| Outcome . | Severe calcification (n = 875) . | Non-severe calcification (n = 6571) . | Hazard ratio (95% CI) . | P-value . | Adjusted hazard ratio (95%) . | P-value . |
|---|---|---|---|---|---|---|
| Primary composite endpoint of all-cause mortality, MI, or stroke | 237 (27.1) | 985 (15.0) | 1.91 (1.66–2.20) | <0.001 | 1.23 (1.06–1.44) | 0.008 |
| Composite endpoint of CV death, MI, stroke TVR, or ST | 230 (26.4) | 928 (14.2) | 1.97 (1.70–2.27) | <0.001 | 1.31 (1.11–1.53) | 0.001 |
| All-cause mortality | 75 (8.6) | 243 (3.7) | 2.38 (1.84–3.09) | <0.001 | 1.34 (1.01–1.77) | 0.039 |
| Cardiovascular death | 52 (6.0) | 154 (2.4) | 2.59 (1.89–3.55) | <0.001 | 1.48 (1.06–2.09) | 0.023 |
| MI | 171 (20.1) | 746 (11.5) | 1.81 (1.53–2.14) | <0.001 | 1.23 (1.02–1.47) | 0.029 |
| Stroke | 7 (0.8) | 40 (0.6) | 1.35 (0.61–3.02) | 0.463 | 0.94 (0.39–2.26) | 0.895 |
| TVR | 50 (6.0) | 160 (2.5) | 2.46 (1.79–3.38) | <0.001 | 1.82 (1.28–2.58) | 0.001 |
| TLR | 57 (6.8) | 225 (3.5) | 1.99 (1.48–2.65) | <0.001 | 1.47 (1.07–2.03) | 0.018 |
| Definite ST | 13 (1.5) | 47 (0.7) | 2.11 (1.14–3.90) | 0.017 | 2.32 (1.17–4.60) | 0.016 |
| Outcome . | Severe calcification (n = 875) . | Non-severe calcification (n = 6571) . | Hazard ratio (95% CI) . | P-value . | Adjusted hazard ratio (95%) . | P-value . |
|---|---|---|---|---|---|---|
| Primary composite endpoint of all-cause mortality, MI, or stroke | 237 (27.1) | 985 (15.0) | 1.91 (1.66–2.20) | <0.001 | 1.23 (1.06–1.44) | 0.008 |
| Composite endpoint of CV death, MI, stroke TVR, or ST | 230 (26.4) | 928 (14.2) | 1.97 (1.70–2.27) | <0.001 | 1.31 (1.11–1.53) | 0.001 |
| All-cause mortality | 75 (8.6) | 243 (3.7) | 2.38 (1.84–3.09) | <0.001 | 1.34 (1.01–1.77) | 0.039 |
| Cardiovascular death | 52 (6.0) | 154 (2.4) | 2.59 (1.89–3.55) | <0.001 | 1.48 (1.06–2.09) | 0.023 |
| MI | 171 (20.1) | 746 (11.5) | 1.81 (1.53–2.14) | <0.001 | 1.23 (1.02–1.47) | 0.029 |
| Stroke | 7 (0.8) | 40 (0.6) | 1.35 (0.61–3.02) | 0.463 | 0.94 (0.39–2.26) | 0.895 |
| TVR | 50 (6.0) | 160 (2.5) | 2.46 (1.79–3.38) | <0.001 | 1.82 (1.28–2.58) | 0.001 |
| TLR | 57 (6.8) | 225 (3.5) | 1.99 (1.48–2.65) | <0.001 | 1.47 (1.07–2.03) | 0.018 |
| Definite ST | 13 (1.5) | 47 (0.7) | 2.11 (1.14–3.90) | 0.017 | 2.32 (1.17–4.60) | 0.016 |
CV, cardiovascular; CI, confidence interval; MI, myocardial infarction; ST, stent thrombosis; TLR, target lesion revascularization; TVR, target vessel revascularization.
| Outcome . | Severe calcification (n = 875) . | Non-severe calcification (n = 6571) . | Hazard ratio (95% CI) . | P-value . | Adjusted hazard ratio (95%) . | P-value . |
|---|---|---|---|---|---|---|
| Primary composite endpoint of all-cause mortality, MI, or stroke | 237 (27.1) | 985 (15.0) | 1.91 (1.66–2.20) | <0.001 | 1.23 (1.06–1.44) | 0.008 |
| Composite endpoint of CV death, MI, stroke TVR, or ST | 230 (26.4) | 928 (14.2) | 1.97 (1.70–2.27) | <0.001 | 1.31 (1.11–1.53) | 0.001 |
| All-cause mortality | 75 (8.6) | 243 (3.7) | 2.38 (1.84–3.09) | <0.001 | 1.34 (1.01–1.77) | 0.039 |
| Cardiovascular death | 52 (6.0) | 154 (2.4) | 2.59 (1.89–3.55) | <0.001 | 1.48 (1.06–2.09) | 0.023 |
| MI | 171 (20.1) | 746 (11.5) | 1.81 (1.53–2.14) | <0.001 | 1.23 (1.02–1.47) | 0.029 |
| Stroke | 7 (0.8) | 40 (0.6) | 1.35 (0.61–3.02) | 0.463 | 0.94 (0.39–2.26) | 0.895 |
| TVR | 50 (6.0) | 160 (2.5) | 2.46 (1.79–3.38) | <0.001 | 1.82 (1.28–2.58) | 0.001 |
| TLR | 57 (6.8) | 225 (3.5) | 1.99 (1.48–2.65) | <0.001 | 1.47 (1.07–2.03) | 0.018 |
| Definite ST | 13 (1.5) | 47 (0.7) | 2.11 (1.14–3.90) | 0.017 | 2.32 (1.17–4.60) | 0.016 |
| Outcome . | Severe calcification (n = 875) . | Non-severe calcification (n = 6571) . | Hazard ratio (95% CI) . | P-value . | Adjusted hazard ratio (95%) . | P-value . |
|---|---|---|---|---|---|---|
| Primary composite endpoint of all-cause mortality, MI, or stroke | 237 (27.1) | 985 (15.0) | 1.91 (1.66–2.20) | <0.001 | 1.23 (1.06–1.44) | 0.008 |
| Composite endpoint of CV death, MI, stroke TVR, or ST | 230 (26.4) | 928 (14.2) | 1.97 (1.70–2.27) | <0.001 | 1.31 (1.11–1.53) | 0.001 |
| All-cause mortality | 75 (8.6) | 243 (3.7) | 2.38 (1.84–3.09) | <0.001 | 1.34 (1.01–1.77) | 0.039 |
| Cardiovascular death | 52 (6.0) | 154 (2.4) | 2.59 (1.89–3.55) | <0.001 | 1.48 (1.06–2.09) | 0.023 |
| MI | 171 (20.1) | 746 (11.5) | 1.81 (1.53–2.14) | <0.001 | 1.23 (1.02–1.47) | 0.029 |
| Stroke | 7 (0.8) | 40 (0.6) | 1.35 (0.61–3.02) | 0.463 | 0.94 (0.39–2.26) | 0.895 |
| TVR | 50 (6.0) | 160 (2.5) | 2.46 (1.79–3.38) | <0.001 | 1.82 (1.28–2.58) | 0.001 |
| TLR | 57 (6.8) | 225 (3.5) | 1.99 (1.48–2.65) | <0.001 | 1.47 (1.07–2.03) | 0.018 |
| Definite ST | 13 (1.5) | 47 (0.7) | 2.11 (1.14–3.90) | 0.017 | 2.32 (1.17–4.60) | 0.016 |
CV, cardiovascular; CI, confidence interval; MI, myocardial infarction; ST, stent thrombosis; TLR, target lesion revascularization; TVR, target vessel revascularization.
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