Table 2. Open in new tab Observed vs...

Table 2.

Observed vs expected number of suicides among NHPP c-hGH recipients, including analyses stratified by sex, GH deficiency type and GH deficiency cause

Group	Patients	Person-years	Observed suicides^a	Expected suicides	SMR (95% CI)	P value
Total	6193	233 369	47	37.8	1.25 (0.91-1.66)	.162
Sex
Female	1949	73 435	2	4.0	0.50 (0.06-1.81)	.477
Male	4244	159 934	45	33.8	1.33 (0.97-1.78)	.073
GH deficiency type
Isolated	1807	70 284	19	12.0	1.59 (0.96-2.48)	.073
Multiple	3351	124 707	18	19.6	0.92 (0.54-1.45)	.829
GH deficiency cause
Idiopathic	3415	135 861	22	22.7	0.97 (0.61-1.47)	.996
Organic	1702	57 595	13	8.6	1.51 (0.80-2.58)	.196

Group	Patients	Person-years	Observed suicides^a	Expected suicides	SMR (95% CI)	P value
Total	6193	233 369	47	37.8	1.25 (0.91-1.66)	.162
Sex
Female	1949	73 435	2	4.0	0.50 (0.06-1.81)	.477
Male	4244	159 934	45	33.8	1.33 (0.97-1.78)	.073
GH deficiency type
Isolated	1807	70 284	19	12.0	1.59 (0.96-2.48)	.073
Multiple	3351	124 707	18	19.6	0.92 (0.54-1.45)	.829
GH deficiency cause
Idiopathic	3415	135 861	22	22.7	0.97 (0.61-1.47)	.996
Organic	1702	57 595	13	8.6	1.51 (0.80-2.58)	.196

Abbreviations: c-hGH, cadaver-derived human growth hormone; NHPP, National Hormone Pituitary Program; SMR, standardized mortality ratio.

^aOnly deaths with suicide ICD-9 and ICD-10 codes are included.