Table 5. Open in new tab Meta-analysis...

SNP

Chr

Position

Locus

pval

p.fdr

I²

CQp

rs145019385

54252139

DIO1

0.036

0.070

.61

.85

0.21

rs12033572

54369674

DIO1

0.019

0.051

.70

.87

<0.05

rs2235544

54375570

DIO1

0.094

0.020

<.001

<.001^a

<0.001

rs954878

54578401

DIO1

−0.048

0.020

.02

.08

0.01

rs4954192

1.36E+08

ACMSD

−0.047

0.021

.02

.08

0.84

rs6785807

1.82E+08

SOX2-OT

−0.026

0.027

.34

.62

0.45

rs6854291

1.71E+08

AADAT

0.101

0.036

<.01

.033^a

<0.001

rs10946313

19381386

ID4

0.023

0.021

.28

.54

0.73

rs9356988

25777481

SLC17A4

−0.005

0.023

.83

.88

0.37

rs137964359

26001742

SLC17A4

−0.051

0.085

.55

.81

0.60

rs17185536

1.01E+08

LOC728012

0.073

0.025

<.01

.033^a

0.68

rs67583169

61212179

CA8

0.013

0.030

.66

.85

>0.99

rs10119187

4223660

GLIS3

−0.023

0.027

.40

.69

0.91

rs10739496

1.01E+08

FOXE1

0.006

0.022

.77

.88

<0.01

rs10984606

1.01E+08

FOXE1

0.047

0.020

.02

.08

<0.05

rs10818937

1.27E+08

NEK6

0.014

0.022

.51

.80

0.52

rs4842131

1.39E+08

LHX3

−0.056

0.021

.01

.06

0.34

rs55679545

1.39E+08

LHX3

0.019

0.024

.43

.71

0.82

rs11039355

47737501

FNBP4

−0.007

0.022

.74

.88

0.03

rs4149056

21331549

SLCO1B1

−0.037

0.029

.20

.41

0.84

rs150816132

80464293

DIO2

−0.146

0.103

.16

.35

0.01

rs978055

80534869

DIO2

−0.010

0.021

.64

.85

0.09

rs225014

80669580

DIO2

−0.003

0.021

.88

.91

0.79

rs12323871

1.02E+08

DIO3OS

−0.060

0.026

.02

.08

0.73

rs11626434

1.02E+08

DIO3OS

0.038

0.021

.07

.19

0.02

rs12907106

63873658

USP3

−0.002

0.023

.92

0.21

rs8063103

12703395

SNX29

−0.042

0.029

.15

.35

0.02

rs11078333

16049626

NCOR1

0.046

0.021

.03

.08

0.16

rs1080094

29173795

SLC25A52

0.005

0.021

.81

.88

0.68

rs113107469

29306737

SLC25A52

0.234

0.055

<.001

<.001^a

<0.01

rs56069042

57914644

MC4R

0.108

0.058

.06

.18

0.44

Table 5.

Open in new tab

Meta-analysis FT4 SNPs with FT3 concentrations.

SNP	Chr	Position	Locus	A1	A2	B	se	pval	p.fdr	I²	CQp
rs145019385	1	54252139	DIO1	t	c	0.036	0.070	.61	.85	37	0.21
rs12033572	1	54369674	DIO1	c	g	0.019	0.051	.70	.87	74	<0.05
rs2235544	1	54375570	DIO1	a	c	0.094	0.020	<.001	<.001^a	98	<0.001
rs954878	1	54578401	DIO1	a	g	−0.048	0.020	.02	.08	83	0.01
rs4954192	2	1.36E+08	ACMSD	t	c	−0.047	0.021	.02	.08	0	0.84
rs6785807	3	1.82E+08	SOX2-OT	a	g	−0.026	0.027	.34	.62	0	0.45
rs6854291	4	1.71E+08	AADAT	a	g	0.101	0.036	<.01	.033^a	95	<0.001
rs10946313	6	19381386	ID4	t	c	0.023	0.021	.28	.54	0	0.73
rs9356988	6	25777481	SLC17A4	a	g	−0.005	0.023	.83	.88	0	0.37
rs137964359	6	26001742	SLC17A4	t	c	−0.051	0.085	.55	.81	0	0.60
rs17185536	6	1.01E+08	LOC728012	t	c	0.073	0.025	<.01	.033^a	0	0.68
rs67583169	8	61212179	CA8	c	g	0.013	0.030	.66	.85	0	>0.99
rs10119187	9	4223660	GLIS3	t	c	−0.023	0.027	.40	.69	0	0.91
rs10739496	9	1.01E+08	FOXE1	t	c	0.006	0.022	.77	.88	91	<0.01
rs10984606	9	1.01E+08	FOXE1	t	g	0.047	0.020	.02	.08	75	<0.05
rs10818937	9	1.27E+08	NEK6	t	c	0.014	0.022	.51	.80	0	0.52
rs4842131	9	1.39E+08	LHX3	t	c	−0.056	0.021	.01	.06	0	0.34
rs55679545	9	1.39E+08	LHX3	a	g	0.019	0.024	.43	.71	0	0.82
rs11039355	11	47737501	FNBP4	t	c	−0.007	0.022	.74	.88	79	0.03
rs4149056	12	21331549	SLCO1B1	t	c	−0.037	0.029	.20	.41	0	0.84
rs150816132	14	80464293	DIO2	a	g	−0.146	0.103	.16	.35	87	0.01
rs978055	14	80534869	DIO2	a	t	−0.010	0.021	.64	.85	65	0.09
rs225014	14	80669580	DIO2	t	c	−0.003	0.021	.88	.91	0	0.79
rs12323871	14	1.02E+08	DIO3OS	t	c	−0.060	0.026	.02	.08	0	0.73
rs11626434	14	1.02E+08	DIO3OS	c	g	0.038	0.021	.07	.19	82	0.02
rs12907106	15	63873658	USP3	c	g	−0.002	0.023	.92	.92	37	0.21
rs8063103	16	12703395	SNX29	c	g	−0.042	0.029	.15	.35	82	0.02
rs11078333	17	16049626	NCOR1	a	t	0.046	0.021	.03	.08	49	0.16
rs1080094	18	29173795	SLC25A52	a	g	0.005	0.021	.81	.88	0	0.68
rs113107469	18	29306737	SLC25A52	t	c	0.234	0.055	<.001	<.001^a	88	<0.01
rs56069042	18	57914644	MC4R	a	g	0.108	0.058	.06	.18	0	0.44

SNP	Chr	Position	Locus	A1	A2	B	se	pval	p.fdr	I²	CQp
rs145019385	1	54252139	DIO1	t	c	0.036	0.070	.61	.85	37	0.21
rs12033572	1	54369674	DIO1	c	g	0.019	0.051	.70	.87	74	<0.05
rs2235544	1	54375570	DIO1	a	c	0.094	0.020	<.001	<.001^a	98	<0.001
rs954878	1	54578401	DIO1	a	g	−0.048	0.020	.02	.08	83	0.01
rs4954192	2	1.36E+08	ACMSD	t	c	−0.047	0.021	.02	.08	0	0.84
rs6785807	3	1.82E+08	SOX2-OT	a	g	−0.026	0.027	.34	.62	0	0.45
rs6854291	4	1.71E+08	AADAT	a	g	0.101	0.036	<.01	.033^a	95	<0.001
rs10946313	6	19381386	ID4	t	c	0.023	0.021	.28	.54	0	0.73
rs9356988	6	25777481	SLC17A4	a	g	−0.005	0.023	.83	.88	0	0.37
rs137964359	6	26001742	SLC17A4	t	c	−0.051	0.085	.55	.81	0	0.60
rs17185536	6	1.01E+08	LOC728012	t	c	0.073	0.025	<.01	.033^a	0	0.68
rs67583169	8	61212179	CA8	c	g	0.013	0.030	.66	.85	0	>0.99
rs10119187	9	4223660	GLIS3	t	c	−0.023	0.027	.40	.69	0	0.91
rs10739496	9	1.01E+08	FOXE1	t	c	0.006	0.022	.77	.88	91	<0.01
rs10984606	9	1.01E+08	FOXE1	t	g	0.047	0.020	.02	.08	75	<0.05
rs10818937	9	1.27E+08	NEK6	t	c	0.014	0.022	.51	.80	0	0.52
rs4842131	9	1.39E+08	LHX3	t	c	−0.056	0.021	.01	.06	0	0.34
rs55679545	9	1.39E+08	LHX3	a	g	0.019	0.024	.43	.71	0	0.82
rs11039355	11	47737501	FNBP4	t	c	−0.007	0.022	.74	.88	79	0.03
rs4149056	12	21331549	SLCO1B1	t	c	−0.037	0.029	.20	.41	0	0.84
rs150816132	14	80464293	DIO2	a	g	−0.146	0.103	.16	.35	87	0.01
rs978055	14	80534869	DIO2	a	t	−0.010	0.021	.64	.85	65	0.09
rs225014	14	80669580	DIO2	t	c	−0.003	0.021	.88	.91	0	0.79
rs12323871	14	1.02E+08	DIO3OS	t	c	−0.060	0.026	.02	.08	0	0.73
rs11626434	14	1.02E+08	DIO3OS	c	g	0.038	0.021	.07	.19	82	0.02
rs12907106	15	63873658	USP3	c	g	−0.002	0.023	.92	.92	37	0.21
rs8063103	16	12703395	SNX29	c	g	−0.042	0.029	.15	.35	82	0.02
rs11078333	17	16049626	NCOR1	a	t	0.046	0.021	.03	.08	49	0.16
rs1080094	18	29173795	SLC25A52	a	g	0.005	0.021	.81	.88	0	0.68
rs113107469	18	29306737	SLC25A52	t	c	0.234	0.055	<.001	<.001^a	88	<0.01
rs56069042	18	57914644	MC4R	a	g	0.108	0.058	.06	.18	0	0.44

Abbreviations: A1, Allele 1; A2, Allele 2; b, beta A1; Chr, chromosome; CQp, P-value of Cochran's Q test for heterogeneity; I², percentage of variance that is attributable to study heterogeneity; p.fdr, false discovery rate corrected P-value; pval, P-value; se, standard error; SNP, single nucleotide polymorphism.

p.fdr >.05 in model with random intercepts.

This Feature Is Available To Subscribers Only