthralgia and/or arthritis | 24.5 (12/49) | 50.0 (31/62) | P = 0.07 |
| Death from any cause | 10.2 (5/49) | 8.2 (7/85) | P = 0.76 |
| Characteristics . | Anti-SAE + DM, n = 49 . | Anti-SAE – DM, n = 85 . | Univariate analysis P-value . |
|---|---|---|---|
| Sex ratio (F/M) | 5.12 (41/8) | 1.93 (56/29) | P = 0.03 |
| Age at diagnosis, years | 53 (43, 62) | 50 (38, 62) | P = 0.39 |
| Skin disease, yes | 95.9 (47/49) | 92.9 (79/85) | P = 0.71 |
| Calcinosis | 10.2 (5/49) | 5.9 (5/85) | P = 0.50 |
| Ulceration | 18.4 (9/49) | 11.8 (10/85) | P = 0.31 |
| Proximal weakness | 69.4 (34/49) | 87.0 (74/85) | P = 0.02 |
| Worst proximal MRC evaluation (deltoid or psoas) | 4 (3, 5) | 3 (3, 4) | P = 0.006 |
| CK levels | 200 (94, 440) | 1967 (786, 7592) | P < 0.0001 |
| Dysphagia | 38.8 (19/49) | 41.2 (35/85) | P = 0.85 |
| Dyspnea | 26.5 (13/49) | 56.1 (32/57) | P = 0.003 |
| Interstitial lung disease | 21.0 (8/39) | 27.9 (19/68) | P = 0.49 |
| Arthralgia and/or arthritis | 24.5 (12/49) | 50.0 (31/62) | P = 0.07 |
| Death from any cause | 10.2 (5/49) | 8.2 (7/85) | P = 0.76 |
Quantitative variables are reported as median and interquartile range (IQR). Qualitative variables are reported as percentage of the total of the available data. Univariate analysis was conducted using Fisher’s exact test for categorical variables and Student’s t test for continuous variables. CK levels are reported in UI/l. Difference was considered statistically significant for P-values of <0.05. F: female; M: male; SAE: small ubiquitin like modifier activating enzyme; MRC: Medical Research Council scale; CK: creatinine kinase.
Characteristics of anti-SAE + DM patients compared with anti-SAE – DM patients
| Characteristics . | Anti-SAE + DM, n = 49 . | Anti-SAE – DM, n = 85 . | Univariate analysis P-value . |
|---|---|---|---|
| Sex ratio (F/M) | 5.12 (41/8) | 1.93 (56/29) | P = 0.03 |
| Age at diagnosis, years | 53 (43, 62) | 50 (38, 62) | P = 0.39 |
| Skin disease, yes | 95.9 (47/49) | 92.9 (79/85) | P = 0.71 |
| Calcinosis | 10.2 (5/49) | 5.9 (5/85) | P = 0.50 |
| Ulceration | 18.4 (9/49) | 11.8 (10/85) | P = 0.31 |
| Proximal weakness | 69.4 (34/49) | 87.0 (74/85) | P = 0.02 |
| Worst proximal MRC evaluation (deltoid or psoas) | 4 (3, 5) | 3 (3, 4) | P = 0.006 |
| CK levels | 200 (94, 440) | 1967 (786, 7592) | P < 0.0001 |
| Dysphagia | 38.8 (19/49) | 41.2 (35/85) | P = 0.85 |
| Dyspnea | 26.5 (13/49) | 56.1 (32/57) | P = 0.003 |
| Interstitial lung disease | 21.0 (8/39) | 27.9 (19/68) | P = 0.49 |
| Arthralgia and/or arthritis | 24.5 (12/49) | 50.0 (31/62) | P = 0.07 |
| Death from any cause | 10.2 (5/49) | 8.2 (7/85) | P = 0.76 |
| Characteristics . | Anti-SAE + DM, n = 49 . | Anti-SAE – DM, n = 85 . | Univariate analysis P-value . |
|---|---|---|---|
| Sex ratio (F/M) | 5.12 (41/8) | 1.93 (56/29) | P = 0.03 |
| Age at diagnosis, years | 53 (43, 62) | 50 (38, 62) | P = 0.39 |
| Skin disease, yes | 95.9 (47/49) | 92.9 (79/85) | P = 0.71 |
| Calcinosis | 10.2 (5/49) | 5.9 (5/85) | P = 0.50 |
| Ulceration | 18.4 (9/49) | 11.8 (10/85) | P = 0.31 |
| Proximal weakness | 69.4 (34/49) | 87.0 (74/85) | P = 0.02 |
| Worst proximal MRC evaluation (deltoid or psoas) | 4 (3, 5) | 3 (3, 4) | P = 0.006 |
| CK levels | 200 (94, 440) | 1967 (786, 7592) | P < 0.0001 |
| Dysphagia | 38.8 (19/49) | 41.2 (35/85) | P = 0.85 |
| Dyspnea | 26.5 (13/49) | 56.1 (32/57) | P = 0.003 |
| Interstitial lung disease | 21.0 (8/39) | 27.9 (19/68) | P = 0.49 |
| Arthralgia and/or arthritis | 24.5 (12/49) | 50.0 (31/62) | P = 0.07 |
| Death from any cause | 10.2 (5/49) | 8.2 (7/85) | P = 0.76 |
Quantitative variables are reported as median and interquartile range (IQR). Qualitative variables are reported as percentage of the total of the available data. Univariate analysis was conducted using Fisher’s exact test for categorical variables and Student’s t test for continuous variables. CK levels are reported in UI/l. Difference was considered statistically significant for P-values of <0.05. F: female; M: male; SAE: small ubiquitin like modifier activating enzyme; MRC: Medical Research Council scale; CK: creatinine kinase.
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