| Year . | Authors . | Journal . | Setting . | Country . | Study type . | Population . | Mean age . | Male (%) . | N . | CXRs (n) . | Diagnosis . | Sensitivity (95% CI) . | Specificity . | Risk of biasa . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2006 | Bjerager et al. | The British Journal of General Practice | Primary care | Denmark | Retrospective | Patients diagnosed with lung cancer in primary care | 66 | 64 | 84 | 58 | NR | 79.31% (66.65% to 88.83%) | U | Concerns |
| 2006 | Stapley et al. | The British Journal of General Practice | Primary care | England | Retrospective | Patients diagnosed with lung cancer in primary care | 71 | 69 | 247 | 164 | Pathological | 76.83% (69.61% to 83.05%) | U | Concerns |
| 2006 | Speets et al. | The British Journal of General Practice | Primary care | Netherlands | Prospective | Patients referred for CXR from primary care | 57 | 53 | 870 | 142 | NR | 100% (71.51% to 100.00%) | U | High |
| 2012 | Harris et al. | Lung Cancer | Acute general hospital | England | Retrospective | Patients referred for CXR from primary care | NR | NR | 798 | 797 | NR | 100.00% (98.31% to 100.00%) | U | High |
| 2014 | Ades et al. | International Journal of Epidemiology | Primary care | England | Retrospective | Patients identified from lung cancer registry with matched controls | NR | NR | 1482 | 268 | Radiological | 91.02% (85.62% to 94.89%) | 56.44% (46.20% to 66.28%) | Concerns |
| 2014 | Robinson et al. | European Respiratory Journal | Acute general hospital | England | Retrospective | Patients referred for TWR from primary care | NR | NR | 143 | 143 | NR | 72.5% (56.11% to 85.40%) | 60.19% (50.08% to 69.71%) | High |
| 2015 | Neal et al. | Primary Health Care Research & Development | Primary care | Wales | Retrospective | Patients diagnosed with lung cancer | 69 | NR | 118 | 79 | Pathological | 70.89% (59.58% to 80.57%) | U | High |
| 2017 | Neal et al. | British Journal of Cancer | Primary care | Wales and England | Prospective | Patients referred for CXR from primary care | 68 | 51 | 255 | 250 | Pathological | 75% (19.41% to 99.37%) | 99.19% (97.09% to 99.90%) | Low |
| 2017 | Kedgley et al. | Lung Cancer | Thoracic medicine clinic in acute hospital | England | Retrospective | Patients referred for TWR from primary care | 64 | NR | 56 | 38 | NR | 76.92% (46.19% to 94.96%) | 40.00% (21.13% to 61.33%) | High |
| 2018 | Woznitza et al. | Clinical Radiology | Acute general hospital | England | Prospective | Patients referred for CXR from primary care | 53 | NR | 1687 | 105 | NR | 80.00% (44.39% to 97.48%) | 82.11% (72.90% to 89.22%) | Concerns |
| Year . | Authors . | Journal . | Setting . | Country . | Study type . | Population . | Mean age . | Male (%) . | N . | CXRs (n) . | Diagnosis . | Sensitivity (95% CI) . | Specificity . | Risk of biasa . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2006 | Bjerager et al. | The British Journal of General Practice | Primary care | Denmark | Retrospective | Patients diagnosed with lung cancer in primary care | 66 | 64 | 84 | 58 | NR | 79.31% (66.65% to 88.83%) | U | Concerns |
| 2006 | Stapley et al. | The British Journal of General Practice | Primary care | England | Retrospective | Patients diagnosed with lung cancer in primary care | 71 | 69 | 247 | 164 | Pathological | 76.83% (69.61% to 83.05%) | U | Concerns |
| 2006 | Speets et al. | The British Journal of General Practice | Primary care | Netherlands | Prospective | Patients referred for CXR from primary care | 57 | 53 | 870 | 142 | NR | 100% (71.51% to 100.00%) | U | High |
| 2012 | Harris et al. | Lung Cancer | Acute general hospital | England | Retrospective | Patients referred for CXR from primary care | NR | NR | 798 | 797 | NR | 100.00% (98.31% to 100.00%) | U | High |
| 2014 | Ades et al. | International Journal of Epidemiology | Primary care | England | Retrospective | Patients identified from lung cancer registry with matched controls | NR | NR | 1482 | 268 | Radiological | 91.02% (85.62% to 94.89%) | 56.44% (46.20% to 66.28%) | Concerns |
| 2014 | Robinson et al. | European Respiratory Journal | Acute general hospital | England | Retrospective | Patients referred for TWR from primary care | NR | NR | 143 | 143 | NR | 72.5% (56.11% to 85.40%) | 60.19% (50.08% to 69.71%) | High |
| 2015 | Neal et al. | Primary Health Care Research & Development | Primary care | Wales | Retrospective | Patients diagnosed with lung cancer | 69 | NR | 118 | 79 | Pathological | 70.89% (59.58% to 80.57%) | U | High |
| 2017 | Neal et al. | British Journal of Cancer | Primary care | Wales and England | Prospective | Patients referred for CXR from primary care | 68 | 51 | 255 | 250 | Pathological | 75% (19.41% to 99.37%) | 99.19% (97.09% to 99.90%) | Low |
| 2017 | Kedgley et al. | Lung Cancer | Thoracic medicine clinic in acute hospital | England | Retrospective | Patients referred for TWR from primary care | 64 | NR | 56 | 38 | NR | 76.92% (46.19% to 94.96%) | 40.00% (21.13% to 61.33%) | High |
| 2018 | Woznitza et al. | Clinical Radiology | Acute general hospital | England | Prospective | Patients referred for CXR from primary care | 53 | NR | 1687 | 105 | NR | 80.00% (44.39% to 97.48%) | 82.11% (72.90% to 89.22%) | Concerns |
CXR, chest radiograph; NR, not reported; U, unable to calculate.
Overall risk, synthesised using QUADAS-2 tool.
| Year . | Authors . | Journal . | Setting . | Country . | Study type . | Population . | Mean age . | Male (%) . | N . | CXRs (n) . | Diagnosis . | Sensitivity (95% CI) . | Specificity . | Risk of biasa . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2006 | Bjerager et al. | The British Journal of General Practice | Primary care | Denmark | Retrospective | Patients diagnosed with lung cancer in primary care | 66 | 64 | 84 | 58 | NR | 79.31% (66.65% to 88.83%) | U | Concerns |
| 2006 | Stapley et al. | The British Journal of General Practice | Primary care | England | Retrospective | Patients diagnosed with lung cancer in primary care | 71 | 69 | 247 | 164 | Pathological | 76.83% (69.61% to 83.05%) | U | Concerns |
| 2006 | Speets et al. | The British Journal of General Practice | Primary care | Netherlands | Prospective | Patients referred for CXR from primary care | 57 | 53 | 870 | 142 | NR | 100% (71.51% to 100.00%) | U | High |
| 2012 | Harris et al. | Lung Cancer | Acute general hospital | England | Retrospective | Patients referred for CXR from primary care | NR | NR | 798 | 797 | NR | 100.00% (98.31% to 100.00%) | U | High |
| 2014 | Ades et al. | International Journal of Epidemiology | Primary care | England | Retrospective | Patients identified from lung cancer registry with matched controls | NR | NR | 1482 | 268 | Radiological | 91.02% (85.62% to 94.89%) | 56.44% (46.20% to 66.28%) | Concerns |
| 2014 | Robinson et al. | European Respiratory Journal | Acute general hospital | England | Retrospective | Patients referred for TWR from primary care | NR | NR | 143 | 143 | NR | 72.5% (56.11% to 85.40%) | 60.19% (50.08% to 69.71%) | High |
| 2015 | Neal et al. | Primary Health Care Research & Development | Primary care | Wales | Retrospective | Patients diagnosed with lung cancer | 69 | NR | 118 | 79 | Pathological | 70.89% (59.58% to 80.57%) | U | High |
| 2017 | Neal et al. | British Journal of Cancer | Primary care | Wales and England | Prospective | Patients referred for CXR from primary care | 68 | 51 | 255 | 250 | Pathological | 75% (19.41% to 99.37%) | 99.19% (97.09% to 99.90%) | Low |
| 2017 | Kedgley et al. | Lung Cancer | Thoracic medicine clinic in acute hospital | England | Retrospective | Patients referred for TWR from primary care | 64 | NR | 56 | 38 | NR | 76.92% (46.19% to 94.96%) | 40.00% (21.13% to 61.33%) | High |
| 2018 | Woznitza et al. | Clinical Radiology | Acute general hospital | England | Prospective | Patients referred for CXR from primary care | 53 | NR | 1687 | 105 | NR | 80.00% (44.39% to 97.48%) | 82.11% (72.90% to 89.22%) | Concerns |
| Year . | Authors . | Journal . | Setting . | Country . | Study type . | Population . | Mean age . | Male (%) . | N . | CXRs (n) . | Diagnosis . | Sensitivity (95% CI) . | Specificity . | Risk of biasa . |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2006 | Bjerager et al. | The British Journal of General Practice | Primary care | Denmark | Retrospective | Patients diagnosed with lung cancer in primary care | 66 | 64 | 84 | 58 | NR | 79.31% (66.65% to 88.83%) | U | Concerns |
| 2006 | Stapley et al. | The British Journal of General Practice | Primary care | England | Retrospective | Patients diagnosed with lung cancer in primary care | 71 | 69 | 247 | 164 | Pathological | 76.83% (69.61% to 83.05%) | U | Concerns |
| 2006 | Speets et al. | The British Journal of General Practice | Primary care | Netherlands | Prospective | Patients referred for CXR from primary care | 57 | 53 | 870 | 142 | NR | 100% (71.51% to 100.00%) | U | High |
| 2012 | Harris et al. | Lung Cancer | Acute general hospital | England | Retrospective | Patients referred for CXR from primary care | NR | NR | 798 | 797 | NR | 100.00% (98.31% to 100.00%) | U | High |
| 2014 | Ades et al. | International Journal of Epidemiology | Primary care | England | Retrospective | Patients identified from lung cancer registry with matched controls | NR | NR | 1482 | 268 | Radiological | 91.02% (85.62% to 94.89%) | 56.44% (46.20% to 66.28%) | Concerns |
| 2014 | Robinson et al. | European Respiratory Journal | Acute general hospital | England | Retrospective | Patients referred for TWR from primary care | NR | NR | 143 | 143 | NR | 72.5% (56.11% to 85.40%) | 60.19% (50.08% to 69.71%) | High |
| 2015 | Neal et al. | Primary Health Care Research & Development | Primary care | Wales | Retrospective | Patients diagnosed with lung cancer | 69 | NR | 118 | 79 | Pathological | 70.89% (59.58% to 80.57%) | U | High |
| 2017 | Neal et al. | British Journal of Cancer | Primary care | Wales and England | Prospective | Patients referred for CXR from primary care | 68 | 51 | 255 | 250 | Pathological | 75% (19.41% to 99.37%) | 99.19% (97.09% to 99.90%) | Low |
| 2017 | Kedgley et al. | Lung Cancer | Thoracic medicine clinic in acute hospital | England | Retrospective | Patients referred for TWR from primary care | 64 | NR | 56 | 38 | NR | 76.92% (46.19% to 94.96%) | 40.00% (21.13% to 61.33%) | High |
| 2018 | Woznitza et al. | Clinical Radiology | Acute general hospital | England | Prospective | Patients referred for CXR from primary care | 53 | NR | 1687 | 105 | NR | 80.00% (44.39% to 97.48%) | 82.11% (72.90% to 89.22%) | Concerns |
CXR, chest radiograph; NR, not reported; U, unable to calculate.
Overall risk, synthesised using QUADAS-2 tool.
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