Table 5. Open in new tab MIC and...

Years/antimicrobial agent	Isolate group	N					Susceptibility
2009–11
AMC^a,b	all	307	1	2	0.06	512	98.4 (97.4)^c	—	1.6 (2.6)^c	93.5 (98.4)	93.5 (85.0)^c	—	6.5 (15.0)^c
	BL−	257	0.5	2	0.06	8	98.8	—	1.2	94.2 (98.8)	94.2	—	5.8
	BL+	50	1	2	0.12	512	96.0	—	4.0	90.0 (96.0)	90.0	—	10.0
ampicillin^d	all	307	0.5	64	0.06	>256	71.3	9.5	19.2	NA	71.3	—	28.7
	BL−	257	0.5	2	0.06	>256	84.4	11.3	4.3	NA	84.4	—	15.6
	BL+	50	64	>256	0.5	>256	4.0	0.0	96.0	NA	4.0	—	96.0
azithromycin^e	all	104	2	4	≤0.015	>256	91.4	—	—	NA	NA	NA	NA
	BL−	85	4	4	≤0.015	8	92.9	—	—	NA	NA	NA	NA
	BL+	19	2	>256	≤0.015	>256	84.2	—	—	NA	NA	NA	NA
cefaclor^b	all	307	2	32	0.25	>256	78.5 (77.5)^c	7.8 (7.2)^c	13.7 (15.3)^c	2.0	NA	NA	NA
	BL−	257	2	32	0.25	>256	79.4	7.8	12.8	2.3	NA	NA	NA
	BL+	50	4	32	1	>256	74.0	8.0	18.0	0.0	NA	NA	NA
cefuroxime^b,f	all	307	1	4	0.06	64	94.8 (92.8)^c	2.9 (2.0)^c	2.3 (5.2)^c	65.5	1.0 (1.0)^c	64.5 (62.9)^c	34.5 (36.2)^c
	BL−	257	1	4	0.06	64	94.6	3.1	2.3	66.9	1.2	65.8	33.1
	BL+	50	1	4	0.25	32	96.0	2.0	2.0	58.0	0.0	58.0	42.0
levofloxacin	all	307	0.06	4	0.008	>32	78.2			78.2	71.7	—	28.3
	BL−	257	0.06	4	0.008	>32	79.8	—	20.2	79.8	72.4	—	27.6
	BL+	50	0.03	8	0.008	>32	70.0	0	30	70.0	68.0	—	32.0
chloramphenicol^g	all	307	NA	NA	NA	NA	90.6	1.3	8.1	NA	91.5	—	8.5
	BL−	257	NA	NA	NA	NA	96.1	1.2	2.7	NA	96.9	—	3.1
	BL+	50	NA	NA	NA	NA	62.0	2.0	36.0	NA	64.0	—	36.0
tetracycline^g	all	292	NA	NA	NA	NA	74.3	9.9	15.8	NA	85.3	2.7	12.0
	BL−	242	NA	NA	NA	NA	79.8	10.3	9.9	NA	90.9	2.5	6.6
	BL+	50	NA	NA	NA	NA	48.0	8.0	44.0	NA	58.0	4.0	38.0
SXT^g	all	307	NA	NA	NA	NA	41.0	2.6	56.4	NA	34.2	4.6	61.2
	BL−	257	NA	NA	NA	NA	46.3	3.1	50.6	NA	38.5	5.1	56.4
	BL+	50	NA	NA	NA	NA	14.0	0.0	86.0	NA	12.0	2.0	86.0
2013–14
AMC^a,b	all	185	1	4	0.12	16	95.7 (89.1)^c	—	4.3 (10.9)^c	78.4 (95.7)	78.4 (73.0)^c	—	21.6 (27.0)^c
	BL−	138	1	2	0.12	8	97.8	—	2.2	81.9 (97.8)	81.9	—	18.1
	BL+	47	2	8	0.5	16	89.4	—	10.6	68.1 (89.4)	68.1	—	31.9
ampicillin^d	all	185	1	>256	0.12	>256	58.4	9.7	31.9	NA	58.4	—	41.6
	BL−	138	1	2	0.12	>256	77.5	13.1	9.4	NA	77.5	—	22.5
	BL+	47	256	>256	1	>256	2.1	0.0	97.9	NA	2.1	—	97.9
ampicillin/sulbactam^b	all	97	1	4	0.12	8	86.6 (80.4)^c	—	13.4 (19.6)^c	NA	63.9 (58.9)^c	—	36.1 (41.1)^c
	BL−	73	1	2	0.12	8	93.2	—	6.8	NA	82.2	—	17.8
	BL+	24	2	8	0.25	8	66.7	—	33.3	NA	8.3	—	91.7
azithromycin^e	all	185	2	16	≤0.015	>256	89.7	—	—	NA	NA	NA	NA
	BL−	138	2	4	≤0.015	>256	97.8	—	—	NA	NA	NA	NA
	BL+	47	4	>256	≤0.015	>256	66.0	—	—	NA	NA	NA	NA
cefaclor^b	all	185	16	>256	1	>256	49.2 (47.6)^c	13.0 (13.0)^c	37.8 (39.5)^c	0.0	NA	NA	NA
	BL−	138	8	>256	1	>256	52.9	10.9	36.2	0.0	NA	NA	NA
	BL+	47	16	>256	1	>256	38.3	19.2	42.5	0.0	NA	NA	NA
cefuroxime^b,f	all	185	2	32	0.25	>256	75.1 (73.0)^c	7.1 (7.0)^c	17.8 (20.0)^c	43.8	0.0 (0.0)^c	43.8 (42.2)^c	56.2 (57.8)^c
	BL−	138	2	32	0.25	>256	76.8	7.3	15.9	46.4	0.0	46.4	53.6
	BL+	47	2	64	0.25	>256	70.2	6.4	23.4	36.2	0.0	36.2	63.8
levofloxacin	all	185	0.015	4	0.008	>32	89.2	—	—	89.2	82.7	—	17.3
	BL−	138	0.015	2	0.008	8	90.6	—	—	90.6	83.3	—	16.7
	BL+	47	0.03	4	0.008	>32	85.1	—	—	85.1	80.9	—	19.2
chloramphenicol^g	all	185	NA	NA	NA	NA	91.4	2.1	6.5	NA	91.9	—	8.1
	BL−	138	NA	NA	NA	NA	96.4	1.4	2.2	NA	97.1	—	2.9
	BL+	47	NA	NA	NA	NA	76.6	4.3	19.1	NA	76.6	—	23.4
tetracycline^g	all	185	NA	NA	NA	NA	86.5	3.8	9.7	NA	90.3	1.6	8.1
	BL−	138	NA	NA	NA	NA	92.0	2.9	5.1	NA	94.9	0.0	5.1
	BL+	47	NA	NA	NA	NA	70.2	6.4	23.4	NA	76.6	6.4	17.0
SXT^g	all	185	NA	NA	NA	NA	41.1	3.2	55.7	NA	38.9	1.6	59.5
	BL−	138	NA	NA	NA	NA	45.7	2.9	51.4	NA	42.8	2.1	55.1
	BL+	47	NA	NA	NA	NA	27.7	4.2	68.1	NA	27.7	0.0	72.3

Years/antimicrobial agent	Isolate group	N					Susceptibility
2009–11
AMC^a,b	all	307	1	2	0.06	512	98.4 (97.4)^c	—	1.6 (2.6)^c	93.5 (98.4)	93.5 (85.0)^c	—	6.5 (15.0)^c
	BL−	257	0.5	2	0.06	8	98.8	—	1.2	94.2 (98.8)	94.2	—	5.8
	BL+	50	1	2	0.12	512	96.0	—	4.0	90.0 (96.0)	90.0	—	10.0
ampicillin^d	all	307	0.5	64	0.06	>256	71.3	9.5	19.2	NA	71.3	—	28.7
	BL−	257	0.5	2	0.06	>256	84.4	11.3	4.3	NA	84.4	—	15.6
	BL+	50	64	>256	0.5	>256	4.0	0.0	96.0	NA	4.0	—	96.0
azithromycin^e	all	104	2	4	≤0.015	>256	91.4	—	—	NA	NA	NA	NA
	BL−	85	4	4	≤0.015	8	92.9	—	—	NA	NA	NA	NA
	BL+	19	2	>256	≤0.015	>256	84.2	—	—	NA	NA	NA	NA
cefaclor^b	all	307	2	32	0.25	>256	78.5 (77.5)^c	7.8 (7.2)^c	13.7 (15.3)^c	2.0	NA	NA	NA
	BL−	257	2	32	0.25	>256	79.4	7.8	12.8	2.3	NA	NA	NA
	BL+	50	4	32	1	>256	74.0	8.0	18.0	0.0	NA	NA	NA
cefuroxime^b,f	all	307	1	4	0.06	64	94.8 (92.8)^c	2.9 (2.0)^c	2.3 (5.2)^c	65.5	1.0 (1.0)^c	64.5 (62.9)^c	34.5 (36.2)^c
	BL−	257	1	4	0.06	64	94.6	3.1	2.3	66.9	1.2	65.8	33.1
	BL+	50	1	4	0.25	32	96.0	2.0	2.0	58.0	0.0	58.0	42.0
levofloxacin	all	307	0.06	4	0.008	>32	78.2			78.2	71.7	—	28.3
	BL−	257	0.06	4	0.008	>32	79.8	—	20.2	79.8	72.4	—	27.6
	BL+	50	0.03	8	0.008	>32	70.0	0	30	70.0	68.0	—	32.0
chloramphenicol^g	all	307	NA	NA	NA	NA	90.6	1.3	8.1	NA	91.5	—	8.5
	BL−	257	NA	NA	NA	NA	96.1	1.2	2.7	NA	96.9	—	3.1
	BL+	50	NA	NA	NA	NA	62.0	2.0	36.0	NA	64.0	—	36.0
tetracycline^g	all	292	NA	NA	NA	NA	74.3	9.9	15.8	NA	85.3	2.7	12.0
	BL−	242	NA	NA	NA	NA	79.8	10.3	9.9	NA	90.9	2.5	6.6
	BL+	50	NA	NA	NA	NA	48.0	8.0	44.0	NA	58.0	4.0	38.0
SXT^g	all	307	NA	NA	NA	NA	41.0	2.6	56.4	NA	34.2	4.6	61.2
	BL−	257	NA	NA	NA	NA	46.3	3.1	50.6	NA	38.5	5.1	56.4
	BL+	50	NA	NA	NA	NA	14.0	0.0	86.0	NA	12.0	2.0	86.0
2013–14
AMC^a,b	all	185	1	4	0.12	16	95.7 (89.1)^c	—	4.3 (10.9)^c	78.4 (95.7)	78.4 (73.0)^c	—	21.6 (27.0)^c
	BL−	138	1	2	0.12	8	97.8	—	2.2	81.9 (97.8)	81.9	—	18.1
	BL+	47	2	8	0.5	16	89.4	—	10.6	68.1 (89.4)	68.1	—	31.9
ampicillin^d	all	185	1	>256	0.12	>256	58.4	9.7	31.9	NA	58.4	—	41.6
	BL−	138	1	2	0.12	>256	77.5	13.1	9.4	NA	77.5	—	22.5
	BL+	47	256	>256	1	>256	2.1	0.0	97.9	NA	2.1	—	97.9
ampicillin/sulbactam^b	all	97	1	4	0.12	8	86.6 (80.4)^c	—	13.4 (19.6)^c	NA	63.9 (58.9)^c	—	36.1 (41.1)^c
	BL−	73	1	2	0.12	8	93.2	—	6.8	NA	82.2	—	17.8
	BL+	24	2	8	0.25	8	66.7	—	33.3	NA	8.3	—	91.7
azithromycin^e	all	185	2	16	≤0.015	>256	89.7	—	—	NA	NA	NA	NA
	BL−	138	2	4	≤0.015	>256	97.8	—	—	NA	NA	NA	NA
	BL+	47	4	>256	≤0.015	>256	66.0	—	—	NA	NA	NA	NA
cefaclor^b	all	185	16	>256	1	>256	49.2 (47.6)^c	13.0 (13.0)^c	37.8 (39.5)^c	0.0	NA	NA	NA
	BL−	138	8	>256	1	>256	52.9	10.9	36.2	0.0	NA	NA	NA
	BL+	47	16	>256	1	>256	38.3	19.2	42.5	0.0	NA	NA	NA
cefuroxime^b,f	all	185	2	32	0.25	>256	75.1 (73.0)^c	7.1 (7.0)^c	17.8 (20.0)^c	43.8	0.0 (0.0)^c	43.8 (42.2)^c	56.2 (57.8)^c
	BL−	138	2	32	0.25	>256	76.8	7.3	15.9	46.4	0.0	46.4	53.6
	BL+	47	2	64	0.25	>256	70.2	6.4	23.4	36.2	0.0	36.2	63.8
levofloxacin	all	185	0.015	4	0.008	>32	89.2	—	—	89.2	82.7	—	17.3
	BL−	138	0.015	2	0.008	8	90.6	—	—	90.6	83.3	—	16.7
	BL+	47	0.03	4	0.008	>32	85.1	—	—	85.1	80.9	—	19.2
chloramphenicol^g	all	185	NA	NA	NA	NA	91.4	2.1	6.5	NA	91.9	—	8.1
	BL−	138	NA	NA	NA	NA	96.4	1.4	2.2	NA	97.1	—	2.9
	BL+	47	NA	NA	NA	NA	76.6	4.3	19.1	NA	76.6	—	23.4
tetracycline^g	all	185	NA	NA	NA	NA	86.5	3.8	9.7	NA	90.3	1.6	8.1
	BL−	138	NA	NA	NA	NA	92.0	2.9	5.1	NA	94.9	0.0	5.1
	BL+	47	NA	NA	NA	NA	70.2	6.4	23.4	NA	76.6	6.4	17.0
SXT^g	all	185	NA	NA	NA	NA	41.1	3.2	55.7	NA	38.9	1.6	59.5
	BL−	138	NA	NA	NA	NA	45.7	2.9	51.4	NA	42.8	2.1	55.1
	BL+	47	NA	NA	NA	NA	27.7	4.2	68.1	NA	27.7	0.0	72.3

Table 5.

MIC and susceptibility data for H. influenzae isolates collected during 2009–11 and 2013–14

Years/antimicrobial agent	Isolate group	N					Susceptibility
			MIC (mg/L)				CLSI			PK/PD	EUCAST
			50%	90%	min.	max.	%S	%I	%R	%S	%S	%I	%R
2009–11
AMC^a,b	all	307	1	2	0.06	512	98.4 (97.4)^c	—	1.6 (2.6)^c	93.5 (98.4)	93.5 (85.0)^c	—	6.5 (15.0)^c
	BL−	257	0.5	2	0.06	8	98.8	—	1.2	94.2 (98.8)	94.2	—	5.8
	BL+	50	1	2	0.12	512	96.0	—	4.0	90.0 (96.0)	90.0	—	10.0
ampicillin^d	all	307	0.5	64	0.06	>256	71.3	9.5	19.2	NA	71.3	—	28.7
	BL−	257	0.5	2	0.06	>256	84.4	11.3	4.3	NA	84.4	—	15.6
	BL+	50	64	>256	0.5	>256	4.0	0.0	96.0	NA	4.0	—	96.0
azithromycin^e	all	104	2	4	≤0.015	>256	91.4	—	—	NA	NA	NA	NA
	BL−	85	4	4	≤0.015	8	92.9	—	—	NA	NA	NA	NA
	BL+	19	2	>256	≤0.015	>256	84.2	—	—	NA	NA	NA	NA
cefaclor^b	all	307	2	32	0.25	>256	78.5 (77.5)^c	7.8 (7.2)^c	13.7 (15.3)^c	2.0	NA	NA	NA
	BL−	257	2	32	0.25	>256	79.4	7.8	12.8	2.3	NA	NA	NA
	BL+	50	4	32	1	>256	74.0	8.0	18.0	0.0	NA	NA	NA
cefuroxime^b,f	all	307	1	4	0.06	64	94.8 (92.8)^c	2.9 (2.0)^c	2.3 (5.2)^c	65.5	1.0 (1.0)^c	64.5 (62.9)^c	34.5 (36.2)^c
	BL−	257	1	4	0.06	64	94.6	3.1	2.3	66.9	1.2	65.8	33.1
	BL+	50	1	4	0.25	32	96.0	2.0	2.0	58.0	0.0	58.0	42.0
levofloxacin	all	307	0.06	4	0.008	>32	78.2			78.2	71.7	—	28.3
	BL−	257	0.06	4	0.008	>32	79.8	—	20.2	79.8	72.4	—	27.6
	BL+	50	0.03	8	0.008	>32	70.0	0	30	70.0	68.0	—	32.0
chloramphenicol^g	all	307	NA	NA	NA	NA	90.6	1.3	8.1	NA	91.5	—	8.5
	BL−	257	NA	NA	NA	NA	96.1	1.2	2.7	NA	96.9	—	3.1
	BL+	50	NA	NA	NA	NA	62.0	2.0	36.0	NA	64.0	—	36.0
tetracycline^g	all	292	NA	NA	NA	NA	74.3	9.9	15.8	NA	85.3	2.7	12.0
	BL−	242	NA	NA	NA	NA	79.8	10.3	9.9	NA	90.9	2.5	6.6
	BL+	50	NA	NA	NA	NA	48.0	8.0	44.0	NA	58.0	4.0	38.0
SXT^g	all	307	NA	NA	NA	NA	41.0	2.6	56.4	NA	34.2	4.6	61.2
	BL−	257	NA	NA	NA	NA	46.3	3.1	50.6	NA	38.5	5.1	56.4
	BL+	50	NA	NA	NA	NA	14.0	0.0	86.0	NA	12.0	2.0	86.0
2013–14
AMC^a,b	all	185	1	4	0.12	16	95.7 (89.1)^c	—	4.3 (10.9)^c	78.4 (95.7)	78.4 (73.0)^c	—	21.6 (27.0)^c
	BL−	138	1	2	0.12	8	97.8	—	2.2	81.9 (97.8)	81.9	—	18.1
	BL+	47	2	8	0.5	16	89.4	—	10.6	68.1 (89.4)	68.1	—	31.9
ampicillin^d	all	185	1	>256	0.12	>256	58.4	9.7	31.9	NA	58.4	—	41.6
	BL−	138	1	2	0.12	>256	77.5	13.1	9.4	NA	77.5	—	22.5
	BL+	47	256	>256	1	>256	2.1	0.0	97.9	NA	2.1	—	97.9
ampicillin/sulbactam^b	all	97	1	4	0.12	8	86.6 (80.4)^c	—	13.4 (19.6)^c	NA	63.9 (58.9)^c	—	36.1 (41.1)^c
	BL−	73	1	2	0.12	8	93.2	—	6.8	NA	82.2	—	17.8
	BL+	24	2	8	0.25	8	66.7	—	33.3	NA	8.3	—	91.7
azithromycin^e	all	185	2	16	≤0.015	>256	89.7	—	—	NA	NA	NA	NA
	BL−	138	2	4	≤0.015	>256	97.8	—	—	NA	NA	NA	NA
	BL+	47	4	>256	≤0.015	>256	66.0	—	—	NA	NA	NA	NA
cefaclor^b	all	185	16	>256	1	>256	49.2 (47.6)^c	13.0 (13.0)^c	37.8 (39.5)^c	0.0	NA	NA	NA
	BL−	138	8	>256	1	>256	52.9	10.9	36.2	0.0	NA	NA	NA
	BL+	47	16	>256	1	>256	38.3	19.2	42.5	0.0	NA	NA	NA
cefuroxime^b,f	all	185	2	32	0.25	>256	75.1 (73.0)^c	7.1 (7.0)^c	17.8 (20.0)^c	43.8	0.0 (0.0)^c	43.8 (42.2)^c	56.2 (57.8)^c
	BL−	138	2	32	0.25	>256	76.8	7.3	15.9	46.4	0.0	46.4	53.6
	BL+	47	2	64	0.25	>256	70.2	6.4	23.4	36.2	0.0	36.2	63.8
levofloxacin	all	185	0.015	4	0.008	>32	89.2	—	—	89.2	82.7	—	17.3
	BL−	138	0.015	2	0.008	8	90.6	—	—	90.6	83.3	—	16.7
	BL+	47	0.03	4	0.008	>32	85.1	—	—	85.1	80.9	—	19.2
chloramphenicol^g	all	185	NA	NA	NA	NA	91.4	2.1	6.5	NA	91.9	—	8.1
	BL−	138	NA	NA	NA	NA	96.4	1.4	2.2	NA	97.1	—	2.9
	BL+	47	NA	NA	NA	NA	76.6	4.3	19.1	NA	76.6	—	23.4
tetracycline^g	all	185	NA	NA	NA	NA	86.5	3.8	9.7	NA	90.3	1.6	8.1
	BL−	138	NA	NA	NA	NA	92.0	2.9	5.1	NA	94.9	0.0	5.1
	BL+	47	NA	NA	NA	NA	70.2	6.4	23.4	NA	76.6	6.4	17.0
SXT^g	all	185	NA	NA	NA	NA	41.1	3.2	55.7	NA	38.9	1.6	59.5
	BL−	138	NA	NA	NA	NA	45.7	2.9	51.4	NA	42.8	2.1	55.1
	BL+	47	NA	NA	NA	NA	27.7	4.2	68.1	NA	27.7	0.0	72.3

Years/antimicrobial agent	Isolate group	N					Susceptibility
			MIC (mg/L)				CLSI			PK/PD	EUCAST
			50%	90%	min.	max.	%S	%I	%R	%S	%S	%I	%R
2009–11
AMC^a,b	all	307	1	2	0.06	512	98.4 (97.4)^c	—	1.6 (2.6)^c	93.5 (98.4)	93.5 (85.0)^c	—	6.5 (15.0)^c
	BL−	257	0.5	2	0.06	8	98.8	—	1.2	94.2 (98.8)	94.2	—	5.8
	BL+	50	1	2	0.12	512	96.0	—	4.0	90.0 (96.0)	90.0	—	10.0
ampicillin^d	all	307	0.5	64	0.06	>256	71.3	9.5	19.2	NA	71.3	—	28.7
	BL−	257	0.5	2	0.06	>256	84.4	11.3	4.3	NA	84.4	—	15.6
	BL+	50	64	>256	0.5	>256	4.0	0.0	96.0	NA	4.0	—	96.0
azithromycin^e	all	104	2	4	≤0.015	>256	91.4	—	—	NA	NA	NA	NA
	BL−	85	4	4	≤0.015	8	92.9	—	—	NA	NA	NA	NA
	BL+	19	2	>256	≤0.015	>256	84.2	—	—	NA	NA	NA	NA
cefaclor^b	all	307	2	32	0.25	>256	78.5 (77.5)^c	7.8 (7.2)^c	13.7 (15.3)^c	2.0	NA	NA	NA
	BL−	257	2	32	0.25	>256	79.4	7.8	12.8	2.3	NA	NA	NA
	BL+	50	4	32	1	>256	74.0	8.0	18.0	0.0	NA	NA	NA
cefuroxime^b,f	all	307	1	4	0.06	64	94.8 (92.8)^c	2.9 (2.0)^c	2.3 (5.2)^c	65.5	1.0 (1.0)^c	64.5 (62.9)^c	34.5 (36.2)^c
	BL−	257	1	4	0.06	64	94.6	3.1	2.3	66.9	1.2	65.8	33.1
	BL+	50	1	4	0.25	32	96.0	2.0	2.0	58.0	0.0	58.0	42.0
levofloxacin	all	307	0.06	4	0.008	>32	78.2			78.2	71.7	—	28.3
	BL−	257	0.06	4	0.008	>32	79.8	—	20.2	79.8	72.4	—	27.6
	BL+	50	0.03	8	0.008	>32	70.0	0	30	70.0	68.0	—	32.0
chloramphenicol^g	all	307	NA	NA	NA	NA	90.6	1.3	8.1	NA	91.5	—	8.5
	BL−	257	NA	NA	NA	NA	96.1	1.2	2.7	NA	96.9	—	3.1
	BL+	50	NA	NA	NA	NA	62.0	2.0	36.0	NA	64.0	—	36.0
tetracycline^g	all	292	NA	NA	NA	NA	74.3	9.9	15.8	NA	85.3	2.7	12.0
	BL−	242	NA	NA	NA	NA	79.8	10.3	9.9	NA	90.9	2.5	6.6
	BL+	50	NA	NA	NA	NA	48.0	8.0	44.0	NA	58.0	4.0	38.0
SXT^g	all	307	NA	NA	NA	NA	41.0	2.6	56.4	NA	34.2	4.6	61.2
	BL−	257	NA	NA	NA	NA	46.3	3.1	50.6	NA	38.5	5.1	56.4
	BL+	50	NA	NA	NA	NA	14.0	0.0	86.0	NA	12.0	2.0	86.0
2013–14
AMC^a,b	all	185	1	4	0.12	16	95.7 (89.1)^c	—	4.3 (10.9)^c	78.4 (95.7)	78.4 (73.0)^c	—	21.6 (27.0)^c
	BL−	138	1	2	0.12	8	97.8	—	2.2	81.9 (97.8)	81.9	—	18.1
	BL+	47	2	8	0.5	16	89.4	—	10.6	68.1 (89.4)	68.1	—	31.9
ampicillin^d	all	185	1	>256	0.12	>256	58.4	9.7	31.9	NA	58.4	—	41.6
	BL−	138	1	2	0.12	>256	77.5	13.1	9.4	NA	77.5	—	22.5
	BL+	47	256	>256	1	>256	2.1	0.0	97.9	NA	2.1	—	97.9
ampicillin/sulbactam^b	all	97	1	4	0.12	8	86.6 (80.4)^c	—	13.4 (19.6)^c	NA	63.9 (58.9)^c	—	36.1 (41.1)^c
	BL−	73	1	2	0.12	8	93.2	—	6.8	NA	82.2	—	17.8
	BL+	24	2	8	0.25	8	66.7	—	33.3	NA	8.3	—	91.7
azithromycin^e	all	185	2	16	≤0.015	>256	89.7	—	—	NA	NA	NA	NA
	BL−	138	2	4	≤0.015	>256	97.8	—	—	NA	NA	NA	NA
	BL+	47	4	>256	≤0.015	>256	66.0	—	—	NA	NA	NA	NA
cefaclor^b	all	185	16	>256	1	>256	49.2 (47.6)^c	13.0 (13.0)^c	37.8 (39.5)^c	0.0	NA	NA	NA
	BL−	138	8	>256	1	>256	52.9	10.9	36.2	0.0	NA	NA	NA
	BL+	47	16	>256	1	>256	38.3	19.2	42.5	0.0	NA	NA	NA
cefuroxime^b,f	all	185	2	32	0.25	>256	75.1 (73.0)^c	7.1 (7.0)^c	17.8 (20.0)^c	43.8	0.0 (0.0)^c	43.8 (42.2)^c	56.2 (57.8)^c
	BL−	138	2	32	0.25	>256	76.8	7.3	15.9	46.4	0.0	46.4	53.6
	BL+	47	2	64	0.25	>256	70.2	6.4	23.4	36.2	0.0	36.2	63.8
levofloxacin	all	185	0.015	4	0.008	>32	89.2	—	—	89.2	82.7	—	17.3
	BL−	138	0.015	2	0.008	8	90.6	—	—	90.6	83.3	—	16.7
	BL+	47	0.03	4	0.008	>32	85.1	—	—	85.1	80.9	—	19.2
chloramphenicol^g	all	185	NA	NA	NA	NA	91.4	2.1	6.5	NA	91.9	—	8.1
	BL−	138	NA	NA	NA	NA	96.4	1.4	2.2	NA	97.1	—	2.9
	BL+	47	NA	NA	NA	NA	76.6	4.3	19.1	NA	76.6	—	23.4
tetracycline^g	all	185	NA	NA	NA	NA	86.5	3.8	9.7	NA	90.3	1.6	8.1
	BL−	138	NA	NA	NA	NA	92.0	2.9	5.1	NA	94.9	0.0	5.1
	BL+	47	NA	NA	NA	NA	70.2	6.4	23.4	NA	76.6	6.4	17.0
SXT^g	all	185	NA	NA	NA	NA	41.1	3.2	55.7	NA	38.9	1.6	59.5
	BL−	138	NA	NA	NA	NA	45.7	2.9	51.4	NA	42.8	2.1	55.1
	BL+	47	NA	NA	NA	NA	27.7	4.2	68.1	NA	27.7	0.0	72.3

NA, no breakpoint data available; BL−, β-lactamase negative; BL+, β-lactamase positive; AMC, amoxicillin/clavulanic acid; SXT, trimethoprim/sulfamethoxazole.

^aAmoxicillin/clavulanic acid PK/PD susceptibility at high dose is shown in parentheses.

^bIn the clinical setting, isolates of BLNAR are considered resistant to amoxicillin/clavulanic acid, ampicillin/sulbactam, cefaclor and cefuroxime (see main text).

^cClinical susceptibility to amoxicillin/clavulanic acid ampicillin/sulbactam, cefaclor and cefuroxime reduced (data in parentheses) due to corrections according to BLNAR (see main text).

^dIn clinical setting, all β-lactamase-positive H. influenzae should be considered resistant.

^ebioMérieux Etest^® breakpoints for incubation in CO₂.

^fBreakpoints used are for cefuroxime axetil.

^gCLSI disc diffusion testing method used.

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