Table 3 Open in new tab Disease-related...

	ET (n = 61)	Parkinson’s disease (n = 29)
TBV
Std. β^a	0.24*	0.21*	−0.29	−0.01
ΔR²	0.09		0.08
ΔF	5.25**		2.14
WM
Std. β^a	0.19	−0.09	0.11	−0.25
ΔR²	0.04		0.06
ΔF	1.20		0.86
GM
Std. β^a	0.06	0.29*	−0.36	0.28
ΔR²	0.08		0.15
ΔF	3.60*		2.08
Cortical GM
Std. β^a	0.08	0.20	−0.42	0.21
ΔR²	0.04		0.16
ΔF	2.06		2.44
Frontal lobe
Std. β^a	0.07	0.07	−0.35	0.40
ΔR²	0.01		0.20
ΔF	0.52		2.96
Parietal lobe
Std. β^a	−0.09	0.03	−0.35	0.09
ΔR²	0.01		0.11
ΔF	0.36		1.64
Occipital lobe
Std. β^a	0.36**	0.08	−0.50*	−0.02
ΔR²	0.13		0.24
ΔF	4.22*		4.03*
Temporal lobe
Std. β^a	−0.04	0.38**	−0.19	< −0.01
ΔR²	0.13		0.04
ΔF	4.37*		0.44
Caudate
Std. β^a	−0.16	−0.20	0.12	−0.01
ΔR²	0.06		0.01
ΔF	1.87		0.15
Putamen
Std. β^a	−0.06	−0.04	0.18	0.53**
ΔR²	0.01		0.37
ΔF	0.14		6.84**
Pallidum
Std. β^a	0.17	0.06	0.10	0.11
ΔR²	0.03		0.03
ΔF	0.81		0.45
Thalamus
Std. β^a	0.13	0.14	−0.09	−0.06
ΔR²	0.03		0.01
ΔF	0.99		0.16
Brainstem
Std. β^a	0.06	−0.02	0.03	0.20
ΔR²	<0.01		0.04
ΔF	0.13		0.51
Mesencephalon
Std. β^a	0.01	−0.08	0.15	0.01
ΔR²	0.01		0.02
ΔF	0.16		0.30
Pons
Std. β^a	0.08	−0.01	0.03	0.21
ΔR²	0.01		0.05
ΔF	0.23		0.64
Cerebellum
Std. β^a	0.01	0.23	−0.02	0.26
ΔR²	0.05		0.07
ΔF	1.34		0.84

ET (n = 61)

Parkinson’s disease (n = 29)

DOT

CRST

DOT

CRST

TBV

Std. β^a

0.24*

0.21*

−0.29

−0.01

ΔR²

0.09

0.08

ΔF

5.25**

2.14

Std. β^a

0.19

−0.09

0.11

−0.25

ΔR²

0.04

0.06

ΔF

1.20

0.86

Std. β^a

0.06

0.29*

−0.36

0.28

ΔR²

0.08

0.15

ΔF

3.60*

2.08

Cortical GM

Std. β^a

0.08

0.20

−0.42

0.21

ΔR²

0.04

0.16

ΔF

2.06

2.44

Frontal lobe

Std. β^a

0.07

−0.35

0.40

ΔR²

0.01

0.20

ΔF

0.52

2.96

Parietal lobe

Std. β^a

−0.09

0.03

−0.35

0.09

ΔR²

0.01

0.11

ΔF

0.36

1.64

Occipital lobe

Std. β^a

0.36**

0.08

−0.50*

−0.02

ΔR²

0.13

0.24

ΔF

4.22*

4.03*

Temporal lobe

Std. β^a

−0.04

0.38**

−0.19

< −0.01

ΔR²

0.13

0.04

ΔF

4.37*

0.44

Caudate

Std. β^a

−0.16

−0.20

0.12

−0.01

ΔR²

0.06

0.01

ΔF

1.87

0.15

Putamen

Std. β^a

−0.06

−0.04

0.18

0.53**

ΔR²

0.01

0.37

ΔF

0.14

6.84**

Pallidum

Std. β^a

0.17

0.06

0.10

0.11

ΔR²

0.03

ΔF

0.81

0.45

Thalamus

Std. β^a

0.13

0.14

−0.09

−0.06

ΔR²

0.03

0.01

ΔF

0.99

0.16

Brainstem

Std. β^a

0.06

−0.02

0.03

0.20

ΔR²

<0.01

0.04

ΔF

0.13

0.51

Mesencephalon

Std. β^a

0.01

−0.08

0.15

0.01

ΔR²

0.01

0.02

ΔF

0.16

0.30

Pons

Std. β^a

0.08

−0.01

0.03

0.21

ΔR²

0.01

0.05

ΔF

0.23

0.64

Cerebellum

Std. β^a

0.01

0.23

−0.02

0.26

ΔR²

0.05

0.07

ΔF

1.34

0.84

	ET (n = 61)	Parkinson’s disease (n = 29)
TBV
Std. β^a	0.24*	0.21*	−0.29	−0.01
ΔR²	0.09		0.08
ΔF	5.25**		2.14
WM
Std. β^a	0.19	−0.09	0.11	−0.25
ΔR²	0.04		0.06
ΔF	1.20		0.86
GM
Std. β^a	0.06	0.29*	−0.36	0.28
ΔR²	0.08		0.15
ΔF	3.60*		2.08
Cortical GM
Std. β^a	0.08	0.20	−0.42	0.21
ΔR²	0.04		0.16
ΔF	2.06		2.44
Frontal lobe
Std. β^a	0.07	0.07	−0.35	0.40
ΔR²	0.01		0.20
ΔF	0.52		2.96
Parietal lobe
Std. β^a	−0.09	0.03	−0.35	0.09
ΔR²	0.01		0.11
ΔF	0.36		1.64
Occipital lobe
Std. β^a	0.36**	0.08	−0.50*	−0.02
ΔR²	0.13		0.24
ΔF	4.22*		4.03*
Temporal lobe
Std. β^a	−0.04	0.38**	−0.19	< −0.01
ΔR²	0.13		0.04
ΔF	4.37*		0.44
Caudate
Std. β^a	−0.16	−0.20	0.12	−0.01
ΔR²	0.06		0.01
ΔF	1.87		0.15
Putamen
Std. β^a	−0.06	−0.04	0.18	0.53**
ΔR²	0.01		0.37
ΔF	0.14		6.84**
Pallidum
Std. β^a	0.17	0.06	0.10	0.11
ΔR²	0.03		0.03
ΔF	0.81		0.45
Thalamus
Std. β^a	0.13	0.14	−0.09	−0.06
ΔR²	0.03		0.01
ΔF	0.99		0.16
Brainstem
Std. β^a	0.06	−0.02	0.03	0.20
ΔR²	<0.01		0.04
ΔF	0.13		0.51
Mesencephalon
Std. β^a	0.01	−0.08	0.15	0.01
ΔR²	0.01		0.02
ΔF	0.16		0.30
Pons
Std. β^a	0.08	−0.01	0.03	0.21
ΔR²	0.01		0.05
ΔF	0.23		0.64
Cerebellum
Std. β^a	0.01	0.23	−0.02	0.26
ΔR²	0.05		0.07
ΔF	1.34		0.84

Table 3

Open in new tab

Disease-related correlates of volumetric measurements in ET and Parkinson’s disease patients

	ET (n = 61)		Parkinson’s disease (n = 29)
	DOT	CRST	DOT	CRST
TBV
Std. β^a	0.24*	0.21*	−0.29	−0.01
ΔR²	0.09		0.08
ΔF	5.25**		2.14
WM
Std. β^a	0.19	−0.09	0.11	−0.25
ΔR²	0.04		0.06
ΔF	1.20		0.86
GM
Std. β^a	0.06	0.29*	−0.36	0.28
ΔR²	0.08		0.15
ΔF	3.60*		2.08
Cortical GM
Std. β^a	0.08	0.20	−0.42	0.21
ΔR²	0.04		0.16
ΔF	2.06		2.44
Frontal lobe
Std. β^a	0.07	0.07	−0.35	0.40
ΔR²	0.01		0.20
ΔF	0.52		2.96
Parietal lobe
Std. β^a	−0.09	0.03	−0.35	0.09
ΔR²	0.01		0.11
ΔF	0.36		1.64
Occipital lobe
Std. β^a	0.36**	0.08	−0.50*	−0.02
ΔR²	0.13		0.24
ΔF	4.22*		4.03*
Temporal lobe
Std. β^a	−0.04	0.38**	−0.19	< −0.01
ΔR²	0.13		0.04
ΔF	4.37*		0.44
Caudate
Std. β^a	−0.16	−0.20	0.12	−0.01
ΔR²	0.06		0.01
ΔF	1.87		0.15
Putamen
Std. β^a	−0.06	−0.04	0.18	0.53**
ΔR²	0.01		0.37
ΔF	0.14		6.84**
Pallidum
Std. β^a	0.17	0.06	0.10	0.11
ΔR²	0.03		0.03
ΔF	0.81		0.45
Thalamus
Std. β^a	0.13	0.14	−0.09	−0.06
ΔR²	0.03		0.01
ΔF	0.99		0.16
Brainstem
Std. β^a	0.06	−0.02	0.03	0.20
ΔR²	<0.01		0.04
ΔF	0.13		0.51
Mesencephalon
Std. β^a	0.01	−0.08	0.15	0.01
ΔR²	0.01		0.02
ΔF	0.16		0.30
Pons
Std. β^a	0.08	−0.01	0.03	0.21
ΔR²	0.01		0.05
ΔF	0.23		0.64
Cerebellum
Std. β^a	0.01	0.23	−0.02	0.26
ΔR²	0.05		0.07
ΔF	1.34		0.84

	ET (n = 61)		Parkinson’s disease (n = 29)
	DOT	CRST	DOT	CRST
TBV
Std. β^a	0.24*	0.21*	−0.29	−0.01
ΔR²	0.09		0.08
ΔF	5.25**		2.14
WM
Std. β^a	0.19	−0.09	0.11	−0.25
ΔR²	0.04		0.06
ΔF	1.20		0.86
GM
Std. β^a	0.06	0.29*	−0.36	0.28
ΔR²	0.08		0.15
ΔF	3.60*		2.08
Cortical GM
Std. β^a	0.08	0.20	−0.42	0.21
ΔR²	0.04		0.16
ΔF	2.06		2.44
Frontal lobe
Std. β^a	0.07	0.07	−0.35	0.40
ΔR²	0.01		0.20
ΔF	0.52		2.96
Parietal lobe
Std. β^a	−0.09	0.03	−0.35	0.09
ΔR²	0.01		0.11
ΔF	0.36		1.64
Occipital lobe
Std. β^a	0.36**	0.08	−0.50*	−0.02
ΔR²	0.13		0.24
ΔF	4.22*		4.03*
Temporal lobe
Std. β^a	−0.04	0.38**	−0.19	< −0.01
ΔR²	0.13		0.04
ΔF	4.37*		0.44
Caudate
Std. β^a	−0.16	−0.20	0.12	−0.01
ΔR²	0.06		0.01
ΔF	1.87		0.15
Putamen
Std. β^a	−0.06	−0.04	0.18	0.53**
ΔR²	0.01		0.37
ΔF	0.14		6.84**
Pallidum
Std. β^a	0.17	0.06	0.10	0.11
ΔR²	0.03		0.03
ΔF	0.81		0.45
Thalamus
Std. β^a	0.13	0.14	−0.09	−0.06
ΔR²	0.03		0.01
ΔF	0.99		0.16
Brainstem
Std. β^a	0.06	−0.02	0.03	0.20
ΔR²	<0.01		0.04
ΔF	0.13		0.51
Mesencephalon
Std. β^a	0.01	−0.08	0.15	0.01
ΔR²	0.01		0.02
ΔF	0.16		0.30
Pons
Std. β^a	0.08	−0.01	0.03	0.21
ΔR²	0.01		0.05
ΔF	0.23		0.64
Cerebellum
Std. β^a	0.01	0.23	−0.02	0.26
ΔR²	0.05		0.07
ΔF	1.34		0.84

Hierarchical multiple regression analyses for ET and Parkinson’s disease patients. Regression analyses consisted of two steps: (i) demographic variables (age and sex) were entered as the first block, and (ii) disease-related factors (DOT and tremor severity measured by the CRST) were entered in the second block. For results of the first block, we refer to the Supplementary Table 5.

** P < 0.01, * P < 0.05.

^aAll standarized regression coefficients are from the final step in the analyses.

Abbreviations: ET, Essential Tremor; DOT, Duration of tremor; CRST, Clinical Rating Scale for Tremor.

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