Comparable bone metabolism in participants with an unremarkable vitamin D metabolite profile, regardless of the 25(OH)D concentration.
| Parameter . | 25(OH)D ≥20 ng/mL . | Individuals with an unremarkable vitamin D metabolite profile . | Individuals with 25(OH)D <20 ng/mL and an unremarkable vitamin D metabolite profile . | P-valuea . | P-valueb . | P-valuec . |
|---|---|---|---|---|---|---|
| DESIRE | ||||||
| No. | 1527 | 1611 | 153 | |||
| PTH, median (IQR), ng/L | 27.0 (20.9–33.7) | 26.8 (20.7–33.8) | 26.2 (20.2–34.6) | 0.906 | 0.707 | 0.876 |
| PINP, median (IQR), µg/L | 47.4 (36.3–62.3) | 47.4 (36.4–62.1) | 47.8 (38.7–63.4) | 0.765 | 0.926 | 0.975 |
| CTX, median (IQR), µg/L | 0.21 (0.15–0.30) | 0.21 (0.15–0.29) | 0.22 (0.16–0.28) | 0.936 | 0.783 | 0.728 |
| LURIC | ||||||
| No. | 755 | 925 | 251 | |||
| PTH, median (IQR), ng/L | 26.0 (20.0–34.0) | 26.0 (20.0–34.0) | 27.0 (20.5–36.0) | 0.153 | 0.950 | 0.165 |
| OCN, median (IQR), µg/L | 18.1 (13.8–22.9) | 17.9 (13.6–22.8) | 16.7 (12.9–22.9) | 0.042 | 0.231 | 0.213 |
| CTX, median (IQR), µg/L | 0.30 (0.22–0.43) | 0.29 (0.21–0.42) | 0.28 (0.19–0.40) | 0.048 | 0.319 | 0.181 |
| Parameter . | 25(OH)D ≥20 ng/mL . | Individuals with an unremarkable vitamin D metabolite profile . | Individuals with 25(OH)D <20 ng/mL and an unremarkable vitamin D metabolite profile . | P-valuea . | P-valueb . | P-valuec . |
|---|---|---|---|---|---|---|
| DESIRE | ||||||
| No. | 1527 | 1611 | 153 | |||
| PTH, median (IQR), ng/L | 27.0 (20.9–33.7) | 26.8 (20.7–33.8) | 26.2 (20.2–34.6) | 0.906 | 0.707 | 0.876 |
| PINP, median (IQR), µg/L | 47.4 (36.3–62.3) | 47.4 (36.4–62.1) | 47.8 (38.7–63.4) | 0.765 | 0.926 | 0.975 |
| CTX, median (IQR), µg/L | 0.21 (0.15–0.30) | 0.21 (0.15–0.29) | 0.22 (0.16–0.28) | 0.936 | 0.783 | 0.728 |
| LURIC | ||||||
| No. | 755 | 925 | 251 | |||
| PTH, median (IQR), ng/L | 26.0 (20.0–34.0) | 26.0 (20.0–34.0) | 27.0 (20.5–36.0) | 0.153 | 0.950 | 0.165 |
| OCN, median (IQR), µg/L | 18.1 (13.8–22.9) | 17.9 (13.6–22.8) | 16.7 (12.9–22.9) | 0.042 | 0.231 | 0.213 |
| CTX, median (IQR), µg/L | 0.30 (0.22–0.43) | 0.29 (0.21–0.42) | 0.28 (0.19–0.40) | 0.048 | 0.319 | 0.181 |
For both cohorts, median (IQR) concentrations are shown for all individuals with 25(OH)D concentrations ≥20 ng/mL, individuals with an unremarkable vitamin D metabolite profile, and those with 25(OH)D concentrations <20 ng/mL, but an unremarkable vitamin D metabolite profile.
a25(OH)D ≥ 20 ng/mL vs 25(OH)D < 20 ng/mL, but without low vitamin D metabolite profile.
b25(OH)D ≥ 20 ng/mL vs all individuals without low vitamin D metabolite profile.
c25(OH)D < 20 ng/mL, but without low vitamin D metabolite profile vs all individuals without low vitamin D metabolite profile.
Comparable bone metabolism in participants with an unremarkable vitamin D metabolite profile, regardless of the 25(OH)D concentration.
| Parameter . | 25(OH)D ≥20 ng/mL . | Individuals with an unremarkable vitamin D metabolite profile . | Individuals with 25(OH)D <20 ng/mL and an unremarkable vitamin D metabolite profile . | P-valuea . | P-valueb . | P-valuec . |
|---|---|---|---|---|---|---|
| DESIRE | ||||||
| No. | 1527 | 1611 | 153 | |||
| PTH, median (IQR), ng/L | 27.0 (20.9–33.7) | 26.8 (20.7–33.8) | 26.2 (20.2–34.6) | 0.906 | 0.707 | 0.876 |
| PINP, median (IQR), µg/L | 47.4 (36.3–62.3) | 47.4 (36.4–62.1) | 47.8 (38.7–63.4) | 0.765 | 0.926 | 0.975 |
| CTX, median (IQR), µg/L | 0.21 (0.15–0.30) | 0.21 (0.15–0.29) | 0.22 (0.16–0.28) | 0.936 | 0.783 | 0.728 |
| LURIC | ||||||
| No. | 755 | 925 | 251 | |||
| PTH, median (IQR), ng/L | 26.0 (20.0–34.0) | 26.0 (20.0–34.0) | 27.0 (20.5–36.0) | 0.153 | 0.950 | 0.165 |
| OCN, median (IQR), µg/L | 18.1 (13.8–22.9) | 17.9 (13.6–22.8) | 16.7 (12.9–22.9) | 0.042 | 0.231 | 0.213 |
| CTX, median (IQR), µg/L | 0.30 (0.22–0.43) | 0.29 (0.21–0.42) | 0.28 (0.19–0.40) | 0.048 | 0.319 | 0.181 |
| Parameter . | 25(OH)D ≥20 ng/mL . | Individuals with an unremarkable vitamin D metabolite profile . | Individuals with 25(OH)D <20 ng/mL and an unremarkable vitamin D metabolite profile . | P-valuea . | P-valueb . | P-valuec . |
|---|---|---|---|---|---|---|
| DESIRE | ||||||
| No. | 1527 | 1611 | 153 | |||
| PTH, median (IQR), ng/L | 27.0 (20.9–33.7) | 26.8 (20.7–33.8) | 26.2 (20.2–34.6) | 0.906 | 0.707 | 0.876 |
| PINP, median (IQR), µg/L | 47.4 (36.3–62.3) | 47.4 (36.4–62.1) | 47.8 (38.7–63.4) | 0.765 | 0.926 | 0.975 |
| CTX, median (IQR), µg/L | 0.21 (0.15–0.30) | 0.21 (0.15–0.29) | 0.22 (0.16–0.28) | 0.936 | 0.783 | 0.728 |
| LURIC | ||||||
| No. | 755 | 925 | 251 | |||
| PTH, median (IQR), ng/L | 26.0 (20.0–34.0) | 26.0 (20.0–34.0) | 27.0 (20.5–36.0) | 0.153 | 0.950 | 0.165 |
| OCN, median (IQR), µg/L | 18.1 (13.8–22.9) | 17.9 (13.6–22.8) | 16.7 (12.9–22.9) | 0.042 | 0.231 | 0.213 |
| CTX, median (IQR), µg/L | 0.30 (0.22–0.43) | 0.29 (0.21–0.42) | 0.28 (0.19–0.40) | 0.048 | 0.319 | 0.181 |
For both cohorts, median (IQR) concentrations are shown for all individuals with 25(OH)D concentrations ≥20 ng/mL, individuals with an unremarkable vitamin D metabolite profile, and those with 25(OH)D concentrations <20 ng/mL, but an unremarkable vitamin D metabolite profile.
a25(OH)D ≥ 20 ng/mL vs 25(OH)D < 20 ng/mL, but without low vitamin D metabolite profile.
b25(OH)D ≥ 20 ng/mL vs all individuals without low vitamin D metabolite profile.
c25(OH)D < 20 ng/mL, but without low vitamin D metabolite profile vs all individuals without low vitamin D metabolite profile.
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