Table 2. Open in new tab Full blood...

	NFAT (n = 215)	CPA-MACS (n = 138)	CPA-CS (n = 22)	P value (Kruskal–Wallis)	P value (group comparison)	P value (Quade test)	P value (group comparison)
FBC values
Leucocytes (×10⁹/L)	7.4 (5.9-8.6)	7.6 (6.69-9.5)	8.65 (7.17-10.32)	<.001	.023^a .002^b .128^c	<.001	.005^a .001^b .058^c
Platelets (×10⁹/L)	261 (208-303)	271 (211-315.25)	241 (223.75-288.75)	.678		.306
Neutrophils (×10⁹/L)	4.45 (3.4-5.6)	5.1 (4-6.22)	5.85 (4.7-7.54)	<.001	.003^a <.001^b .120^c	<.001	.001^a <.001^b .014^c
Lymphocytes (×10⁹/L)	1.9 (1.5-2.4)	1.8 (1.4-2.6)	2.1 (1.52-3.12)	.850		.392
Monocytes (×10⁹/L)	0.5 (0.4-0.6)	0.6 (0.47-0.8)	0.77 (0.6-0.92)	<.001	.002^a <.001^b .005^c	<.001	.003^a <.001^b <.001^c
Eosinophils (×10⁹/L)	0.14 (0.1-0.2)	0.14 (0.1-0.2)	0.1 (0.04-0.27)	.077		.076
Basophils (×10⁹/L)	0.2 (0.1-0.3)	0.2 (0.1-0.3)	0.11 (0.1-0.22)	.062		.102
Inflammation-based scores
NLR	2.2 (1.71-2.93)	2.69 (2.02-3.61)	3.80 (1.92-4.37)	<.001	<.001^a .002^b .363^c	<.001	.005^a <.001^b .001^c
PLR	133.5 (100.71–178.33)	151.42 (104.95-183.01)	124.96 (112.68-172.38)	.508		.874
SII	558.26 (413.4-803.71)	727 (465.98-953.32)	859.55 (459.71-1355.20)	<.001	.006^a .021^b .747^c	<.001	.009^a .001^b .046^c
LMR	3.66 (2.98-4.6)	3.12 (2.42-4.5)	2.23 (1.82-3.47)	<.001	.010^a <.001^b .007^c	<.001	.096^a <.001^b <.001^c
PNI Unknown	52 (48-56.5) n = 68	51.25 (47-56) n = 56	53 (51.5-55.25) n = 5	.325		.921
NPS 0/1/2 (%)	197/17/1 (91.6%/7.9%/0.5%)	126/11/1 (91.3%/8%/0.7%)	16/5/1 (72.7%/22.7%/4.5%)	.044

NFAT (n = 215)

CPA-MACS (n = 138)

CPA-CS (n = 22)

P value (Kruskal–Wallis)

P value (group comparison)

P value (Quade test)

P value (group comparison)

FBC values

Leucocytes (×10⁹/L)

7.4 (5.9-8.6)

7.6 (6.69-9.5)

8.65 (7.17-10.32)

<.001

.023^a
.002^b
.128^c

<.001

.005^a
.001^b
.058^c

Platelets (×10⁹/L)

261 (208-303)

271 (211-315.25)

241 (223.75-288.75)

.678

.306

Neutrophils (×10⁹/L)

4.45 (3.4-5.6)

5.1 (4-6.22)

5.85 (4.7-7.54)

<.001

.003^a
<.001^b
.120^c

<.001

.001^a
<.001^b
.014^c

Lymphocytes (×10⁹/L)

1.9 (1.5-2.4)

1.8 (1.4-2.6)

2.1 (1.52-3.12)

.850

.392

Monocytes (×10⁹/L)

0.5 (0.4-0.6)

0.6 (0.47-0.8)

0.77 (0.6-0.92)

<.001

.002^a
<.001^b
.005^c

<.001

.003^a
<.001^b
<.001^c

Eosinophils (×10⁹/L)

0.14 (0.1-0.2)

0.1 (0.04-0.27)

.077

.076

Basophils (×10⁹/L)

0.2 (0.1-0.3)

0.11 (0.1-0.22)

.062

.102

Inflammation-based scores

NLR

2.2 (1.71-2.93)

2.69 (2.02-3.61)

3.80 (1.92-4.37)

<.001

<.001^a
.002^b
.363^c

<.001

.005^a
<.001^b
.001^c

PLR

133.5 (100.71–178.33)

151.42 (104.95-183.01)

124.96 (112.68-172.38)

.508

.874

SII

558.26 (413.4-803.71)

727 (465.98-953.32)

859.55 (459.71-1355.20)

<.001

.006^a
.021^b
.747^c

<.001

.009^a
.001^b
.046^c

LMR

3.66 (2.98-4.6)

3.12 (2.42-4.5)

2.23 (1.82-3.47)

<.001

.010^a
<.001^b
.007^c

<.001

.096^a
<.001^b
<.001^c

PNI
Unknown

52 (48-56.5)
n = 68

51.25 (47-56)
n = 56

53 (51.5-55.25)
n = 5

.325

.921

NPS 0/1/2 (%)

197/17/1 (91.6%/7.9%/0.5%)

126/11/1 (91.3%/8%/0.7%)

16/5/1 (72.7%/22.7%/4.5%)

.044

	NFAT (n = 215)	CPA-MACS (n = 138)	CPA-CS (n = 22)	P value (Kruskal–Wallis)	P value (group comparison)	P value (Quade test)	P value (group comparison)
FBC values
Leucocytes (×10⁹/L)	7.4 (5.9-8.6)	7.6 (6.69-9.5)	8.65 (7.17-10.32)	<.001	.023^a .002^b .128^c	<.001	.005^a .001^b .058^c
Platelets (×10⁹/L)	261 (208-303)	271 (211-315.25)	241 (223.75-288.75)	.678		.306
Neutrophils (×10⁹/L)	4.45 (3.4-5.6)	5.1 (4-6.22)	5.85 (4.7-7.54)	<.001	.003^a <.001^b .120^c	<.001	.001^a <.001^b .014^c
Lymphocytes (×10⁹/L)	1.9 (1.5-2.4)	1.8 (1.4-2.6)	2.1 (1.52-3.12)	.850		.392
Monocytes (×10⁹/L)	0.5 (0.4-0.6)	0.6 (0.47-0.8)	0.77 (0.6-0.92)	<.001	.002^a <.001^b .005^c	<.001	.003^a <.001^b <.001^c
Eosinophils (×10⁹/L)	0.14 (0.1-0.2)	0.14 (0.1-0.2)	0.1 (0.04-0.27)	.077		.076
Basophils (×10⁹/L)	0.2 (0.1-0.3)	0.2 (0.1-0.3)	0.11 (0.1-0.22)	.062		.102
Inflammation-based scores
NLR	2.2 (1.71-2.93)	2.69 (2.02-3.61)	3.80 (1.92-4.37)	<.001	<.001^a .002^b .363^c	<.001	.005^a <.001^b .001^c
PLR	133.5 (100.71–178.33)	151.42 (104.95-183.01)	124.96 (112.68-172.38)	.508		.874
SII	558.26 (413.4-803.71)	727 (465.98-953.32)	859.55 (459.71-1355.20)	<.001	.006^a .021^b .747^c	<.001	.009^a .001^b .046^c
LMR	3.66 (2.98-4.6)	3.12 (2.42-4.5)	2.23 (1.82-3.47)	<.001	.010^a <.001^b .007^c	<.001	.096^a <.001^b <.001^c
PNI Unknown	52 (48-56.5) n = 68	51.25 (47-56) n = 56	53 (51.5-55.25) n = 5	.325		.921
NPS 0/1/2 (%)	197/17/1 (91.6%/7.9%/0.5%)	126/11/1 (91.3%/8%/0.7%)	16/5/1 (72.7%/22.7%/4.5%)	.044

Table 2.

Open in new tab

Full blood count and inflammation-based scores of patients with non–aldosterone-producing adrenocortical adenomas.

	NFAT (n = 215)	CPA-MACS (n = 138)	CPA-CS (n = 22)	P value (Kruskal–Wallis)	P value (group comparison)	P value (Quade test)	P value (group comparison)
FBC values
Leucocytes (×10⁹/L)	7.4 (5.9-8.6)	7.6 (6.69-9.5)	8.65 (7.17-10.32)	<.001	.023^a .002^b .128^c	<.001	.005^a .001^b .058^c
Platelets (×10⁹/L)	261 (208-303)	271 (211-315.25)	241 (223.75-288.75)	.678		.306
Neutrophils (×10⁹/L)	4.45 (3.4-5.6)	5.1 (4-6.22)	5.85 (4.7-7.54)	<.001	.003^a <.001^b .120^c	<.001	.001^a <.001^b .014^c
Lymphocytes (×10⁹/L)	1.9 (1.5-2.4)	1.8 (1.4-2.6)	2.1 (1.52-3.12)	.850		.392
Monocytes (×10⁹/L)	0.5 (0.4-0.6)	0.6 (0.47-0.8)	0.77 (0.6-0.92)	<.001	.002^a <.001^b .005^c	<.001	.003^a <.001^b <.001^c
Eosinophils (×10⁹/L)	0.14 (0.1-0.2)	0.14 (0.1-0.2)	0.1 (0.04-0.27)	.077		.076
Basophils (×10⁹/L)	0.2 (0.1-0.3)	0.2 (0.1-0.3)	0.11 (0.1-0.22)	.062		.102
Inflammation-based scores
NLR	2.2 (1.71-2.93)	2.69 (2.02-3.61)	3.80 (1.92-4.37)	<.001	<.001^a .002^b .363^c	<.001	.005^a <.001^b .001^c
PLR	133.5 (100.71–178.33)	151.42 (104.95-183.01)	124.96 (112.68-172.38)	.508		.874
SII	558.26 (413.4-803.71)	727 (465.98-953.32)	859.55 (459.71-1355.20)	<.001	.006^a .021^b .747^c	<.001	.009^a .001^b .046^c
LMR	3.66 (2.98-4.6)	3.12 (2.42-4.5)	2.23 (1.82-3.47)	<.001	.010^a <.001^b .007^c	<.001	.096^a <.001^b <.001^c
PNI Unknown	52 (48-56.5) n = 68	51.25 (47-56) n = 56	53 (51.5-55.25) n = 5	.325		.921
NPS 0/1/2 (%)	197/17/1 (91.6%/7.9%/0.5%)	126/11/1 (91.3%/8%/0.7%)	16/5/1 (72.7%/22.7%/4.5%)	.044

	NFAT (n = 215)	CPA-MACS (n = 138)	CPA-CS (n = 22)	P value (Kruskal–Wallis)	P value (group comparison)	P value (Quade test)	P value (group comparison)
FBC values
Leucocytes (×10⁹/L)	7.4 (5.9-8.6)	7.6 (6.69-9.5)	8.65 (7.17-10.32)	<.001	.023^a .002^b .128^c	<.001	.005^a .001^b .058^c
Platelets (×10⁹/L)	261 (208-303)	271 (211-315.25)	241 (223.75-288.75)	.678		.306
Neutrophils (×10⁹/L)	4.45 (3.4-5.6)	5.1 (4-6.22)	5.85 (4.7-7.54)	<.001	.003^a <.001^b .120^c	<.001	.001^a <.001^b .014^c
Lymphocytes (×10⁹/L)	1.9 (1.5-2.4)	1.8 (1.4-2.6)	2.1 (1.52-3.12)	.850		.392
Monocytes (×10⁹/L)	0.5 (0.4-0.6)	0.6 (0.47-0.8)	0.77 (0.6-0.92)	<.001	.002^a <.001^b .005^c	<.001	.003^a <.001^b <.001^c
Eosinophils (×10⁹/L)	0.14 (0.1-0.2)	0.14 (0.1-0.2)	0.1 (0.04-0.27)	.077		.076
Basophils (×10⁹/L)	0.2 (0.1-0.3)	0.2 (0.1-0.3)	0.11 (0.1-0.22)	.062		.102
Inflammation-based scores
NLR	2.2 (1.71-2.93)	2.69 (2.02-3.61)	3.80 (1.92-4.37)	<.001	<.001^a .002^b .363^c	<.001	.005^a <.001^b .001^c
PLR	133.5 (100.71–178.33)	151.42 (104.95-183.01)	124.96 (112.68-172.38)	.508		.874
SII	558.26 (413.4-803.71)	727 (465.98-953.32)	859.55 (459.71-1355.20)	<.001	.006^a .021^b .747^c	<.001	.009^a .001^b .046^c
LMR	3.66 (2.98-4.6)	3.12 (2.42-4.5)	2.23 (1.82-3.47)	<.001	.010^a <.001^b .007^c	<.001	.096^a <.001^b <.001^c
PNI Unknown	52 (48-56.5) n = 68	51.25 (47-56) n = 56	53 (51.5-55.25) n = 5	.325		.921
NPS 0/1/2 (%)	197/17/1 (91.6%/7.9%/0.5%)	126/11/1 (91.3%/8%/0.7%)	16/5/1 (72.7%/22.7%/4.5%)	.044

Categorical variables are reported as n (%), and statistical comparison was performed by χ² test. Continuous variables are reported as median (IQR), and statistical analyses were performed by the Kruskal–Wallis test followed by Dunn's post hoc test. Dunn’s post hoc test P values are shown in the table only if the Kruskal–Wallis was significant. For continuous variables, the Quade non-parametric analysis of covariance has been used to adjust for age and BMI, and P values of ANCOVA pairwise comparison are shown in the table only if the Quade test was significant. Bold: significant P values.

Abbreviations: CPA-CS, cortisol-producing adenoma with overt Cushing's syndrome; CPA-MACS, cortisol-producing adenoma with mild autonomous cortisol secretion; FBC, full blood count; LMR, lymphocyte-to-monocyte ratio; NFAT, non-functioning adrenal tumour; NLR, neutrophil-to-lymphocyte ratio; NPS, neutrophil-to-platelet score; PLR, platelet-to-lymphocyte ratio; PNI, prognostic nutrition index; SII, systemic immune-inflammation index.

^aNFAT vs MACS.

^bNFAT vs CS.

^cMACS vs CS.

This Feature Is Available To Subscribers Only