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Table 1.

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Clinical and melanocytic lesion characteristics

Sample	Age	Sex	Main Nevus Size*	Method for NCM Diagnosis	NCM Symptoms	Prior Therapy	Tissue Mmelanocytic Lesion Site	Tumor Mutation	Follow-up Time
P01S	1 y 5 mo	Male	G2	MRI/autopsy	Hydrocephalus	Sorafenib, temozolomide, and radiation	Spinal cord	NRAS p.Q61R	Autopsy
P09B	6 y	Male	L2	MRI/autopsy	Seizure	Brain surgery	Frontal lobe	NRAS p.Q61K	Autopsy
C76N	1 y 9 mo	Male	G2	MRI	No	Surgery	Skin	NRAS p.Q61K	1 y 5 mo
PD1N	2 y 5 mo	Male	G2	MRI	Tethered cord	Surgery	Skin	NRAS p.Q61K	2 y

Sample	Age	Sex	Main Nevus Size*	Method for NCM Diagnosis	NCM Symptoms	Prior Therapy	Tissue Mmelanocytic Lesion Site	Tumor Mutation	Follow-up Time
P01S	1 y 5 mo	Male	G2	MRI/autopsy	Hydrocephalus	Sorafenib, temozolomide, and radiation	Spinal cord	NRAS p.Q61R	Autopsy
P09B	6 y	Male	L2	MRI/autopsy	Seizure	Brain surgery	Frontal lobe	NRAS p.Q61K	Autopsy
C76N	1 y 9 mo	Male	G2	MRI	No	Surgery	Skin	NRAS p.Q61K	1 y 5 mo
PD1N	2 y 5 mo	Male	G2	MRI	Tethered cord	Surgery	Skin	NRAS p.Q61K	2 y

Main nevus size categorization according to Krengel et al.¹⁰

Table 1.

Open in new tab

Clinical and melanocytic lesion characteristics

Sample	Age	Sex	Main Nevus Size*	Method for NCM Diagnosis	NCM Symptoms	Prior Therapy	Tissue Mmelanocytic Lesion Site	Tumor Mutation	Follow-up Time
P01S	1 y 5 mo	Male	G2	MRI/autopsy	Hydrocephalus	Sorafenib, temozolomide, and radiation	Spinal cord	NRAS p.Q61R	Autopsy
P09B	6 y	Male	L2	MRI/autopsy	Seizure	Brain surgery	Frontal lobe	NRAS p.Q61K	Autopsy
C76N	1 y 9 mo	Male	G2	MRI	No	Surgery	Skin	NRAS p.Q61K	1 y 5 mo
PD1N	2 y 5 mo	Male	G2	MRI	Tethered cord	Surgery	Skin	NRAS p.Q61K	2 y

Sample	Age	Sex	Main Nevus Size*	Method for NCM Diagnosis	NCM Symptoms	Prior Therapy	Tissue Mmelanocytic Lesion Site	Tumor Mutation	Follow-up Time
P01S	1 y 5 mo	Male	G2	MRI/autopsy	Hydrocephalus	Sorafenib, temozolomide, and radiation	Spinal cord	NRAS p.Q61R	Autopsy
P09B	6 y	Male	L2	MRI/autopsy	Seizure	Brain surgery	Frontal lobe	NRAS p.Q61K	Autopsy
C76N	1 y 9 mo	Male	G2	MRI	No	Surgery	Skin	NRAS p.Q61K	1 y 5 mo
PD1N	2 y 5 mo	Male	G2	MRI	Tethered cord	Surgery	Skin	NRAS p.Q61K	2 y

Main nevus size categorization according to Krengel et al.¹⁰