Table 2
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Baseline cognitive performance: symptomatic DIAD versus sEOAD

CharacteristicDIADsEOADSignificance level
(P-value*)
Logical memory (immediate recall), mean (SD), n6.1 (4.6)
n = 113		4.7 (4.3)
n = 45		0.08
Logical memory (delayed recall), mean (SD), n4.3 (4.5)
n = 111		4.0 (4.3)
n = 43		0.69
Category fluency (vegetables), mean (SD), n9.3 (4.3)
n = 101		6.7 (4.7)
n = 43		<0.001
Category fluency (animals), mean (SD), n15.3 (6.0)
n = 113		10.5 (5.5)
n = 101		<0.001
Letter fluency, mean (SD), n10.6 (4.8)
n = 99		11.8 (5.1)
n = 35		0.54
Digit span forward, mean (SD), n6.6 (2.5)
n = 113		5.7 (2.4)
n = 101		<0.01
Digit span backward, mean (SD), n4.9 (2.3)
n = 113		3.8 (2.2)
n = 101		0.001
Trail Making Test Part A, mean (SD), n54.9 (41.1)
n = 106		81.6 (51.6)
n = 66		<0.001
Trail Making Test Part B, mean (SD), n147.7 (102.4)
n = 86		207.8 (97.8)
n = 47		<0.001
Boston Naming Test, mean (SD), n23.6 (5.7)
n = 106		22.7 (7.3)
n = 43		0.27
Digit symbol, mean (SD), n34.9 (19.1)
n = 106		22.7 (13.9)
n = 28		<0.001
CharacteristicDIADsEOADSignificance level
(P-value*)
Logical memory (immediate recall), mean (SD), n6.1 (4.6)
n = 113		4.7 (4.3)
n = 45		0.08
Logical memory (delayed recall), mean (SD), n4.3 (4.5)
n = 111		4.0 (4.3)
n = 43		0.69
Category fluency (vegetables), mean (SD), n9.3 (4.3)
n = 101		6.7 (4.7)
n = 43		<0.001
Category fluency (animals), mean (SD), n15.3 (6.0)
n = 113		10.5 (5.5)
n = 101		<0.001
Letter fluency, mean (SD), n10.6 (4.8)
n = 99		11.8 (5.1)
n = 35		0.54
Digit span forward, mean (SD), n6.6 (2.5)
n = 113		5.7 (2.4)
n = 101		<0.01
Digit span backward, mean (SD), n4.9 (2.3)
n = 113		3.8 (2.2)
n = 101		0.001
Trail Making Test Part A, mean (SD), n54.9 (41.1)
n = 106		81.6 (51.6)
n = 66		<0.001
Trail Making Test Part B, mean (SD), n147.7 (102.4)
n = 86		207.8 (97.8)
n = 47		<0.001
Boston Naming Test, mean (SD), n23.6 (5.7)
n = 106		22.7 (7.3)
n = 43		0.27
Digit symbol, mean (SD), n34.9 (19.1)
n = 106		22.7 (13.9)
n = 28		<0.001

Logical memory, category fluency, letter fluency, digit span, Boston Naming Test and digit symbol: lower scores indicating poorer cognitive performance. Trail Making Test scores: higher scores indicating poorer cognitive performance. *P-values were adjusted for baseline EYO, sex, education and APOE4 status. Significant differences are highlighted as bold values.

Table 2
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Baseline cognitive performance: symptomatic DIAD versus sEOAD

CharacteristicDIADsEOADSignificance level
(P-value*)
Logical memory (immediate recall), mean (SD), n6.1 (4.6)
n = 113		4.7 (4.3)
n = 45		0.08
Logical memory (delayed recall), mean (SD), n4.3 (4.5)
n = 111		4.0 (4.3)
n = 43		0.69
Category fluency (vegetables), mean (SD), n9.3 (4.3)
n = 101		6.7 (4.7)
n = 43		<0.001
Category fluency (animals), mean (SD), n15.3 (6.0)
n = 113		10.5 (5.5)
n = 101		<0.001
Letter fluency, mean (SD), n10.6 (4.8)
n = 99		11.8 (5.1)
n = 35		0.54
Digit span forward, mean (SD), n6.6 (2.5)
n = 113		5.7 (2.4)
n = 101		<0.01
Digit span backward, mean (SD), n4.9 (2.3)
n = 113		3.8 (2.2)
n = 101		0.001
Trail Making Test Part A, mean (SD), n54.9 (41.1)
n = 106		81.6 (51.6)
n = 66		<0.001
Trail Making Test Part B, mean (SD), n147.7 (102.4)
n = 86		207.8 (97.8)
n = 47		<0.001
Boston Naming Test, mean (SD), n23.6 (5.7)
n = 106		22.7 (7.3)
n = 43		0.27
Digit symbol, mean (SD), n34.9 (19.1)
n = 106		22.7 (13.9)
n = 28		<0.001
CharacteristicDIADsEOADSignificance level
(P-value*)
Logical memory (immediate recall), mean (SD), n6.1 (4.6)
n = 113		4.7 (4.3)
n = 45		0.08
Logical memory (delayed recall), mean (SD), n4.3 (4.5)
n = 111		4.0 (4.3)
n = 43		0.69
Category fluency (vegetables), mean (SD), n9.3 (4.3)
n = 101		6.7 (4.7)
n = 43		<0.001
Category fluency (animals), mean (SD), n15.3 (6.0)
n = 113		10.5 (5.5)
n = 101		<0.001
Letter fluency, mean (SD), n10.6 (4.8)
n = 99		11.8 (5.1)
n = 35		0.54
Digit span forward, mean (SD), n6.6 (2.5)
n = 113		5.7 (2.4)
n = 101		<0.01
Digit span backward, mean (SD), n4.9 (2.3)
n = 113		3.8 (2.2)
n = 101		0.001
Trail Making Test Part A, mean (SD), n54.9 (41.1)
n = 106		81.6 (51.6)
n = 66		<0.001
Trail Making Test Part B, mean (SD), n147.7 (102.4)
n = 86		207.8 (97.8)
n = 47		<0.001
Boston Naming Test, mean (SD), n23.6 (5.7)
n = 106		22.7 (7.3)
n = 43		0.27
Digit symbol, mean (SD), n34.9 (19.1)
n = 106		22.7 (13.9)
n = 28		<0.001

Logical memory, category fluency, letter fluency, digit span, Boston Naming Test and digit symbol: lower scores indicating poorer cognitive performance. Trail Making Test scores: higher scores indicating poorer cognitive performance. *P-values were adjusted for baseline EYO, sex, education and APOE4 status. Significant differences are highlighted as bold values.

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