Table 2. Open in new tab Differences in...

	Patients with restless legs syndrome (N = 69)	Patients with drug-naïve RLS (N = 44)	Treated patients with RLS (N = 25)	Heathy controls (N = 51)	*P-value	^†P-value	^‡P-value	^§P-value
Projection fiber
Dxx	0.610 ± 0.081	0.611 ± 0.085	0.611 ± 0.077	0.629 ± 0.066	0.194	0.246	0.288	0.125
Dyy	0.467 ± 0.094	0.471 ± 0.095	0.460 ± 0.094	0.422 ± 0.074	0.005	0.006	0.062	0.064
Dzz	1.112 ± 0.096	1.115 ± 0.105	1.153 ± 0.074	1.112 ± 0.092	0.612	0.813	0.124	0.399
Association fiber
Dxx	0.627 ± 0.095	0.614 ± 0.100	0.651 ± 0.084	0.636 ± 0.097	0.626	0.281	0.519	0.995
Dyy	1.159 ± 0.130	1.181 ± 0.134	1.121 ± 0.115	1.114 ± 0.134	0.067	0.018	0.836	0.638
Dzz	0.384 ± 0.083	0.378 ± 0.084	0.396 ± 0.085	0.381 ± 0.089	0.879	0.82	0.522	0.118
Subcortical fiber
Dxx	0.997 ± 0.144	1.015 ± 0.184	0.967 ± 0.137	1.013 ± 0.134	0.558	0.931	0.168	0.183
Dyy	0.648 ± 0.144	0.649 ± 0.150	0.647 ± 0.136	0.654 ± 0.122	0.787	0.827	0.802	0.964
Dzz	0.627 ± 0.133	0.629 ± 0.120	0.624 ± 0.156	0.598 ± 0.131	0.232	0.233	0.445	0.883
DTI-ALPS index	1.481 ± 0.241	1.4715 ± 0.259	1.498 ± 0.213	1.601 ± 0.245	0.008	0.014	0.076	0.667

Patients with restless legs syndrome (N = 69)

Patients with drug-naïve RLS (N = 44)

Treated patients with RLS (N = 25)

Heathy controls (N = 51)

*P-value

^†P-value

^‡P-value

^§P-value

Projection fiber

Dxx

0.610 ± 0.081

0.611 ± 0.085

0.611 ± 0.077

0.629 ± 0.066

0.194

0.246

0.288

0.125

Dyy

0.467 ± 0.094

0.471 ± 0.095

0.460 ± 0.094

0.422 ± 0.074

0.005

0.006

0.062

0.064

Dzz

1.112 ± 0.096

1.115 ± 0.105

1.153 ± 0.074

1.112 ± 0.092

0.612

0.813

0.124

0.399

Association fiber

Dxx

0.627 ± 0.095

0.614 ± 0.100

0.651 ± 0.084

0.636 ± 0.097

0.626

0.281

0.519

0.995

Dyy

1.159 ± 0.130

1.181 ± 0.134

1.121 ± 0.115

1.114 ± 0.134

0.067

0.018

0.836

0.638

Dzz

0.384 ± 0.083

0.378 ± 0.084

0.396 ± 0.085

0.381 ± 0.089

0.879

0.82

0.522

0.118

Subcortical fiber

Dxx

0.997 ± 0.144

1.015 ± 0.184

0.967 ± 0.137

1.013 ± 0.134

0.558

0.931

0.168

0.183

Dyy

0.648 ± 0.144

0.649 ± 0.150

0.647 ± 0.136

0.654 ± 0.122

0.787

0.827

0.802

0.964

Dzz

0.627 ± 0.133

0.629 ± 0.120

0.624 ± 0.156

0.598 ± 0.131

0.232

0.233

0.445

0.883

DTI-ALPS index

1.481 ± 0.241

1.4715 ± 0.259

1.498 ± 0.213

1.601 ± 0.245

0.008

0.014

0.076

0.667

	Patients with restless legs syndrome (N = 69)	Patients with drug-naïve RLS (N = 44)	Treated patients with RLS (N = 25)	Heathy controls (N = 51)	*P-value	^†P-value	^‡P-value	^§P-value
Projection fiber
Dxx	0.610 ± 0.081	0.611 ± 0.085	0.611 ± 0.077	0.629 ± 0.066	0.194	0.246	0.288	0.125
Dyy	0.467 ± 0.094	0.471 ± 0.095	0.460 ± 0.094	0.422 ± 0.074	0.005	0.006	0.062	0.064
Dzz	1.112 ± 0.096	1.115 ± 0.105	1.153 ± 0.074	1.112 ± 0.092	0.612	0.813	0.124	0.399
Association fiber
Dxx	0.627 ± 0.095	0.614 ± 0.100	0.651 ± 0.084	0.636 ± 0.097	0.626	0.281	0.519	0.995
Dyy	1.159 ± 0.130	1.181 ± 0.134	1.121 ± 0.115	1.114 ± 0.134	0.067	0.018	0.836	0.638
Dzz	0.384 ± 0.083	0.378 ± 0.084	0.396 ± 0.085	0.381 ± 0.089	0.879	0.82	0.522	0.118
Subcortical fiber
Dxx	0.997 ± 0.144	1.015 ± 0.184	0.967 ± 0.137	1.013 ± 0.134	0.558	0.931	0.168	0.183
Dyy	0.648 ± 0.144	0.649 ± 0.150	0.647 ± 0.136	0.654 ± 0.122	0.787	0.827	0.802	0.964
Dzz	0.627 ± 0.133	0.629 ± 0.120	0.624 ± 0.156	0.598 ± 0.131	0.232	0.233	0.445	0.883
DTI-ALPS index	1.481 ± 0.241	1.4715 ± 0.259	1.498 ± 0.213	1.601 ± 0.245	0.008	0.014	0.076	0.667

Table 2.

Open in new tab

Differences in Diffusivity and Diffusion Tensor Image Analysis Along the Perivascular Space Index Between Patients With Restless Legs Syndrome and Healthy Controls

	Patients with restless legs syndrome (N = 69)	Patients with drug-naïve RLS (N = 44)	Treated patients with RLS (N = 25)	Heathy controls (N = 51)	*P-value	^†P-value	^‡P-value	^§P-value
Projection fiber
Dxx	0.610 ± 0.081	0.611 ± 0.085	0.611 ± 0.077	0.629 ± 0.066	0.194	0.246	0.288	0.125
Dyy	0.467 ± 0.094	0.471 ± 0.095	0.460 ± 0.094	0.422 ± 0.074	0.005	0.006	0.062	0.064
Dzz	1.112 ± 0.096	1.115 ± 0.105	1.153 ± 0.074	1.112 ± 0.092	0.612	0.813	0.124	0.399
Association fiber
Dxx	0.627 ± 0.095	0.614 ± 0.100	0.651 ± 0.084	0.636 ± 0.097	0.626	0.281	0.519	0.995
Dyy	1.159 ± 0.130	1.181 ± 0.134	1.121 ± 0.115	1.114 ± 0.134	0.067	0.018	0.836	0.638
Dzz	0.384 ± 0.083	0.378 ± 0.084	0.396 ± 0.085	0.381 ± 0.089	0.879	0.82	0.522	0.118
Subcortical fiber
Dxx	0.997 ± 0.144	1.015 ± 0.184	0.967 ± 0.137	1.013 ± 0.134	0.558	0.931	0.168	0.183
Dyy	0.648 ± 0.144	0.649 ± 0.150	0.647 ± 0.136	0.654 ± 0.122	0.787	0.827	0.802	0.964
Dzz	0.627 ± 0.133	0.629 ± 0.120	0.624 ± 0.156	0.598 ± 0.131	0.232	0.233	0.445	0.883
DTI-ALPS index	1.481 ± 0.241	1.4715 ± 0.259	1.498 ± 0.213	1.601 ± 0.245	0.008	0.014	0.076	0.667

	Patients with restless legs syndrome (N = 69)	Patients with drug-naïve RLS (N = 44)	Treated patients with RLS (N = 25)	Heathy controls (N = 51)	*P-value	^†P-value	^‡P-value	^§P-value
Projection fiber
Dxx	0.610 ± 0.081	0.611 ± 0.085	0.611 ± 0.077	0.629 ± 0.066	0.194	0.246	0.288	0.125
Dyy	0.467 ± 0.094	0.471 ± 0.095	0.460 ± 0.094	0.422 ± 0.074	0.005	0.006	0.062	0.064
Dzz	1.112 ± 0.096	1.115 ± 0.105	1.153 ± 0.074	1.112 ± 0.092	0.612	0.813	0.124	0.399
Association fiber
Dxx	0.627 ± 0.095	0.614 ± 0.100	0.651 ± 0.084	0.636 ± 0.097	0.626	0.281	0.519	0.995
Dyy	1.159 ± 0.130	1.181 ± 0.134	1.121 ± 0.115	1.114 ± 0.134	0.067	0.018	0.836	0.638
Dzz	0.384 ± 0.083	0.378 ± 0.084	0.396 ± 0.085	0.381 ± 0.089	0.879	0.82	0.522	0.118
Subcortical fiber
Dxx	0.997 ± 0.144	1.015 ± 0.184	0.967 ± 0.137	1.013 ± 0.134	0.558	0.931	0.168	0.183
Dyy	0.648 ± 0.144	0.649 ± 0.150	0.647 ± 0.136	0.654 ± 0.122	0.787	0.827	0.802	0.964
Dzz	0.627 ± 0.133	0.629 ± 0.120	0.624 ± 0.156	0.598 ± 0.131	0.232	0.233	0.445	0.883
DTI-ALPS index	1.481 ± 0.241	1.4715 ± 0.259	1.498 ± 0.213	1.601 ± 0.245	0.008	0.014	0.076	0.667

(×10⁻³ mm²/ s).

Data are mean ± standard deviation values.

Dxx, diffusivity along the x-axis; Dyy, diffusivity along the y-axis; Dzz, diffusivity along the z-axis.

*P-value between patients with RLS and healthy controls.

^†P-value between patients with drug-naïve RLS and healthy controls.

^‡P-value between patients with drug-treated RLS and healthy controls.

^§P-value for drug-naïve- versus drug-treated patients with RLS.

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