| Trait . | Exposure/Outcome/potential mediator . | Description of data source . | Name of consortium/cohort . | Ancestry . | Sample size . | No. SNVs . | Explained variance by lead SNPs . |
|---|---|---|---|---|---|---|---|
| EA | Exposure | Coding of EA variable in these data followed previous large-scale GWASs of EA. Previous GWAS excluded individuals aged <30 y when EA was measured, but this GWAS included individuals aged 16-29 y | 69 cohorts (excluding UKBB and 23andMe), 23andMe, and UKBB | European | 3 037 499 | 10 946 469 | 0.0102 |
| Hypothyroidism | Outcome | Hypothyroidism defined as self-reported history of hypothyroidism/myxedema | UKBB | European | 484 598 | 9 886 868 | 0.0327 |
| Hyperthyroidism | Outcome | Hyperthyroidism defined as self-reported history of hyperthyroidism/thyrotoxicosis | UKBB | European | 484 598 | 9 886 868 | 0.0089 |
| TSH | Outcome | HUNT study: patients with self-reported thyroid disease excluded MGI: individuals with any thyroid disorders excluded ThyroidOmics Consortium: individuals of non-European ancestry, use of thyroid medication, or previous thyroid surgery excluded | HUNT, MGI, and ThyroidOmics Consortium | European | 119 715 | 22 397 080 | 0.0900 |
| FT4 | Outcome | Individuals of non-European ancestry, use of thyroid medication, or previous thyroid surgery were excluded, and FT4 levels were within reference range | ThyroidOmics Consortium | European | 72 167 | 7 963 150 | 0.0264 |
| Smoking | Potential mediator | GWAS data for smoking defined as ever smoker (whether one has ever been a smoker) | – | European | 518 633 | 11 514 654 | 0.0138 |
| Trait . | Exposure/Outcome/potential mediator . | Description of data source . | Name of consortium/cohort . | Ancestry . | Sample size . | No. SNVs . | Explained variance by lead SNPs . |
|---|---|---|---|---|---|---|---|
| EA | Exposure | Coding of EA variable in these data followed previous large-scale GWASs of EA. Previous GWAS excluded individuals aged <30 y when EA was measured, but this GWAS included individuals aged 16-29 y | 69 cohorts (excluding UKBB and 23andMe), 23andMe, and UKBB | European | 3 037 499 | 10 946 469 | 0.0102 |
| Hypothyroidism | Outcome | Hypothyroidism defined as self-reported history of hypothyroidism/myxedema | UKBB | European | 484 598 | 9 886 868 | 0.0327 |
| Hyperthyroidism | Outcome | Hyperthyroidism defined as self-reported history of hyperthyroidism/thyrotoxicosis | UKBB | European | 484 598 | 9 886 868 | 0.0089 |
| TSH | Outcome | HUNT study: patients with self-reported thyroid disease excluded MGI: individuals with any thyroid disorders excluded ThyroidOmics Consortium: individuals of non-European ancestry, use of thyroid medication, or previous thyroid surgery excluded | HUNT, MGI, and ThyroidOmics Consortium | European | 119 715 | 22 397 080 | 0.0900 |
| FT4 | Outcome | Individuals of non-European ancestry, use of thyroid medication, or previous thyroid surgery were excluded, and FT4 levels were within reference range | ThyroidOmics Consortium | European | 72 167 | 7 963 150 | 0.0264 |
| Smoking | Potential mediator | GWAS data for smoking defined as ever smoker (whether one has ever been a smoker) | – | European | 518 633 | 11 514 654 | 0.0138 |
Abbreviations: EA, educational attainment; FT4, free thyroxine; GWAS, genome-wide association study; HUNT, Nord-Trøndelag Health Study; MGI, Michigan Genomics Initiative; SNV, single-nucleotide variation; TSH, thyrotropin; UKBB, UK Biobank.
| Trait . | Exposure/Outcome/potential mediator . | Description of data source . | Name of consortium/cohort . | Ancestry . | Sample size . | No. SNVs . | Explained variance by lead SNPs . |
|---|---|---|---|---|---|---|---|
| EA | Exposure | Coding of EA variable in these data followed previous large-scale GWASs of EA. Previous GWAS excluded individuals aged <30 y when EA was measured, but this GWAS included individuals aged 16-29 y | 69 cohorts (excluding UKBB and 23andMe), 23andMe, and UKBB | European | 3 037 499 | 10 946 469 | 0.0102 |
| Hypothyroidism | Outcome | Hypothyroidism defined as self-reported history of hypothyroidism/myxedema | UKBB | European | 484 598 | 9 886 868 | 0.0327 |
| Hyperthyroidism | Outcome | Hyperthyroidism defined as self-reported history of hyperthyroidism/thyrotoxicosis | UKBB | European | 484 598 | 9 886 868 | 0.0089 |
| TSH | Outcome | HUNT study: patients with self-reported thyroid disease excluded MGI: individuals with any thyroid disorders excluded ThyroidOmics Consortium: individuals of non-European ancestry, use of thyroid medication, or previous thyroid surgery excluded | HUNT, MGI, and ThyroidOmics Consortium | European | 119 715 | 22 397 080 | 0.0900 |
| FT4 | Outcome | Individuals of non-European ancestry, use of thyroid medication, or previous thyroid surgery were excluded, and FT4 levels were within reference range | ThyroidOmics Consortium | European | 72 167 | 7 963 150 | 0.0264 |
| Smoking | Potential mediator | GWAS data for smoking defined as ever smoker (whether one has ever been a smoker) | – | European | 518 633 | 11 514 654 | 0.0138 |
| Trait . | Exposure/Outcome/potential mediator . | Description of data source . | Name of consortium/cohort . | Ancestry . | Sample size . | No. SNVs . | Explained variance by lead SNPs . |
|---|---|---|---|---|---|---|---|
| EA | Exposure | Coding of EA variable in these data followed previous large-scale GWASs of EA. Previous GWAS excluded individuals aged <30 y when EA was measured, but this GWAS included individuals aged 16-29 y | 69 cohorts (excluding UKBB and 23andMe), 23andMe, and UKBB | European | 3 037 499 | 10 946 469 | 0.0102 |
| Hypothyroidism | Outcome | Hypothyroidism defined as self-reported history of hypothyroidism/myxedema | UKBB | European | 484 598 | 9 886 868 | 0.0327 |
| Hyperthyroidism | Outcome | Hyperthyroidism defined as self-reported history of hyperthyroidism/thyrotoxicosis | UKBB | European | 484 598 | 9 886 868 | 0.0089 |
| TSH | Outcome | HUNT study: patients with self-reported thyroid disease excluded MGI: individuals with any thyroid disorders excluded ThyroidOmics Consortium: individuals of non-European ancestry, use of thyroid medication, or previous thyroid surgery excluded | HUNT, MGI, and ThyroidOmics Consortium | European | 119 715 | 22 397 080 | 0.0900 |
| FT4 | Outcome | Individuals of non-European ancestry, use of thyroid medication, or previous thyroid surgery were excluded, and FT4 levels were within reference range | ThyroidOmics Consortium | European | 72 167 | 7 963 150 | 0.0264 |
| Smoking | Potential mediator | GWAS data for smoking defined as ever smoker (whether one has ever been a smoker) | – | European | 518 633 | 11 514 654 | 0.0138 |
Abbreviations: EA, educational attainment; FT4, free thyroxine; GWAS, genome-wide association study; HUNT, Nord-Trøndelag Health Study; MGI, Michigan Genomics Initiative; SNV, single-nucleotide variation; TSH, thyrotropin; UKBB, UK Biobank.
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