| . | Overall derivation . | Train (derivation) . | Test (internal validation) . | APACE (external validation) . |
|---|---|---|---|---|
| . | N = 4075 . | N = 3260 . | N = 815 . | N = 3609 . |
| Age (years) | 56.0 (44.0–68.0) | 55.0 (44.0–68.0) | 57.0 (44.0–69.0) | 54.0 (44.0–66.0) |
| Sex (women) | 1913 (46.9%) | 1546 (47.4%) | 367 (45.0%) | 1287 (35.6%) |
| Hypertension | 1633 (40.1%) | 1298 (39.8%) | 335 (41.1%) | 1699 (47.1%) |
| Hypercholesterolaemia | 1723 (42.3%) | 1362 (41.8%) | 361 (44.3%) | 1395 (38.6%) |
| Diabetes mellitus | 555 (13.6%) | 432 (13.3%) | 123 (15.1%) | 423 (11.7%) |
| Current smokers | 1045 (25.7%) | 829 (25.4%) | 216 (26.5%) | 1041 (28.8%) |
| Previous myocardial infraction | 466 (11.4%) | 367 (11.3%) | 99 (12.1%) | 595 (16.5%) |
| Previous revascularization | 442 (10.8%) | 350 (10.7%) | 92 (11.3%) | 744 (20.6%) |
| Previous stroke | 129 (3.17%) | 104 (3.19%) | 25 (3.07%) | 117 (3.24%) |
| Effort-related chest pain | 455 (11.2%) | 369 (11.3%) | 86 (10.6%) | 196 (33.1%) |
| Recurrent chest pain | 272 (6.67%) | 218 (6.6%) | 54 (6.63%) | 144 (3.99%) |
| hs-cTnT (ng/L) | 5.60 (4.90–8.40) | 5.60 (4.90–8.40) | 5.60 (4.90–8.40) | 5.0 (4.9–8.0) |
| Time from chest pain onset (min) | 270 (162–652) | 270 (160–645) | 272 (171–660) | 330.0 (120.0–1116.0) |
| Early presenters (≤180 min) | 1835 (33.4%) | 1111 (34.5%) | 274 (33.6%) | 1333 (36.9%) |
| Presentation systolic blood pressure (mmHg) | 138 (124–152) | 137 (124–151) | 140 (125–152) | 139.0 (126.0–154.0) |
| Presentation diastolic blood pressure (mmHg) | 80.0 (70.0–89.0) | 80.0 (71.0–89.0) | 80.0 (70.0–89.0) | 82.0 (73.0–91.0) |
| Admission heart rate (beats/min) | 78.0 (68.0–90.0) | 78.0 (68.0–90.0) | 76.0 (66.0–88.0) | 76.0 (66.0–88.0) |
| ST-segment depression >0.5 mm | 143 (3.51%) | 111 (3.40%) | 32 (3.93%) | 105 (2.90%) |
| T-wave inversion >1 mm | 264 (6.48%) | 210 (6.44%) | 54 (6.63%) | 260 (7.20%) |
| Admission atrial fibrillation | 158 (3.88%) | 124 (3.80%) | 34 (4.17%) | 71 (1.97%) |
| Left bundle branch block | 62 (1.52%) | 54 (1.66%) | 8 (0.98%) | 64 (1.77%) |
| Creatinine (mg/dL) | 0.83 (0.71–0.96) | 0.83 (0.71–0.96) | 0.83 (0.71–0.96) | 0.8 (0.7–1.0) |
| Haemoglobin (g/dL) | 14.2 (13.2–15.2) | 14.2 (13.2–15.2) | 14.1 (13.1–15.1) | 14.5 (13.5–15.4) |
| Death or myocardial infarction (90 days) | 105 (2.6%) | 84 (2.6%) | 21 (2.6%) | 98 (2.7%) |
| Death (90 days) | 10 (0.2%) | 9 (0.2%) | 1 (0.1%) | 13 (0.3%) |
| Myocardial infarction (90 days) | 96 (2.4%) | 76 (2.3%) | 20 (2.4%) | 85 (2.4%) |
| . | Overall derivation . | Train (derivation) . | Test (internal validation) . | APACE (external validation) . |
|---|---|---|---|---|
| . | N = 4075 . | N = 3260 . | N = 815 . | N = 3609 . |
| Age (years) | 56.0 (44.0–68.0) | 55.0 (44.0–68.0) | 57.0 (44.0–69.0) | 54.0 (44.0–66.0) |
| Sex (women) | 1913 (46.9%) | 1546 (47.4%) | 367 (45.0%) | 1287 (35.6%) |
| Hypertension | 1633 (40.1%) | 1298 (39.8%) | 335 (41.1%) | 1699 (47.1%) |
| Hypercholesterolaemia | 1723 (42.3%) | 1362 (41.8%) | 361 (44.3%) | 1395 (38.6%) |
| Diabetes mellitus | 555 (13.6%) | 432 (13.3%) | 123 (15.1%) | 423 (11.7%) |
| Current smokers | 1045 (25.7%) | 829 (25.4%) | 216 (26.5%) | 1041 (28.8%) |
| Previous myocardial infraction | 466 (11.4%) | 367 (11.3%) | 99 (12.1%) | 595 (16.5%) |
| Previous revascularization | 442 (10.8%) | 350 (10.7%) | 92 (11.3%) | 744 (20.6%) |
| Previous stroke | 129 (3.17%) | 104 (3.19%) | 25 (3.07%) | 117 (3.24%) |
| Effort-related chest pain | 455 (11.2%) | 369 (11.3%) | 86 (10.6%) | 196 (33.1%) |
| Recurrent chest pain | 272 (6.67%) | 218 (6.6%) | 54 (6.63%) | 144 (3.99%) |
| hs-cTnT (ng/L) | 5.60 (4.90–8.40) | 5.60 (4.90–8.40) | 5.60 (4.90–8.40) | 5.0 (4.9–8.0) |
| Time from chest pain onset (min) | 270 (162–652) | 270 (160–645) | 272 (171–660) | 330.0 (120.0–1116.0) |
| Early presenters (≤180 min) | 1835 (33.4%) | 1111 (34.5%) | 274 (33.6%) | 1333 (36.9%) |
| Presentation systolic blood pressure (mmHg) | 138 (124–152) | 137 (124–151) | 140 (125–152) | 139.0 (126.0–154.0) |
| Presentation diastolic blood pressure (mmHg) | 80.0 (70.0–89.0) | 80.0 (71.0–89.0) | 80.0 (70.0–89.0) | 82.0 (73.0–91.0) |
| Admission heart rate (beats/min) | 78.0 (68.0–90.0) | 78.0 (68.0–90.0) | 76.0 (66.0–88.0) | 76.0 (66.0–88.0) |
| ST-segment depression >0.5 mm | 143 (3.51%) | 111 (3.40%) | 32 (3.93%) | 105 (2.90%) |
| T-wave inversion >1 mm | 264 (6.48%) | 210 (6.44%) | 54 (6.63%) | 260 (7.20%) |
| Admission atrial fibrillation | 158 (3.88%) | 124 (3.80%) | 34 (4.17%) | 71 (1.97%) |
| Left bundle branch block | 62 (1.52%) | 54 (1.66%) | 8 (0.98%) | 64 (1.77%) |
| Creatinine (mg/dL) | 0.83 (0.71–0.96) | 0.83 (0.71–0.96) | 0.83 (0.71–0.96) | 0.8 (0.7–1.0) |
| Haemoglobin (g/dL) | 14.2 (13.2–15.2) | 14.2 (13.2–15.2) | 14.1 (13.1–15.1) | 14.5 (13.5–15.4) |
| Death or myocardial infarction (90 days) | 105 (2.6%) | 84 (2.6%) | 21 (2.6%) | 98 (2.7%) |
| Death (90 days) | 10 (0.2%) | 9 (0.2%) | 1 (0.1%) | 13 (0.3%) |
| Myocardial infarction (90 days) | 96 (2.4%) | 76 (2.3%) | 20 (2.4%) | 85 (2.4%) |
hs-cTnT, high-sensitivity cardiac troponin T.
| . | Overall derivation . | Train (derivation) . | Test (internal validation) . | APACE (external validation) . |
|---|---|---|---|---|
| . | N = 4075 . | N = 3260 . | N = 815 . | N = 3609 . |
| Age (years) | 56.0 (44.0–68.0) | 55.0 (44.0–68.0) | 57.0 (44.0–69.0) | 54.0 (44.0–66.0) |
| Sex (women) | 1913 (46.9%) | 1546 (47.4%) | 367 (45.0%) | 1287 (35.6%) |
| Hypertension | 1633 (40.1%) | 1298 (39.8%) | 335 (41.1%) | 1699 (47.1%) |
| Hypercholesterolaemia | 1723 (42.3%) | 1362 (41.8%) | 361 (44.3%) | 1395 (38.6%) |
| Diabetes mellitus | 555 (13.6%) | 432 (13.3%) | 123 (15.1%) | 423 (11.7%) |
| Current smokers | 1045 (25.7%) | 829 (25.4%) | 216 (26.5%) | 1041 (28.8%) |
| Previous myocardial infraction | 466 (11.4%) | 367 (11.3%) | 99 (12.1%) | 595 (16.5%) |
| Previous revascularization | 442 (10.8%) | 350 (10.7%) | 92 (11.3%) | 744 (20.6%) |
| Previous stroke | 129 (3.17%) | 104 (3.19%) | 25 (3.07%) | 117 (3.24%) |
| Effort-related chest pain | 455 (11.2%) | 369 (11.3%) | 86 (10.6%) | 196 (33.1%) |
| Recurrent chest pain | 272 (6.67%) | 218 (6.6%) | 54 (6.63%) | 144 (3.99%) |
| hs-cTnT (ng/L) | 5.60 (4.90–8.40) | 5.60 (4.90–8.40) | 5.60 (4.90–8.40) | 5.0 (4.9–8.0) |
| Time from chest pain onset (min) | 270 (162–652) | 270 (160–645) | 272 (171–660) | 330.0 (120.0–1116.0) |
| Early presenters (≤180 min) | 1835 (33.4%) | 1111 (34.5%) | 274 (33.6%) | 1333 (36.9%) |
| Presentation systolic blood pressure (mmHg) | 138 (124–152) | 137 (124–151) | 140 (125–152) | 139.0 (126.0–154.0) |
| Presentation diastolic blood pressure (mmHg) | 80.0 (70.0–89.0) | 80.0 (71.0–89.0) | 80.0 (70.0–89.0) | 82.0 (73.0–91.0) |
| Admission heart rate (beats/min) | 78.0 (68.0–90.0) | 78.0 (68.0–90.0) | 76.0 (66.0–88.0) | 76.0 (66.0–88.0) |
| ST-segment depression >0.5 mm | 143 (3.51%) | 111 (3.40%) | 32 (3.93%) | 105 (2.90%) |
| T-wave inversion >1 mm | 264 (6.48%) | 210 (6.44%) | 54 (6.63%) | 260 (7.20%) |
| Admission atrial fibrillation | 158 (3.88%) | 124 (3.80%) | 34 (4.17%) | 71 (1.97%) |
| Left bundle branch block | 62 (1.52%) | 54 (1.66%) | 8 (0.98%) | 64 (1.77%) |
| Creatinine (mg/dL) | 0.83 (0.71–0.96) | 0.83 (0.71–0.96) | 0.83 (0.71–0.96) | 0.8 (0.7–1.0) |
| Haemoglobin (g/dL) | 14.2 (13.2–15.2) | 14.2 (13.2–15.2) | 14.1 (13.1–15.1) | 14.5 (13.5–15.4) |
| Death or myocardial infarction (90 days) | 105 (2.6%) | 84 (2.6%) | 21 (2.6%) | 98 (2.7%) |
| Death (90 days) | 10 (0.2%) | 9 (0.2%) | 1 (0.1%) | 13 (0.3%) |
| Myocardial infarction (90 days) | 96 (2.4%) | 76 (2.3%) | 20 (2.4%) | 85 (2.4%) |
| . | Overall derivation . | Train (derivation) . | Test (internal validation) . | APACE (external validation) . |
|---|---|---|---|---|
| . | N = 4075 . | N = 3260 . | N = 815 . | N = 3609 . |
| Age (years) | 56.0 (44.0–68.0) | 55.0 (44.0–68.0) | 57.0 (44.0–69.0) | 54.0 (44.0–66.0) |
| Sex (women) | 1913 (46.9%) | 1546 (47.4%) | 367 (45.0%) | 1287 (35.6%) |
| Hypertension | 1633 (40.1%) | 1298 (39.8%) | 335 (41.1%) | 1699 (47.1%) |
| Hypercholesterolaemia | 1723 (42.3%) | 1362 (41.8%) | 361 (44.3%) | 1395 (38.6%) |
| Diabetes mellitus | 555 (13.6%) | 432 (13.3%) | 123 (15.1%) | 423 (11.7%) |
| Current smokers | 1045 (25.7%) | 829 (25.4%) | 216 (26.5%) | 1041 (28.8%) |
| Previous myocardial infraction | 466 (11.4%) | 367 (11.3%) | 99 (12.1%) | 595 (16.5%) |
| Previous revascularization | 442 (10.8%) | 350 (10.7%) | 92 (11.3%) | 744 (20.6%) |
| Previous stroke | 129 (3.17%) | 104 (3.19%) | 25 (3.07%) | 117 (3.24%) |
| Effort-related chest pain | 455 (11.2%) | 369 (11.3%) | 86 (10.6%) | 196 (33.1%) |
| Recurrent chest pain | 272 (6.67%) | 218 (6.6%) | 54 (6.63%) | 144 (3.99%) |
| hs-cTnT (ng/L) | 5.60 (4.90–8.40) | 5.60 (4.90–8.40) | 5.60 (4.90–8.40) | 5.0 (4.9–8.0) |
| Time from chest pain onset (min) | 270 (162–652) | 270 (160–645) | 272 (171–660) | 330.0 (120.0–1116.0) |
| Early presenters (≤180 min) | 1835 (33.4%) | 1111 (34.5%) | 274 (33.6%) | 1333 (36.9%) |
| Presentation systolic blood pressure (mmHg) | 138 (124–152) | 137 (124–151) | 140 (125–152) | 139.0 (126.0–154.0) |
| Presentation diastolic blood pressure (mmHg) | 80.0 (70.0–89.0) | 80.0 (71.0–89.0) | 80.0 (70.0–89.0) | 82.0 (73.0–91.0) |
| Admission heart rate (beats/min) | 78.0 (68.0–90.0) | 78.0 (68.0–90.0) | 76.0 (66.0–88.0) | 76.0 (66.0–88.0) |
| ST-segment depression >0.5 mm | 143 (3.51%) | 111 (3.40%) | 32 (3.93%) | 105 (2.90%) |
| T-wave inversion >1 mm | 264 (6.48%) | 210 (6.44%) | 54 (6.63%) | 260 (7.20%) |
| Admission atrial fibrillation | 158 (3.88%) | 124 (3.80%) | 34 (4.17%) | 71 (1.97%) |
| Left bundle branch block | 62 (1.52%) | 54 (1.66%) | 8 (0.98%) | 64 (1.77%) |
| Creatinine (mg/dL) | 0.83 (0.71–0.96) | 0.83 (0.71–0.96) | 0.83 (0.71–0.96) | 0.8 (0.7–1.0) |
| Haemoglobin (g/dL) | 14.2 (13.2–15.2) | 14.2 (13.2–15.2) | 14.1 (13.1–15.1) | 14.5 (13.5–15.4) |
| Death or myocardial infarction (90 days) | 105 (2.6%) | 84 (2.6%) | 21 (2.6%) | 98 (2.7%) |
| Death (90 days) | 10 (0.2%) | 9 (0.2%) | 1 (0.1%) | 13 (0.3%) |
| Myocardial infarction (90 days) | 96 (2.4%) | 76 (2.3%) | 20 (2.4%) | 85 (2.4%) |
hs-cTnT, high-sensitivity cardiac troponin T.
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