Clinical outcomes at 30 days and 1- and 2-years for myocardial infarction patients with premature or non-premature coronary artery disease
| . | Premature coronary artery disease . | . | . | . | . | |
|---|---|---|---|---|---|---|
| Variable . | Yes (n = 582) . | No (n = 2741) . | HR (95% CI) . | Plog-rank . | Adjusted HR (95% CI)c . | Plog-rank . |
| 30 days | ||||||
| Major adverse cardiac eventsa | 1 (0.2) | 43 (1.6) | 0.11 (0.02–0.79) | 0.008 | — | — |
| Target vessel failureb | 2 (0.3) | 42 (1.5) | 0.22 (0.05–0.92) | 0.023 | — | — |
| All-cause death | 0 | 12 (0.5) | — | — | — | — |
| Cardiac death | 0 | 9 (0.3) | — | — | — | — |
| Any myocardial infarction | 0 | 26 (1.0) | — | — | — | — |
| Target vessel–related myocardial infarction | 0 | 23 (0.8) | — | — | — | — |
| Target vessel revascularization | 2 (0.3) | 16 (0.6) | 0.59 (0.14–2.56) | 0.47 | — | — |
| Target lesion revascularization | 1 (0.2) | 11 (0.4) | 0.43 (0.06–3.31) | 0.40 | — | — |
| 1 year | ||||||
| Major adverse cardiac eventsa | 10 (1.7) | 107 (3.9) | 0.44 (0.23–0.83) | 0.010 | 0.50 (0.26–0.96) | 0.037 |
| Target vessel failureb | 11 (1.9) | 101 (3.7) | 0.51 (0.27–0.95) | 0.003 | 0.56 (0.30–1.05) | 0.07 |
| All-cause death | 2 (0.3) | 48 (1.8) | 0.20 (0.05–0.80) | 0.012 | 0.24 (0.06–0.98) | 0.046 |
| Cardiac death | 1 (0.2) | 27 (1.0) | 0.17 (0.02–1.28) | 0.051 | 0.22 (0.03–1.60) | 0.13 |
| Any myocardial infarction | 1 (0.2) | 31 (1.1) | 0.15 (0.02–1.11) | 0.031 | 0.17 (0.02–1.28) | 0.08 |
| Target vessel–related myocardial infarction | 1 (0.2) | 27 (1.0) | 0.17 (0.02–1.28) | 0.051 | 0.21 (0.03–1.54) | 0.12 |
| Target vessel revascularization | 11 (1.9) | 60 (2.2) | 0.86 (0.45–1.63) | 0.64 | 0.90 (0.47–1.73) | 0.76 |
| Target lesion revascularization | 9 (1.6) | 38 (1.4) | 1.10 (0.54–2.30) | 0.78 | 1.27 (0.61–2.66) | 0.53 |
| 2 years | ||||||
| Major adverse cardiac eventsa | 21 (3.6) | 164 (6.0) | 0.60 (0.38–0.94) | 0.024 | 0.72 (0.49–1.06) | 0.10 |
| Target vessel failureb | 21 (3.6) | 136 (5.0) | 0.72 (0.45–1.14) | 0.20 | 0.95 (0.64–1.41) | 0.81 |
| All-cause death | 3 (0.5) | 76 (2.8) | 0.19 (0.06–0.59) | <0.001 | 0.16 (0.05–0.50) | 0.002 |
| Cardiac death | 1 (0.2) | 33 (1.2) | 0.14 (0.02–1.04) | 0.025 | 0.13 (0.02–0.97) | 0.047 |
| Any myocardial infarction | 9 (1.6) | 53 (1.9) | 0.79 (0.39–1.60) | 0.51 | 1.03 (0.56–1.87) | 0.94 |
| Target vessel–related myocardial infarction | 6 (1.0) | 40 (1.5) | 0.70 (0.30–1.65) | 0.41 | 0.78 (0.35–1.74) | 0.55 |
| Target vessel revascularization | 20 (3.5) | 85 (3.2) | 1.10 (0.68–1.79) | 0.71 | 1.38 (0.90–2.10) | 0.14 |
| Target lesion revascularization | 15 (2.6) | 57 (2.1) | 1.23 (0.70–2.18) | 0.47 | 1.48 (0.90–2.46) | 0.12 |
| . | Premature coronary artery disease . | . | . | . | . | |
|---|---|---|---|---|---|---|
| Variable . | Yes (n = 582) . | No (n = 2741) . | HR (95% CI) . | Plog-rank . | Adjusted HR (95% CI)c . | Plog-rank . |
| 30 days | ||||||
| Major adverse cardiac eventsa | 1 (0.2) | 43 (1.6) | 0.11 (0.02–0.79) | 0.008 | — | — |
| Target vessel failureb | 2 (0.3) | 42 (1.5) | 0.22 (0.05–0.92) | 0.023 | — | — |
| All-cause death | 0 | 12 (0.5) | — | — | — | — |
| Cardiac death | 0 | 9 (0.3) | — | — | — | — |
| Any myocardial infarction | 0 | 26 (1.0) | — | — | — | — |
| Target vessel–related myocardial infarction | 0 | 23 (0.8) | — | — | — | — |
| Target vessel revascularization | 2 (0.3) | 16 (0.6) | 0.59 (0.14–2.56) | 0.47 | — | — |
| Target lesion revascularization | 1 (0.2) | 11 (0.4) | 0.43 (0.06–3.31) | 0.40 | — | — |
| 1 year | ||||||
| Major adverse cardiac eventsa | 10 (1.7) | 107 (3.9) | 0.44 (0.23–0.83) | 0.010 | 0.50 (0.26–0.96) | 0.037 |
| Target vessel failureb | 11 (1.9) | 101 (3.7) | 0.51 (0.27–0.95) | 0.003 | 0.56 (0.30–1.05) | 0.07 |
| All-cause death | 2 (0.3) | 48 (1.8) | 0.20 (0.05–0.80) | 0.012 | 0.24 (0.06–0.98) | 0.046 |
| Cardiac death | 1 (0.2) | 27 (1.0) | 0.17 (0.02–1.28) | 0.051 | 0.22 (0.03–1.60) | 0.13 |
| Any myocardial infarction | 1 (0.2) | 31 (1.1) | 0.15 (0.02–1.11) | 0.031 | 0.17 (0.02–1.28) | 0.08 |
| Target vessel–related myocardial infarction | 1 (0.2) | 27 (1.0) | 0.17 (0.02–1.28) | 0.051 | 0.21 (0.03–1.54) | 0.12 |
| Target vessel revascularization | 11 (1.9) | 60 (2.2) | 0.86 (0.45–1.63) | 0.64 | 0.90 (0.47–1.73) | 0.76 |
| Target lesion revascularization | 9 (1.6) | 38 (1.4) | 1.10 (0.54–2.30) | 0.78 | 1.27 (0.61–2.66) | 0.53 |
| 2 years | ||||||
| Major adverse cardiac eventsa | 21 (3.6) | 164 (6.0) | 0.60 (0.38–0.94) | 0.024 | 0.72 (0.49–1.06) | 0.10 |
| Target vessel failureb | 21 (3.6) | 136 (5.0) | 0.72 (0.45–1.14) | 0.20 | 0.95 (0.64–1.41) | 0.81 |
| All-cause death | 3 (0.5) | 76 (2.8) | 0.19 (0.06–0.59) | <0.001 | 0.16 (0.05–0.50) | 0.002 |
| Cardiac death | 1 (0.2) | 33 (1.2) | 0.14 (0.02–1.04) | 0.025 | 0.13 (0.02–0.97) | 0.047 |
| Any myocardial infarction | 9 (1.6) | 53 (1.9) | 0.79 (0.39–1.60) | 0.51 | 1.03 (0.56–1.87) | 0.94 |
| Target vessel–related myocardial infarction | 6 (1.0) | 40 (1.5) | 0.70 (0.30–1.65) | 0.41 | 0.78 (0.35–1.74) | 0.55 |
| Target vessel revascularization | 20 (3.5) | 85 (3.2) | 1.10 (0.68–1.79) | 0.71 | 1.38 (0.90–2.10) | 0.14 |
| Target lesion revascularization | 15 (2.6) | 57 (2.1) | 1.23 (0.70–2.18) | 0.47 | 1.48 (0.90–2.46) | 0.12 |
Data are n (%), unless otherwise indicated.
Italic values are statistically significant.
aMajor adverse cardiac events is a composite of all-cause death, any myocardial infarction, emergent coronary artery bypass surgery, and clinically indicated target lesion revascularization.
bTarget vessel failure is a composite of cardiac death, target vessel–related myocardial infarction, and clinically indicated target vessel revascularization.
cAt 30-days, no multivariable analysis was performed as the number of events was low.
Clinical outcomes at 30 days and 1- and 2-years for myocardial infarction patients with premature or non-premature coronary artery disease
| . | Premature coronary artery disease . | . | . | . | . | |
|---|---|---|---|---|---|---|
| Variable . | Yes (n = 582) . | No (n = 2741) . | HR (95% CI) . | Plog-rank . | Adjusted HR (95% CI)c . | Plog-rank . |
| 30 days | ||||||
| Major adverse cardiac eventsa | 1 (0.2) | 43 (1.6) | 0.11 (0.02–0.79) | 0.008 | — | — |
| Target vessel failureb | 2 (0.3) | 42 (1.5) | 0.22 (0.05–0.92) | 0.023 | — | — |
| All-cause death | 0 | 12 (0.5) | — | — | — | — |
| Cardiac death | 0 | 9 (0.3) | — | — | — | — |
| Any myocardial infarction | 0 | 26 (1.0) | — | — | — | — |
| Target vessel–related myocardial infarction | 0 | 23 (0.8) | — | — | — | — |
| Target vessel revascularization | 2 (0.3) | 16 (0.6) | 0.59 (0.14–2.56) | 0.47 | — | — |
| Target lesion revascularization | 1 (0.2) | 11 (0.4) | 0.43 (0.06–3.31) | 0.40 | — | — |
| 1 year | ||||||
| Major adverse cardiac eventsa | 10 (1.7) | 107 (3.9) | 0.44 (0.23–0.83) | 0.010 | 0.50 (0.26–0.96) | 0.037 |
| Target vessel failureb | 11 (1.9) | 101 (3.7) | 0.51 (0.27–0.95) | 0.003 | 0.56 (0.30–1.05) | 0.07 |
| All-cause death | 2 (0.3) | 48 (1.8) | 0.20 (0.05–0.80) | 0.012 | 0.24 (0.06–0.98) | 0.046 |
| Cardiac death | 1 (0.2) | 27 (1.0) | 0.17 (0.02–1.28) | 0.051 | 0.22 (0.03–1.60) | 0.13 |
| Any myocardial infarction | 1 (0.2) | 31 (1.1) | 0.15 (0.02–1.11) | 0.031 | 0.17 (0.02–1.28) | 0.08 |
| Target vessel–related myocardial infarction | 1 (0.2) | 27 (1.0) | 0.17 (0.02–1.28) | 0.051 | 0.21 (0.03–1.54) | 0.12 |
| Target vessel revascularization | 11 (1.9) | 60 (2.2) | 0.86 (0.45–1.63) | 0.64 | 0.90 (0.47–1.73) | 0.76 |
| Target lesion revascularization | 9 (1.6) | 38 (1.4) | 1.10 (0.54–2.30) | 0.78 | 1.27 (0.61–2.66) | 0.53 |
| 2 years | ||||||
| Major adverse cardiac eventsa | 21 (3.6) | 164 (6.0) | 0.60 (0.38–0.94) | 0.024 | 0.72 (0.49–1.06) | 0.10 |
| Target vessel failureb | 21 (3.6) | 136 (5.0) | 0.72 (0.45–1.14) | 0.20 | 0.95 (0.64–1.41) | 0.81 |
| All-cause death | 3 (0.5) | 76 (2.8) | 0.19 (0.06–0.59) | <0.001 | 0.16 (0.05–0.50) | 0.002 |
| Cardiac death | 1 (0.2) | 33 (1.2) | 0.14 (0.02–1.04) | 0.025 | 0.13 (0.02–0.97) | 0.047 |
| Any myocardial infarction | 9 (1.6) | 53 (1.9) | 0.79 (0.39–1.60) | 0.51 | 1.03 (0.56–1.87) | 0.94 |
| Target vessel–related myocardial infarction | 6 (1.0) | 40 (1.5) | 0.70 (0.30–1.65) | 0.41 | 0.78 (0.35–1.74) | 0.55 |
| Target vessel revascularization | 20 (3.5) | 85 (3.2) | 1.10 (0.68–1.79) | 0.71 | 1.38 (0.90–2.10) | 0.14 |
| Target lesion revascularization | 15 (2.6) | 57 (2.1) | 1.23 (0.70–2.18) | 0.47 | 1.48 (0.90–2.46) | 0.12 |
| . | Premature coronary artery disease . | . | . | . | . | |
|---|---|---|---|---|---|---|
| Variable . | Yes (n = 582) . | No (n = 2741) . | HR (95% CI) . | Plog-rank . | Adjusted HR (95% CI)c . | Plog-rank . |
| 30 days | ||||||
| Major adverse cardiac eventsa | 1 (0.2) | 43 (1.6) | 0.11 (0.02–0.79) | 0.008 | — | — |
| Target vessel failureb | 2 (0.3) | 42 (1.5) | 0.22 (0.05–0.92) | 0.023 | — | — |
| All-cause death | 0 | 12 (0.5) | — | — | — | — |
| Cardiac death | 0 | 9 (0.3) | — | — | — | — |
| Any myocardial infarction | 0 | 26 (1.0) | — | — | — | — |
| Target vessel–related myocardial infarction | 0 | 23 (0.8) | — | — | — | — |
| Target vessel revascularization | 2 (0.3) | 16 (0.6) | 0.59 (0.14–2.56) | 0.47 | — | — |
| Target lesion revascularization | 1 (0.2) | 11 (0.4) | 0.43 (0.06–3.31) | 0.40 | — | — |
| 1 year | ||||||
| Major adverse cardiac eventsa | 10 (1.7) | 107 (3.9) | 0.44 (0.23–0.83) | 0.010 | 0.50 (0.26–0.96) | 0.037 |
| Target vessel failureb | 11 (1.9) | 101 (3.7) | 0.51 (0.27–0.95) | 0.003 | 0.56 (0.30–1.05) | 0.07 |
| All-cause death | 2 (0.3) | 48 (1.8) | 0.20 (0.05–0.80) | 0.012 | 0.24 (0.06–0.98) | 0.046 |
| Cardiac death | 1 (0.2) | 27 (1.0) | 0.17 (0.02–1.28) | 0.051 | 0.22 (0.03–1.60) | 0.13 |
| Any myocardial infarction | 1 (0.2) | 31 (1.1) | 0.15 (0.02–1.11) | 0.031 | 0.17 (0.02–1.28) | 0.08 |
| Target vessel–related myocardial infarction | 1 (0.2) | 27 (1.0) | 0.17 (0.02–1.28) | 0.051 | 0.21 (0.03–1.54) | 0.12 |
| Target vessel revascularization | 11 (1.9) | 60 (2.2) | 0.86 (0.45–1.63) | 0.64 | 0.90 (0.47–1.73) | 0.76 |
| Target lesion revascularization | 9 (1.6) | 38 (1.4) | 1.10 (0.54–2.30) | 0.78 | 1.27 (0.61–2.66) | 0.53 |
| 2 years | ||||||
| Major adverse cardiac eventsa | 21 (3.6) | 164 (6.0) | 0.60 (0.38–0.94) | 0.024 | 0.72 (0.49–1.06) | 0.10 |
| Target vessel failureb | 21 (3.6) | 136 (5.0) | 0.72 (0.45–1.14) | 0.20 | 0.95 (0.64–1.41) | 0.81 |
| All-cause death | 3 (0.5) | 76 (2.8) | 0.19 (0.06–0.59) | <0.001 | 0.16 (0.05–0.50) | 0.002 |
| Cardiac death | 1 (0.2) | 33 (1.2) | 0.14 (0.02–1.04) | 0.025 | 0.13 (0.02–0.97) | 0.047 |
| Any myocardial infarction | 9 (1.6) | 53 (1.9) | 0.79 (0.39–1.60) | 0.51 | 1.03 (0.56–1.87) | 0.94 |
| Target vessel–related myocardial infarction | 6 (1.0) | 40 (1.5) | 0.70 (0.30–1.65) | 0.41 | 0.78 (0.35–1.74) | 0.55 |
| Target vessel revascularization | 20 (3.5) | 85 (3.2) | 1.10 (0.68–1.79) | 0.71 | 1.38 (0.90–2.10) | 0.14 |
| Target lesion revascularization | 15 (2.6) | 57 (2.1) | 1.23 (0.70–2.18) | 0.47 | 1.48 (0.90–2.46) | 0.12 |
Data are n (%), unless otherwise indicated.
Italic values are statistically significant.
aMajor adverse cardiac events is a composite of all-cause death, any myocardial infarction, emergent coronary artery bypass surgery, and clinically indicated target lesion revascularization.
bTarget vessel failure is a composite of cardiac death, target vessel–related myocardial infarction, and clinically indicated target vessel revascularization.
cAt 30-days, no multivariable analysis was performed as the number of events was low.
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