Table 3

Incidence of MACCE according to smoking cessation

Smoking status
Pre-PCI/post-PCI
nEvents
(n)
Follow-up
duration (person-years)
Incidence rate
(per 1000 person-years)
Unadjusted
HR (95% CI)
Multivariable model 1
HR (95% CI)
Multivariable model 2
HR (95% CI)
Persistent non-smokers17 602285856 92250.2091 (ref)1 (ref)1 (ref)
Quitters after PCI
 <10 PYs757111243445.605.907 (.750–1.096)1.193 (.981–1.451)1.182 (.971–1.438)
 10–20 PYs1594222514443.160.859 (.750–.985)1.138 (.984–1.316)1.114 (.963–1.290)
 20–30 PYs1786276592046.619.935 (.826–1.058)1.213 (1.061–1.387)1.206 (1.054–1.380)
 ≥30 PYs340963111 13656.6641.131 (1.037–1.233)1.238 (1.124–1.364)1.227 (1.113–1.352)
Persistent smokers6739117821 22955.4891.100 (1.028–1.177)1.249 (1.151–1.356)1.223 (1.126–1.328)
P for interaction.009<.001<.001
Smoking status
Pre-PCI/post-PCI
nEvents
(n)
Follow-up
duration (person-years)
Incidence rate
(per 1000 person-years)
Unadjusted
HR (95% CI)
Multivariable model 1
HR (95% CI)
Multivariable model 2
HR (95% CI)
Persistent non-smokers17 602285856 92250.2091 (ref)1 (ref)1 (ref)
Quitters after PCI
 <10 PYs757111243445.605.907 (.750–1.096)1.193 (.981–1.451)1.182 (.971–1.438)
 10–20 PYs1594222514443.160.859 (.750–.985)1.138 (.984–1.316)1.114 (.963–1.290)
 20–30 PYs1786276592046.619.935 (.826–1.058)1.213 (1.061–1.387)1.206 (1.054–1.380)
 ≥30 PYs340963111 13656.6641.131 (1.037–1.233)1.238 (1.124–1.364)1.227 (1.113–1.352)
Persistent smokers6739117821 22955.4891.100 (1.028–1.177)1.249 (1.151–1.356)1.223 (1.126–1.328)
P for interaction.009<.001<.001

CI, confidence interval; HR, hazard ratio; MACCE, major adverse cardiovascular and cerebrovascular events; PCI, percutaneous coronary intervention; PYs, pack-years.

Multivariable model 1: HRs are adjusted for age, sex, hypertension, diabetes mellitus, dyslipidaemia, body mass index, social income, regular exercise, and alcohol drinking status.

Multivariable model 2: HRs are adjusted for age, sex, hypertension, diabetes mellitus, dyslipidaemia, body mass index, social income, regular exercise, alcohol drinking status, myocardial infarction, heart failure, aspirin, clopidogrel, potent P2Y12 inhibitors, and statin.

Table 3

Incidence of MACCE according to smoking cessation

Smoking status
Pre-PCI/post-PCI
nEvents
(n)
Follow-up
duration (person-years)
Incidence rate
(per 1000 person-years)
Unadjusted
HR (95% CI)
Multivariable model 1
HR (95% CI)
Multivariable model 2
HR (95% CI)
Persistent non-smokers17 602285856 92250.2091 (ref)1 (ref)1 (ref)
Quitters after PCI
 <10 PYs757111243445.605.907 (.750–1.096)1.193 (.981–1.451)1.182 (.971–1.438)
 10–20 PYs1594222514443.160.859 (.750–.985)1.138 (.984–1.316)1.114 (.963–1.290)
 20–30 PYs1786276592046.619.935 (.826–1.058)1.213 (1.061–1.387)1.206 (1.054–1.380)
 ≥30 PYs340963111 13656.6641.131 (1.037–1.233)1.238 (1.124–1.364)1.227 (1.113–1.352)
Persistent smokers6739117821 22955.4891.100 (1.028–1.177)1.249 (1.151–1.356)1.223 (1.126–1.328)
P for interaction.009<.001<.001
Smoking status
Pre-PCI/post-PCI
nEvents
(n)
Follow-up
duration (person-years)
Incidence rate
(per 1000 person-years)
Unadjusted
HR (95% CI)
Multivariable model 1
HR (95% CI)
Multivariable model 2
HR (95% CI)
Persistent non-smokers17 602285856 92250.2091 (ref)1 (ref)1 (ref)
Quitters after PCI
 <10 PYs757111243445.605.907 (.750–1.096)1.193 (.981–1.451)1.182 (.971–1.438)
 10–20 PYs1594222514443.160.859 (.750–.985)1.138 (.984–1.316)1.114 (.963–1.290)
 20–30 PYs1786276592046.619.935 (.826–1.058)1.213 (1.061–1.387)1.206 (1.054–1.380)
 ≥30 PYs340963111 13656.6641.131 (1.037–1.233)1.238 (1.124–1.364)1.227 (1.113–1.352)
Persistent smokers6739117821 22955.4891.100 (1.028–1.177)1.249 (1.151–1.356)1.223 (1.126–1.328)
P for interaction.009<.001<.001

CI, confidence interval; HR, hazard ratio; MACCE, major adverse cardiovascular and cerebrovascular events; PCI, percutaneous coronary intervention; PYs, pack-years.

Multivariable model 1: HRs are adjusted for age, sex, hypertension, diabetes mellitus, dyslipidaemia, body mass index, social income, regular exercise, and alcohol drinking status.

Multivariable model 2: HRs are adjusted for age, sex, hypertension, diabetes mellitus, dyslipidaemia, body mass index, social income, regular exercise, alcohol drinking status, myocardial infarction, heart failure, aspirin, clopidogrel, potent P2Y12 inhibitors, and statin.

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