| Virus . | Mouse . | Rat . | Hamster . | Ferret . | NHP . |
|---|---|---|---|---|---|
| Phenuiviridae | … | … | … | … | … |
| RVFV | Lethal hepatic disease by all routes and ages | Hepatic or neurologic disease, depending on strain and inoculation route. Vertical transmission in pregnant rats. | Lethal hepatic disease | Neurologic disease, depending on inoculation route | Mild febrile disease or lethal neurologic disease depending on exposure route and NHP species |
| PTV | Lethal in newborn mice; virus strain-dependent lethality in adult animals | N/A | Virus strain-dependent lethality in adult animals | N/A | N/A |
| TOSV | Lethal in adult mice after IC infection with a neuroadapted strain | N/A | N/A | N/A | N/A |
| SFTSV | Lethal in immunodeficient mice | Lethal in newborn rats; nonlethal infection in adult rats | Lethal in STAT2 KO hamsters | Lethal disease in aged animals | Mild disease |
| HRTV | Lethal in immunodeficient mice | Lethal in newborn rats; nonlethal infection in adult rats | Lethal in STAT2 KO hamsters | N/A | Mild disease |
| Peribunyaviridae | … | … | … | … | … |
| LACV | Lethal in newborn mice; lethal by IN or IC infection in adult mice | N/A | N/A | N/A | Mild disease in rhesus macaques |
| OROV | Lethal in newborn mice; lethal by IC infection of adult mice | N/A | Neurologic disease after IP or IC inoculation of adult animals | N/A | N/A |
| CVV | Lethal in adult immunodeficient mice; vertical transmission in pregnant mice | N/A | N/A | N/A | N/A |
| SBV | Lethal in adult immunodeficient mice | N/A | N/A | N/A | N/A |
| Nairoviridae | … | … | … | … | … |
| CCHFV | Lethal disease in immunodeficient, immunosuppressed, humanized adult mice | N/A | STAT2 KO | N/A | Mild disease; severe disease with Hoti strain |
| HAZV | Lethal disease in immunodeficient adult mice | N/A | N/A | N/A | N/A |
| DUGV | Lethal in newborn mice; lethal by IN or IC infection in adult mice | N/A | N/A | N/A | N/A |
| Hantaviridae | … | … | … | … | … |
| ANDV | Asymptomatic transient infection of deer mice | N/A | Lethal in adult animals | N/A | N/A |
| SNV | Asymptomatic persistent infection of deer mice | N/A | Mild sublethal disease in immunocompetent hamsters; lethal disease in immunosuppressed hamsters; hamster-adapted strain causes more severe disease in adults | … | Lethal in rhesus macaques after respiratory exposure (deer-mice passaged virus only) |
| HTNV | Lethal in newborn mice; some adult mouse strains susceptible to disease when injected IP; lethal in immunodeficient adult mice | N/A | Persistent asymptomatic infection | Persistent asymptomatic infection | Asymptomatic disease in marmosets |
| SEOV | Lethal in immunodeficient adult mice | Persistent asymptomatic infection | Persistent asymptomatic infection | … | … |
| PUUV | No disease in adult mice | N/A | Persistent asymptomatic infection | Persistent asymptomatic infection | Mild clinical disease in cynomolgus macaques |
| Virus . | Mouse . | Rat . | Hamster . | Ferret . | NHP . |
|---|---|---|---|---|---|
| Phenuiviridae | … | … | … | … | … |
| RVFV | Lethal hepatic disease by all routes and ages | Hepatic or neurologic disease, depending on strain and inoculation route. Vertical transmission in pregnant rats. | Lethal hepatic disease | Neurologic disease, depending on inoculation route | Mild febrile disease or lethal neurologic disease depending on exposure route and NHP species |
| PTV | Lethal in newborn mice; virus strain-dependent lethality in adult animals | N/A | Virus strain-dependent lethality in adult animals | N/A | N/A |
| TOSV | Lethal in adult mice after IC infection with a neuroadapted strain | N/A | N/A | N/A | N/A |
| SFTSV | Lethal in immunodeficient mice | Lethal in newborn rats; nonlethal infection in adult rats | Lethal in STAT2 KO hamsters | Lethal disease in aged animals | Mild disease |
| HRTV | Lethal in immunodeficient mice | Lethal in newborn rats; nonlethal infection in adult rats | Lethal in STAT2 KO hamsters | N/A | Mild disease |
| Peribunyaviridae | … | … | … | … | … |
| LACV | Lethal in newborn mice; lethal by IN or IC infection in adult mice | N/A | N/A | N/A | Mild disease in rhesus macaques |
| OROV | Lethal in newborn mice; lethal by IC infection of adult mice | N/A | Neurologic disease after IP or IC inoculation of adult animals | N/A | N/A |
| CVV | Lethal in adult immunodeficient mice; vertical transmission in pregnant mice | N/A | N/A | N/A | N/A |
| SBV | Lethal in adult immunodeficient mice | N/A | N/A | N/A | N/A |
| Nairoviridae | … | … | … | … | … |
| CCHFV | Lethal disease in immunodeficient, immunosuppressed, humanized adult mice | N/A | STAT2 KO | N/A | Mild disease; severe disease with Hoti strain |
| HAZV | Lethal disease in immunodeficient adult mice | N/A | N/A | N/A | N/A |
| DUGV | Lethal in newborn mice; lethal by IN or IC infection in adult mice | N/A | N/A | N/A | N/A |
| Hantaviridae | … | … | … | … | … |
| ANDV | Asymptomatic transient infection of deer mice | N/A | Lethal in adult animals | N/A | N/A |
| SNV | Asymptomatic persistent infection of deer mice | N/A | Mild sublethal disease in immunocompetent hamsters; lethal disease in immunosuppressed hamsters; hamster-adapted strain causes more severe disease in adults | … | Lethal in rhesus macaques after respiratory exposure (deer-mice passaged virus only) |
| HTNV | Lethal in newborn mice; some adult mouse strains susceptible to disease when injected IP; lethal in immunodeficient adult mice | N/A | Persistent asymptomatic infection | Persistent asymptomatic infection | Asymptomatic disease in marmosets |
| SEOV | Lethal in immunodeficient adult mice | Persistent asymptomatic infection | Persistent asymptomatic infection | … | … |
| PUUV | No disease in adult mice | N/A | Persistent asymptomatic infection | Persistent asymptomatic infection | Mild clinical disease in cynomolgus macaques |
Abbreviations: ANDV, Andes virus; DUGV, Dugbe virus; HAZV, Hazara virus; HRTV, Heartland virus; IC, intracerebral; IN, intranasal; IP, intraperitoneal; KO, knockout; LACV, La Crosse virus; N/A, no information available or not tested; NHP, nonhuman primate; PTV, Punta Toro virus; PUUV, Puumala virus; RVFV, Rift Valley fever virus; SEOV, Seoul virus; SFTSV, severe fever with thrombocytopenia syndrome virus; SNV, Sin Nombre virus; TOSV, Toscana virus.
| Virus . | Mouse . | Rat . | Hamster . | Ferret . | NHP . |
|---|---|---|---|---|---|
| Phenuiviridae | … | … | … | … | … |
| RVFV | Lethal hepatic disease by all routes and ages | Hepatic or neurologic disease, depending on strain and inoculation route. Vertical transmission in pregnant rats. | Lethal hepatic disease | Neurologic disease, depending on inoculation route | Mild febrile disease or lethal neurologic disease depending on exposure route and NHP species |
| PTV | Lethal in newborn mice; virus strain-dependent lethality in adult animals | N/A | Virus strain-dependent lethality in adult animals | N/A | N/A |
| TOSV | Lethal in adult mice after IC infection with a neuroadapted strain | N/A | N/A | N/A | N/A |
| SFTSV | Lethal in immunodeficient mice | Lethal in newborn rats; nonlethal infection in adult rats | Lethal in STAT2 KO hamsters | Lethal disease in aged animals | Mild disease |
| HRTV | Lethal in immunodeficient mice | Lethal in newborn rats; nonlethal infection in adult rats | Lethal in STAT2 KO hamsters | N/A | Mild disease |
| Peribunyaviridae | … | … | … | … | … |
| LACV | Lethal in newborn mice; lethal by IN or IC infection in adult mice | N/A | N/A | N/A | Mild disease in rhesus macaques |
| OROV | Lethal in newborn mice; lethal by IC infection of adult mice | N/A | Neurologic disease after IP or IC inoculation of adult animals | N/A | N/A |
| CVV | Lethal in adult immunodeficient mice; vertical transmission in pregnant mice | N/A | N/A | N/A | N/A |
| SBV | Lethal in adult immunodeficient mice | N/A | N/A | N/A | N/A |
| Nairoviridae | … | … | … | … | … |
| CCHFV | Lethal disease in immunodeficient, immunosuppressed, humanized adult mice | N/A | STAT2 KO | N/A | Mild disease; severe disease with Hoti strain |
| HAZV | Lethal disease in immunodeficient adult mice | N/A | N/A | N/A | N/A |
| DUGV | Lethal in newborn mice; lethal by IN or IC infection in adult mice | N/A | N/A | N/A | N/A |
| Hantaviridae | … | … | … | … | … |
| ANDV | Asymptomatic transient infection of deer mice | N/A | Lethal in adult animals | N/A | N/A |
| SNV | Asymptomatic persistent infection of deer mice | N/A | Mild sublethal disease in immunocompetent hamsters; lethal disease in immunosuppressed hamsters; hamster-adapted strain causes more severe disease in adults | … | Lethal in rhesus macaques after respiratory exposure (deer-mice passaged virus only) |
| HTNV | Lethal in newborn mice; some adult mouse strains susceptible to disease when injected IP; lethal in immunodeficient adult mice | N/A | Persistent asymptomatic infection | Persistent asymptomatic infection | Asymptomatic disease in marmosets |
| SEOV | Lethal in immunodeficient adult mice | Persistent asymptomatic infection | Persistent asymptomatic infection | … | … |
| PUUV | No disease in adult mice | N/A | Persistent asymptomatic infection | Persistent asymptomatic infection | Mild clinical disease in cynomolgus macaques |
| Virus . | Mouse . | Rat . | Hamster . | Ferret . | NHP . |
|---|---|---|---|---|---|
| Phenuiviridae | … | … | … | … | … |
| RVFV | Lethal hepatic disease by all routes and ages | Hepatic or neurologic disease, depending on strain and inoculation route. Vertical transmission in pregnant rats. | Lethal hepatic disease | Neurologic disease, depending on inoculation route | Mild febrile disease or lethal neurologic disease depending on exposure route and NHP species |
| PTV | Lethal in newborn mice; virus strain-dependent lethality in adult animals | N/A | Virus strain-dependent lethality in adult animals | N/A | N/A |
| TOSV | Lethal in adult mice after IC infection with a neuroadapted strain | N/A | N/A | N/A | N/A |
| SFTSV | Lethal in immunodeficient mice | Lethal in newborn rats; nonlethal infection in adult rats | Lethal in STAT2 KO hamsters | Lethal disease in aged animals | Mild disease |
| HRTV | Lethal in immunodeficient mice | Lethal in newborn rats; nonlethal infection in adult rats | Lethal in STAT2 KO hamsters | N/A | Mild disease |
| Peribunyaviridae | … | … | … | … | … |
| LACV | Lethal in newborn mice; lethal by IN or IC infection in adult mice | N/A | N/A | N/A | Mild disease in rhesus macaques |
| OROV | Lethal in newborn mice; lethal by IC infection of adult mice | N/A | Neurologic disease after IP or IC inoculation of adult animals | N/A | N/A |
| CVV | Lethal in adult immunodeficient mice; vertical transmission in pregnant mice | N/A | N/A | N/A | N/A |
| SBV | Lethal in adult immunodeficient mice | N/A | N/A | N/A | N/A |
| Nairoviridae | … | … | … | … | … |
| CCHFV | Lethal disease in immunodeficient, immunosuppressed, humanized adult mice | N/A | STAT2 KO | N/A | Mild disease; severe disease with Hoti strain |
| HAZV | Lethal disease in immunodeficient adult mice | N/A | N/A | N/A | N/A |
| DUGV | Lethal in newborn mice; lethal by IN or IC infection in adult mice | N/A | N/A | N/A | N/A |
| Hantaviridae | … | … | … | … | … |
| ANDV | Asymptomatic transient infection of deer mice | N/A | Lethal in adult animals | N/A | N/A |
| SNV | Asymptomatic persistent infection of deer mice | N/A | Mild sublethal disease in immunocompetent hamsters; lethal disease in immunosuppressed hamsters; hamster-adapted strain causes more severe disease in adults | … | Lethal in rhesus macaques after respiratory exposure (deer-mice passaged virus only) |
| HTNV | Lethal in newborn mice; some adult mouse strains susceptible to disease when injected IP; lethal in immunodeficient adult mice | N/A | Persistent asymptomatic infection | Persistent asymptomatic infection | Asymptomatic disease in marmosets |
| SEOV | Lethal in immunodeficient adult mice | Persistent asymptomatic infection | Persistent asymptomatic infection | … | … |
| PUUV | No disease in adult mice | N/A | Persistent asymptomatic infection | Persistent asymptomatic infection | Mild clinical disease in cynomolgus macaques |
Abbreviations: ANDV, Andes virus; DUGV, Dugbe virus; HAZV, Hazara virus; HRTV, Heartland virus; IC, intracerebral; IN, intranasal; IP, intraperitoneal; KO, knockout; LACV, La Crosse virus; N/A, no information available or not tested; NHP, nonhuman primate; PTV, Punta Toro virus; PUUV, Puumala virus; RVFV, Rift Valley fever virus; SEOV, Seoul virus; SFTSV, severe fever with thrombocytopenia syndrome virus; SNV, Sin Nombre virus; TOSV, Toscana virus.
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