Baseline characteristics of participants according to allocated treatment (intention to treat).
| . | Scratch (n = 2059) . | Control (n = 2053) . | ||
|---|---|---|---|---|
| Female age (years)a | 34.3 | (31.0–37.9) | 34.6 | (31.3–38.0) |
| Female BMI (kg/m2)b | 23.3 | (21.0–26.4) | 23.7 | (21.3–26.8) |
| Duration of infertility (months)c | 36.0 | (24.0–58.3) | 36.0 | (24.0–60.0) |
| Number of previous failed embryo transfersd | ||||
| 0 | 564 | (27.4%) | 564 | (27.5%) |
| 1 | 552 | (26.8%) | 626 | (30.5%) |
| 2 | 401 | (19.5%) | 347 | (16.9%) |
| 3 | 194 | (9.4%) | 190 | (9.3%) |
| ≥4 | 208 | (10.1%) | 200 | (9.7%) |
| Smoking status of the femalee | ||||
| No | 1445 | (70.2%) | 1447 | (70.5%) |
| Yes | 103 | (5.0%) | 105 | (5.1%) |
| Quit | 10 | (0.5%) | 6 | (0.3%) |
| Gravidity of the femalef | ||||
| 0 | 812 | (39.4%) | 780 | (38.0%) |
| 1 | 377 | (18.3%) | 394 | (19.2%) |
| 2 | 147 | (7.1%) | 146 | (7.1%) |
| ≥3 | 100 | (4.9%) | 114 | (5.6%) |
| Parity of the femaleg | ||||
| 0 | 719 | (34.9%) | 759 | (37.0%) |
| 1 | 154 | (7.5%) | 133 | (6.5%) |
| 2 | 19 | (0.9%) | 14 | (0.7%) |
| ≥3 | 6 | (0.3%) | 8 | (0.4%) |
| Primary infertility of the female?h | ||||
| No | 658 | (32.0%) | 685 | (33.4%) |
| Yes | 1062 | (51.6%) | 1038 | (50.6%) |
| Cause of infertilityi | ||||
| Unexplained | 477 | (23.2%) | 454 | (22.1%) |
| Male factor | 477 | (23.2%) | 461 | (22.5%) |
| Other | 792 | (38.5%) | 800 | (40.0%) |
| . | Scratch (n = 2059) . | Control (n = 2053) . | ||
|---|---|---|---|---|
| Female age (years)a | 34.3 | (31.0–37.9) | 34.6 | (31.3–38.0) |
| Female BMI (kg/m2)b | 23.3 | (21.0–26.4) | 23.7 | (21.3–26.8) |
| Duration of infertility (months)c | 36.0 | (24.0–58.3) | 36.0 | (24.0–60.0) |
| Number of previous failed embryo transfersd | ||||
| 0 | 564 | (27.4%) | 564 | (27.5%) |
| 1 | 552 | (26.8%) | 626 | (30.5%) |
| 2 | 401 | (19.5%) | 347 | (16.9%) |
| 3 | 194 | (9.4%) | 190 | (9.3%) |
| ≥4 | 208 | (10.1%) | 200 | (9.7%) |
| Smoking status of the femalee | ||||
| No | 1445 | (70.2%) | 1447 | (70.5%) |
| Yes | 103 | (5.0%) | 105 | (5.1%) |
| Quit | 10 | (0.5%) | 6 | (0.3%) |
| Gravidity of the femalef | ||||
| 0 | 812 | (39.4%) | 780 | (38.0%) |
| 1 | 377 | (18.3%) | 394 | (19.2%) |
| 2 | 147 | (7.1%) | 146 | (7.1%) |
| ≥3 | 100 | (4.9%) | 114 | (5.6%) |
| Parity of the femaleg | ||||
| 0 | 719 | (34.9%) | 759 | (37.0%) |
| 1 | 154 | (7.5%) | 133 | (6.5%) |
| 2 | 19 | (0.9%) | 14 | (0.7%) |
| ≥3 | 6 | (0.3%) | 8 | (0.4%) |
| Primary infertility of the female?h | ||||
| No | 658 | (32.0%) | 685 | (33.4%) |
| Yes | 1062 | (51.6%) | 1038 | (50.6%) |
| Cause of infertilityi | ||||
| Unexplained | 477 | (23.2%) | 454 | (22.1%) |
| Male factor | 477 | (23.2%) | 461 | (22.5%) |
| Other | 792 | (38.5%) | 800 | (40.0%) |
Observed data only. Data are median (interquartile range) or n (% of randomized population). 13 trials.
Overview of the participant characteristics at randomization. The number of previous failed embryo transfers refers to the number of failed attempts for the current childwish, i.e. excluding embryo transfers for a previous child. For cause of infertility, ‘other’ includes tubal factor, endometriosis (grade I–IV), ovulatory disorder, and other causes.
Data are missing for: Overall analysis: 10 and 11 participants, resp.
Data are missing for: Overall analysis: 124 and 133 participants, resp.
Data are missing for: Overall analysis: 559 and 549 participants, resp.
Data are missing for: Overall analysis: 140 and 126 participants, resp.
Data are missing for: Overall analysis: 501 and 495 participants, resp.
Data are missing for: Overall analysis: 623 and 619 participants, resp.
Data are missing for: Overall analysis: 1161 and 1139 participants, resp.
Data are missing for: Overall analysis: 339 and 330 participants, resp.
Data are missing for: Overall analysis: 328 and 323 participants, resp.
Baseline characteristics of participants according to allocated treatment (intention to treat).
| . | Scratch (n = 2059) . | Control (n = 2053) . | ||
|---|---|---|---|---|
| Female age (years)a | 34.3 | (31.0–37.9) | 34.6 | (31.3–38.0) |
| Female BMI (kg/m2)b | 23.3 | (21.0–26.4) | 23.7 | (21.3–26.8) |
| Duration of infertility (months)c | 36.0 | (24.0–58.3) | 36.0 | (24.0–60.0) |
| Number of previous failed embryo transfersd | ||||
| 0 | 564 | (27.4%) | 564 | (27.5%) |
| 1 | 552 | (26.8%) | 626 | (30.5%) |
| 2 | 401 | (19.5%) | 347 | (16.9%) |
| 3 | 194 | (9.4%) | 190 | (9.3%) |
| ≥4 | 208 | (10.1%) | 200 | (9.7%) |
| Smoking status of the femalee | ||||
| No | 1445 | (70.2%) | 1447 | (70.5%) |
| Yes | 103 | (5.0%) | 105 | (5.1%) |
| Quit | 10 | (0.5%) | 6 | (0.3%) |
| Gravidity of the femalef | ||||
| 0 | 812 | (39.4%) | 780 | (38.0%) |
| 1 | 377 | (18.3%) | 394 | (19.2%) |
| 2 | 147 | (7.1%) | 146 | (7.1%) |
| ≥3 | 100 | (4.9%) | 114 | (5.6%) |
| Parity of the femaleg | ||||
| 0 | 719 | (34.9%) | 759 | (37.0%) |
| 1 | 154 | (7.5%) | 133 | (6.5%) |
| 2 | 19 | (0.9%) | 14 | (0.7%) |
| ≥3 | 6 | (0.3%) | 8 | (0.4%) |
| Primary infertility of the female?h | ||||
| No | 658 | (32.0%) | 685 | (33.4%) |
| Yes | 1062 | (51.6%) | 1038 | (50.6%) |
| Cause of infertilityi | ||||
| Unexplained | 477 | (23.2%) | 454 | (22.1%) |
| Male factor | 477 | (23.2%) | 461 | (22.5%) |
| Other | 792 | (38.5%) | 800 | (40.0%) |
| . | Scratch (n = 2059) . | Control (n = 2053) . | ||
|---|---|---|---|---|
| Female age (years)a | 34.3 | (31.0–37.9) | 34.6 | (31.3–38.0) |
| Female BMI (kg/m2)b | 23.3 | (21.0–26.4) | 23.7 | (21.3–26.8) |
| Duration of infertility (months)c | 36.0 | (24.0–58.3) | 36.0 | (24.0–60.0) |
| Number of previous failed embryo transfersd | ||||
| 0 | 564 | (27.4%) | 564 | (27.5%) |
| 1 | 552 | (26.8%) | 626 | (30.5%) |
| 2 | 401 | (19.5%) | 347 | (16.9%) |
| 3 | 194 | (9.4%) | 190 | (9.3%) |
| ≥4 | 208 | (10.1%) | 200 | (9.7%) |
| Smoking status of the femalee | ||||
| No | 1445 | (70.2%) | 1447 | (70.5%) |
| Yes | 103 | (5.0%) | 105 | (5.1%) |
| Quit | 10 | (0.5%) | 6 | (0.3%) |
| Gravidity of the femalef | ||||
| 0 | 812 | (39.4%) | 780 | (38.0%) |
| 1 | 377 | (18.3%) | 394 | (19.2%) |
| 2 | 147 | (7.1%) | 146 | (7.1%) |
| ≥3 | 100 | (4.9%) | 114 | (5.6%) |
| Parity of the femaleg | ||||
| 0 | 719 | (34.9%) | 759 | (37.0%) |
| 1 | 154 | (7.5%) | 133 | (6.5%) |
| 2 | 19 | (0.9%) | 14 | (0.7%) |
| ≥3 | 6 | (0.3%) | 8 | (0.4%) |
| Primary infertility of the female?h | ||||
| No | 658 | (32.0%) | 685 | (33.4%) |
| Yes | 1062 | (51.6%) | 1038 | (50.6%) |
| Cause of infertilityi | ||||
| Unexplained | 477 | (23.2%) | 454 | (22.1%) |
| Male factor | 477 | (23.2%) | 461 | (22.5%) |
| Other | 792 | (38.5%) | 800 | (40.0%) |
Observed data only. Data are median (interquartile range) or n (% of randomized population). 13 trials.
Overview of the participant characteristics at randomization. The number of previous failed embryo transfers refers to the number of failed attempts for the current childwish, i.e. excluding embryo transfers for a previous child. For cause of infertility, ‘other’ includes tubal factor, endometriosis (grade I–IV), ovulatory disorder, and other causes.
Data are missing for: Overall analysis: 10 and 11 participants, resp.
Data are missing for: Overall analysis: 124 and 133 participants, resp.
Data are missing for: Overall analysis: 559 and 549 participants, resp.
Data are missing for: Overall analysis: 140 and 126 participants, resp.
Data are missing for: Overall analysis: 501 and 495 participants, resp.
Data are missing for: Overall analysis: 623 and 619 participants, resp.
Data are missing for: Overall analysis: 1161 and 1139 participants, resp.
Data are missing for: Overall analysis: 339 and 330 participants, resp.
Data are missing for: Overall analysis: 328 and 323 participants, resp.
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