Performance evaluation of ProsperousPlus based on the 10-fold cross-validation on the training dataset for six proteases: C14.001 (caspase-1), C14.003 (caspase-3), C14.005 (caspase-6), M10.003 (MMP-2), M10.005 (MMP-3) and S01.010 (Granzyme B). The results are presented as the averages over the 10-folds ± the corresponding standard deviations
| Protease . | Accuracy . | AUC . | Sensitivity . | Precision . | F1 . | MCC . |
|---|---|---|---|---|---|---|
| C14.001 | 0.875 |$\pm$| 0.058 | 0.910 |$\pm$| 0.053 | 0.846 |$\pm$| 0.112 | 0.913 |$\pm$| 0.067 | 0.872 |$\pm$| 0.062 | 0.762 |$\pm$| 0.111 |
| C14.003 | 0.970 |$\pm$| 0.015 | 0.989 |$\pm$| 0.011 | 0.902 |$\pm$| 0.047 | 0.924 |$\pm$| 0.050 | 0.913 |$\pm$| 0.044 | 0.895 |$\pm$| 0.053 |
| C14.005 | 0.970 |$\pm$| 0.006 | 0.992 |$\pm$| 0.006 | 0.974 |$\pm$| 0.014 | 0.968 |$\pm$| 0.015 | 0.971 |$\pm$| 0.005 | 0.941 |$\pm$| 0.011 |
| M10.003 | 0.863 |$\pm$| 0.023 | 0.922 |$\pm$| 0.022 | 0.879 |$\pm$| 0.026 | 0.847 |$\pm$| 0.024 | 0.863 |$\pm$| 0.023 | 0.728 |$\pm$| 0.045 |
| M10.005 | 0.869 |$\pm$| 0.019 | 0.931 |$\pm$| 0.015 | 0.881 |$\pm$| 0.025 | 0.860 |$\pm$| 0.026 | 0.870 |$\pm$| 0.019 | 0.738 |$\pm$| 0.038 |
| S01.010 | 0.909 |$\pm$| 0.030 | 0.953 |$\pm$| 0.015 | 0.887 |$\pm$| 0.041 | 0.925 |$\pm$| 0.033 | 0.906 |$\pm$| 0.033 | 0.819 |$\pm$| 0.060 |
| Protease . | Accuracy . | AUC . | Sensitivity . | Precision . | F1 . | MCC . |
|---|---|---|---|---|---|---|
| C14.001 | 0.875 |$\pm$| 0.058 | 0.910 |$\pm$| 0.053 | 0.846 |$\pm$| 0.112 | 0.913 |$\pm$| 0.067 | 0.872 |$\pm$| 0.062 | 0.762 |$\pm$| 0.111 |
| C14.003 | 0.970 |$\pm$| 0.015 | 0.989 |$\pm$| 0.011 | 0.902 |$\pm$| 0.047 | 0.924 |$\pm$| 0.050 | 0.913 |$\pm$| 0.044 | 0.895 |$\pm$| 0.053 |
| C14.005 | 0.970 |$\pm$| 0.006 | 0.992 |$\pm$| 0.006 | 0.974 |$\pm$| 0.014 | 0.968 |$\pm$| 0.015 | 0.971 |$\pm$| 0.005 | 0.941 |$\pm$| 0.011 |
| M10.003 | 0.863 |$\pm$| 0.023 | 0.922 |$\pm$| 0.022 | 0.879 |$\pm$| 0.026 | 0.847 |$\pm$| 0.024 | 0.863 |$\pm$| 0.023 | 0.728 |$\pm$| 0.045 |
| M10.005 | 0.869 |$\pm$| 0.019 | 0.931 |$\pm$| 0.015 | 0.881 |$\pm$| 0.025 | 0.860 |$\pm$| 0.026 | 0.870 |$\pm$| 0.019 | 0.738 |$\pm$| 0.038 |
| S01.010 | 0.909 |$\pm$| 0.030 | 0.953 |$\pm$| 0.015 | 0.887 |$\pm$| 0.041 | 0.925 |$\pm$| 0.033 | 0.906 |$\pm$| 0.033 | 0.819 |$\pm$| 0.060 |
Performance evaluation of ProsperousPlus based on the 10-fold cross-validation on the training dataset for six proteases: C14.001 (caspase-1), C14.003 (caspase-3), C14.005 (caspase-6), M10.003 (MMP-2), M10.005 (MMP-3) and S01.010 (Granzyme B). The results are presented as the averages over the 10-folds ± the corresponding standard deviations
| Protease . | Accuracy . | AUC . | Sensitivity . | Precision . | F1 . | MCC . |
|---|---|---|---|---|---|---|
| C14.001 | 0.875 |$\pm$| 0.058 | 0.910 |$\pm$| 0.053 | 0.846 |$\pm$| 0.112 | 0.913 |$\pm$| 0.067 | 0.872 |$\pm$| 0.062 | 0.762 |$\pm$| 0.111 |
| C14.003 | 0.970 |$\pm$| 0.015 | 0.989 |$\pm$| 0.011 | 0.902 |$\pm$| 0.047 | 0.924 |$\pm$| 0.050 | 0.913 |$\pm$| 0.044 | 0.895 |$\pm$| 0.053 |
| C14.005 | 0.970 |$\pm$| 0.006 | 0.992 |$\pm$| 0.006 | 0.974 |$\pm$| 0.014 | 0.968 |$\pm$| 0.015 | 0.971 |$\pm$| 0.005 | 0.941 |$\pm$| 0.011 |
| M10.003 | 0.863 |$\pm$| 0.023 | 0.922 |$\pm$| 0.022 | 0.879 |$\pm$| 0.026 | 0.847 |$\pm$| 0.024 | 0.863 |$\pm$| 0.023 | 0.728 |$\pm$| 0.045 |
| M10.005 | 0.869 |$\pm$| 0.019 | 0.931 |$\pm$| 0.015 | 0.881 |$\pm$| 0.025 | 0.860 |$\pm$| 0.026 | 0.870 |$\pm$| 0.019 | 0.738 |$\pm$| 0.038 |
| S01.010 | 0.909 |$\pm$| 0.030 | 0.953 |$\pm$| 0.015 | 0.887 |$\pm$| 0.041 | 0.925 |$\pm$| 0.033 | 0.906 |$\pm$| 0.033 | 0.819 |$\pm$| 0.060 |
| Protease . | Accuracy . | AUC . | Sensitivity . | Precision . | F1 . | MCC . |
|---|---|---|---|---|---|---|
| C14.001 | 0.875 |$\pm$| 0.058 | 0.910 |$\pm$| 0.053 | 0.846 |$\pm$| 0.112 | 0.913 |$\pm$| 0.067 | 0.872 |$\pm$| 0.062 | 0.762 |$\pm$| 0.111 |
| C14.003 | 0.970 |$\pm$| 0.015 | 0.989 |$\pm$| 0.011 | 0.902 |$\pm$| 0.047 | 0.924 |$\pm$| 0.050 | 0.913 |$\pm$| 0.044 | 0.895 |$\pm$| 0.053 |
| C14.005 | 0.970 |$\pm$| 0.006 | 0.992 |$\pm$| 0.006 | 0.974 |$\pm$| 0.014 | 0.968 |$\pm$| 0.015 | 0.971 |$\pm$| 0.005 | 0.941 |$\pm$| 0.011 |
| M10.003 | 0.863 |$\pm$| 0.023 | 0.922 |$\pm$| 0.022 | 0.879 |$\pm$| 0.026 | 0.847 |$\pm$| 0.024 | 0.863 |$\pm$| 0.023 | 0.728 |$\pm$| 0.045 |
| M10.005 | 0.869 |$\pm$| 0.019 | 0.931 |$\pm$| 0.015 | 0.881 |$\pm$| 0.025 | 0.860 |$\pm$| 0.026 | 0.870 |$\pm$| 0.019 | 0.738 |$\pm$| 0.038 |
| S01.010 | 0.909 |$\pm$| 0.030 | 0.953 |$\pm$| 0.015 | 0.887 |$\pm$| 0.041 | 0.925 |$\pm$| 0.033 | 0.906 |$\pm$| 0.033 | 0.819 |$\pm$| 0.060 |
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