Table 3 Open in new tab Estimated annual...

		DIAD	sEOAD
Cognitive Composite	1	−0.20 (0.06)	<0.001	−0.31 (0.10)	<0.01	0.32
5	−0.35 (0.07)	<0.001	−0.28 (0.07)	<0.001	0.37
	10	−0.54 (0.16)	<0.001	−0.24 (0.16)	0.15	0.17
CDR-SB, mean (SE)	1	0.89 (0.29)	0.003	1.36 (0.33)	<0.001	0.25
5	2.11 (0.32)	<0.001	1.57 (0.23)	<0.001	0.11
10	3.63 (0.71)	<0.001	1.82 (0.54)	<0.001	0.03
MMSE mean (SE)	1	−1.30 (0.48)	0.008	−3.66 (0.60)	<0.001	<0.01
5	−3.03 (0.56)	<0.001	−2.77 (0.42)	<0.001	0.67
10	−5.18 (1.24)	<0.001	−1.67 (0.97)	0.09	0.02
NPI-Q mean (SE)	1	0.33 (0.83)	0.69	1.32 (0.90)	0.15	0.39
5	1.62 (1.03)	0.12	0.72 (0.67)	0.29	0.41
10	3.22 (2.33)	0.17	−0.02 (1.64)	0.99	0.24
Category fluency (animals), mean (SE)	1	−0.93 (0.49)	0.06	−1.19 (0.88)	0.18	0.78
5	−1.84 (0.65)	0.01	−0.77 (0.60)	0.19	0.15
10	−2.98 (1.44)	0.04	−0.25 (1.44)	0.86	0.16
Category fluency (vegetable), mean (SE)	1	−0.62 (0.37)	0.11	−0.62 (0.75)	0.41	0.99
5	−1.40 (0.51)	0.01	−1.65 (0.49)	0.001	0.66
10	−2.37 (1.11)	0.03	−2.95 (1.13)	0.01	0.71
Letter fluency, mean (SE)	1	−0.32 (0.37)	0.40	2.63 (1.33)	0.052	0.03
5	−1.09 (0.56)	0.06	−1.41 (0.82)	0.09	0.71
10	−2.05 (1.21)	0.09	−6.45 (2.29)	0.01	0.08
Logical memory (immediate recall), mean (SE)	1	−0.52 (0.32)	0.11	−0.37 (0.82)	0.65	0.85
5	−1.00 (0.44)	0.02	−1.41 (0.53)	0.01	0.49
10	−1.60 (0.94)	0.09	−2.71 (1.40)	0.06	0.50
Logical memory (delayed recall), mean (SE)	1	−0.17 (0.28)	0.55	−0.05 (0.73)	0.95	0.87
5	−0.76 (0.39)	0.05	−1.84 (0.49)	<0.001	0.05
10	−1.50 (0.84)	0.08	−4.09 (1.28)	<0.001	0.089
Digit symbol, mean (SE)	1	−4.32 (1.37)	<0.001	−5.97 (4.36)	0.18	0.70
5	−7.18 (1.89)	<0.001	−4.19 (2.80)	0.14	0.32
10	−10.75 (4.04)	<0.001	−1.96 (7.01)	0.78	0.28
Digit span forward, mean (SE)	1	−0.37 (0.19)	0.06	−0.51 (0.35)	0.15	0.69
5	−1.48 (0.25)	<0.001	−0.62 (0.23)	0.01	0.004
10	−2.87 (0.56)	<0.001	−0.76 (0.57)	0.18	0.01
Digit span backward, mean (SE)	1	−0.30 (0.14)	0.04	−0.08 (0.26)	0.77	0.17
5	−0.30 (0.21)	0.17	−0.77 (0.19)	<0.001	0.054
10	−0.29 (0.48)	0.54	−1.83 (0.47)	<0.001	0.02
Trail Making Test Part A, mean (SE)	1	6.80 (3.81)	0.081	2.72 (9.58)	0.78	0.68
5	22.00 (4.99)	<0.001	10.48 (5.74)	0.07	0.07
10	41.00 (11.02)	<0.001	20.18 (14.67)	0.17	0.24
Trail Making Test Part B, mean (SE)	1	17.55 (9.12)	0.06	−41.65 (25.77)	0.11	0.03
5	21.77 (15.70)	0.17	26.81 (16.62)	0.11	0.78
10	27.05 (35.80)	0.45	112.39 (41.84)	0.01	0.11
Boston Naming Test, mean (SE)	1	−0.79 (0.55)	0.15	−1.72 (1.49)	0.25	0.54
5	−2.11 (0.68)	<0.001	−2.74 (0.86)	<0.01	0.51
10	−3.75 (1.45)	0.01	−4.01 (2.29)	0.08	0.92

DIAD

sEOAD

EYO

Rate of change

P-value*

Rate of change

P-value*

P-value* comparing DIAD versus sEOAD

Cognitive Composite

−0.20 (0.06)

<0.001

−0.31 (0.10)

<0.01

0.32

−0.35 (0.07)

<0.001

−0.28 (0.07)

<0.001

0.37

−0.54 (0.16)

<0.001

−0.24 (0.16)

0.15

0.17

CDR-SB, mean (SE)

0.89 (0.29)

0.003

1.36 (0.33)

<0.001

0.25

2.11 (0.32)

<0.001

1.57 (0.23)

<0.001

0.11

3.63 (0.71)

<0.001

1.82 (0.54)

<0.001

0.03

MMSE mean (SE)

−1.30 (0.48)

0.008

−3.66 (0.60)

<0.001

<0.01

−3.03 (0.56)

<0.001

−2.77 (0.42)

<0.001

0.67

−5.18 (1.24)

<0.001

−1.67 (0.97)

0.09

0.02

NPI-Q mean (SE)

0.33 (0.83)

0.69

1.32 (0.90)

0.15

0.39

1.62 (1.03)

0.12

0.72 (0.67)

0.29

0.41

3.22 (2.33)

0.17

−0.02 (1.64)

0.99

0.24

Category fluency (animals), mean (SE)

−0.93 (0.49)

0.06

−1.19 (0.88)

0.18

0.78

−1.84 (0.65)

0.01

−0.77 (0.60)

0.19

0.15

−2.98 (1.44)

0.04

−0.25 (1.44)

0.86

0.16

Category fluency (vegetable), mean (SE)

−0.62 (0.37)

0.11

−0.62 (0.75)

0.41

0.99

−1.40 (0.51)

0.01

−1.65 (0.49)

0.001

0.66

−2.37 (1.11)

0.03

−2.95 (1.13)

0.01

0.71

Letter fluency, mean (SE)

−0.32 (0.37)

0.40

2.63 (1.33)

0.052

0.03

−1.09 (0.56)

0.06

−1.41 (0.82)

0.09

0.71

−2.05 (1.21)

0.09

−6.45 (2.29)

0.01

0.08

Logical memory (immediate recall), mean (SE)

−0.52 (0.32)

0.11

−0.37 (0.82)

0.65

0.85

−1.00 (0.44)

0.02

−1.41 (0.53)

0.01

0.49

−1.60 (0.94)

0.09

−2.71 (1.40)

0.06

0.50

Logical memory (delayed recall), mean (SE)

−0.17 (0.28)

0.55

−0.05 (0.73)

0.95

0.87

−0.76 (0.39)

0.05

−1.84 (0.49)

<0.001

0.05

−1.50 (0.84)

0.08

−4.09 (1.28)

<0.001

0.089

Digit symbol, mean (SE)

−4.32 (1.37)

<0.001

−5.97 (4.36)

0.18

0.70

−7.18 (1.89)

<0.001

−4.19 (2.80)

0.14

0.32

−10.75 (4.04)

<0.001

−1.96 (7.01)

0.78

0.28

Digit span forward, mean (SE)

−0.37 (0.19)

0.06

−0.51 (0.35)

0.15

0.69

−1.48 (0.25)

<0.001

−0.62 (0.23)

0.01

0.004

−2.87 (0.56)

<0.001

−0.76 (0.57)

0.18

0.01

Digit span backward, mean (SE)

−0.30 (0.14)

0.04

−0.08 (0.26)

0.77

0.17

−0.30 (0.21)

0.17

−0.77 (0.19)

<0.001

0.054

−0.29 (0.48)

0.54

−1.83 (0.47)

<0.001

0.02

Trail Making Test Part A, mean (SE)

6.80 (3.81)

0.081

2.72 (9.58)

0.78

0.68

22.00 (4.99)

<0.001

10.48 (5.74)

0.07

41.00 (11.02)

<0.001

20.18 (14.67)

0.17

0.24

Trail Making Test Part B, mean (SE)

17.55 (9.12)

0.06

−41.65 (25.77)

0.11

0.03

21.77 (15.70)

0.17

26.81 (16.62)

0.11

0.78

27.05 (35.80)

0.45

112.39 (41.84)

0.01

0.11

Boston Naming Test, mean (SE)

−0.79 (0.55)

0.15

−1.72 (1.49)

0.25

0.54

−2.11 (0.68)

<0.001

−2.74 (0.86)

<0.01

0.51

−3.75 (1.45)

0.01

−4.01 (2.29)

0.08

0.92

		DIAD	sEOAD
Cognitive Composite	1	−0.20 (0.06)	<0.001	−0.31 (0.10)	<0.01	0.32
5	−0.35 (0.07)	<0.001	−0.28 (0.07)	<0.001	0.37
	10	−0.54 (0.16)	<0.001	−0.24 (0.16)	0.15	0.17
CDR-SB, mean (SE)	1	0.89 (0.29)	0.003	1.36 (0.33)	<0.001	0.25
5	2.11 (0.32)	<0.001	1.57 (0.23)	<0.001	0.11
10	3.63 (0.71)	<0.001	1.82 (0.54)	<0.001	0.03
MMSE mean (SE)	1	−1.30 (0.48)	0.008	−3.66 (0.60)	<0.001	<0.01
5	−3.03 (0.56)	<0.001	−2.77 (0.42)	<0.001	0.67
10	−5.18 (1.24)	<0.001	−1.67 (0.97)	0.09	0.02
NPI-Q mean (SE)	1	0.33 (0.83)	0.69	1.32 (0.90)	0.15	0.39
5	1.62 (1.03)	0.12	0.72 (0.67)	0.29	0.41
10	3.22 (2.33)	0.17	−0.02 (1.64)	0.99	0.24
Category fluency (animals), mean (SE)	1	−0.93 (0.49)	0.06	−1.19 (0.88)	0.18	0.78
5	−1.84 (0.65)	0.01	−0.77 (0.60)	0.19	0.15
10	−2.98 (1.44)	0.04	−0.25 (1.44)	0.86	0.16
Category fluency (vegetable), mean (SE)	1	−0.62 (0.37)	0.11	−0.62 (0.75)	0.41	0.99
5	−1.40 (0.51)	0.01	−1.65 (0.49)	0.001	0.66
10	−2.37 (1.11)	0.03	−2.95 (1.13)	0.01	0.71
Letter fluency, mean (SE)	1	−0.32 (0.37)	0.40	2.63 (1.33)	0.052	0.03
5	−1.09 (0.56)	0.06	−1.41 (0.82)	0.09	0.71
10	−2.05 (1.21)	0.09	−6.45 (2.29)	0.01	0.08
Logical memory (immediate recall), mean (SE)	1	−0.52 (0.32)	0.11	−0.37 (0.82)	0.65	0.85
5	−1.00 (0.44)	0.02	−1.41 (0.53)	0.01	0.49
10	−1.60 (0.94)	0.09	−2.71 (1.40)	0.06	0.50
Logical memory (delayed recall), mean (SE)	1	−0.17 (0.28)	0.55	−0.05 (0.73)	0.95	0.87
5	−0.76 (0.39)	0.05	−1.84 (0.49)	<0.001	0.05
10	−1.50 (0.84)	0.08	−4.09 (1.28)	<0.001	0.089
Digit symbol, mean (SE)	1	−4.32 (1.37)	<0.001	−5.97 (4.36)	0.18	0.70
5	−7.18 (1.89)	<0.001	−4.19 (2.80)	0.14	0.32
10	−10.75 (4.04)	<0.001	−1.96 (7.01)	0.78	0.28
Digit span forward, mean (SE)	1	−0.37 (0.19)	0.06	−0.51 (0.35)	0.15	0.69
5	−1.48 (0.25)	<0.001	−0.62 (0.23)	0.01	0.004
10	−2.87 (0.56)	<0.001	−0.76 (0.57)	0.18	0.01
Digit span backward, mean (SE)	1	−0.30 (0.14)	0.04	−0.08 (0.26)	0.77	0.17
5	−0.30 (0.21)	0.17	−0.77 (0.19)	<0.001	0.054
10	−0.29 (0.48)	0.54	−1.83 (0.47)	<0.001	0.02
Trail Making Test Part A, mean (SE)	1	6.80 (3.81)	0.081	2.72 (9.58)	0.78	0.68
5	22.00 (4.99)	<0.001	10.48 (5.74)	0.07	0.07
10	41.00 (11.02)	<0.001	20.18 (14.67)	0.17	0.24
Trail Making Test Part B, mean (SE)	1	17.55 (9.12)	0.06	−41.65 (25.77)	0.11	0.03
5	21.77 (15.70)	0.17	26.81 (16.62)	0.11	0.78
10	27.05 (35.80)	0.45	112.39 (41.84)	0.01	0.11
Boston Naming Test, mean (SE)	1	−0.79 (0.55)	0.15	−1.72 (1.49)	0.25	0.54
5	−2.11 (0.68)	<0.001	−2.74 (0.86)	<0.01	0.51
10	−3.75 (1.45)	0.01	−4.01 (2.29)	0.08	0.92

DIAD

sEOAD

EYO

Rate of change

P-value*

Rate of change

P-value*

P-value* comparing DIAD versus sEOAD

Cognitive Composite

−0.20 (0.06)

<0.001

−0.31 (0.10)

<0.01

0.32

−0.35 (0.07)

<0.001

−0.28 (0.07)

<0.001

0.37

−0.54 (0.16)

<0.001

−0.24 (0.16)

0.15

0.17

CDR-SB, mean (SE)

0.89 (0.29)

0.003

1.36 (0.33)

<0.001

0.25

2.11 (0.32)

<0.001

1.57 (0.23)

<0.001

0.11

3.63 (0.71)

<0.001

1.82 (0.54)

<0.001

0.03

MMSE mean (SE)

−1.30 (0.48)

0.008

−3.66 (0.60)

<0.001

<0.01

−3.03 (0.56)

<0.001

−2.77 (0.42)

<0.001

0.67

−5.18 (1.24)

<0.001

−1.67 (0.97)

0.09

0.02

NPI-Q mean (SE)

0.33 (0.83)

0.69

1.32 (0.90)

0.15

0.39

1.62 (1.03)

0.12

0.72 (0.67)

0.29

0.41

3.22 (2.33)

0.17

−0.02 (1.64)

0.99

0.24

Category fluency (animals), mean (SE)

−0.93 (0.49)

0.06

−1.19 (0.88)

0.18

0.78

−1.84 (0.65)

0.01

−0.77 (0.60)

0.19

0.15

−2.98 (1.44)

0.04

−0.25 (1.44)

0.86

0.16

Category fluency (vegetable), mean (SE)

−0.62 (0.37)

0.11

−0.62 (0.75)

0.41

0.99

−1.40 (0.51)

0.01

−1.65 (0.49)

0.001

0.66

−2.37 (1.11)

0.03

−2.95 (1.13)

0.01

0.71

Letter fluency, mean (SE)

−0.32 (0.37)

0.40

2.63 (1.33)

0.052

0.03

−1.09 (0.56)

0.06

−1.41 (0.82)

0.09

0.71

−2.05 (1.21)

0.09

−6.45 (2.29)

0.01

0.08

Logical memory (immediate recall), mean (SE)

−0.52 (0.32)

0.11

−0.37 (0.82)

0.65

0.85

−1.00 (0.44)

0.02

−1.41 (0.53)

0.01

0.49

−1.60 (0.94)

0.09

−2.71 (1.40)

0.06

0.50

Logical memory (delayed recall), mean (SE)

−0.17 (0.28)

0.55

−0.05 (0.73)

0.95

0.87

−0.76 (0.39)

0.05

−1.84 (0.49)

<0.001

0.05

−1.50 (0.84)

0.08

−4.09 (1.28)

<0.001

0.089

Digit symbol, mean (SE)

−4.32 (1.37)

<0.001

−5.97 (4.36)

0.18

0.70

−7.18 (1.89)

<0.001

−4.19 (2.80)

0.14

0.32

−10.75 (4.04)

<0.001

−1.96 (7.01)

0.78

0.28

Digit span forward, mean (SE)

−0.37 (0.19)

0.06

−0.51 (0.35)

0.15

0.69

−1.48 (0.25)

<0.001

−0.62 (0.23)

0.01

0.004

−2.87 (0.56)

<0.001

−0.76 (0.57)

0.18

0.01

Digit span backward, mean (SE)

−0.30 (0.14)

0.04

−0.08 (0.26)

0.77

0.17

−0.30 (0.21)

0.17

−0.77 (0.19)

<0.001

0.054

−0.29 (0.48)

0.54

−1.83 (0.47)

<0.001

0.02

Trail Making Test Part A, mean (SE)

6.80 (3.81)

0.081

2.72 (9.58)

0.78

0.68

22.00 (4.99)

<0.001

10.48 (5.74)

0.07

41.00 (11.02)

<0.001

20.18 (14.67)

0.17

0.24

Trail Making Test Part B, mean (SE)

17.55 (9.12)

0.06

−41.65 (25.77)

0.11

0.03

21.77 (15.70)

0.17

26.81 (16.62)

0.11

0.78

27.05 (35.80)

0.45

112.39 (41.84)

0.01

0.11

Boston Naming Test, mean (SE)

−0.79 (0.55)

0.15

−1.72 (1.49)

0.25

0.54

−2.11 (0.68)

<0.001

−2.74 (0.86)

<0.01

0.51

−3.75 (1.45)

0.01

−4.01 (2.29)

0.08

0.92

Table 3

Open in new tab

Estimated annual rate of change (standard error): symptomatic DIAD versus sEOAD by baseline EYO = 1, 5 and 10

		DIAD		sEOAD
	EYO	Rate of change	P-value*	Rate of change	P-value*	P-value* comparing DIAD versus sEOAD
Cognitive Composite	1	−0.20 (0.06)	<0.001	−0.31 (0.10)	<0.01	0.32
Cognitive Composite	5	−0.35 (0.07)	<0.001	−0.28 (0.07)	<0.001	0.37
	10	−0.54 (0.16)	<0.001	−0.24 (0.16)	0.15	0.17
CDR-SB, mean (SE)	1	0.89 (0.29)	0.003	1.36 (0.33)	<0.001	0.25
	5	2.11 (0.32)	<0.001	1.57 (0.23)	<0.001	0.11
	10	3.63 (0.71)	<0.001	1.82 (0.54)	<0.001	0.03
MMSE mean (SE)	1	−1.30 (0.48)	0.008	−3.66 (0.60)	<0.001	<0.01
	5	−3.03 (0.56)	<0.001	−2.77 (0.42)	<0.001	0.67
	10	−5.18 (1.24)	<0.001	−1.67 (0.97)	0.09	0.02
NPI-Q mean (SE)	1	0.33 (0.83)	0.69	1.32 (0.90)	0.15	0.39
	5	1.62 (1.03)	0.12	0.72 (0.67)	0.29	0.41
	10	3.22 (2.33)	0.17	−0.02 (1.64)	0.99	0.24
Category fluency (animals), mean (SE)	1	−0.93 (0.49)	0.06	−1.19 (0.88)	0.18	0.78
	5	−1.84 (0.65)	0.01	−0.77 (0.60)	0.19	0.15
	10	−2.98 (1.44)	0.04	−0.25 (1.44)	0.86	0.16
Category fluency (vegetable), mean (SE)	1	−0.62 (0.37)	0.11	−0.62 (0.75)	0.41	0.99
	5	−1.40 (0.51)	0.01	−1.65 (0.49)	0.001	0.66
	10	−2.37 (1.11)	0.03	−2.95 (1.13)	0.01	0.71
Letter fluency, mean (SE)	1	−0.32 (0.37)	0.40	2.63 (1.33)	0.052	0.03
	5	−1.09 (0.56)	0.06	−1.41 (0.82)	0.09	0.71
	10	−2.05 (1.21)	0.09	−6.45 (2.29)	0.01	0.08
Logical memory (immediate recall), mean (SE)	1	−0.52 (0.32)	0.11	−0.37 (0.82)	0.65	0.85
	5	−1.00 (0.44)	0.02	−1.41 (0.53)	0.01	0.49
	10	−1.60 (0.94)	0.09	−2.71 (1.40)	0.06	0.50
Logical memory (delayed recall), mean (SE)	1	−0.17 (0.28)	0.55	−0.05 (0.73)	0.95	0.87
	5	−0.76 (0.39)	0.05	−1.84 (0.49)	<0.001	0.05
	10	−1.50 (0.84)	0.08	−4.09 (1.28)	<0.001	0.089
Digit symbol, mean (SE)	1	−4.32 (1.37)	<0.001	−5.97 (4.36)	0.18	0.70
	5	−7.18 (1.89)	<0.001	−4.19 (2.80)	0.14	0.32
	10	−10.75 (4.04)	<0.001	−1.96 (7.01)	0.78	0.28
Digit span forward, mean (SE)	1	−0.37 (0.19)	0.06	−0.51 (0.35)	0.15	0.69
	5	−1.48 (0.25)	<0.001	−0.62 (0.23)	0.01	0.004
	10	−2.87 (0.56)	<0.001	−0.76 (0.57)	0.18	0.01
Digit span backward, mean (SE)	1	−0.30 (0.14)	0.04	−0.08 (0.26)	0.77	0.17
	5	−0.30 (0.21)	0.17	−0.77 (0.19)	<0.001	0.054
	10	−0.29 (0.48)	0.54	−1.83 (0.47)	<0.001	0.02
Trail Making Test Part A, mean (SE)	1	6.80 (3.81)	0.081	2.72 (9.58)	0.78	0.68
	5	22.00 (4.99)	<0.001	10.48 (5.74)	0.07	0.07
	10	41.00 (11.02)	<0.001	20.18 (14.67)	0.17	0.24
Trail Making Test Part B, mean (SE)	1	17.55 (9.12)	0.06	−41.65 (25.77)	0.11	0.03
	5	21.77 (15.70)	0.17	26.81 (16.62)	0.11	0.78
	10	27.05 (35.80)	0.45	112.39 (41.84)	0.01	0.11
Boston Naming Test, mean (SE)	1	−0.79 (0.55)	0.15	−1.72 (1.49)	0.25	0.54
	5	−2.11 (0.68)	<0.001	−2.74 (0.86)	<0.01	0.51
	10	−3.75 (1.45)	0.01	−4.01 (2.29)	0.08	0.92

		DIAD		sEOAD
	EYO	Rate of change	P-value*	Rate of change	P-value*	P-value* comparing DIAD versus sEOAD
Cognitive Composite	1	−0.20 (0.06)	<0.001	−0.31 (0.10)	<0.01	0.32
Cognitive Composite	5	−0.35 (0.07)	<0.001	−0.28 (0.07)	<0.001	0.37
	10	−0.54 (0.16)	<0.001	−0.24 (0.16)	0.15	0.17
CDR-SB, mean (SE)	1	0.89 (0.29)	0.003	1.36 (0.33)	<0.001	0.25
	5	2.11 (0.32)	<0.001	1.57 (0.23)	<0.001	0.11
	10	3.63 (0.71)	<0.001	1.82 (0.54)	<0.001	0.03
MMSE mean (SE)	1	−1.30 (0.48)	0.008	−3.66 (0.60)	<0.001	<0.01
	5	−3.03 (0.56)	<0.001	−2.77 (0.42)	<0.001	0.67
	10	−5.18 (1.24)	<0.001	−1.67 (0.97)	0.09	0.02
NPI-Q mean (SE)	1	0.33 (0.83)	0.69	1.32 (0.90)	0.15	0.39
	5	1.62 (1.03)	0.12	0.72 (0.67)	0.29	0.41
	10	3.22 (2.33)	0.17	−0.02 (1.64)	0.99	0.24
Category fluency (animals), mean (SE)	1	−0.93 (0.49)	0.06	−1.19 (0.88)	0.18	0.78
	5	−1.84 (0.65)	0.01	−0.77 (0.60)	0.19	0.15
	10	−2.98 (1.44)	0.04	−0.25 (1.44)	0.86	0.16
Category fluency (vegetable), mean (SE)	1	−0.62 (0.37)	0.11	−0.62 (0.75)	0.41	0.99
	5	−1.40 (0.51)	0.01	−1.65 (0.49)	0.001	0.66
	10	−2.37 (1.11)	0.03	−2.95 (1.13)	0.01	0.71
Letter fluency, mean (SE)	1	−0.32 (0.37)	0.40	2.63 (1.33)	0.052	0.03
	5	−1.09 (0.56)	0.06	−1.41 (0.82)	0.09	0.71
	10	−2.05 (1.21)	0.09	−6.45 (2.29)	0.01	0.08
Logical memory (immediate recall), mean (SE)	1	−0.52 (0.32)	0.11	−0.37 (0.82)	0.65	0.85
	5	−1.00 (0.44)	0.02	−1.41 (0.53)	0.01	0.49
	10	−1.60 (0.94)	0.09	−2.71 (1.40)	0.06	0.50
Logical memory (delayed recall), mean (SE)	1	−0.17 (0.28)	0.55	−0.05 (0.73)	0.95	0.87
	5	−0.76 (0.39)	0.05	−1.84 (0.49)	<0.001	0.05
	10	−1.50 (0.84)	0.08	−4.09 (1.28)	<0.001	0.089
Digit symbol, mean (SE)	1	−4.32 (1.37)	<0.001	−5.97 (4.36)	0.18	0.70
	5	−7.18 (1.89)	<0.001	−4.19 (2.80)	0.14	0.32
	10	−10.75 (4.04)	<0.001	−1.96 (7.01)	0.78	0.28
Digit span forward, mean (SE)	1	−0.37 (0.19)	0.06	−0.51 (0.35)	0.15	0.69
	5	−1.48 (0.25)	<0.001	−0.62 (0.23)	0.01	0.004
	10	−2.87 (0.56)	<0.001	−0.76 (0.57)	0.18	0.01
Digit span backward, mean (SE)	1	−0.30 (0.14)	0.04	−0.08 (0.26)	0.77	0.17
	5	−0.30 (0.21)	0.17	−0.77 (0.19)	<0.001	0.054
	10	−0.29 (0.48)	0.54	−1.83 (0.47)	<0.001	0.02
Trail Making Test Part A, mean (SE)	1	6.80 (3.81)	0.081	2.72 (9.58)	0.78	0.68
	5	22.00 (4.99)	<0.001	10.48 (5.74)	0.07	0.07
	10	41.00 (11.02)	<0.001	20.18 (14.67)	0.17	0.24
Trail Making Test Part B, mean (SE)	1	17.55 (9.12)	0.06	−41.65 (25.77)	0.11	0.03
	5	21.77 (15.70)	0.17	26.81 (16.62)	0.11	0.78
	10	27.05 (35.80)	0.45	112.39 (41.84)	0.01	0.11
Boston Naming Test, mean (SE)	1	−0.79 (0.55)	0.15	−1.72 (1.49)	0.25	0.54
	5	−2.11 (0.68)	<0.001	−2.74 (0.86)	<0.01	0.51
	10	−3.75 (1.45)	0.01	−4.01 (2.29)	0.08	0.92

Logical memory, category fluency, letter fluency, digit span, Boston Naming Test and digit symbol: lower scores indicating poorer cognitive performance. Trail Making Test scores: higher scores indicating poorer cognitive performance. Cognitive composite is the mean of the standardized scores for animal naming, delayed recall, digit symbol and MMSE tests. *P-values were adjusted for baseline EYO, sex, education and APOE4 status. Significant differences are highlighted as bold values.

This Feature Is Available To Subscribers Only