Statistical analysis of percentage susceptibility (%S) to antimicrobials in H. influenzae
| Antimicrobial . | CLSI %S . | P value . | Conclusion . | ||
|---|---|---|---|---|---|
| 2002–03 . | 2004–05 . | 2007–09 . | |||
| Ampicillin | 95.5 | 90.8 | 95.2 | 0.379 | non-significant change in susceptibility |
| Amoxicillin/clavulanic acid | 100.0 | 99.5a | 100.0a | 0.539 | non-significant change in susceptibility |
| Cefaclor | 99.2 | 96.3 | 90.4 | <0.0001 | significant decrease in susceptibility |
| Clarithromycinb | 100.0 | 95.2 | 96.7 | 0.287 | non-significant change in susceptibility |
| Antimicrobial . | CLSI %S . | P value . | Conclusion . | ||
|---|---|---|---|---|---|
| 2002–03 . | 2004–05 . | 2007–09 . | |||
| Ampicillin | 95.5 | 90.8 | 95.2 | 0.379 | non-significant change in susceptibility |
| Amoxicillin/clavulanic acid | 100.0 | 99.5a | 100.0a | 0.539 | non-significant change in susceptibility |
| Cefaclor | 99.2 | 96.3 | 90.4 | <0.0001 | significant decrease in susceptibility |
| Clarithromycinb | 100.0 | 95.2 | 96.7 | 0.287 | non-significant change in susceptibility |
aThe percentage susceptibility of BLNAR was 0.5% (2004–05) and 2.2% (2007–09). Rare BLNAR strains of H. influenzae should be considered resistant to amoxicillin/clavulanic acid, despite apparent in vitro susceptibility.
bClarithromycin data in 2002–03 and 2004–05 from Etests incubated in 5% CO2 and ambient atmosphere in 2007–09, with differing associated breakpoints used as shown in Table 1.
Statistical analysis of percentage susceptibility (%S) to antimicrobials in H. influenzae
| Antimicrobial . | CLSI %S . | P value . | Conclusion . | ||
|---|---|---|---|---|---|
| 2002–03 . | 2004–05 . | 2007–09 . | |||
| Ampicillin | 95.5 | 90.8 | 95.2 | 0.379 | non-significant change in susceptibility |
| Amoxicillin/clavulanic acid | 100.0 | 99.5a | 100.0a | 0.539 | non-significant change in susceptibility |
| Cefaclor | 99.2 | 96.3 | 90.4 | <0.0001 | significant decrease in susceptibility |
| Clarithromycinb | 100.0 | 95.2 | 96.7 | 0.287 | non-significant change in susceptibility |
| Antimicrobial . | CLSI %S . | P value . | Conclusion . | ||
|---|---|---|---|---|---|
| 2002–03 . | 2004–05 . | 2007–09 . | |||
| Ampicillin | 95.5 | 90.8 | 95.2 | 0.379 | non-significant change in susceptibility |
| Amoxicillin/clavulanic acid | 100.0 | 99.5a | 100.0a | 0.539 | non-significant change in susceptibility |
| Cefaclor | 99.2 | 96.3 | 90.4 | <0.0001 | significant decrease in susceptibility |
| Clarithromycinb | 100.0 | 95.2 | 96.7 | 0.287 | non-significant change in susceptibility |
aThe percentage susceptibility of BLNAR was 0.5% (2004–05) and 2.2% (2007–09). Rare BLNAR strains of H. influenzae should be considered resistant to amoxicillin/clavulanic acid, despite apparent in vitro susceptibility.
bClarithromycin data in 2002–03 and 2004–05 from Etests incubated in 5% CO2 and ambient atmosphere in 2007–09, with differing associated breakpoints used as shown in Table 1.
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