Table 4. Open in new tab MIC and...

						Susceptibility
Amoxicillin	57	0.015	0.06	0.015	0.06	100.0	0	0	100.0	NA	NA	NA
AMC^a	57	0.015	1	≤0.015	4	96.5	3.5	0	96.5 (100)	NA	NA	NA
Azithromycin	57	0.5	>256	≤0.015	>256	73.7	0	26.3	NA	NA	NA	NA
Cefaclor	57	0.25	8	0.06	8	79.0	7.0	14.0	71.9	0	71.9	28.1
Cefepime	57	0.03	0.03	0.03	0.03	100.0	0	0	NA	100.0	0	0
Cefixime	57	0.25	0.5	0.25	0.5	NA	NA	NA	100.0	NA	NA	NA
Cefpodoxime	57	0.03	2	≤0.015	4	79.0	7.0	14.0	79.0	79.0	0	21.1
Ceftriaxone	57	0.03	0.06	0.03	0.06	100.0	0	0	100.0	100.0	0	0
Cefuroxime	57	0.03	1	≤0.015	4	91.2	5.3	3.5	91.2	86.0	1.8	12.3
Ciprofloxacin	57	0.03	0.5	0.015	2	NA	NA	NA	96.5	71.9	28.1	0
Clarithromycin	57	0.03	>256	≤0.015	>256	73.7	0	26.3	NA	NA	NA	NA
Levofloxacin	57	0.25	4	0.12	4	100.0	0	0	100.0	100.0	—	0
Moxifloxacin	57	0.015	0.03	0.015	0.5	100.0	0	0	100.0	100.0	—	0
Penicillin (oral)	57	0.015	0.03	0.015	0.06	59.6	40.4	0	NA	59.6	40.4	0
Penicillin (iv)	57	0.03	0.5	0.004	1	100.0	0	0	NA	94.7–100.0	NA	NA
Erythromycin^b	57	NT	NT	NT	NT	73.7	0	26.3	NA	73.7	0	26.3

Susceptibility

MIC (mg/L)

CLSI

PK/PD

EUCAST

Antimicrobial

50%

90%

min

max

Amoxicillin

0.015

0.06

0.015

0.06

100.0

AMC^a

0.015

≤0.015

96.5

3.5

96.5 (100)

Azithromycin

0.5

>256

≤0.015

>256

73.7

26.3

Cefaclor

0.25

0.06

79.0

7.0

14.0

71.9

28.1

Cefepime

0.03

100.0

Cefixime

0.25

0.5

0.25

0.5

100.0

Cefpodoxime

0.03

≤0.015

79.0

7.0

14.0

79.0

21.1

Ceftriaxone

0.03

0.06

0.03

0.06

100.0

Cefuroxime

0.03

≤0.015

91.2

5.3

3.5

91.2

86.0

1.8

12.3

Ciprofloxacin

0.03

0.5

0.015

96.5

71.9

28.1

Clarithromycin

0.03

>256

≤0.015

>256

73.7

26.3

Levofloxacin

0.25

0.12

100.0

—

Moxifloxacin

0.015

0.03

0.015

0.5

100.0

—

Penicillin (oral)

0.015

0.03

0.015

0.06

59.6

40.4

59.6

40.4

Penicillin (iv)

0.03

0.5

0.004

100.0

94.7–100.0

Erythromycin^b

73.7

26.3

73.7

26.3

						Susceptibility
Amoxicillin	57	0.015	0.06	0.015	0.06	100.0	0	0	100.0	NA	NA	NA
AMC^a	57	0.015	1	≤0.015	4	96.5	3.5	0	96.5 (100)	NA	NA	NA
Azithromycin	57	0.5	>256	≤0.015	>256	73.7	0	26.3	NA	NA	NA	NA
Cefaclor	57	0.25	8	0.06	8	79.0	7.0	14.0	71.9	0	71.9	28.1
Cefepime	57	0.03	0.03	0.03	0.03	100.0	0	0	NA	100.0	0	0
Cefixime	57	0.25	0.5	0.25	0.5	NA	NA	NA	100.0	NA	NA	NA
Cefpodoxime	57	0.03	2	≤0.015	4	79.0	7.0	14.0	79.0	79.0	0	21.1
Ceftriaxone	57	0.03	0.06	0.03	0.06	100.0	0	0	100.0	100.0	0	0
Cefuroxime	57	0.03	1	≤0.015	4	91.2	5.3	3.5	91.2	86.0	1.8	12.3
Ciprofloxacin	57	0.03	0.5	0.015	2	NA	NA	NA	96.5	71.9	28.1	0
Clarithromycin	57	0.03	>256	≤0.015	>256	73.7	0	26.3	NA	NA	NA	NA
Levofloxacin	57	0.25	4	0.12	4	100.0	0	0	100.0	100.0	—	0
Moxifloxacin	57	0.015	0.03	0.015	0.5	100.0	0	0	100.0	100.0	—	0
Penicillin (oral)	57	0.015	0.03	0.015	0.06	59.6	40.4	0	NA	59.6	40.4	0
Penicillin (iv)	57	0.03	0.5	0.004	1	100.0	0	0	NA	94.7–100.0	NA	NA
Erythromycin^b	57	NT	NT	NT	NT	73.7	0	26.3	NA	73.7	0	26.3

Table 4.

Open in new tab

MIC and susceptibility results for all S. pneumoniae isolates from Lebanon

						Susceptibility
		MIC (mg/L)				CLSI			PK/PD	EUCAST
Antimicrobial	n	50%	90%	min	max	%S	%I	%R	%S	%S	%I	%R
Amoxicillin	57	0.015	0.06	0.015	0.06	100.0	0	0	100.0	NA	NA	NA
AMC^a	57	0.015	1	≤0.015	4	96.5	3.5	0	96.5 (100)	NA	NA	NA
Azithromycin	57	0.5	>256	≤0.015	>256	73.7	0	26.3	NA	NA	NA	NA
Cefaclor	57	0.25	8	0.06	8	79.0	7.0	14.0	71.9	0	71.9	28.1
Cefepime	57	0.03	0.03	0.03	0.03	100.0	0	0	NA	100.0	0	0
Cefixime	57	0.25	0.5	0.25	0.5	NA	NA	NA	100.0	NA	NA	NA
Cefpodoxime	57	0.03	2	≤0.015	4	79.0	7.0	14.0	79.0	79.0	0	21.1
Ceftriaxone	57	0.03	0.06	0.03	0.06	100.0	0	0	100.0	100.0	0	0
Cefuroxime	57	0.03	1	≤0.015	4	91.2	5.3	3.5	91.2	86.0	1.8	12.3
Ciprofloxacin	57	0.03	0.5	0.015	2	NA	NA	NA	96.5	71.9	28.1	0
Clarithromycin	57	0.03	>256	≤0.015	>256	73.7	0	26.3	NA	NA	NA	NA
Levofloxacin	57	0.25	4	0.12	4	100.0	0	0	100.0	100.0	—	0
Moxifloxacin	57	0.015	0.03	0.015	0.5	100.0	0	0	100.0	100.0	—	0
Penicillin (oral)	57	0.015	0.03	0.015	0.06	59.6	40.4	0	NA	59.6	40.4	0
Penicillin (iv)	57	0.03	0.5	0.004	1	100.0	0	0	NA	94.7–100.0	NA	NA
Erythromycin^b	57	NT	NT	NT	NT	73.7	0	26.3	NA	73.7	0	26.3

						Susceptibility
		MIC (mg/L)				CLSI			PK/PD	EUCAST
Antimicrobial	n	50%	90%	min	max	%S	%I	%R	%S	%S	%I	%R
Amoxicillin	57	0.015	0.06	0.015	0.06	100.0	0	0	100.0	NA	NA	NA
AMC^a	57	0.015	1	≤0.015	4	96.5	3.5	0	96.5 (100)	NA	NA	NA
Azithromycin	57	0.5	>256	≤0.015	>256	73.7	0	26.3	NA	NA	NA	NA
Cefaclor	57	0.25	8	0.06	8	79.0	7.0	14.0	71.9	0	71.9	28.1
Cefepime	57	0.03	0.03	0.03	0.03	100.0	0	0	NA	100.0	0	0
Cefixime	57	0.25	0.5	0.25	0.5	NA	NA	NA	100.0	NA	NA	NA
Cefpodoxime	57	0.03	2	≤0.015	4	79.0	7.0	14.0	79.0	79.0	0	21.1
Ceftriaxone	57	0.03	0.06	0.03	0.06	100.0	0	0	100.0	100.0	0	0
Cefuroxime	57	0.03	1	≤0.015	4	91.2	5.3	3.5	91.2	86.0	1.8	12.3
Ciprofloxacin	57	0.03	0.5	0.015	2	NA	NA	NA	96.5	71.9	28.1	0
Clarithromycin	57	0.03	>256	≤0.015	>256	73.7	0	26.3	NA	NA	NA	NA
Levofloxacin	57	0.25	4	0.12	4	100.0	0	0	100.0	100.0	—	0
Moxifloxacin	57	0.015	0.03	0.015	0.5	100.0	0	0	100.0	100.0	—	0
Penicillin (oral)	57	0.015	0.03	0.015	0.06	59.6	40.4	0	NA	59.6	40.4	0
Penicillin (iv)	57	0.03	0.5	0.004	1	100.0	0	0	NA	94.7–100.0	NA	NA
Erythromycin^b	57	NT	NT	NT	NT	73.7	0	26.3	NA	73.7	0	26.3

min, minimum; max, maximum; AMC, amoxicillin/clavulanate; S, susceptible; I, intermediate; R, resistant; NT, not tested; NA, no breakpoint data available (NA for azithromycin and clarithromycin by EUCAST because Etest^® breakpoints in CO₂ not available).

^aPK/PD susceptibility at high dose is shown in parentheses.

^bUsing S/I/R zone diameters (mm) of CLSI (≤15/16–20/≥21) and EUCAST (≤18/19–21/≥22).

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