Table 1 Open in new tab Baseline and...

General characteristics	Premature coronary artery disease	P-value
Age (years)	45.3 ± 4.9	65.0 ± 9.0	<0.001
Women	177 (30.4)	746 (27.2)	0.12
Body mass index (kg/m²)	28.3 ± 4.8	27.3 ± 4.3	<0.001
Smoker	402/577 (69.7)	915/2685 (34.1)	<0.001
Medical history
Diabetes mellitus	55 (9.5)	398 (14.5)	0.001
Renal failure^a	6 (1.0)	85 (3.1)	0.005
Hypertension	152/581 (26.2)	1194/2727 (43.8)	<0.001
Hypercholesterolaemia	162/577 (28.2)	821/2713 (30.3)	0.34
Previous stroke	7 (1.2)	123 (4.5)	<0.001
PADs^b	8 (1.4)	137 (5.0)	<0.001
LVEF < 30%	1 (0.2)	10 (0.4)	0.46
Family history of coronary artery disease	321/573 (56.0)	1093/2664 (41.0)	<0.001
Clinical syndrome at presentation			<0.001
STEMI	358 (61.5)	1464 (53.4)
Non-STEMI	224 (38.5)	1277 (46.6)
Procedural characteristics
Multi-vessel treatment	58 (10.0)	464 (16.9)	<0.001
Target vessel
Left main	2 (0.3)	27 (1.0)	0.13
Right coronary artery	228 (39.2)	1068 (39.0)	0.92
Left anterior descending artery	277 (47.6)	1377 (50.2)	0.25
Left circumflex artery	135 (23.2)	784 (28.6)	0.008
Total stent length (mm)	32.6 ± 20.2	36.4 ± 24.3	0.001
Calcified lesion treatment	55 (9.5)	476 (17.4)	<0.001
Ostial lesion treatment	22 (3.8)	121 (4.4)	0.49
Bifurcated lesion treatment^c	152 (26.1)	916 (33.4)	0.001
Chronic total occlusion treatment	12 (2.1)	37 (1.9)	0.20

General characteristics

Premature coronary artery disease

P-value

Yes (n = 582)

No (n = 2741)

Age (years)

45.3 ± 4.9

65.0 ± 9.0

<0.001

Women

177 (30.4)

746 (27.2)

0.12

Body mass index (kg/m²)

28.3 ± 4.8

27.3 ± 4.3

<0.001

Smoker

402/577 (69.7)

915/2685 (34.1)

<0.001

Medical history

Diabetes mellitus

55 (9.5)

398 (14.5)

0.001

Renal failure^a

6 (1.0)

85 (3.1)

0.005

Hypertension

152/581 (26.2)

1194/2727 (43.8)

<0.001

Hypercholesterolaemia

162/577 (28.2)

821/2713 (30.3)

0.34

Previous stroke

7 (1.2)

123 (4.5)

<0.001

PADs^b

8 (1.4)

137 (5.0)

<0.001

LVEF < 30%

1 (0.2)

10 (0.4)

0.46

Family history of coronary artery disease

321/573 (56.0)

1093/2664 (41.0)

<0.001

Clinical syndrome at presentation

<0.001

STEMI

358 (61.5)

1464 (53.4)

Non-STEMI

224 (38.5)

1277 (46.6)

Procedural characteristics

Multi-vessel treatment

58 (10.0)

464 (16.9)

<0.001

Target vessel

Left main

2 (0.3)

27 (1.0)

0.13

Right coronary artery

228 (39.2)

1068 (39.0)

0.92

Left anterior descending artery

277 (47.6)

1377 (50.2)

0.25

Left circumflex artery

135 (23.2)

784 (28.6)

0.008

Total stent length (mm)

32.6 ± 20.2

36.4 ± 24.3

0.001

Calcified lesion treatment

55 (9.5)

476 (17.4)

<0.001

Ostial lesion treatment

22 (3.8)

121 (4.4)

0.49

Bifurcated lesion treatment^c

152 (26.1)

916 (33.4)

0.001

Chronic total occlusion treatment

12 (2.1)

37 (1.9)

0.20

General characteristics	Premature coronary artery disease	P-value
Age (years)	45.3 ± 4.9	65.0 ± 9.0	<0.001
Women	177 (30.4)	746 (27.2)	0.12
Body mass index (kg/m²)	28.3 ± 4.8	27.3 ± 4.3	<0.001
Smoker	402/577 (69.7)	915/2685 (34.1)	<0.001
Medical history
Diabetes mellitus	55 (9.5)	398 (14.5)	0.001
Renal failure^a	6 (1.0)	85 (3.1)	0.005
Hypertension	152/581 (26.2)	1194/2727 (43.8)	<0.001
Hypercholesterolaemia	162/577 (28.2)	821/2713 (30.3)	0.34
Previous stroke	7 (1.2)	123 (4.5)	<0.001
PADs^b	8 (1.4)	137 (5.0)	<0.001
LVEF < 30%	1 (0.2)	10 (0.4)	0.46
Family history of coronary artery disease	321/573 (56.0)	1093/2664 (41.0)	<0.001
Clinical syndrome at presentation			<0.001
STEMI	358 (61.5)	1464 (53.4)
Non-STEMI	224 (38.5)	1277 (46.6)
Procedural characteristics
Multi-vessel treatment	58 (10.0)	464 (16.9)	<0.001
Target vessel
Left main	2 (0.3)	27 (1.0)	0.13
Right coronary artery	228 (39.2)	1068 (39.0)	0.92
Left anterior descending artery	277 (47.6)	1377 (50.2)	0.25
Left circumflex artery	135 (23.2)	784 (28.6)	0.008
Total stent length (mm)	32.6 ± 20.2	36.4 ± 24.3	0.001
Calcified lesion treatment	55 (9.5)	476 (17.4)	<0.001
Ostial lesion treatment	22 (3.8)	121 (4.4)	0.49
Bifurcated lesion treatment^c	152 (26.1)	916 (33.4)	0.001
Chronic total occlusion treatment	12 (2.1)	37 (1.9)	0.20

Table 1

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Baseline and procedural characteristics for myocardial infarction patients with premature or non-premature coronary artery disease

General characteristics	Premature coronary artery disease		P-value
General characteristics	Yes (n = 582)	No (n = 2741)	P-value
Age (years)	45.3 ± 4.9	65.0 ± 9.0	<0.001
Women	177 (30.4)	746 (27.2)	0.12
Body mass index (kg/m²)	28.3 ± 4.8	27.3 ± 4.3	<0.001
Smoker	402/577 (69.7)	915/2685 (34.1)	<0.001
Medical history
Diabetes mellitus	55 (9.5)	398 (14.5)	0.001
Renal failure^a	6 (1.0)	85 (3.1)	0.005
Hypertension	152/581 (26.2)	1194/2727 (43.8)	<0.001
Hypercholesterolaemia	162/577 (28.2)	821/2713 (30.3)	0.34
Previous stroke	7 (1.2)	123 (4.5)	<0.001
PADs^b	8 (1.4)	137 (5.0)	<0.001
LVEF < 30%	1 (0.2)	10 (0.4)	0.46
Family history of coronary artery disease	321/573 (56.0)	1093/2664 (41.0)	<0.001
Clinical syndrome at presentation			<0.001
STEMI	358 (61.5)	1464 (53.4)
Non-STEMI	224 (38.5)	1277 (46.6)
Procedural characteristics
Multi-vessel treatment	58 (10.0)	464 (16.9)	<0.001
Target vessel
Left main	2 (0.3)	27 (1.0)	0.13
Right coronary artery	228 (39.2)	1068 (39.0)	0.92
Left anterior descending artery	277 (47.6)	1377 (50.2)	0.25
Left circumflex artery	135 (23.2)	784 (28.6)	0.008
Total stent length (mm)	32.6 ± 20.2	36.4 ± 24.3	0.001
Calcified lesion treatment	55 (9.5)	476 (17.4)	<0.001
Ostial lesion treatment	22 (3.8)	121 (4.4)	0.49
Bifurcated lesion treatment^c	152 (26.1)	916 (33.4)	0.001
Chronic total occlusion treatment	12 (2.1)	37 (1.9)	0.20

General characteristics	Premature coronary artery disease		P-value
General characteristics	Yes (n = 582)	No (n = 2741)	P-value
Age (years)	45.3 ± 4.9	65.0 ± 9.0	<0.001
Women	177 (30.4)	746 (27.2)	0.12
Body mass index (kg/m²)	28.3 ± 4.8	27.3 ± 4.3	<0.001
Smoker	402/577 (69.7)	915/2685 (34.1)	<0.001
Medical history
Diabetes mellitus	55 (9.5)	398 (14.5)	0.001
Renal failure^a	6 (1.0)	85 (3.1)	0.005
Hypertension	152/581 (26.2)	1194/2727 (43.8)	<0.001
Hypercholesterolaemia	162/577 (28.2)	821/2713 (30.3)	0.34
Previous stroke	7 (1.2)	123 (4.5)	<0.001
PADs^b	8 (1.4)	137 (5.0)	<0.001
LVEF < 30%	1 (0.2)	10 (0.4)	0.46
Family history of coronary artery disease	321/573 (56.0)	1093/2664 (41.0)	<0.001
Clinical syndrome at presentation			<0.001
STEMI	358 (61.5)	1464 (53.4)
Non-STEMI	224 (38.5)	1277 (46.6)
Procedural characteristics
Multi-vessel treatment	58 (10.0)	464 (16.9)	<0.001
Target vessel
Left main	2 (0.3)	27 (1.0)	0.13
Right coronary artery	228 (39.2)	1068 (39.0)	0.92
Left anterior descending artery	277 (47.6)	1377 (50.2)	0.25
Left circumflex artery	135 (23.2)	784 (28.6)	0.008
Total stent length (mm)	32.6 ± 20.2	36.4 ± 24.3	0.001
Calcified lesion treatment	55 (9.5)	476 (17.4)	<0.001
Ostial lesion treatment	22 (3.8)	121 (4.4)	0.49
Bifurcated lesion treatment^c	152 (26.1)	916 (33.4)	0.001
Chronic total occlusion treatment	12 (2.1)	37 (1.9)	0.20

Values are mean ± SD, n (%) or n/N (%). Procedures present patient-level data.

Italic values are statistically significant.

^aDefined as previous renal failure, creatinine ≥ 130 μmol/L, or the need for dialysis.

^bDefined as a history of symptomatic atherosclerotic lesion in the lower or upper extremities, atherosclerotic lesion in the aorta-causing symptoms or requiring treatment, atherosclerotic lesion in the carotid or vertebral arteries related to a non-embolic ischaemic cerebrovascular event, or symptomatic atherosclerotic lesion in a mesenteric artery.

^cTarget lesions were classified as bifurcated if a side branch ≥ 1.5 mm originated from them.

LVEF, left ventricle ejection fraction; non-STEMI, non–ST-segment elevation myocardial infarction; PADs, peripheral arterial disease; STEMI, ST-segment elevation myocardial infarction.

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